| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acute Kidney Injury | D058186 | 34 associated lipids |
| Airway Remodeling | D056151 | 3 associated lipids |
| Acute Coronary Syndrome | D054058 | 11 associated lipids |
| Hypoalphalipoproteinemias | D052456 | 5 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Dyslipidemias | D050171 | 7 associated lipids |
| Cholecystitis, Acute | D041881 | 1 associated lipids |
| Pulmonary Disease, Chronic Obstructive | D029424 | 16 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Coronary Stenosis | D023921 | 6 associated lipids |
Thromboxane b2
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
Cross Reference
Introduction
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thromboxane b2?
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
PubChem Associated disorders and diseases
What pathways are associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thromboxane b2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Thromboxane b2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Thromboxane b2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thromboxane b2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Best LC et al. | The interrelationship between thromboxane biosynthesis, aggregation and 5-hydroxytryptamine secretion in human platelets in vitro. | 1980 | Thromb. Haemost. | pmid:6773171 |
| Miller KW and Keith JC | Effect of thromboxane synthetase inhibition on platelet function and morphology during ovine pregnancy-induced hypertension. | 1988 | Thromb. Haemost. | pmid:3238644 |
| Joseph S et al. | Effect of the polyamine-spermine on agonist-induced human platelet activation--specific inhibition of "aggregation-independent" events induced by thrombin, but not by collagen, thromboxane mimetic, phorbol ester or calcium ionophore. | 1987 | Thromb. Haemost. | pmid:3110996 |
| Hansen JB et al. | The effect of lipopolysaccharides (LPS) on generation of thromboxane A2 and thromboplastin activity in whole blood of males, females and females on oral contraceptives. | 1989 | Thromb. Haemost. | pmid:2799762 |
| Siess W et al. | Stimulated platelet aggregation, thromboxane B2 formation and platelet sensitivity to prostacyclin - a critical evaluation. | 1981 | Thromb. Haemost. | pmid:7025338 |
| Watanabe J et al. | Effect of vitamin E on platelet aggregation in diabetes mellitus. | 1984 | Thromb. Haemost. | pmid:6495252 |
| Matsumoto M et al. | Thromboxane generation in patients with essential hypertension or cerebrovascular disease and effect of oral aspirin. | 1980 | Thromb. Haemost. | pmid:7423441 |
| Spectre G et al. | Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications. | 2011 | Thromb. Haemost. | pmid:21800009 |
| Gresele P et al. | Picotamide protects mice from death in a pulmonary embolism model by a mechanism independent from thromboxane suppression. | 1990 | Thromb. Haemost. | pmid:2274931 |
| Scharf RE | In vitro thromboxane synthesis of depleted blood platelets following renal transplantation. | 1990 | Thromb. Haemost. | pmid:2148845 |
| Hoet B et al. | Ridogrel, a combined thromboxane synthase inhibitor and receptor blocker, decreases elevated plasma beta-thromboglobulin levels in patients with documented peripheral arterial disease. | 1990 | Thromb. Haemost. | pmid:2148849 |
| Cattaneo M et al. | Human platelet aggregation and release reaction induced by platelet activating factor (PAF-acether)--effects of acetylsalicylic acid and external ionized calcium. | 1985 | Thromb. Haemost. | pmid:3927505 |
| Crescente M et al. | Gallic acid, a dietary polyphenolic component, blunts the inhibition of platelet COX-1 by aspirin: preliminary in-vitro findings. | 2007 | Thromb. Haemost. | pmid:17549313 |
