Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

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Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Cholecystitis, Acute D041881 1 associated lipids
Bluetongue D001819 1 associated lipids
Atrial Premature Complexes D018880 1 associated lipids
Gastric Dilatation D013271 1 associated lipids
Latex Hypersensitivity D020315 1 associated lipids
Stomach Volvulus D013277 1 associated lipids
Foot Rot D005535 1 associated lipids
Frostbite D005627 1 associated lipids
Strongyle Infections, Equine D013319 1 associated lipids
Basal Ganglia Hemorrhage D020145 1 associated lipids
Edema, Cardiac D004489 1 associated lipids
Osteoblastoma D018215 1 associated lipids
Radiculopathy D011843 1 associated lipids
Oligomenorrhea D009839 1 associated lipids
Erythromelalgia D004916 1 associated lipids
Intracranial Hemorrhage, Hypertensive D020299 1 associated lipids
Fibromuscular Dysplasia D005352 2 associated lipids
Heart Septal Defects D006343 2 associated lipids
Retinal Vein Occlusion D012170 2 associated lipids
Weil Disease D014895 2 associated lipids
Drowning D004332 2 associated lipids
Pulmonary Heart Disease D011660 2 associated lipids
Aortic Arch Syndromes D001015 2 associated lipids
Mixed Connective Tissue Disease D008947 2 associated lipids
Tachycardia, Paroxysmal D013614 2 associated lipids
Aortic Rupture D001019 3 associated lipids
Hemorrhagic Fever with Renal Syndrome D006480 3 associated lipids
Yang Deficiency D016711 3 associated lipids
Bronchopulmonary Sequestration D001998 3 associated lipids
Airway Remodeling D056151 3 associated lipids
Angina Pectoris, Variant D000788 3 associated lipids
Jejunal Diseases D007579 3 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Tachycardia, Supraventricular D013617 3 associated lipids
Platelet Storage Pool Deficiency D010981 3 associated lipids
Takayasu Arteritis D013625 3 associated lipids
Pneumonia, Aspiration D011015 3 associated lipids
Infertility D007246 3 associated lipids
Macular Edema D008269 3 associated lipids
Hydatidiform Mole D006828 3 associated lipids
Contusions D003288 3 associated lipids
Bronchopulmonary Dysplasia D001997 4 associated lipids
Thrombasthenia D013915 4 associated lipids
Menorrhagia D008595 4 associated lipids
Systemic Inflammatory Response Syndrome D018746 4 associated lipids
Diseases in Twins D004200 4 associated lipids
Hyperaldosteronism D006929 4 associated lipids
Glomerulosclerosis, Focal Segmental D005923 4 associated lipids
Chediak-Higashi Syndrome D002609 4 associated lipids
Chest Pain D002637 4 associated lipids
Heart Valve Diseases D006349 4 associated lipids
Streptococcal Infections D013290 4 associated lipids
Retinal Diseases D012164 4 associated lipids
Leiomyosarcoma D007890 4 associated lipids
Thromboangiitis Obliterans D013919 4 associated lipids
Embolism, Fat D004620 4 associated lipids
Intracranial Embolism and Thrombosis D002542 5 associated lipids
Hypoalphalipoproteinemias D052456 5 associated lipids
Facial Pain D005157 5 associated lipids
Bartter Syndrome D001477 5 associated lipids
Abortion, Habitual D000026 5 associated lipids
Mastocytosis D008415 5 associated lipids
Aortic Aneurysm, Abdominal D017544 5 associated lipids
Hypercapnia D006935 5 associated lipids
Respiration Disorders D012120 5 associated lipids
Asthenia D001247 5 associated lipids
Purpura, Schoenlein-Henoch D011695 5 associated lipids
Sclerosis D012598 5 associated lipids
Pulmonary Embolism D011655 5 associated lipids
Ductus Arteriosus, Patent D004374 5 associated lipids
beta-Thalassemia D017086 5 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Placenta Diseases D010922 5 associated lipids
Hyperlipoproteinemia Type IV D006953 6 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Coronary Stenosis D023921 6 associated lipids
Sneezing D012912 6 associated lipids
Thromboembolism D013923 6 associated lipids
Bronchitis D001991 6 associated lipids
Intermittent Claudication D007383 6 associated lipids
