Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Herrick AL et al. | Von Willebrand factor, thrombomodulin, thromboxane, beta-thromboglobulin and markers of fibrinolysis in primary Raynaud's phenomenon and systemic sclerosis. | 1996 | Ann. Rheum. Dis. | pmid:8712862 |
Yan Y et al. | [Study on mechanism of eye-signs in blood stasis syndrome]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9206243 |
Tishler M et al. | Salivary eicosanoid concentration in patients with Sjögren's syndrome. | 1996 | Ann. Rheum. Dis. | pmid:8712887 |
Myers SI et al. | Estrogen increases male rat aortic endothelial cell (RAEC) PGI2 release. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888351 |
Izaki S et al. | Platelet-activating factor and arachidonic acid metabolites in psoriatic inflammation. | 1996 | Br. J. Dermatol. | pmid:8763425 |
Myers SI et al. | Long-term resuscitation of hemorrhage/reperfusion injury (H/R) stimulates renal PGE2 release. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8832762 |
Abernathy VJ et al. | C-reactive protein inhibits increased pulmonary vascular permeability induced by fMLP in isolated rabbit lungs. | 1996 | Am. J. Physiol. | pmid:8770090 |
Closa D et al. | Hepatic involvement in pancreatitis-induced lung damage. | 1996 | Am. J. Physiol. | pmid:8772495 |
Fleisch JH et al. | Recombinant human secretory phospholipase A2 released thromboxane from guinea pig bronchoalveolar lavage cells: in vitro and ex vivo evaluation of a novel secretory phospholipase A2 inhibitor. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8764358 |
Jacoby RF et al. | Chemoprevention of spontaneous intestinal adenomas in the Apc Min mouse model by the nonsteroidal anti-inflammatory drug piroxicam. | 1996 | Cancer Res. | pmid:8631000 |
Wahle KW and Peacock LI | Effects of isomeric cis and trans eighteen carbon monounsaturated fatty acids on porcine platelet function. | 1996 | Biochim. Biophys. Acta | pmid:8652649 |
Krämer HJ et al. | Fish oil fatty acids and human platelets: dose-dependent decrease in dienoic and increase in trienoic thromboxane generation. | 1996 | Biochem. Pharmacol. | pmid:8937428 |
Belisario MA et al. | In vitro effect of avarone and avarol, a quinone/hydroquinone couple of marine origin, on platelet aggregation. | 1996 | Pharmacol. Toxicol. | pmid:9000256 |
Haimovich B et al. | The FcgammaRII receptor triggers pp125FAK phosphorylation in platelets. | 1996 | J. Biol. Chem. | pmid:8663117 |
Jancinová V et al. | Inhibition of blood platelet functions by cationic amphiphilic drugs in relation to their physico-chemical properties. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735816 |
Ravn HB et al. | Magnesium inhibits human platelets. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735829 |
Young JM et al. | Human whole blood assays for inhibition of prostaglandin G/H synthases-1 and -2 using A23187 and lipopolysaccharide stimulation of thromboxane B2 production. | 1996 | Inflamm. Res. | pmid:8737748 |
Laffi G et al. | Defective aggregation in cirrhosis is independent of in vivo platelet activation. | 1996 | J. Hepatol. | pmid:8738730 |
Ko FN et al. | Mechanism of action of p-chlorobiphenyl on the inhibition of platelet aggregation. | 1996 | J. Pharm. Pharmacol. | pmid:8794990 |
Yoshida T et al. | Abnormal prostanoid metabolism in lupus nephritis and the effects of a thromboxane A2 synthetase inhibitor, DP-1904. | 1996 | Lupus | pmid:8743126 |
Fritsche KL and Cassity NA | Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981628 |
Oláh L et al. | [Low doses of acetylsalicylic acid effectively inhibits thrombocyte aggregation after ischemic stroke]. | 1996 | Orv Hetil | pmid:8714038 |
Kruse-Elliott KT et al. | Attenuation of endotoxin-induced pathophysiology by a new potent PAF receptor antagonist. | 1996 | Shock | pmid:8721386 |
Li KL et al. | The effect of ketoprofen creams on periodontal disease in rhesus monkeys. | 1996 | J. Periodont. Res. | pmid:8971650 |
Yanase T et al. | Dibutyryl cAMP improves systemic vasoconstriction caused by endotoxin in dogs. | 1996 | Shock | pmid:8721389 |
