Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Cuiper LL et al. | Systemic and pulmonary hypertension after abrupt cessation of prostacyclin: role of thromboxane A2. | 1996 | J. Appl. Physiol. | pmid:8847301 |
Nowak J et al. | Thromboxane metabolite excretion in patients with hand-arm vibration syndrome. | 1996 | Clin Physiol | pmid:8842572 |
Stichtenoth DO et al. | Increased total body synthesis of prostacyclin in rats with adjuvant arthritis. | 1995 Nov-Dec | Prostaglandins | pmid:8838242 |
Muller M and Sorrell TC | Inhibition of the human platelet cyclooxygenase response by the naturally occurring phenazine derivative, 1-hydroxyphenazine. | 1995 Nov-Dec | Prostaglandins | pmid:8838240 |
Fylling AC et al. | Kinetic and structural evidence for the identification of 11-hydroxythromboxane B2 dehydrogenase as cytosolic aldehyde dehydrogenase. | 1995 Nov-Dec | Prostaglandins | pmid:8838239 |
Meade CJ et al. | Pulmonary pharmacology of DT-TX 30 SE, a potent selective combined thromboxane synthetase inhibitor and receptor antagonist, in guinea pigs. | 1996 | Jpn. J. Pharmacol. | pmid:8835638 |
Osiovich H et al. | Cardiopulmonary effects of tumor necrosis factor-alpha in the piglet: influence of cyclooxygenase inhibition. | 1995 | Biol. Neonate | pmid:8835089 |
Myers SI et al. | Long-term resuscitation of hemorrhage/reperfusion injury (H/R) stimulates renal PGE2 release. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8832762 |
Mizugaki M et al. | Microdetermination of 11-dehydrothromboxane B3 in human urine by gas chromatography--selected-ion monitoring using (18O2) analogue as an internal standard. | 1995 | Rapid Commun. Mass Spectrom. | pmid:8829485 |
Ishibashi M et al. | Identification of 11-dehydro-2,3-dinorthromboxane B3 in human urine based on the mass spectral properties of 11-dehydrothromboxane B3 and related compounds. | 1995 | Rapid Commun. Mass Spectrom. | pmid:8829476 |
Mitten LA et al. | Phenylbutazone increases right atrial pressure and heart rate of running horses. | 1996 | J. Appl. Physiol. | pmid:8828679 |
Watanabe M et al. | [Changes in platelet sensitivity to thromboxane A2 in pediatric patients with nephrotic syndrome]. | 1996 | Nihon Jinzo Gakkai Shi | pmid:8828355 |
Meenan J et al. | Lexipafant (BB-882), a platelet activating factor receptor antagonist, ameliorates mucosal inflammation in an animal model of colitis. | 1996 | Eur J Gastroenterol Hepatol | pmid:8823572 |
Wagner RS et al. | Activation of thromboxane A2 receptors alters lipopolysaccharide-induced adherence of THP-1 cells. | 1996 | Shock | pmid:8821102 |
Davì G et al. | Influence of metabolic control on thromboxane biosynthesis and plasma plasminogen activator inhibitor type-1 in non-insulin-dependent diabetes mellitus. | 1996 | Thromb. Haemost. | pmid:8819248 |
Galbraith EA and McKellar QA | Protein binding and in vitro serum thromboxane B2 inhibition by flunixin meglumine and meclofenamic acid in dog, goat and horse blood. | 1996 | Res. Vet. Sci. | pmid:8819199 |
Landoni MF et al. | Pharmacokinetics and pharmacodynamics of tolfenamic acid in calves. | 1996 | Res. Vet. Sci. | pmid:8819190 |
Yoshida SH et al. | Dietary Juniperis virginiensis seed oil decreased pentobarbital-associated mortalities among DBA/1 mice treated with collagen-adjuvant emulsions. | 1996 | J Lipid Mediat Cell Signal | pmid:8816989 |
Pace-Asciak CR et al. | Wines and grape juices as modulators of platelet aggregation in healthy human subjects. | 1996 | Clin. Chim. Acta | pmid:8814965 |
