Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Heinonen PK and Metsä-Ketelä T | Prostaglandin and thromboxane production in ovarian cancer tissue. | 1984 | Gynecol. Obstet. Invest. | pmid:6396175 |
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Hwang DH et al. | Zinc deficiency affects neither platelet arachidonic acid metabolism nor platelet aggregation in rats. | 1984 | J. Nutr. | pmid:6582232 |
Brown CG and Poyser NL | Studies on ovarian prostaglandin production in relation to ovulation in the rat. | 1984 | J. Reprod. Fertil. | pmid:6595406 |
Mitrovic D et al. | Anti-inflammatory drugs, prostanoid and proteoglycan production by cultured bovine articular chondrocytes. | 1984 | Prostaglandins | pmid:6595718 |
Kirton OC et al. | The development of a model of subacute lung injury after intra-abdominal infection. | 1984 | Surgery | pmid:6379962 |
Roy AC et al. | Thromboxane A2 and prostacyclin levels in molar pregnancy. | 1984 | Br J Obstet Gynaecol | pmid:6383461 |
Runkle B et al. | Cardiovascular changes in group B streptococcal sepsis in the piglet: response to indomethacin and relationship to prostacyclin and thromboxane A2. | 1984 | Pediatr. Res. | pmid:6384909 |
Stegmeier K et al. | The pharmacological profile of the thromboxane A2 antagonist BM 13.177. A new anti-platelet and anti-thrombotic drug. | 1984 | Thromb. Res. | pmid:6385334 |
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Vicenzi E et al. | Human mononuclear phagocytes from different anatomical sites differ in their capacity to metabolize arachidonic acid. | 1984 | Clin. Exp. Immunol. | pmid:6432383 |
Schneidkraut MJ et al. | Thromboxane and prostacyclin synthesis following whole body irradiation in rats. | 1984 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6386769 |
Puustinen T et al. | Glucocorticoids do not decrease thromboxane and prostacyclin levels in human blood. | 1984 | Prostaglandins Leukot Med | pmid:6387721 |
Essien EM et al. | Blood changes and enhanced thromboxane and 6-keto prostaglandin F1 alpha production in experimental acute Plasmodium bergei infection in hamsters. | 1984 | Thromb. Haemost. | pmid:6388013 |
Mäkäräinen L and Ylikorkala O | Amniotic fluid 6-keto-prostaglandin F1 alpha and thromboxane B2 during labor. | 1984 | Am. J. Obstet. Gynecol. | pmid:6388335 |
Baughman RP et al. | Prostaglandins and thromboxanes in the bronchoalveolar lavage fluid: possible immunoregulation in sarcoidosis. | 1984 | Am. Rev. Respir. Dis. | pmid:6388445 |
Ninnemann JL and Stockland AE | Participation of prostaglandin E in immunosuppression following thermal injury. | 1984 | J Trauma | pmid:6231383 |
Sekiya K and Okuda H | Inhibitory action of soluble elastin on thromboxane B2 formation in blood platelets. | 1984 | Biochim. Biophys. Acta | pmid:6320905 |
Fitscha P et al. | Follow-up of in-vivo platelet function (platelet half-life, thromboxane B2) in patients with coronary heart disease. | 1984 | VASA | pmid:6516563 |
Olanoff LS et al. | Effects of oleic acid on pulmonary capillary leak and thromboxanes. | 1984 | J. Surg. Res. | pmid:6233456 |
Block HU et al. | Estimation of thromboxane B2 in the clotting human whole blood by gas chromatography. | 1984 | Biomed. Biochim. Acta | pmid:6517904 |
Beitz A et al. | Thromboxane B2 (TXB2) formation in clotting whole blood of healthy and diabetic humans in vitro. | 1984 | Biomed. Biochim. Acta | pmid:6517908 |
Hartung HP et al. | Release of prostaglandin E and thromboxane from macrophages by stimulation with factor H. | 1984 | Clin. Exp. Immunol. | pmid:6234114 |
Keinänen-Kiukaanniemi S et al. | Decreased thromboxane production in migraine patients during headache-free period. | 1984 | Headache | pmid:6519984 |
Uehara Y et al. | [A solid phase direct radioimmunoassay for urinary thromboxane B2 and its clinical application]. | 1984 | Nihon Jinzo Gakkai Shi | pmid:6527429 |
Wang JP et al. | Antiplatelet effect of capsaicin. | 1984 | Thromb. Res. | pmid:6528310 |
Riess H et al. | Effects of BM 13.177, a new antiplatelet drug in patients with atherosclerotic disease. | 1984 | Thromb. Res. | pmid:6237460 |
Nichols AB et al. | Effect of heparin bonding on catheter-induced fibrin formation and platelet activation. | 1984 | Circulation | pmid:6237807 |
Sicard GA et al. | Prostaglandin production and platelet reactivity of small-diameter grafts. | 1984 | J. Vasc. Surg. | pmid:6238179 |
