Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ersöz G et al. | Effect of submaximal and incremental upper extremity exercise on platelet function and the role of blood shear stress. | 2002 | Thromb. Res. | pmid:12676189 |
Svensson J and Samuelsson K | Inhibition of platelet function by low dose acetylsalicylic acid in patients with cerebrovascular disease. | 1983 | Thromb. Res. | pmid:20218005 |
Weide I and Simmet T | Leukotriene formation by peripheral monocytes in contact-activated human blood. | 1993 | Thromb. Res. | pmid:8211886 |
Saldeen P et al. | Increased synthesis of thromboxane B2 and 6-keto-PGF1 alpha in hand veins from patients with deep venous thrombosis. | 1983 | Thromb. Res. | pmid:6658723 |
Bradlow BA and Chetty N | Dosage frequency for suppression of platelet function by low dose aspirin therapy. | 1982 | Thromb. Res. | pmid:7123514 |
Buchanan MR et al. | Aspirin inhibits platelet function independent of the acetylation of cyclo-oxygenase. | 1982 | Thromb. Res. | pmid:7071811 |
Martin JF et al. | Effect of acetylsalicylic acid on platelet aggregation and thromboxane B2 production in flowing aortic blood in the rat studied with a filter loop technique. | 1982 | Thromb. Res. | pmid:6814004 |
Agren JJ et al. | Dose responses in platelet fatty acid composition, aggregation and prostanoid metabolism during moderate freshwater fish diet. | 1990 | Thromb. Res. | pmid:2326774 |
Winter M et al. | Synthesis of thromboxane B2 in uraemia and the effects of dialysis. | 1983 | Thromb. Res. | pmid:6868024 |
Pedersen AK et al. | Inhibition of thromboxane biosynthesis in serum: limitations of the measurement of immunoreactive 6-keto-PGF1 alpha. | 1984 | Thromb. Res. | pmid:6546456 |
Huang CG et al. | Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells. | 2002 | Thromb. Res. | pmid:12297129 |
Teng CM et al. | Two antiplatelet agents from Magnolia officinalis. | 1988 | Thromb. Res. | pmid:3413728 |
Udvardy M et al. | Plasma thromboxane and prostacyclin metabolite ratio in atherosclerosis and diabetes mellitus. | 1987 | Thromb. Res. | pmid:3116717 |
Cholette JM et al. | Aspirin resistance following pediatric cardiac surgery. | 2010 | Thromb. Res. | pmid:20550971 |
Umemura K et al. | Effect of dietary docosahexaenoic acid in the rat middle cerebral artery thrombosis model. | 1995 | Thromb. Res. | pmid:7660354 |
GarcÃa Frade LJ et al. | Diabetes mellitus as a hypercoagulable state: its relationship with fibrin fragments and vascular damage. | 1987 | Thromb. Res. | pmid:3118498 |
Davì G et al. | Thromboxane B2 formation and platelet sensitivity to prostacyclin in insulin-dependent and insulin-independent diabetics. | 1982 | Thromb. Res. | pmid:6761893 |
Cerskus AL et al. | Effects of indomethacin and sulfinpyrazone on in vivo formation of thromboxane B2 and prostaglandin D2 during arachidonate infusion in rabbits. | 1978 | Thromb. Res. | pmid:653641 |
Hernández R et al. | Influence of co-incubation and cell number of platelets and polymorphonuclear leukocytes in cellular inhibition and activation phenomena. | 1994 | Thromb. Res. | pmid:8042192 |
Tsuboi T et al. | Effect of gliclazide on prostaglandin and thromboxane synthesis in guinea-pig platelets. | 1981 Jan 1-15 | Thromb. Res. | pmid:7233394 |
Hanasaki K and Arita H | Characterization of a new compound, S-145, as a specific TXA2 receptor antagonist in platelets. | 1988 | Thromb. Res. | pmid:2839912 |
Ditter H et al. | Effects of prostacyclin during cardiopulmonary bypass in men on plasma levels of beta-thromboglobulin, platelet factor 4, thromboxane B2, 6-keto-prostaglandin F1 alpha and heparin. | 1983 | Thromb. Res. | pmid:6197766 |