| Undas A et al. | Lack of aspirin-induced decrease in thrombin formation in subjects resistant to aspirin. | 2007 | Thromb. Haemost. | pmid:17549314 |
| Perneby C et al. | Dose- and time-dependent antiplatelet effects of aspirin. | 2006 | Thromb. Haemost. | pmid:16601836 |
| Hampton KK et al. | Coagulation, fibrinolytic and platelet function in patients on long-term therapy with aspirin 300 mg or 1,200 mg daily compared with placebo. | 1990 | Thromb. Haemost. | pmid:2073296 |
| Dragani A et al. | Oxidative stress and platelet activation in subjects with moderate hyperhomocysteinaemia due to MTHFR 677 C→T polymorphism. | 2012 | Thromb. Haemost. | pmid:22782530 |
| Gordge MP et al. | Platelet function and the bleeding time in progressive renal failure. | 1988 | Thromb. Haemost. | pmid:3187950 |
| D'Angelo A et al. | Effect of des-amino-D-arginine vasopressin (DDAVP) on plasma levels of platelet and endothelial cell release products. | 1983 | Thromb. Haemost. | pmid:6687766 |
| Vezza R et al. | Antivasoconstrictor and antiaggregatory activities of picotamide unrelated to thromboxane A2 antagonism. | 1997 | Thromb. Haemost. | pmid:9408024 |
| Han P et al. | Verapamil and collagen-induced platelet reactions--evidence for a role for intracellular calcium in platelet activation. | 1983 | Thromb. Haemost. | pmid:6415847 |
| Guthikonda S et al. | Increased platelet sensitivity among individuals with aspirin resistance - platelet aggregation to submaximal concentration of arachidonic acid predicts response to antiplatelet therapy. | 2008 | Thromb. Haemost. | pmid:18612542 |
| Gresele P et al. | Platelet activation markers in patients with peripheral arterial disease--a prospective comparison of different platelet function tests. | 1997 | Thromb. Haemost. | pmid:9423790 |
| Naesh O et al. | Platelet function in surgical stress. | 1985 | Thromb. Haemost. | pmid:2935969 |
| Davì G et al. | The effect of two low doses of aspirin on whole blood thromboxane and prostacyclin generation in healthy subjects. | 1983 | Thromb. Haemost. | pmid:6417815 |
| Michelson AD et al. | Reversible inhibition of human platelet activation by hypothermia in vivo and in vitro. | 1994 | Thromb. Haemost. | pmid:7522354 |
| Hornby EJ et al. | The inhibitory effect of GR32191, a thromboxane receptor blocking drug, on human platelet aggregation, adhesion and secretion. | 1989 | Thromb. Haemost. | pmid:2529661 |
| Husted SE et al. | Intravenous acetylsalicylic acid--dose-related effects on platelet function and fibrinolysis in healthy males. | 1992 | Thromb. Haemost. | pmid:1412171 |
| Subbiah MT et al. | Studies of aggregation and thromboxane B2 synthesis in avian thrombocytes: comparison between atherosclerosis-susceptible and resistant breeds. | 1980 | Thromb. Haemost. | pmid:7455983 |
| Halawani SH et al. | Aspirin failure in patients presenting with acute cerebrovascular ischaemia. | 2011 | Thromb. Haemost. | pmid:21544317 |
| Patrono C et al. | Characterization of biochemical and functional effects of antiplatelet drugs as a key to their clinical development. | 1995 | Thromb. Haemost. | pmid:8578493 |
| Cortellaro M et al. | Transcoronary platelet thromboxane A2 formation without platelet trapping in patients with coronary stenosis-effect of sulphinpyrazone treatment. | 1983 | Thromb. Haemost. | pmid:6665767 |
| Szczeklik A et al. | Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever. | 1986 | Thromb. Haemost. | pmid:3563961 |
| Falcon CR et al. | The in vitro production of thromboxane B2 by platelets of diabetic patients is normal at physiological concentrations of ionized calcium. | 1993 | Thromb. Haemost. | pmid:8259535 |
