Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Mäkilä UM et al. | Relation between umbilical prostacyclin production and blood-flow in the fetus. | 1983 | Lancet | pmid:6132081 |
Thorngren M et al. | Thromboxane A2 in skin-bleeding-time blood and in clotted venous blood before and after administration of acetylsalicylic acid. | 1983 | Lancet | pmid:6133107 |
Stenson WF and Lobos E | Inhibition of platelet thromboxane synthetase by sulfasalazine. | 1983 | Biochem. Pharmacol. | pmid:6135423 |
Düsing R et al. | Dietary linoleic acid deprivation: effects on blood pressure and PGI2 synthesis. | 1983 | Am. J. Physiol. | pmid:6337507 |
Hartung HP and Toyka KV | Activation of macrophages by substance P: induction of oxidative burst and thromboxane release. | 1983 | Eur. J. Pharmacol. | pmid:6191998 |
Tanganelli I et al. | [Thromboxane, beta-thromboglobulin and the degree of blood sugar control in type 1 diabetes mellitus]. | 1983 | Boll. Soc. Ital. Biol. Sper. | pmid:6194801 |
Capodicasa G et al. | Platelet thromboxane formation and BTG levels after intensive charcoal HP in uremics or regular hemodialytic treatment (RHT). | 1983 | Int J Artif Organs | pmid:6195116 |
Ditter H et al. | Effects of prostacyclin during cardiopulmonary bypass in men on plasma levels of beta-thromboglobulin, platelet factor 4, thromboxane B2, 6-keto-prostaglandin F1 alpha and heparin. | 1983 | Thromb. Res. | pmid:6197766 |
Horellou MH et al. | Familial and constitutional bleeding disorder due to platelet cyclo-oxygenase deficiency. | 1983 | Am. J. Hematol. | pmid:6404162 |
Stratta P et al. | Warning: platelet factor 4, beta-thromboglobulin and thromboxane in donor's plasma units. | 1983 | Thromb. Haemost. | pmid:6189235 |
de Kergommeaux BD et al. | Effects of ASA on thromboxane and prostacyclin synthesis by rabbit aorta and pulmonary artery. | 1983 | Prostaglandins Leukot Med | pmid:6410417 |
Ahlquist DA et al. | Factors influencing metabolism of arachidonic acid in guinea pig gastric mucosa. | 1983 | Am. J. Physiol. | pmid:6401937 |
Buchanan MR et al. | The sex-related differences in aspirin pharmacokinetics in rabbits and man and its relationship to antiplatelet effects. | 1983 | Thromb. Res. | pmid:6221436 |
Davi' G et al. | Platelet activation after adrenergic stimulation in hypertensive patients: effects of acebutolol. | 1983 | Eur. Heart J. | pmid:6352266 |
FitzGerald GA et al. | Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man. | 1983 | J. Clin. Invest. | pmid:6355181 |
Jouve R et al. | [Plasma thromboxane B2 and capacity of the aorta to produce prostacyclin in arteriopathies of the lower extremities]. | 1983 | J Mal Vasc | pmid:6355348 |
Mehta J et al. | Stimulation of vessel wall prostacyclin by selective thromboxane synthetase inhibitor OKY 1581. | 1983 | Prostaglandins Leukot Med | pmid:6356153 |
Henriksen RA and Brotherton AF | Evidence that activation of platelets and endothelium by thrombin involves distinct sites of interaction. Studies with the dysthrombin, Thrombin Quick I. | 1983 | J. Biol. Chem. | pmid:6358210 |
Kaliman J et al. | [Venous prostacycline synthesis and plasma thromboxane B2 after low-dose aspirin]. | 1983 | Wien. Klin. Wochenschr. | pmid:6359724 |
Ylikorkala O et al. | Prostacyclin and thromboxane in ovarian cancer: effect of cytostatics and prostaglandin synthesis inhibitors. | 1983 | Gynecol. Oncol. | pmid:6360817 |
Tada M et al. | [Biochemistry of coronary artery disease--prostaglandins]. | 1983 | Rinsho Byori | pmid:6361336 |
Hardisty RM et al. | A new congenital defect of platelet secretion: impaired responsiveness of the platelets to cytoplasmic free calcium. | 1983 | Br. J. Haematol. | pmid:6830700 |
Randall MJ and Wilding RI | Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with dazoxiben hydrochloride (UK 37,248-01). | 1983 | Br J Clin Pharmacol | pmid:6687429 |
Bruckner G et al. | Dietary trilinoelaidate: effects on hematological parameters, serum eicosanoids and tissue fatty acid composition in rats. | 1983 | J. Nutr. | pmid:6687476 |
Bessin P et al. | Acute circulatory collapse caused by platelet-activating factor (PAF-acether) in dogs. | 1983 | Eur. J. Pharmacol. | pmid:6687572 |