Zhen ZY et al. | Experimental study on microthrombi and myocardial injuries. | 1996 | Microvasc. Res. | pmid:8812763 |
Giulian D et al. | Activated microglia are the principal glial source of thromboxane in the central nervous system. | 1996 | Neurochem. Int. | pmid:8808790 |
González ET et al. | Prostanoid modulation of glucose transport in isolated diabetic rat uterus. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804128 |
Feng J et al. | Beneficial effects of iloprost cardioplegia in ischemic arrest in isolated working rat heart. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804125 |
Fekkes D et al. | Eicosanoid and amino acid metabolism in transient acute psychoses with psychedelic symptoms. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804122 |
Lewy RI et al. | Intravenous heparin initiates in-vivo synthesis and release of thromboxane in angina pectoris. | 1979 | Lancet | pmid:87990 |
Morrow JD et al. | Nonenzymatic free radical-catalyzed generation of thromboxane-like compounds (isothromboxanes) in vivo. | 1996 | J. Biol. Chem. | pmid:8798513 |
Fox GA et al. | Cyclooxygenase inhibition and vascular reactivity in a rat model of hyperdynamic sepsis. | 1996 | J. Cardiovasc. Pharmacol. | pmid:8797133 |
Sakurai S et al. | Synthesis of [[(benzenesulfonamido)alkyl]phenyl]alkanoic acid derivatives containing pyridyl or imidazolyl groups and their thromboxane A2 receptor antagonistic and thromboxane A2 synthase inhibitory activities. | 1996 | Chem. Pharm. Bull. | pmid:8795270 |
Ko FN et al. | Mechanism of action of p-chlorobiphenyl on the inhibition of platelet aggregation. | 1996 | J. Pharm. Pharmacol. | pmid:8794990 |
Uematsu T et al. | Pharmacokinetic and pharmacodynamic properties of FK070 (KDI-792), a novel thromboxane receptor antagonist/thromboxane synthetase inhibitor, after single and multiple oral administrations to healthy volunteers. | 1996 | J. Pharm. Pharmacol. | pmid:8794987 |
Eriksson M et al. | Beneficial effects of pre-treatment with vitamin A on cardiac and pulmonary functions in endotoxaemic pigs. | 1996 | Acta Anaesthesiol Scand | pmid:8792882 |
Collins CE et al. | Picotamide inhibition of excess in vitro thromboxane B2 release by colorectal mucosa in inflammatory bowel disease. | 1996 | Aliment. Pharmacol. Ther. | pmid:8791957 |
Aïssa J et al. | Biochemical and cellular effects of heparin-protamine injection in rabbits are partially inhibited by a PAF-acether receptor antagonist. | 1996 | Eur. J. Pharmacol. | pmid:8791000 |
Vaskonen T et al. | Interrelationships between salt and fish oil in stroke-prone spontaneously hypertensive rat. | 1996 | Blood Press. | pmid:8790929 |
Raptopoulos D et al. | The effect of xylazine on plasma thromboxane B2 concentration in sheep. | 1995 | J. Vet. Pharmacol. Ther. | pmid:8789696 |
Bell SJ et al. | Dietary fish oil and cytokine and eicosanoid production during human immunodeficiency virus infection. | 1996 Jan-Feb | JPEN J Parenter Enteral Nutr | pmid:8788262 |
Zheng NX et al. | Pharmacokinetic and pharmacodynamic studies of a thromboxane synthetase inhibitor, ozagrel, in rabbits. | 1995 | Biol. Pharm. Bull. | pmid:8787798 |
Cuzzolin L et al. | Effect of single and repeated doses of a new nitroderivative of acetylsalicylic acid on platelet TXA2 production in rats. | 1996 | Life Sci. | pmid:8786689 |
