Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Nath KA et al. | Regulatory role of prostanoids in glomerular microcirculation of remnant nephrons. | 1987 | Am. J. Physiol. | pmid:3578532 |
Yamamoto S et al. | Endothelin causes portal and pulmonary hypertension in porcine endotoxemic shock. | 1997 | Am. J. Physiol. | pmid:9087598 |
Düsing R et al. | Dietary linoleic acid deprivation: effects on blood pressure and PGI2 synthesis. | 1983 | Am. J. Physiol. | pmid:6337507 |
Wilkes BM and Mento PF | Bradykinin-induced vasoconstriction and thromboxane release in perfused human placenta. | 1988 | Am. J. Physiol. | pmid:3377072 |
Strand JC et al. | Effect of imidazole on renal function in unilateral ureteral-obstructed rat kidneys. | 1981 | Am. J. Physiol. | pmid:6787931 |
Simonson MS et al. | Identification and transmembrane signaling of leukotriene D4 receptors in human mesangial cells. | 1988 | Am. J. Physiol. | pmid:2849305 |
Toyofuku T et al. | Pulmonary vascular response to platelet-activating factor in conscious sheep. | 1988 | Am. J. Physiol. | pmid:3414811 |
Zipser RD and Martin K | Urinary excretion of arterial blood prostaglandins and thromboxanes in man. | 1982 | Am. J. Physiol. | pmid:6950668 |
Amsterdam EA et al. | Contractile actions of C5a on isolated porcine myocardium. | 1992 | Am. J. Physiol. | pmid:1357981 |
Utsunomiya T et al. | Modification of inflammatory response to aspiration with ibuprofen. | 1982 | Am. J. Physiol. | pmid:6756172 |
Del Maschio A et al. | Platelet activation by polymorphonuclear leukocytes exposed to chemotactic agents. | 1990 | Am. J. Physiol. | pmid:2156456 |
Kruse-Elliott KT and Olson NC | CGS 8515 and indomethacin attenuate cytokine-induced cardiopulmonary dysfunction in pigs. | 1993 | Am. J. Physiol. | pmid:8386479 |
Greenberg S et al. | Pulmonary vascular smooth muscle function in porcine splanchnic arterial occlusion shock. | 1981 | Am. J. Physiol. | pmid:7246787 |
Schlondorff D and Satriano JA | Interactions of vasopressin, cAMP, and prostaglandins in toad urinary bladder. | 1985 | Am. J. Physiol. | pmid:2579584 |
Stahl RA et al. | Glomerular prostaglandin formation in two-kidney, one-clip hypertensive rats. | 1984 | Am. J. Physiol. | pmid:6507633 |
Scharschmidt LA et al. | Angiotensin II and eicosanoids in the control of glomerular size in the rat and human. | 1986 | Am. J. Physiol. | pmid:2936254 |
Adler S et al. | Biphasic effect of oxygen radicals on prostaglandin production by rat mesangial cells. | 1987 | Am. J. Physiol. | pmid:3105332 |
Cudd TA and Wood CE | Thromboxane A2 receptor antagonism prevents hormonal and cardiovascular responses to mineral acid infusion. | 1994 | Am. J. Physiol. | pmid:7977850 |
Wagerle LC et al. | Effect of dexamethasone on cerebral prostanoid formation and pial arteriolar reactivity to CO2 in newborn pigs. | 1991 | Am. J. Physiol. | pmid:1901460 |
Del Balzo U et al. | Complement C5a-mediated myocardial ischemia and neutrophil sequestration: two independent phenomena. | 1993 | Am. J. Physiol. | pmid:8447449 |
Titos E et al. | Hepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A(4). | 1999 | Am. J. Physiol. | pmid:10564079 |
Takashio T et al. | Inhibitory effect of pindolol on hypoxic pulmonary vasoconstriction. | 1992 | Am. J. Physiol. | pmid:1310232 |
Schrör K et al. | Preservation of ischemic myocardium by pinane thromboxane A2. | 1980 | Am. J. Physiol. | pmid:7356037 |
Sata T et al. | Paraquat-induced lung injury: prevention by N-tert-butyl-alpha-phenylnitrone, a free-radical spin-trapping agent. | 1992 | Am. J. Physiol. | pmid:1311515 |
Garfield RE et al. | Gap junction formation in myometrium: control by estrogens, progesterone, and prostaglandins. | 1980 | Am. J. Physiol. | pmid:7369350 |