Purpura, Thrombotic Thrombocytopenic D011697 6 associated lipids
Thrombophilia D019851 6 associated lipids
Periapical Periodontitis D010485 6 associated lipids
Bronchopneumonia D001996 7 associated lipids
Raynaud Disease D011928 7 associated lipids
Tachycardia D013610 7 associated lipids
Dyslipidemias D050171 7 associated lipids
Keratitis D007634 7 associated lipids
Glomerulonephritis, IGA D005922 7 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
Coronary Thrombosis D003328 7 associated lipids
Varicose Veins D014648 7 associated lipids
Behcet Syndrome D001528 7 associated lipids
Agranulocytosis D000380 7 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Infant, Premature, Diseases D007235 7 associated lipids
Biliary Tract Neoplasms D001661 7 associated lipids
Femoral Fractures D005264 7 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Obesity, Morbid D009767 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

Download all related citations
Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Ersöz G et al. Effect of submaximal and incremental upper extremity exercise on platelet function and the role of blood shear stress. 2002 Thromb. Res. pmid:12676189
Svensson J and Samuelsson K Inhibition of platelet function by low dose acetylsalicylic acid in patients with cerebrovascular disease. 1983 Thromb. Res. pmid:20218005
Weide I and Simmet T Leukotriene formation by peripheral monocytes in contact-activated human blood. 1993 Thromb. Res. pmid:8211886
Saldeen P et al. Increased synthesis of thromboxane B2 and 6-keto-PGF1 alpha in hand veins from patients with deep venous thrombosis. 1983 Thromb. Res. pmid:6658723
Bradlow BA and Chetty N Dosage frequency for suppression of platelet function by low dose aspirin therapy. 1982 Thromb. Res. pmid:7123514
Buchanan MR et al. Aspirin inhibits platelet function independent of the acetylation of cyclo-oxygenase. 1982 Thromb. Res. pmid:7071811
Martin JF et al. Effect of acetylsalicylic acid on platelet aggregation and thromboxane B2 production in flowing aortic blood in the rat studied with a filter loop technique. 1982 Thromb. Res. pmid:6814004
Agren JJ et al. Dose responses in platelet fatty acid composition, aggregation and prostanoid metabolism during moderate freshwater fish diet. 1990 Thromb. Res. pmid:2326774
Winter M et al. Synthesis of thromboxane B2 in uraemia and the effects of dialysis. 1983 Thromb. Res. pmid:6868024
Pedersen AK et al. Inhibition of thromboxane biosynthesis in serum: limitations of the measurement of immunoreactive 6-keto-PGF1 alpha. 1984 Thromb. Res. pmid:6546456
Huang CG et al. Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells. 2002 Thromb. Res. pmid:12297129
Teng CM et al. Two antiplatelet agents from Magnolia officinalis. 1988 Thromb. Res. pmid:3413728
Udvardy M et al. Plasma thromboxane and prostacyclin metabolite ratio in atherosclerosis and diabetes mellitus. 1987 Thromb. Res. pmid:3116717
Cholette JM et al. Aspirin resistance following pediatric cardiac surgery. 2010 Thromb. Res. pmid:20550971
Umemura K et al. Effect of dietary docosahexaenoic acid in the rat middle cerebral artery thrombosis model. 1995 Thromb. Res. pmid:7660354
García Frade LJ et al. Diabetes mellitus as a hypercoagulable state: its relationship with fibrin fragments and vascular damage. 1987 Thromb. Res. pmid:3118498
Davì G et al. Thromboxane B2 formation and platelet sensitivity to prostacyclin in insulin-dependent and insulin-independent diabetics. 1982 Thromb. Res. pmid:6761893
Cerskus AL et al. Effects of indomethacin and sulfinpyrazone on in vivo formation of thromboxane B2 and prostaglandin D2 during arachidonate infusion in rabbits. 1978 Thromb. Res. pmid:653641
Hernández R et al. Influence of co-incubation and cell number of platelets and polymorphonuclear leukocytes in cellular inhibition and activation phenomena. 1994 Thromb. Res. pmid:8042192
Tsuboi T et al. Effect of gliclazide on prostaglandin and thromboxane synthesis in guinea-pig platelets. 1981 Jan 1-15 Thromb. Res. pmid:7233394