Uhlig S et al. | Cyclooxygenase-2-dependent bronchoconstriction in perfused rat lungs exposed to endotoxin. | 1996 | Mol. Med. | pmid:8784790 |
Gennaro M et al. | Perfluorocarbon emulsion prevents eicoasanoid release in skeletal muscle ischemia and reperfusion. | 1996 | Cardiovasc Surg | pmid:8782946 |
Nabe T et al. | Sephadex G-200-induced eosinophil infiltration into airways in non-sensitized and sensitized guinea pigs, and responsiveness of the cells to stimuli in vitro. | 1996 | Jpn. J. Pharmacol. | pmid:8774762 |
Quoc KP and Pascaud M | Effects of dietary gamma-linolenic acid on the tissue phospholipid fatty acid composition and the synthesis of eicosanoids in rats. | 1996 | Ann. Nutr. Metab. | pmid:8773734 |
Madan ZM and Sainani GS | Effect of aspirin treatment on plasma levels of keto PGF 1 alpha and thromboxane B2. | 1995 | J Assoc Physicians India | pmid:8773058 |
Mehta PJ et al. | More uses of known drugs. | 1995 | J Assoc Physicians India | pmid:8773057 |
Closa D et al. | Hepatic involvement in pancreatitis-induced lung damage. | 1996 | Am. J. Physiol. | pmid:8772495 |
Abernathy VJ et al. | C-reactive protein inhibits increased pulmonary vascular permeability induced by fMLP in isolated rabbit lungs. | 1996 | Am. J. Physiol. | pmid:8770090 |
Shirabe K et al. | Inhibition of thromboxane A2 activity during warm ischemia of the liver. | 1996 | J. Surg. Res. | pmid:8769950 |
Qiu BS et al. | Protection by recombinant human interleukin-11 against experimental TNB-induced colitis in rats. | 1996 | Dig. Dis. Sci. | pmid:8769290 |
Hrboticky N et al. | Linoleic acid esterified in low density lipoprotein serves as substrate for increased arachidonic acid synthesis in differentiating monocytic cells. | 1996 | Biochim. Biophys. Acta | pmid:8765140 |
Fleisch JH et al. | Recombinant human secretory phospholipase A2 released thromboxane from guinea pig bronchoalveolar lavage cells: in vitro and ex vivo evaluation of a novel secretory phospholipase A2 inhibitor. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8764358 |
Izaki S et al. | Platelet-activating factor and arachidonic acid metabolites in psoriatic inflammation. | 1996 | Br. J. Dermatol. | pmid:8763425 |
Fuse I et al. | Vascular thromboxane formation in hemostasis mechanism: correlation between bleeding time and vascular TXB2 in a patient with congenital platelet cyclo-oxygenase deficiency. | 1996 | Int. J. Hematol. | pmid:8762815 |
Kuroiwa M et al. | Effects of granulocyte colony-stimulating factor on the hemostatic system in healthy volunteers. | 1996 | Int. J. Hematol. | pmid:8762814 |
Xiao J et al. | [Effects of platelet activating factor and platelet activating factor receptor antagonist on spinal cord blood flow after spinal cord injury]. | 1995 | Zhonghua Wai Ke Za Zhi | pmid:8762548 |
Zhang M et al. | [Reduction of incidence of ischemia-reperfusion induced ventricular fibrillation by captopril]. | 1995 | Sheng Li Xue Bao | pmid:8762446 |
Yan GT et al. | [Tumor necrosis factor induced enhancement of neutrophil chemotaxis and adhesion through mediating of phospholipase A2 activation]. | 1995 | Sheng Li Xue Bao | pmid:8762444 |
Fimognari FL et al. | Associated daily biosynthesis of cortisol and thromboxane A2: a preliminary report. | 1996 | J. Lab. Clin. Med. | pmid:8759943 |
Hibi S et al. | Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase. | 1996 | J. Med. Chem. | pmid:8759636 |