Lampugnani MG and de Gaetano G | Effects of metabolized and unmetabolized arachidonate on rat platelet shape change. | 1984 | Am. J. Physiol. | pmid:6433724 |
Ahlquist DA et al. | Factors influencing metabolism of arachidonic acid in guinea pig gastric mucosa. | 1983 | Am. J. Physiol. | pmid:6401937 |
Murray MJ et al. | Select dietary fatty acids attenuate cardiopulmonary dysfunction during acute lung injury in pigs. | 1995 | Am. J. Physiol. | pmid:8594921 |
Wilkes BM et al. | Characterization of glomerular thromboxane receptor sites in the rat. | 1989 | Am. J. Physiol. | pmid:2525345 |
Grimminger F et al. | Differential influence of arachidonic vs. eicosapentaenoic acid on experimental pulmonary hypertension. | 1995 | Am. J. Physiol. | pmid:7611475 |
Kalichman MW et al. | Effects of cocaine on blood flow and prostaglandin metabolites in rat sciatic nerve. | 1994 | Am. J. Physiol. | pmid:8024013 |
Reyes AA and Klahr S | Bladder contributes to eicosanoids excreted in urine. | 1990 | Am. J. Physiol. | pmid:2240235 |
Klotman PE et al. | Thromboxane synthetase inhibition improves function of hydronephrotic rat kidneys. | 1986 | Am. J. Physiol. | pmid:3456211 |
Chen L et al. | Cyclooxygenase inhibition decreases nitric oxide synthase activity in human platelets. | 1997 | Am. J. Physiol. | pmid:9362253 |
Wilkes BM et al. | Endothelin receptors in human placenta: relationship to vascular resistance and thromboxane release. | 1990 | Am. J. Physiol. | pmid:2159236 |
Beck N and Shaw JO | Thromboxane B2 and prostaglandin E2 in the K+-depleted rat kidney. | 1981 | Am. J. Physiol. | pmid:7468800 |
Reinke M | Monitoring thromboxane in body fluids: a specific ELISA for 11-dehydrothromboxane B2 using a monoclonal antibody. | 1992 | Am. J. Physiol. | pmid:1590375 |
Addonizio VP et al. | Effects of verapamil and diltiazem on human platelet function. | 1986 | Am. J. Physiol. | pmid:3006516 |
Havill AM et al. | alpha-Naphthylthiourea produces dose-dependent lung vascular injury in sheep. | 1982 | Am. J. Physiol. | pmid:6812437 |
Gyenes M and De Groot H | Prostanoid release by Kupffer cells upon hypoxia-reoxygenation: role of pHi and Cai2+. | 1993 | Am. J. Physiol. | pmid:8384798 |
Brown GP and Venuto RC | In vitro renal eicosanoid production during pregnancy in rabbits. | 1988 | Am. J. Physiol. | pmid:3287949 |
Burch RM and Halushka PV | Vasopressin stimulates prostaglandin and thromboxane synthesis in toad bladder epithelial cells. | 1982 | Am. J. Physiol. | pmid:6816073 |
Bradley LM et al. | Circulatory effects of PAF-acether in newborn piglets. | 1989 | Am. J. Physiol. | pmid:2912183 |
Zipser RD | Effects of selective inhibition of thromboxane synthesis on renal function in humans. | 1985 | Am. J. Physiol. | pmid:3839111 |
Fletcher MP et al. | C5a-induced myocardial ischemia: role for CD18-dependent PMN localization and PMN-platelet interactions. | 1993 | Am. J. Physiol. | pmid:7902015 |
Kauser K and Rubanyi GM | Gender difference in bioassayable endothelium-derived nitric oxide from isolated rat aortae. | 1994 | Am. J. Physiol. | pmid:7810731 |
Sirko S et al. | Prostaglandin formation in the hypothalamus in vivo: effect of pyrogens. | 1989 | Am. J. Physiol. | pmid:2784289 |
Farman N et al. | PGE2, PGF2 alpha, 6-keto-PGF1 alpha, and TxB2 synthesis along the rabbit nephron. | 1987 | Am. J. Physiol. | pmid:3101513 |
Brown GP and Venuto RC | Eicosanoid production in rabbit vascular tissues and placentas. | 1990 | Am. J. Physiol. | pmid:2316640 |
Miyazaki Y et al. | Selective turnover of sarcolemmal phospholipids with lethal cardiac myocyte injury. | 1990 | Am. J. Physiol. | pmid:2382705 |