| Fruzzetti F et al. | Platelet-vessel wall interactions with third-generation oral contraceptives: no evidence of detrimental effects. | 1999 | Thromb. Haemost. | pmid:10494782 |
| Cattaneo M et al. | Conditions influencing the interaction of asialo von Willebrand factor with human platelets--the effects of external ionized calcium concentration and the role of arachidonate pathway. | 1988 | Thromb. Haemost. | pmid:3146144 |
| Fimognari FL et al. | Nocturnal rise of urinary thromboxane B 2 in patients with coronary artery disease. | 2005 | Thromb. Haemost. | pmid:15735822 |
| De Caterina R et al. | Organic nitrates: direct antiplatelet effects and synergism with prostacyclin. Antiplatelet effects of organic nitrates. | 1988 | Thromb. Haemost. | pmid:3291182 |
| Teng CM and Ko FN | Comparison of the platelet aggregation induced by three thrombin-like enzymes of snake venoms and thrombin. | 1988 | Thromb. Haemost. | pmid:3291184 |
| de Castellarnau C et al. | Prostacyclin and thromboxane production by autogenous femoral veins grafted into the arterial circulation of the dog. | 1989 | Thromb. Haemost. | pmid:2665174 |
| Davì G et al. | Demonstration of Rickettsia Conorii-induced coagulative and platelet activation in vivo in patients with Mediterranean spotted fever. | 1995 | Thromb. Haemost. | pmid:8584998 |
| Habib A et al. | Increased expression of inducible cyclooxygenase-2 in human endothelial cells by antiphospholipid antibodies. | 1995 | Thromb. Haemost. | pmid:8585020 |
| Evangelista V et al. | Defibrotide inhibits platelet activation by cathepsin G released from stimulated polymorphonuclear leukocytes. | 1992 | Thromb. Haemost. | pmid:1509406 |
| Pettinella C et al. | Cyclooxygenase-1 haplotype C50T/A-842G does not affect platelet response to aspirin. | 2009 | Thromb. Haemost. | pmid:19350112 |
| Totani L et al. | Prasugrel inhibits platelet-leukocyte interaction and reduces inflammatory markers in a model of endotoxic shock in the mouse. | 2012 | Thromb. Haemost. | pmid:22436970 |
| Véricel E et al. | Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. | 2015 | Thromb. Haemost. | pmid:25832443 |
| Spowart K et al. | Haemostatic effects of ketorolac with and without concomitant heparin in normal volunteers. | 1988 | Thromb. Haemost. | pmid:3266379 |
| Cerletti C et al. | Aspirin kinetics and inhibition of platelet thromboxane generation-relevance for a solution of the "aspirin dilemma". | 1985 | Thromb. Haemost. | pmid:4049312 |
| Dotevall A et al. | Cigarette smoking increases thromboxane A2 formation without affecting platelet survival in young healthy females. | 1992 | Thromb. Haemost. | pmid:1455405 |
| de Boer A et al. | Interaction study between Org 10172, a low molecular weight heparinoid, and acetylsalicylic acid in healthy male volunteers. | 1991 | Thromb. Haemost. | pmid:1722918 |
| Davì G et al. | Influence of metabolic control on thromboxane biosynthesis and plasma plasminogen activator inhibitor type-1 in non-insulin-dependent diabetes mellitus. | 1996 | Thromb. Haemost. | pmid:8819248 |
| Forastiero R et al. | Anti-beta2 glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: association with increased excretion of platelet-derived thromboxane urinary metabolites. | 1998 | Thromb. Haemost. | pmid:9459320 |
| Carter AJ and Hanley SP | The effect of platelet number and haematocrit on whole blood thromboxane synthesis. | 1985 | Thromb. Haemost. | pmid:4024033 |
| Schorer AE | Discordant effects on eicosanoids and fibrin degradation products in two murine models of antiphospholipid antibody. | 1997 | Thromb. Res. | pmid:9062953 |
| Watanabe T et al. | Enhanced platelet sensitivity to prostacyclin in patients in an active stage of Takayasu arteritis. | 2001 | Thromb. Res. | pmid:11672751 |