Ingerman-Wojenski CM et al. | Early morphological changes in the endothelium of a peripheral artery of rabbits fed an atherogenic diet. | 1983 | Exp. Mol. Pathol. | pmid:6687574 |
Hartung HP and Toyka KV | Tuftsin stimulates the release of oxygen radicals and thromboxane from macrophages. | 1983 | Immunol. Lett. | pmid:6687720 |
D'Angelo A et al. | Effect of des-amino-D-arginine vasopressin (DDAVP) on plasma levels of platelet and endothelial cell release products. | 1983 | Thromb. Haemost. | pmid:6687766 |
Ku EC et al. | Characterization of imidazo[1,5-a]pyridine-5-hexanoic acid (CGS 13080) as a selective thromboxane synthetase inhibitor using in vitro and in vivo biochemical models. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6687803 |
Anderegg K et al. | Effects of a pyridine derivative thromboxane synthetase inhibitor and its inactive isomer in endotoxic shock in the rat. | 1983 | Br. J. Pharmacol. | pmid:6687819 |
Higgs GA et al. | The source of thromboxane and prostaglandins in experimental inflammation. | 1983 | Br. J. Pharmacol. | pmid:6652359 |
Anton RF et al. | In vivo regional levels of PGE and thromboxane in mouse brain: effect of decapitation, focused microwave fixation, and indomethacin. | 1983 | Prostaglandins | pmid:6658001 |
Mahoney D et al. | Influence of dietary polyunsaturated fatty acids on renal & aortic prostaglandin synthesis in 1 kidney 1 clip Goldblatt hypertensive rats. | 1983 | Prostaglandins | pmid:6658002 |
Martin JF et al. | The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. | 1983 | Thromb. Res. | pmid:6658722 |
Cohen RA et al. | 5-Hydroxytryptamine can mediate endothelium-dependent relaxation of coronary arteries. | 1983 | Am. J. Physiol. | pmid:6660308 |
Cortellaro M et al. | Transcoronary platelet thromboxane A2 formation without platelet trapping in patients with coronary stenosis-effect of sulphinpyrazone treatment. | 1983 | Thromb. Haemost. | pmid:6665767 |
De Caterina R et al. | Antiplatelet effects of isosorbide dinitrate in man. | 1983 | Z Kardiol | pmid:6666233 |
Smith EF et al. | RCS from human platelets: is it only thromboxane? | 1983 | Eur. J. Pharmacol. | pmid:6667711 |
Hoult JR and Robinson C | Selective inhibition of thromboxane B2 accumulation and metabolism in perfused guinea-pig lung. | 1983 | Br. J. Pharmacol. | pmid:6824820 |
Hirsh PD et al. | Effects of provocation on transcardiac thromboxane in patients with coronary artery disease. | 1983 | Am. J. Cardiol. | pmid:6829431 |
Walinsky P et al. | Beneficial effects of ibuprofen in pacing-induced myocardial ischemia. | 1983 | Am. J. Cardiol. | pmid:6829434 |
Fukumoto S and Tanaka K | Protective effects of thromboxane A2 synthetase inhibitors on endotoxin shock. | 1983 | Prostaglandins Leukot Med | pmid:6576388 |
Kinney EL et al. | Mechanism of action of amrinone: role of thromboxane synthetase inhibition. | 1983 | Prostaglandins Leukot Med | pmid:6576389 |
Hawkey CJ et al. | Imbalance of prostacyclin and thromboxane synthesis in Crohn's disease. | 1983 | Gut | pmid:6578172 |
Zijlstra FJ et al. | Separation of the two components of the contractile activity of leukotriene C4 on the guinea pig lung parenchymal strip. | 1983 | Prostaglandins Leukot Med | pmid:6578519 |
Roy L et al. | Increased plasma concentrations of prostacyclin metabolite 6-keto-PGF1 alpha in essential hypertension. Influence of therapy with labetalol. | 1983 | Am. J. Cardiol. | pmid:6823861 |
Mahoney DP et al. | Radioimmunoassay of prostaglandins and thromboxane B2 in extracted and unextracted urine and serum using an iodinated ligand. | 1983 | Prostaglandins Leukot Med | pmid:6579570 |
Güllner HG et al. | Renal thromboxane excretion in Brattleboro rats with hereditary hypothalamic diabetes insipidus. Effect of vasopressin treatment. | 1983 | Prostaglandins Leukot Med | pmid:6580653 |
Sakanishi N et al. | Thromboxane A2 and hemodynamic-biochemical parameters in canine endotoxin shock. | 1983 | Bull. Tokyo Med. Dent. Univ. | pmid:6580966 |
Orlandi M et al. | Normal plasma thromboxane B2 (TXB2) and 6-keto-PGF1 alpha levels in childhood diabetes. | 1983 | Prostaglandins Leukot Med | pmid:6583712 |