Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Calzada C et al. | 12(S)-Hydroperoxy-eicosatetraenoic acid increases arachidonic acid availability in collagen-primed platelets. | 2001 | J. Lipid Res. | pmid:11518767 |
Dowd NP et al. | Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo. | 2001 | J. Clin. Invest. | pmid:11518732 |
Muramatsu H et al. | [Correlation between the clinical effects of Seratrodast and the level of 11-dehydrothromboxane B2 in urine/sputum in bronchial asthma patients]. | 2001 | Arerugi | pmid:11517517 |
Takeyoshi I et al. | The effect of a selective cyclooxygenase-2 inhibitor in extended liver resection with ischemia in dogs. | 2001 | J. Surg. Res. | pmid:11516201 |
Bölke E et al. | Changes of gut barrier function during anesthesia and cardiac surgery. | 2001 | Angiology | pmid:11515987 |
Tomida T et al. | Altered expression of prostacyclin synthase in a subset of the thick ascending limb cells and mesangial cells in 5/6-nephrectomized rats. | 2001 | Hypertens. Res. | pmid:11510754 |
Diebolt M et al. | Wine polyphenols decrease blood pressure, improve NO vasodilatation, and induce gene expression. | 2001 | Hypertension | pmid:11509469 |
Ploner F et al. | Effects of combined selective iNOS inhibition and peroxynitrite blockade during endotoxemia in pigs. | 2001 | Shock | pmid:11508865 |
Wang W et al. | Effects of magnesium lithospermate B on aggregation and 5-HT release in rabbit washed platelets. | 2000 | Acta Pharmacol. Sin. | pmid:11501172 |
Chen G et al. | [The effect of the molecular triggers of hemostatic activity on thrombosis in early stage of electrical injuries]. | 1999 | Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi | pmid:11501103 |
Khan HH et al. | Plasma CPU-86017 concentrations regarding suppression of ouabain-induced cardiac arrhythmias and decrease of heart rate in guinea pigs. | 2000 | Acta Pharmacol. Sin. | pmid:11501061 |
Valeri CR et al. | Anemia-induced increase in the bleeding time: implications for treatment of nonsurgical blood loss. | 2001 | Transfusion | pmid:11493727 |
Rebrov BA | [Role of thromboxane A2 (B2) in the pathogenesis of stress proteinuria in healthy persons]. | 2001 Mar-Apr | Urologiia | pmid:11490711 |
Urquhart P et al. | Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487303 |
Xu J et al. | [Study on relativity between oxygen free radical and thromboxane B2, 6-keto-PGF1 alpha during ligustrazine treatment of intrauterine growth retardation]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11477921 |
Huang R et al. | [Effects in tetramethylpyrazine on TXA2 and PGI2 by cardio-pulmonary bypass in congenital heart diseases with pulmonary hypertension patients]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11477904 |
Lin S et al. | [Clinical study on active factors of vascular endothelial cells in acute cerebral infarction patients and therapeutical effect of activating blood stasis]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11477811 |
Lang J et al. | [Comparative study on effect of Panax notoginseng and ticlid in treating early diabetic nephropathy]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11475719 |
Wu Y et al. | [Clinical study on improving effect of Buyang Huanwu decoction on plasma thromboxane B2, 6-keto-prostaglandin F1 alpha, endothelin and calcitonin gene related peptide in primary nephrotic syndrome patients]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11475715 |
Zoja C et al. | Mycophenolate mofetil combined with a cyclooxygenase-2 inhibitor ameliorates murine lupus nephritis. | 2001 | Kidney Int. | pmid:11473648 |
Catella-Lawson F et al. | Oral glycoprotein IIb/IIIa antagonism in patients with coronary artery disease. | 2001 | Am. J. Cardiol. | pmid:11472700 |
Rosón MI et al. | Serotonin hypersensitivity in aorta of two kidney-two clip hypertensive rats: calcium contribution and prostanoids-nitric oxide interactions. | 2001 | Arch. Physiol. Biochem. | pmid:11471069 |
Wojakowski W and Gmiński J | Plasma levels of von willebrand factor, endothelin-1, prostacyclin and thromboxane in children from families with high risk of premature coronary artery disease. | 2001 | Scand. J. Clin. Lab. Invest. | pmid:11465346 |
Coelho-Filho OR et al. | Pravastatin reduces myocardial lesions induced by acute inhibition of nitric oxide biosynthesis in normocholesterolemic rats. | 2001 | Int. J. Cardiol. | pmid:11461744 |
Tran HS et al. | Prostacyclin is neither sufficient alone nor necessary to cause pulmonary dysfunction: results from infusions of prostacyclin and antiprostacyclin antibody in porcine septic shock. | 2001 | Crit. Care Med. | pmid:11445706 |