| Carroll RC et al. | Post interventional cardiology urinary thromboxane correlates with PlateletMapping detected aspirin resistance. | 2010 | Thromb. Res. | pmid:19962724 |
| Ziegler BK et al. | Incomplete thromboxane inhibition with 100 mg of intravenous acetylsalicylic acid in patients with acute ST elevation myocardial infarction: a placebo-controlled pilot trial. | 2001 | Thromb. Res. | pmid:11672759 |
| Ersöz G et al. | The effect of submaximal exercise on platelet aggregation during late follicular and midluteal phases in women. | 2002 | Thromb. Res. | pmid:12590951 |
| Kawamura M et al. | Evaluation of plasma 11-dehydro-thromboxane B2 as an indicator for thromboxane A2 synthesis in vivo in laboratory animals. | 1995 | Thromb. Res. | pmid:7778061 |
| Ersöz G et al. | Effect of sodium selenite treatment on platelet aggregation of streptozotocin-induced diabetic rats. | 2003 | Thromb. Res. | pmid:14698654 |
| Teng CM et al. | Two antiplatelet agents from Magnolia officinalis. | 1988 | Thromb. Res. | pmid:3413728 |
| Addonizio VP et al. | Inhibition of human platelet function by verapamil. | 1982 | Thromb. Res. | pmid:7164035 |
| Vargaftig BB et al. | Adrenaline and PAF-acether synergize to trigger cyclooxygenase-independent activation of plasma-free human platelets. | 1982 | Thromb. Res. | pmid:7164036 |
| Vlodavsky I et al. | Platelet interaction with the extracellular matrix produced by cultured endothelial cells: a model to study the thrombogenicity of isolated subendothelial basal lamina. | 1982 | Thromb. Res. | pmid:7179215 |
| Cholette JM et al. | Aspirin resistance following pediatric cardiac surgery. | 2010 | Thromb. Res. | pmid:20550971 |
| Umemura K et al. | Effect of dietary docosahexaenoic acid in the rat middle cerebral artery thrombosis model. | 1995 | Thromb. Res. | pmid:7660354 |
| Carter AJ et al. | Human pulmonary vessels obtained from necropsy produce less prostacyclin and thromboxane than fresh vessels obtained from operations. | 1984 | Thromb. Res. | pmid:6547546 |
| Rousson D et al. | Acute myocardial infarction: measurement of arachidonate end-products in whole blood as an index of platelet cyclo-oxygenase activity in vivo. | 1987 | Thromb. Res. | pmid:3122356 |
| Hanasaki K and Arita H | Characterization of a new compound, S-145, as a specific TXA2 receptor antagonist in platelets. | 1988 | Thromb. Res. | pmid:2839912 |
| Navran SS et al. | Human platelet activation by bacterial phospholipase C is mediated by phosphatidylinositol hydrolysis but not generation of phosphatidic acid: inhibition by a selective inhibitor of phospholipase C. | 1984 | Thromb. Res. | pmid:6372157 |
| Ishikawa Y et al. | Effect of cytoplasmic pH on platelet activation by arachidonic acid. | 1989 | Thromb. Res. | pmid:2499076 |
| Lages B and Weiss HJ | Inhibition of human platelet function in vitro and ex vivo by acetaminophen. | 1989 | Thromb. Res. | pmid:2499947 |
| Küster LJ et al. | Mechanism of PAF-induced platelet aggregation in man. | 1986 | Thromb. Res. | pmid:3764802 |
| Reimers HJ et al. | Impaired thromboxane synthesis in preactivated human blood platelets: agonist-specific, irreversible desensitization to thrombin. | 1987 | Thromb. Res. | pmid:3126557 |
| Mercer JB et al. | The effect of short-term cold exposure on risk factors for cardiovascular disease. | 1999 | Thromb. Res. | pmid:10418798 |
| Perneby C et al. | Prothrombotic responses to exercise are little influenced by clopidogrel treatment. | 2004 | Thromb. Res. | pmid:15381386 |
| Hall ER et al. | The reduction of platelet thrombi on damaged vessel wall by a thromboxane synthetase inhibitor in rabbits. | 1982 | Thromb. Res. | pmid:6891109 |