Shorr RI et al. | In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis. | 1985 | Thromb. Res. | pmid:3923647 |
Ishikawa Y et al. | Effect of cytoplasmic pH on platelet activation by arachidonic acid. | 1989 | Thromb. Res. | pmid:2499076 |
Gachályi B et al. | In vitro effect of cimetidine on ADP induced platelet aggregation and thromboxane A2 synthesis in man. | 1984 | Thromb. Res. | pmid:6474407 |
Fitzpatrick F et al. | Development of a gas chromatographic-mass spectrometric method using a stable isotope internal standard for quantitation of thromboxane B2. | 1984 | Thromb. Res. | pmid:6474413 |
Lages B and Weiss HJ | Inhibition of human platelet function in vitro and ex vivo by acetaminophen. | 1989 | Thromb. Res. | pmid:2499947 |
Küster LJ et al. | Mechanism of PAF-induced platelet aggregation in man. | 1986 | Thromb. Res. | pmid:3764802 |
Dalli E et al. | Effects of hawthorn (Crataegus laevigata) on platelet aggregation in healthy volunteers. | 2011 | Thromb. Res. | pmid:21737127 |
Toivanen J et al. | Differential inhibition of platelet thromboxane and lung prostacyclin production by sulphinpyrazone, acetylsalicylic acid and indomethacin by human tissues in vitro. | 1985 | Thromb. Res. | pmid:3920778 |
Ishii H et al. | The effect of plasma on platelet function in hypercholesterolemic rabbits and the changes in fatty acid composition of the plasma. | 1984 | Thromb. Res. | pmid:6234679 |
Reimers HJ et al. | Impaired thromboxane synthesis in preactivated human blood platelets: agonist-specific, irreversible desensitization to thrombin. | 1987 | Thromb. Res. | pmid:3126557 |
Stegmeier K et al. | The pharmacological profile of the thromboxane A2 antagonist BM 13.177. A new anti-platelet and anti-thrombotic drug. | 1984 | Thromb. Res. | pmid:6385334 |
Lukasik M et al. | Aspirin treatment influences platelet-related inflammatory biomarkers in healthy individuals but not in acute stroke patients. | 2011 | Thromb. Res. | pmid:21788065 |
Davis RB et al. | Evaluation of platelet function in pregnancy. Comparative studies in non-smokers and smokers. | 1987 | Thromb. Res. | pmid:2955542 |
Gerrard JM et al. | Studies in patients with bleeding disorders show that platelet-vessel interaction is important for thromboxane formation in bleeding time wounds. | 1990 | Thromb. Res. | pmid:2278038 |
Ali M et al. | Synthesis of prostaglandin D2 and thromboxane B2 by human platelets. | 1977 | Thromb. Res. | pmid:918907 |
Reis F et al. | The peripheral serotonergic system and platelet aggregation in cyclosporin A-induced hypertensive rats. | 1999 | Thromb. Res. | pmid:10605951 |
Wang JP et al. | Antiplatelet effect of capsaicin. | 1984 | Thromb. Res. | pmid:6528310 |
Udvardy M et al. | Alterations of primary haemostasis in mixed connective tissue disease (MCTD). | 1991 | Thromb. Res. | pmid:1835548 |
Lin CH et al. | HA-29: an inhibitor of thromboxane A2 formation with antagonism of thromboxane A2/prostaglandin endoperoxide receptor in rabbit platelets. | 1992 | Thromb. Res. | pmid:1412184 |
Marasini B et al. | Cigarette smoking and platelet function. | 1986 | Thromb. Res. | pmid:3787563 |
Matsuo T et al. | A new thrombin inhibitor MD805 and thrombocytopenia encountered with heparin hemodialysis. | 1986 | Thromb. Res. | pmid:3787568 |
Chakroun T et al. | Screening for aspirin resistance in stable coronary artery patients by three different tests. | 2007 | Thromb. Res. | pmid:17553552 |
Simmet T and Luck W | Clotting of whole human blood induces cysteinyl-leukotriene formation. | 1989 | Thromb. Res. | pmid:2549655 |