Grauer GF et al. | Effects of dietary n-3 fatty acid supplementation versus thromboxane synthetase inhibition on gentamicin-induced nephrotoxicosis in healthy male dogs. | 1996 | Am. J. Vet. Res. | pmid:8725828 |
Delatour P et al. | Pharmacodynamics and chiral pharmacokinetics of carprofen in calves. | 1996 | Br. Vet. J. | pmid:8680841 |
Jensen N et al. | Recovery of endothelial cells and prostanoid production in endothelial cell-seeded grafts. | 1996 | Eur J Vasc Endovasc Surg | pmid:8696898 |
Nosál R et al. | The H1-histamine antagonist Dithiaden inhibits human platelets in vitro. | 1996 | Inflamm. Res. | pmid:8696916 |
Janssen PL et al. | Consumption of ginger (Zingiber officinale roscoe) does not affect ex vivo platelet thromboxane production in humans. | 1996 | Eur J Clin Nutr | pmid:8933126 |
Liao CH et al. | Antiplatelet effect of demethyldiisoeugenol. | 1996 | Can. J. Physiol. Pharmacol. | pmid:9022830 |
Tarnow P et al. | Effects of D-myo-Inositol-1,2,6-triphosphate on eicosanoid formation in burned skin. | 1996 | J. Surg. Res. | pmid:8606494 |
Okada M et al. | Two mechanisms for platelet-mediated killing of tumour cells: one cyclo-oxygenase dependent and the other nitric oxide dependent. | 1996 | Immunology | pmid:8911154 |
Berdeaux O et al. | Effects of a trans isomer of arachidonic acid on rat platelet aggregation and eicosanoid production. | 1996 | J. Lipid Res. | pmid:8906600 |
Cuiper LL et al. | Systemic and pulmonary hypertension after abrupt cessation of prostacyclin: role of thromboxane A2. | 1996 | J. Appl. Physiol. | pmid:8847301 |
Horiguchi T et al. | Pulmonary responses to heparin-protamine complexes: the effects of age and species. | 1996 | J. Appl. Physiol. | pmid:8847332 |
Gabriel A et al. | Influence of prostaglandin E1 on tissue ischemia during surgical repair of the abdominal aorta. | 1996 | J. Cardiothorac. Vasc. Anesth. | pmid:8850397 |
Chen SJ et al. | Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate. | 1996 | Gen. Pharmacol. | pmid:8853295 |
Suehiro T et al. | Thromboxane A2 in preservation-reperfusion injury: the effect of thromboxane A2 synthetase inhibitor. | 1996 | J. Surg. Res. | pmid:8632642 |
Garvin PJ et al. | Evaluation of the thromboxane A2 synthetase inhibitor OKY-046 in a warm ischemia-reperfusion rat model. | 1996 | Transplantation | pmid:8633364 |
Isenring P et al. | Eicosanoid modulation of the norepinephrine effect on blood pressure and renal hemodynamics in humans. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8992495 |
Leung S et al. | Isolation and purification of anticardiolipin antibody from plasma of a patient with antiphospholipid syndrome: induced generation of platelet thromboxane A2 synthesis. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014216 |
Hirakata H et al. | Sevoflurane inhibits human platelet aggregation and thromboxane A2 formation, possibly by suppression of cyclooxygenase activity. | 1996 | Anesthesiology | pmid:8968193 |
Sheu JR et al. | Mechanism of inhibition of platelet aggregation by rutaecarpine, an alkaloid isolated from Evodia rutaecarpa. | 1996 | Eur. J. Pharmacol. | pmid:9016940 |
Leung LK and Glauert HP | Reduction of the concentrations of prostaglandins E2 and F2alpha, and thromboxane B2 in cultured rat hepatocytes treated with the peroxisome proliferator ciprofibrate. | 1996 | Toxicol. Lett. | pmid:8644126 |
Karck U et al. | PGE2 and PGF2 alpha release by human peritoneal macrophages in endometriosis. | 1996 | Prostaglandins | pmid:8900443 |
Blache D | Enhanced arachidonic acid and calcium metabolism in cholesteryl sulfate-enriched rat platelets. | 1996 | J Lipid Mediat Cell Signal | pmid:8925194 |
Pancera P et al. | Changes in peripheral hemodynamics and vasodilating prostaglandins after high-dose short-term ibuprofen in chronically treated hypertensive patients. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8860111 |
van der Weiden RM et al. | Prostanoid excretion in incipient singleton and twin pregnancies. | 1996 | Am. J. Obstet. Gynecol. | pmid:9065139 |
Cheng Z et al. | Pharmacokinetics and pharmacodynamics of phenylbutazone and oxyphenbutazone in the donkey. | 1996 | J. Vet. Pharmacol. Ther. | pmid:8735424 |
Pregnolato P et al. | Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981629 |