| Lukasik M et al. | Aspirin treatment influences platelet-related inflammatory biomarkers in healthy individuals but not in acute stroke patients. | 2011 | Thromb. Res. | pmid:21788065 |
| Udvardy M et al. | Alterations of primary haemostasis in mixed connective tissue disease (MCTD). | 1991 | Thromb. Res. | pmid:1835548 |
| Marasini B et al. | Cigarette smoking and platelet function. | 1986 | Thromb. Res. | pmid:3787563 |
| Deckmyn H et al. | Prostacyclin production by whole blood from children: impairment in the hemolytic uremic syndrome and excessive formation in chronic renal failure. | 1983 | Thromb. Res. | pmid:6344317 |
| Neiman J et al. | Composition of platelet phosphatidylinositol and phosphatidylcholine after ethanol withdrawal. | 1987 | Thromb. Res. | pmid:3603426 |
| Vesterqvist O et al. | Development of a GC-MS method for quantitation of 2,3-dinor-TxB2 and determinations of the daily urinary excretion rates in healthy humans. | 1984 | Thromb. Res. | pmid:6695361 |
| Todd MK et al. | Effect of exercise intensity on 6-keto-PGF1 alpha, TXB2, and 6-keto-PGF1 alpha/TXB2 ratios. | 1992 | Thromb. Res. | pmid:1615492 |
| Dembinska-Kiec A et al. | Ticlopidine and platelet function in healthy volunteers. | 1992 | Thromb. Res. | pmid:1615496 |
| Maguire ED and Wallis RB | In vivo redirection of prostaglandin endoperoxides into 6-keto PGF1 alpha formation by thromboxane synthetase inhibitors in the rat. | 1983 | Thromb. Res. | pmid:6689221 |
| Ames PR et al. | Aspirin insensitive thromboxane generation is associated with oxidative stress in type 2 diabetes mellitus. | 2012 | Thromb. Res. | pmid:22521214 |
| Vesterqvist O et al. | In vivo production of thromboxane in acute human myocardial infarction: a preliminary study. | 1985 | Thromb. Res. | pmid:3992528 |
| Chiang TM and Kang AH | The effect of platelet surface protein phosphorylation on collagen-platelet interaction. | 1986 | Thromb. Res. | pmid:3810565 |
| Hofmann D et al. | Evidence for sustained platelet activation in patients with early postinfarction angina. | 1993 | Thromb. Res. | pmid:8303651 |
| Knapp HR et al. | Effects of low-dose aspirin on endogenous eicosanoid formation in normal and atherosclerotic men. | 1988 | Thromb. Res. | pmid:3293263 |
| Selley ML et al. | The effect of cholesterol oxidation products on human platelet aggregation. | 1996 | Thromb. Res. | pmid:8885139 |
| Kritz H et al. | Isradipine increases vascular prostaglandin I2-formation while the thromboxane B2-synthesis is diminished. | 1995 | Thromb. Res. | pmid:8610276 |
| Bergqvist D et al. | The effect of inhibition of thromboxane synthesis in experimental thrombosis and hemostasis. | 1985 | Thromb. Res. | pmid:3838828 |
| Domoto DT et al. | Combined aspirin and sulfinpyrazone in the prevention of recurrent hemodialysis vascular access thrombosis. | 1991 | Thromb. Res. | pmid:1926064 |
| Küster LJ and Frölich JC | PAF-induced platelet aggregation and TXB2 formation. | 1989 | Thromb. Res. | pmid:2922704 |
| Antonino MJ et al. | Antiplatelet effects of aspirin with phytosterols: comparison with non-enteric coated aspirin alone. | 2010 | Thromb. Res. | pmid:19446864 |
| Altman R et al. | Why single daily dose of aspirin may not prevent platelet aggregation. | 1988 | Thromb. Res. | pmid:3140408 |
| Simmet T and Weide I | Thromboxane and cysteinyl-leukotriene formation are differentially activated in spontaneously clotting whole human blood in vitro. | 1991 | Thromb. Res. | pmid:1866709 |
| Meyers KM et al. | An evaluation of the arachidonate pathway of platelets from companion and food-producing animals, mink, and man. | 1980 | Thromb. Res. | pmid:7209869 |