Hanasaki K and Arita H Characterization of a new compound, S-145, as a specific TXA2 receptor antagonist in platelets. 1988 Thromb. Res. pmid:2839912
Ditter H et al. Effects of prostacyclin during cardiopulmonary bypass in men on plasma levels of beta-thromboglobulin, platelet factor 4, thromboxane B2, 6-keto-prostaglandin F1 alpha and heparin. 1983 Thromb. Res. pmid:6197766
Shorr RI et al. In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis. 1985 Thromb. Res. pmid:3923647
Ishikawa Y et al. Effect of cytoplasmic pH on platelet activation by arachidonic acid. 1989 Thromb. Res. pmid:2499076
Gachályi B et al. In vitro effect of cimetidine on ADP induced platelet aggregation and thromboxane A2 synthesis in man. 1984 Thromb. Res. pmid:6474407
Fitzpatrick F et al. Development of a gas chromatographic-mass spectrometric method using a stable isotope internal standard for quantitation of thromboxane B2. 1984 Thromb. Res. pmid:6474413
Lages B and Weiss HJ Inhibition of human platelet function in vitro and ex vivo by acetaminophen. 1989 Thromb. Res. pmid:2499947
Küster LJ et al. Mechanism of PAF-induced platelet aggregation in man. 1986 Thromb. Res. pmid:3764802
Dalli E et al. Effects of hawthorn (Crataegus laevigata) on platelet aggregation in healthy volunteers. 2011 Thromb. Res. pmid:21737127
Toivanen J et al. Differential inhibition of platelet thromboxane and lung prostacyclin production by sulphinpyrazone, acetylsalicylic acid and indomethacin by human tissues in vitro. 1985 Thromb. Res. pmid:3920778
Ishii H et al. The effect of plasma on platelet function in hypercholesterolemic rabbits and the changes in fatty acid composition of the plasma. 1984 Thromb. Res. pmid:6234679
Reimers HJ et al. Impaired thromboxane synthesis in preactivated human blood platelets: agonist-specific, irreversible desensitization to thrombin. 1987 Thromb. Res. pmid:3126557
Stegmeier K et al. The pharmacological profile of the thromboxane A2 antagonist BM 13.177. A new anti-platelet and anti-thrombotic drug. 1984 Thromb. Res. pmid:6385334
Lukasik M et al. Aspirin treatment influences platelet-related inflammatory biomarkers in healthy individuals but not in acute stroke patients. 2011 Thromb. Res. pmid:21788065
Davis RB et al. Evaluation of platelet function in pregnancy. Comparative studies in non-smokers and smokers. 1987 Thromb. Res. pmid:2955542
Gerrard JM et al. Studies in patients with bleeding disorders show that platelet-vessel interaction is important for thromboxane formation in bleeding time wounds. 1990 Thromb. Res. pmid:2278038
Ali M et al. Synthesis of prostaglandin D2 and thromboxane B2 by human platelets. 1977 Thromb. Res. pmid:918907
Reis F et al. The peripheral serotonergic system and platelet aggregation in cyclosporin A-induced hypertensive rats. 1999 Thromb. Res. pmid:10605951
Wang JP et al. Antiplatelet effect of capsaicin. 1984 Thromb. Res. pmid:6528310
Udvardy M et al. Alterations of primary haemostasis in mixed connective tissue disease (MCTD). 1991 Thromb. Res. pmid:1835548
Lin CH et al. HA-29: an inhibitor of thromboxane A2 formation with antagonism of thromboxane A2/prostaglandin endoperoxide receptor in rabbit platelets. 1992 Thromb. Res. pmid:1412184
Marasini B et al. Cigarette smoking and platelet function. 1986 Thromb. Res. pmid:3787563
Matsuo T et al. A new thrombin inhibitor MD805 and thrombocytopenia encountered with heparin hemodialysis. 1986 Thromb. Res. pmid:3787568
Chakroun T et al. Screening for aspirin resistance in stable coronary artery patients by three different tests. 2007 Thromb. Res. pmid:17553552
Simmet T and Luck W Clotting of whole human blood induces cysteinyl-leukotriene formation. 1989 Thromb. Res. pmid:2549655
Buchanan MR et al. The sex-related differences in aspirin pharmacokinetics in rabbits and man and its relationship to antiplatelet effects. 1983 Thromb. Res. pmid:6221436
Neiman J et al. Composition of platelet phosphatidylinositol and phosphatidylcholine after ethanol withdrawal. 1987 Thromb. Res. pmid:3603426