Siler-Khodr TM et al. | Dose-related action of estradiol on placental prostanoid prediction. | 1996 | Prostaglandins | pmid:8873234 |
Prié S et al. | Eosinophils and neutrophils modify arachidonic acid-induced relaxation of guinea-pig trachea. | 1996 | Eur. J. Pharmacol. | pmid:8997620 |
Lechi C et al. | In vitro study of the anti-aggregating activity of two nitroderivatives of acetylsalicylic acid. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735820 |
Cirino G et al. | Indomethacin and thromboxane A2/prostaglandin H2 antagonist SQ29,548 impair in vitro contractions of aortic rings of ex vivo-treated lipopolysaccharide rats. | 1996 | J Lipid Mediat Cell Signal | pmid:8925198 |
Hirashima Y et al. | Prevention of cerebrovasospasm following subarachnoid hemorrhage in rabbits by the platelet-activating factor antagonist, E5880. | 1996 | J. Neurosurg. | pmid:8622157 |
Korn RL et al. | The effects of Carmeda Bioactive Surface on human blood components during simulated extracorporeal circulation. | 1996 | J. Thorac. Cardiovasc. Surg. | pmid:8622305 |
McAdam B et al. | Transdermal modification of platelet function: an aspirin patch system results in marked suppression of platelet cyclooxygenase. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8627531 |
Chou TC et al. | The inhibitory effect of 2-thienyl 2'-hydroxyphenyl ketone (C85) on platelet thromboxane formation. | 1996 | Thromb. Res. | pmid:8897698 |
Harada Y et al. | Role of prostaglandin H synthase-2 in prostaglandin E2 formation in rat carrageenin-induced pleurisy. | 1996 | Prostaglandins | pmid:8900441 |
Saji T et al. | [Short- and long-term effects of the new oral prostacyclin analogue, beraprost sodium, in patients with severe pulmonary hypertension]. | 1996 | J Cardiol | pmid:8642506 |
Tsunomori M et al. | 15-Hydroperoxyeicosapentaenoic acid inhibits arachidonic acid metabolism in rabbit platelets more potently than eicosapentaenoic acid. | 1996 | Biochim. Biophys. Acta | pmid:8679681 |
Livingston ER et al. | Increased activation of the coagulation and fibrinolytic systems leads to hemorrhagic complications during left ventricular assist implantation. | 1996 | Circulation | pmid:8901751 |
Serebruany VL et al. | Mac-1 inhibitor affects certain hemostatic parameters during myocardial stunning in swine. | 1996 | Pharmacology | pmid:8902873 |
Martin W et al. | Respiratory dysfunction and white cell activation following cardiopulmonary bypass: comparison of membrane and bubble oxygenators. | 1996 | Eur J Cardiothorac Surg | pmid:8905281 |
Montuschi P et al. | Tachykinin NK2 receptor antagonists decrease eicosanoid release in lung anaphylaxis. | 1996 | Eur. J. Pharmacol. | pmid:8905345 |
Friedman M et al. | Neutrophil adhesion blockade with NPC 15669 decreases pulmonary injury after total cardiopulmonary bypass. | 1996 | J. Thorac. Cardiovasc. Surg. | pmid:8583821 |
Schmid P et al. | Passive smoking and platelet thromboxane. | 1996 | Thromb. Res. | pmid:8907294 |
Chello M et al. | Reduction by indobufen of neutrophil activation in peripheral arterial occlusive disease. | 1996 | J. Cardiovasc. Pharmacol. | pmid:8907804 |
Szekacs B et al. | Prostacyclin and thromboxane production of rat and cat arterial tissue is altered independently by several vasoactive substances. | 1996 | Prostaglandins | pmid:8908622 |
Serebruany VL et al. | Hemostatic changes after early versus late intracoronary magnesium during acute myocardial infarction in swine. | 1996 | J. Cardiovasc. Pharmacol. | pmid:8961080 |
Gries A et al. | Lipoprotein(a) inhibits collagen-induced aggregation of thrombocytes. | 1996 | Arterioscler. Thromb. Vasc. Biol. | pmid:8963722 |
Sreedhara R et al. | Uremic patients have decreased shear-induced platelet aggregation mediated by decreased availability of glycoprotein IIb-IIIa receptors. | 1996 | Am. J. Kidney Dis. | pmid:8604704 |
Fukushima C et al. | Inhibitory effect of thromboxane A2 synthetase inhibitor, DP-1904, on antigen-induced contraction of human lung parenchyma. | 1996 | Ann. Allergy Asthma Immunol. | pmid:8970439 |
Shibasaki T et al. | Mizoribine reduces urinary protein excretion in rats given puromycin aminonucleoside. | 1996 | Am. J. Nephrol. | pmid:8919236 |