Dubé JN et al. | Characterization of a partial prostaglandin endoperoxide H synthase-1 deficiency in a patient with a bleeding disorder. | 2001 | Br. J. Haematol. | pmid:11442478 |
Gossmann J et al. | Pathophysiology of cyclosporine-induced nephrotoxicity in humans: a role for nitric oxide? | 2001 | Kidney Blood Press. Res. | pmid:11435743 |
Minuz P et al. | NCX4016 (NO-aspirin) inhibits thromboxane biosynthesis and tissue factor expression and activity in human monocytes. | 2001 Jul-Aug | Med. Sci. Monit. | pmid:11433179 |
Oketani K et al. | In vitro effects of E3040, a dual inhibitor of 5-lipoxygenase and thromboxane A(2) synthetase, on eicosanoid production. | 2001 | Eur. J. Pharmacol. | pmid:11430933 |
Engström K et al. | Effect of low-dose aspirin in combination with stable fish oil on whole blood production of eicosanoids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11427037 |
Feldman M et al. | Effects of low-dose aspirin on serum C-reactive protein and thromboxane B2 concentrations: a placebo-controlled study using a highly sensitive C-reactive protein assay. | 2001 | J. Am. Coll. Cardiol. | pmid:11419884 |
Okita M et al. | Effect of arachidonic acid-rich oil on lipids and arachidonate metabolites in ethanol- treated rats. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418023 |
Karamouzis M et al. | The response of muscle interstitial prostaglandin E(2)(PGE(2)), prostacyclin I(2)(PGI(2)) and thromboxane A(2)(TXA(2)) levels during incremental dynamic exercise in humans determined by in vivo microdialysis. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418021 |
Norio K et al. | Eicosanoids and delayed graft function in human renal transplantation. | 2001 | Transplant. Proc. | pmid:11406239 |
Sontag W | Release of mediators by DMSO-differentiated HL-60 cells exposed to electric interferential current and the requirement of biochemical prestimulation. | 2001 | Int. J. Radiat. Biol. | pmid:11403712 |
Tuppo EE et al. | Sign of lipid peroxidation as measured in the urine of patients with probable Alzheimer's disease. | 2001 | Brain Res. Bull. | pmid:11397549 |
Cantaro S et al. | Urinary excretion of vasoactive substances in chronic renal failure. | 2001 | Clin. Nephrol. | pmid:11393385 |
Miyake K et al. | Effects of olopatadine hydrochloride on the increase of histamine and peptide-leukotrienes concentrations in nasal lavage fluid following the antigen-antibody reaction in actively sensitized guinea pigs. | 2001 | Jpn. J. Pharmacol. | pmid:11388650 |
Katoh M et al. | Inhibitory effects of TA-993 and its metabolite MB3 on platelet activation induced by collagen and U-46619 in human platelets. | 2001 | Biol. Pharm. Bull. | pmid:11379769 |
Ogata K et al. | Attenuation of ischemia and reperfusion injury of canine livers by inhibition of type II phospholipase A2 with LY329722. | 2001 | Transplantation | pmid:11374398 |
Yoshinari D et al. | Effects of a dual inhibitor of tumor necrosis factor-alpha and interleukin-1 on lipopolysaccharide-induced lung injury in rats: involvement of the p38 mitogen-activated protein kinase pathway. | 2001 | Crit. Care Med. | pmid:11373433 |
Loew D et al. | Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo. | 2001 | Clin. Pharmacol. Ther. | pmid:11372004 |
Franconi F et al. | Effect of gamma-hydroxybutyric acid on human platelet aggregation in vitro. | 2001 | Thromb. Res. | pmid:11369419 |
Yu Y et al. | [Changes of prostaglandins in kidney tissue in gentamicin-induced acute renal tubular injury in rats]. | 1998 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:11367732 |
Zhang T et al. | [Clinical observation on preventing and treating coronary atherosclerotic heart disease with tongmai jiangzhi oral liquid]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11367649 |
Wang LL et al. | Effects of MN-9202 on platelet aggregation, 5-HT release, TXB2 synthesis, and calcium mobilization in rabbit platelets in vitro. | 2000 | Acta Pharmacol. Sin. | pmid:11360670 |
Burch RM et al. | Vasopressin stimulates thromboxane synthesis in the toad urinary bladder: effects of imidazole. | 1979 | J. Pharmacol. Exp. Ther. | pmid:113526 |
Cracowski JL et al. | Enhanced in vivo lipid peroxidation in scleroderma spectrum disorders. | 2001 | Arthritis Rheum. | pmid:11352247 |
Karamouzis M et al. | In situ microdialysis of intramuscular prostaglandin and thromboxane in contracting skeletal muscle in humans. | 2001 | Acta Physiol. Scand. | pmid:11350265 |
Kijima Y et al. | Transcardiac 8-iso-prostaglandin F(2 alpha)generation from acute myocardial infarction heart: insight into abrupt reperfusion and oxidant stress. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334551 |