Randall MJ and Wilding RI Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with thromboxane synthetase inhibitor dazoxiben hydrochloride, (UK-37, 248-01). 1982 Thromb. Res. pmid:6897751
Di Minno G and Violi F Aspirin resistance and diabetic angiopathy: back to the future. 2004 Thromb. Res. pmid:15115664
Best LC et al. Mode of action of dipyridamole on human platelets. 1979 Thromb. Res. pmid:229583
Jørgensen KA et al. The survival of pig to rabbit renal xenografts during inhibition of thromboxane synthesis. 1983 Thromb. Res. pmid:6364449
Naran NH and Chetty N The in vitro effect of ridogrel on platelet function in normocholesterolaemic and familial hypercholesterolaemic type IIa subjects. 1997 Thromb. Res. pmid:9556227
Franconi F et al. Effect of gamma-hydroxybutyric acid on human platelet aggregation in vitro. 2001 Thromb. Res. pmid:11369419
Todd MH et al. The involvement of prostaglandins and thromboxanes in the response to pulmonary embolism in anaesthetized rabbits and isolated perfused lungs. 1983 Thromb. Res. pmid:6687961
Maderna P et al. Differential effects of oral administrations to human volunteers of acetylsalicylic acid, sodium salicylate and indomethacin on 12-hydroxyeicosatetraenoic acid formation by stimulated platelets. 1988 Thromb. Res. pmid:3194896
Todd MK et al. Effect of exercise intensity on 6-keto-PGF1 alpha, TXB2, and 6-keto-PGF1 alpha/TXB2 ratios. 1992 Thromb. Res. pmid:1615492
Dembinska-Kiec A et al. Ticlopidine and platelet function in healthy volunteers. 1992 Thromb. Res. pmid:1615496
Platelet function during long-term treatment with ketanserin of claudicating patients with peripheral atherosclerosis. A multi-center, double-blind, placebo-controlled trial. The PACK Trial Group. 1989 Thromb. Res. pmid:2528841
Hashimoto Y et al. Characteristics of protein kinase C-independent exocytosis in human platelets. 1997 Thromb. Res. pmid:9336873
Igawa T et al. Potentiation of anti-platelet aggregating activity of cilostazol with vascular endothelial cells. 1990 Thromb. Res. pmid:2158154
Yue TL et al. Pharmacological profile of G619, a new platelet aggregation inhibitor. 1992 Thromb. Res. pmid:1412200
Russell NH et al. Platelet adenine nucleotides and arachidonic acid metabolism in the myeloproliferative disorders. 1981 Thromb. Res. pmid:6794179
Thorwest M et al. Dietary fish oil reduces microvascular thrombosis in a porcine experimental model. 2000 Thromb. Res. pmid:10946095
Ames PR et al. Aspirin insensitive thromboxane generation is associated with oxidative stress in type 2 diabetes mellitus. 2012 Thromb. Res. pmid:22521214
Martin JF et al. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. 1983 Thromb. Res. pmid:6658722
Togna GI et al. Cisplatin triggers platelet activation. 2000 Thromb. Res. pmid:10973681
Saloheimo P et al. Thromboxane and prostacyclin biosynthesis in patients with acute spontaneous intracerebral hemorrhage. 2005 Thromb. Res. pmid:15733969
Vesterqvist O et al. In vivo production of thromboxane in acute human myocardial infarction: a preliminary study. 1985 Thromb. Res. pmid:3992528
Chiang TM and Kang AH The effect of platelet surface protein phosphorylation on collagen-platelet interaction. 1986 Thromb. Res. pmid:3810565
Serebruany VL and Gurbel PA Assessment of platelet activity by measuring platelet-derived substances in plasma from patients with acute myocardial infarction: surprising lessons from the GUSTO-III Platelet Study. 1999 Thromb. Res. pmid:10030832
Kelton JG et al. A study of the bioavailability and platelet inhibitory effects of a new enteric-coated acetylsalicylic acid preparation. 1984 Thromb. Res. pmid:6740573
Chou TC et al. The inhibitory effect of 2-thienyl 2'-hydroxyphenyl ketone (C85) on platelet thromboxane formation. 1996 Thromb. Res. pmid:8897698
Teng CM et al. Antiplatelet actions of some coumarin compounds isolated from plant sources. 1992 Thromb. Res. pmid:1523611