Janabi N et al. | Endogenous nitric oxide activates prostaglandin F2 alpha production in human microglial cells but not in astrocytes: a study of interactions between eicosanoids, nitric oxide, and superoxide anion (O2-) regulatory pathways. | 1996 | J. Immunol. | pmid:8757337 |
Mito Y | [Thromboxane B2 (TXB2)]. | 1995 | Nippon Rinsho | pmid:8753342 |
Gu YJ et al. | Leukocyte depletion results in improved lung function and reduced inflammatory response after cardiac surgery. | 1996 | J. Thorac. Cardiovasc. Surg. | pmid:8751518 |
Yokoyama I et al. | Liberation of vasoactive substances and its prevention with thromboxane A2 synthase inhibitor in pig liver transplantation. | 1996 | Transpl. Int. | pmid:8748415 |
Mathie RT et al. | The haemodynamic effects of the thromboxane A2 receptor antagonist GR32191B during cardiopulmonary bypass in the dog. | 1995 | Perfusion | pmid:8747897 |
Yoshida T et al. | Abnormal prostanoid metabolism in lupus nephritis and the effects of a thromboxane A2 synthetase inhibitor, DP-1904. | 1996 | Lupus | pmid:8743126 |
Yang JM et al. | Sodium nonivamide acetate: a non-pungently antinociceptive capsaicin derivative with unusual anti-inflammatory properties. | 1996 | Gen. Pharmacol. | pmid:8742512 |
Laffi G et al. | Defective aggregation in cirrhosis is independent of in vivo platelet activation. | 1996 | J. Hepatol. | pmid:8738730 |
Young JM et al. | Human whole blood assays for inhibition of prostaglandin G/H synthases-1 and -2 using A23187 and lipopolysaccharide stimulation of thromboxane B2 production. | 1996 | Inflamm. Res. | pmid:8737748 |
Ravn HB et al. | Magnesium inhibits human platelets. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735829 |
Lechi C et al. | In vitro study of the anti-aggregating activity of two nitroderivatives of acetylsalicylic acid. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735820 |
Jancinová V et al. | Inhibition of blood platelet functions by cationic amphiphilic drugs in relation to their physico-chemical properties. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735816 |
Cheng Z et al. | Pharmacokinetics and pharmacodynamics of phenylbutazone and oxyphenbutazone in the donkey. | 1996 | J. Vet. Pharmacol. Ther. | pmid:8735424 |
Li H | [Research on plasma TXA2, PGI2 levels, blood stasis syndrome and promoting blood circulation]. | 1995 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8732157 |
Liang-min LD et al. | [Effect of age on hemostasis and plasma level of TXB2 and 6-keto-PGF1 alpha]. | 1995 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8732148 |
Liang XC et al. | [Study on relationship of lipid peroxide in coronary heart disease with and without diabetes]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8732128 |
Xiong YL and Zhao HY | Experimental studies on preventive effects of API0134 on vessel reocclusion after thrombolysis. | 1995 | J. Tongji Med. Univ. | pmid:8731957 |
Xiong YL and Zhao HY | Effect of captopril on antithrombus function of endothelium. | 1995 | J. Tongji Med. Univ. | pmid:8731927 |
Isozaki H et al. | Urinary thromboxane B2 as an indicator of acute rejection in human liver transplantation. | 1996 | Surg. Today | pmid:8727944 |
Grauer GF et al. | Effects of dietary n-3 fatty acid supplementation versus thromboxane synthetase inhibition on gentamicin-induced nephrotoxicosis in healthy male dogs. | 1996 | Am. J. Vet. Res. | pmid:8725828 |
Yanase T et al. | Dibutyryl cAMP improves systemic vasoconstriction caused by endotoxin in dogs. | 1996 | Shock | pmid:8721389 |