Sedor JR et al. | Effects of sulindac and indomethacin on renal prostaglandin synthesis. | 1984 | Clin. Pharmacol. Ther. | pmid:6428794 |
Goodman MG and Weigle WO | Regulation of B-lymphocyte proliferative responses by arachidonate metabolites: effects on membrane-directed versus intracellular activators. | 1984 | J. Allergy Clin. Immunol. | pmid:6432883 |
Robson MC et al. | A new explanation for the progressive tissue loss in electrical injuries. | 1984 | Plast. Reconstr. Surg. | pmid:6422484 |
McGoon MD and Vanhoutte PM | Aggregating platelets contract isolated canine pulmonary arteries by releasing 5-hydroxytryptamine. | 1984 | J. Clin. Invest. | pmid:6470141 |
Lampugnani MG and de Gaetano G | Effects of metabolized and unmetabolized arachidonate on rat platelet shape change. | 1984 | Am. J. Physiol. | pmid:6433724 |
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Lefkowith JB et al. | Macrophage-dependent arachidonate metabolism in hydronephrosis. | 1984 | Kidney Int. | pmid:6434790 |
Stuart MJ et al. | Differences in thromboxane production between neonatal and adult platelets in response to arachidonic acid and epinephrine. | 1984 | Pediatr. Res. | pmid:6435080 |
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Burghuber O et al. | Lung edema due to hydrogen peroxide is independent of cyclooxygenase products. | 1984 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6427146 |
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Seregi A et al. | Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils. | 1984 | Brain Res. | pmid:6430471 |
Worthington RE and Fuller GC | Dibutyryl cyclic guanosine monophosphate elevates bovine endothelial cell thromboxane production without affecting prostacyclin metabolism. | 1984 | Thromb. Res. | pmid:6322377 |
Holgate ST and Robinson C | 6,9-deepoxy-6,9-(phenylimino)-delta 6,8-Prostaglandin I1, (U-60,257) stimulates prostaglandin D2 and inhibits thromboxane B2 release from ionophore challenged human dispersed lung cells. | 1984 | Br. J. Pharmacol. | pmid:6439267 |
Foegh ML et al. | Urine thromboxane as an immunologic monitor in kidney transplant patients. | 1984 | Transplant. Proc. | pmid:6390872 |
Foegh ML et al. | Monitoring of rat heart allograft rejection by urinary thromboxane. | 1984 | Transplant. Proc. | pmid:6390873 |
Willerson JT et al. | Conversion from chronic to acute coronary artery disease: speculation regarding mechanisms. | 1984 | Am. J. Cardiol. | pmid:6391133 |
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Burch RM and Halushka PV | Alterations in extracellular calcium concentration differentially influence prostaglandin and thromboxane synthesis in epithelial cells from the toad urinary bladder. | 1984 | Arch. Biochem. Biophys. | pmid:6422855 |
Crutchley DJ | Effects of inhibitors of arachidonic acid metabolism on thromboplastin activity in human monocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422935 |
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Walenga RW et al. | Recovery of megakaryocyte thromboxane production in vitro after aspirin inhibition. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6712680 |
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Pedersen AK and FitzGerald GA | Dose-related kinetics of aspirin. Presystemic acetylation of platelet cyclooxygenase. | 1984 | N. Engl. J. Med. | pmid:6436696 |
Eldor A et al. | The effect of oral administration of dipyrone on the capacity of blood platelets to synthesize thromboxane A2 in man. | 1984 | Eur. J. Clin. Pharmacol. | pmid:6723755 |
Cerletti C et al. | Plasma levels of salicylate and aspirin in healthy volunteers: relevance to drug interaction on platelet function. | 1984 | J. Lab. Clin. Med. | pmid:6726057 |
Anderson CB et al. | Renal thromboxane synthesis in excised kidney distal to renovascular lesions. | 1984 | JAMA | pmid:6726983 |
Grignani G et al. | Activation of platelet prostaglandin biosynthesis pathway during neoplastic cell-induced platelet aggregation. | 1984 | Thromb. Res. | pmid:6729776 |
Rehr RB et al. | Mechanism of nitroglycerin-induced coronary dilatation: lack of relation to intracoronary thromboxane concentrations. | 1984 | Am. J. Cardiol. | pmid:6437206 |
Tremoli E et al. | Increased platelet sensitivity and thromboxane B2 formation in type-II hyperlipoproteinaemic patients. | 1984 | Eur. J. Clin. Invest. | pmid:6437830 |