González ET et al. | Prostanoid modulation of glucose transport in isolated diabetic rat uterus. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804128 |
Takase B et al. | Arachidonic acid metabolites in acute myocardial infarction. | 1996 | Angiology | pmid:8686958 |
Mustad V et al. | Seasonal variation in parameters related to coronary heart disease risk in young men. | 1996 | Atherosclerosis | pmid:8879440 |
Selley ML et al. | The effect of cholesterol oxidation products on human platelet aggregation. | 1996 | Thromb. Res. | pmid:8885139 |
Carbajal D et al. | Possible cytoprotective mechanism in rats of D-002, an anti-ulcerogenic product isolated from beeswax. | 1996 | J. Pharm. Pharmacol. | pmid:8887738 |
Nowak J et al. | Thromboxane metabolite excretion in patients with hand-arm vibration syndrome. | 1996 | Clin Physiol | pmid:8842572 |
Huang JZ et al. | Study on characteristics of blast-fragment combined injury in dogs. | 1996 | J Trauma | pmid:8606426 |
Fekkes D et al. | Eicosanoid and amino acid metabolism in transient acute psychoses with psychedelic symptoms. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804122 |
Feng J et al. | Beneficial effects of iloprost cardioplegia in ischemic arrest in isolated working rat heart. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804125 |
Gennaro M et al. | Perfluorocarbon emulsion prevents eicoasanoid release in skeletal muscle ischemia and reperfusion. | 1996 | Cardiovasc Surg | pmid:8782946 |
Fimognari FL et al. | Associated daily biosynthesis of cortisol and thromboxane A2: a preliminary report. | 1996 | J. Lab. Clin. Med. | pmid:8759943 |
Xing X and Xia S | [The injury of liver sinusoidal endothelial cells in a rat's isolated liver perfusion (ILP) model for regional chemotherapy]. | 1996 | Zhonghua Wai Ke Za Zhi | pmid:9275689 |
Kuroiwa M et al. | Effects of granulocyte colony-stimulating factor on the hemostatic system in healthy volunteers. | 1996 | Int. J. Hematol. | pmid:8762814 |
Fuse I et al. | Vascular thromboxane formation in hemostasis mechanism: correlation between bleeding time and vascular TXB2 in a patient with congenital platelet cyclo-oxygenase deficiency. | 1996 | Int. J. Hematol. | pmid:8762815 |
Yoshida SH et al. | Dietary Juniperis virginiensis seed oil decreased pentobarbital-associated mortalities among DBA/1 mice treated with collagen-adjuvant emulsions. | 1996 | J Lipid Mediat Cell Signal | pmid:8816989 |
Galbraith EA and McKellar QA | Protein binding and in vitro serum thromboxane B2 inhibition by flunixin meglumine and meclofenamic acid in dog, goat and horse blood. | 1996 | Res. Vet. Sci. | pmid:8819199 |
Davì G et al. | Influence of metabolic control on thromboxane biosynthesis and plasma plasminogen activator inhibitor type-1 in non-insulin-dependent diabetes mellitus. | 1996 | Thromb. Haemost. | pmid:8819248 |
Wagner RS et al. | Activation of thromboxane A2 receptors alters lipopolysaccharide-induced adherence of THP-1 cells. | 1996 | Shock | pmid:8821102 |
Nishisho T et al. | Experimental and clinical studies of eicosanoids in cerebrospinal fluid after spinal cord injury. | 1996 | Neurosurgery | pmid:8905750 |
Watanabe M et al. | [Changes in platelet sensitivity to thromboxane A2 in pediatric patients with nephrotic syndrome]. | 1996 | Nihon Jinzo Gakkai Shi | pmid:8828355 |
Meenan J et al. | Lexipafant (BB-882), a platelet activating factor receptor antagonist, ameliorates mucosal inflammation in an animal model of colitis. | 1996 | Eur J Gastroenterol Hepatol | pmid:8823572 |
Giulian D et al. | Activated microglia are the principal glial source of thromboxane in the central nervous system. | 1996 | Neurochem. Int. | pmid:8808790 |
Zhen ZY et al. | Experimental study on microthrombi and myocardial injuries. | 1996 | Microvasc. Res. | pmid:8812763 |
Pace-Asciak CR et al. | Wines and grape juices as modulators of platelet aggregation in healthy human subjects. | 1996 | Clin. Chim. Acta | pmid:8814965 |
Uhlig S et al. | Cyclooxygenase-2-dependent bronchoconstriction in perfused rat lungs exposed to endotoxin. | 1996 | Mol. Med. | pmid:8784790 |