Kruse-Elliott KT et al. | Attenuation of endotoxin-induced pathophysiology by a new potent PAF receptor antagonist. | 1996 | Shock | pmid:8721386 |
Oláh L et al. | [Low doses of acetylsalicylic acid effectively inhibits thrombocyte aggregation after ischemic stroke]. | 1996 | Orv Hetil | pmid:8714038 |
Tishler M et al. | Salivary eicosanoid concentration in patients with Sjögren's syndrome. | 1996 | Ann. Rheum. Dis. | pmid:8712887 |
Herrick AL et al. | Von Willebrand factor, thrombomodulin, thromboxane, beta-thromboglobulin and markers of fibrinolysis in primary Raynaud's phenomenon and systemic sclerosis. | 1996 | Ann. Rheum. Dis. | pmid:8712862 |
Howarth SR et al. | Role of thromboxane A2 in the vasoconstrictor response to endothelin-1, angiotensin II and 5-hydroxytryptamine in human placental vessels. | 1995 | Placenta | pmid:8710799 |
Liu H et al. | [Effects of low dose aspirin on platelet function and prostaglandins metabolism in systemic and coronary circulation in patients with ischemia heart disease]. | 1995 | Zhonghua Nei Ke Za Zhi | pmid:8697924 |
Sun B et al. | [The experimental observation on the procedure of atherosclerotic restenosis following PTCA]. | 1995 | Zhonghua Nei Ke Za Zhi | pmid:8697911 |
Nosál R et al. | The H1-histamine antagonist Dithiaden inhibits human platelets in vitro. | 1996 | Inflamm. Res. | pmid:8696916 |
Jensen N et al. | Recovery of endothelial cells and prostanoid production in endothelial cell-seeded grafts. | 1996 | Eur J Vasc Endovasc Surg | pmid:8696898 |
Takase B et al. | Arachidonic acid metabolites in acute myocardial infarction. | 1996 | Angiology | pmid:8686958 |
Malý J et al. | Migraine--a haematological disorder? | 1995 | Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove | pmid:8685625 |
Taylor PM et al. | Pharmacodynamics and enantioselective pharmacokinetics of carprofen in the cat. | 1996 | Res. Vet. Sci. | pmid:8685536 |
Cervar M et al. | Altered release of endothelin-1,2 and thromboxane B2 from trophoblastic cells in pre-eclampsia. | 1996 | Eur. J. Clin. Invest. | pmid:8682152 |
Delatour P et al. | Pharmacodynamics and chiral pharmacokinetics of carprofen in calves. | 1996 | Br. Vet. J. | pmid:8680841 |
Tsunomori M et al. | 15-Hydroperoxyeicosapentaenoic acid inhibits arachidonic acid metabolism in rabbit platelets more potently than eicosapentaenoic acid. | 1996 | Biochim. Biophys. Acta | pmid:8679681 |
Myers SI et al. | Regulation of eicosanoid synthesis in fibroblasts from inflamed gallbladders. | 1995 | Mol. Cell. Endocrinol. | pmid:8674862 |
Stein CM et al. | Evidence of free radical-mediated injury (isoprostane overproduction) in scleroderma. | 1996 | Arthritis Rheum. | pmid:8670323 |
Saitta A et al. | Effects of gallopamil on epinephrine and norepinephrine plasmatic levels and on TxB2 and beta-tg release in patients with coronary artery disease during adrenergic stimulus with cold pressor test. | 1995 Jul-Aug | Pharmacol. Res. | pmid:8668647 |
Haimovich B et al. | The FcgammaRII receptor triggers pp125FAK phosphorylation in platelets. | 1996 | J. Biol. Chem. | pmid:8663117 |
Wahle KW and Peacock LI | Effects of isomeric cis and trans eighteen carbon monounsaturated fatty acids on porcine platelet function. | 1996 | Biochim. Biophys. Acta | pmid:8652649 |
Dehmlow C et al. | Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells. | 1996 | Life Sci. | pmid:8649189 |