Preston FE et al. Low-dose aspirin inhibits platelet and venous cyclo-oxygenase in man. 1982 Thromb. Res. pmid:6815823
Knapp HR et al. Effects of low-dose aspirin on endogenous eicosanoid formation in normal and atherosclerotic men. 1988 Thromb. Res. pmid:3293263
Randall MJ et al. UK-37, 248, a novel, selective thromboxane synthetase inhibitor with platelet anti-aggregatory and anti-thrombotic activity. 1981 Jul 1-15 Thromb. Res. pmid:6795753
De Caterina R et al. Inhibition of platelet aggregation and thromboxane B2 production during aspirin treatment: dependence on the dose of the aggregating agent. 1985 Thromb. Res. pmid:3975876
Worthington RE and Fuller GC Dibutyryl cyclic guanosine monophosphate elevates bovine endothelial cell thromboxane production without affecting prostacyclin metabolism. 1984 Thromb. Res. pmid:6322377
Armstrong RA et al. No effect of dietary trans isomers of alpha-linolenic acid on platelet aggregation and haemostatic factors in european healthy men. The TRANSLinE study. 2000 Thromb. Res. pmid:11108899
De Caterina R et al. Long-term maintenance of thromboxane inhibition by two different aspirin regimens in patients with unstable angina. 1990 Thromb. Res. pmid:2126400
Bergqvist D et al. The effect of inhibition of thromboxane synthesis in experimental thrombosis and hemostasis. 1985 Thromb. Res. pmid:3838828
Kelton JG et al. Sex-related differences in the efficacy of acetylsalicylic acid (ASA) : the absorption of ASA and its effect on collagen-induced thromboxane B2 generation. 1981 Oct 1-15 Thromb. Res. pmid:7330835
De La Cruz JP et al. Effect of DT-TX 30, a combined thromboxane synthase inhibitor and thromboxane receptor antagonist, on retinal vascularity in experimental diabetes mellitus. 2000 Thromb. Res. pmid:10680643
Domoto DT et al. Combined aspirin and sulfinpyrazone in the prevention of recurrent hemodialysis vascular access thrombosis. 1991 Thromb. Res. pmid:1926064
Weber AA et al. 40 mg of aspirin are not sufficient to inhibit platelet function under conditions of limited compliance. 2000 Thromb. Res. pmid:10709913
Wu TM et al. Inhibitory effect of hexapeptide (RGRHGD) on platelet aggregation. 2000 Thromb. Res. pmid:10674405
Wang JP et al. XC 386: a new antiplatelet agent. 1984 Thromb. Res. pmid:6438827
Küster LJ and Frölich JC PAF-induced platelet aggregation and TXB2 formation. 1989 Thromb. Res. pmid:2922704
Driss F et al. Inhibition of platelet aggregation and thromboxane synthesis after intake of small amount of icosapentaenoic acid. 1984 Thromb. Res. pmid:6098051
Vila V et al. Fibrinopeptide A release from intraplatelet fibrinogen is related to thrombin platelet activation. 1997 Thromb. Res. pmid:9175247
Mogensen F et al. Effect of specific thromboxane-synthetase inhibition on thromboxane and prostaglandin synthesis in stable angina induced by exercise test. 1985 Thromb. Res. pmid:4038824
Tzeng SH et al. Inhibition of platelet aggregation by some flavonoids. 1991 Thromb. Res. pmid:1776142
Neiman J et al. Platelet uptake of serotonin (5-HT) during ethanol withdrawal in male alcoholics. 1987 Thromb. Res. pmid:2820078
Altman R et al. Why single daily dose of aspirin may not prevent platelet aggregation. 1988 Thromb. Res. pmid:3140408
Simmet T and Weide I Thromboxane and cysteinyl-leukotriene formation are differentially activated in spontaneously clotting whole human blood in vitro. 1991 Thromb. Res. pmid:1866709
Weigel G et al. Regulation of eicosanoid release in human umbilical endothelial cells. 1991 Thromb. Res. pmid:1656543
Delvos U et al. Direct radioimmunological measurement of thromboxane B2 in plasma. 1985 Thromb. Res. pmid:4082109
Ko FN et al. Antiplatelet effects of protopine isolated from Corydalis tubers. 1989 Thromb. Res. pmid:2559491
Grignani G et al. Activation of platelet prostaglandin biosynthesis pathway during neoplastic cell-induced platelet aggregation. 1984 Thromb. Res. pmid:6729776
Patterson WR et al. Aggregation of killer whale platelets. 1993 Thromb. Res. pmid:8327987