Buchanan MR et al. | The sex-related differences in aspirin pharmacokinetics in rabbits and man and its relationship to antiplatelet effects. | 1983 | Thromb. Res. | pmid:6221436 |
Neiman J et al. | Composition of platelet phosphatidylinositol and phosphatidylcholine after ethanol withdrawal. | 1987 | Thromb. Res. | pmid:3603426 |
Randall MJ and Wilding RI | Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with thromboxane synthetase inhibitor dazoxiben hydrochloride, (UK-37, 248-01). | 1982 | Thromb. Res. | pmid:6897751 |
Di Minno G and Violi F | Aspirin resistance and diabetic angiopathy: back to the future. | 2004 | Thromb. Res. | pmid:15115664 |
Best LC et al. | Mode of action of dipyridamole on human platelets. | 1979 | Thromb. Res. | pmid:229583 |
Jørgensen KA et al. | The survival of pig to rabbit renal xenografts during inhibition of thromboxane synthesis. | 1983 | Thromb. Res. | pmid:6364449 |
Naran NH and Chetty N | The in vitro effect of ridogrel on platelet function in normocholesterolaemic and familial hypercholesterolaemic type IIa subjects. | 1997 | Thromb. Res. | pmid:9556227 |
Franconi F et al. | Effect of gamma-hydroxybutyric acid on human platelet aggregation in vitro. | 2001 | Thromb. Res. | pmid:11369419 |
Todd MH et al. | The involvement of prostaglandins and thromboxanes in the response to pulmonary embolism in anaesthetized rabbits and isolated perfused lungs. | 1983 | Thromb. Res. | pmid:6687961 |
Maderna P et al. | Differential effects of oral administrations to human volunteers of acetylsalicylic acid, sodium salicylate and indomethacin on 12-hydroxyeicosatetraenoic acid formation by stimulated platelets. | 1988 | Thromb. Res. | pmid:3194896 |
Todd MK et al. | Effect of exercise intensity on 6-keto-PGF1 alpha, TXB2, and 6-keto-PGF1 alpha/TXB2 ratios. | 1992 | Thromb. Res. | pmid:1615492 |
Dembinska-Kiec A et al. | Ticlopidine and platelet function in healthy volunteers. | 1992 | Thromb. Res. | pmid:1615496 |
Platelet function during long-term treatment with ketanserin of claudicating patients with peripheral atherosclerosis. A multi-center, double-blind, placebo-controlled trial. The PACK Trial Group. | 1989 | Thromb. Res. | pmid:2528841 | |
Hashimoto Y et al. | Characteristics of protein kinase C-independent exocytosis in human platelets. | 1997 | Thromb. Res. | pmid:9336873 |
Igawa T et al. | Potentiation of anti-platelet aggregating activity of cilostazol with vascular endothelial cells. | 1990 | Thromb. Res. | pmid:2158154 |
Yue TL et al. | Pharmacological profile of G619, a new platelet aggregation inhibitor. | 1992 | Thromb. Res. | pmid:1412200 |
Russell NH et al. | Platelet adenine nucleotides and arachidonic acid metabolism in the myeloproliferative disorders. | 1981 | Thromb. Res. | pmid:6794179 |
Thorwest M et al. | Dietary fish oil reduces microvascular thrombosis in a porcine experimental model. | 2000 | Thromb. Res. | pmid:10946095 |
Ames PR et al. | Aspirin insensitive thromboxane generation is associated with oxidative stress in type 2 diabetes mellitus. | 2012 | Thromb. Res. | pmid:22521214 |
Martin JF et al. | The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. | 1983 | Thromb. Res. | pmid:6658722 |
Togna GI et al. | Cisplatin triggers platelet activation. | 2000 | Thromb. Res. | pmid:10973681 |
Saloheimo P et al. | Thromboxane and prostacyclin biosynthesis in patients with acute spontaneous intracerebral hemorrhage. | 2005 | Thromb. Res. | pmid:15733969 |
Vesterqvist O et al. | In vivo production of thromboxane in acute human myocardial infarction: a preliminary study. | 1985 | Thromb. Res. | pmid:3992528 |
Chiang TM and Kang AH | The effect of platelet surface protein phosphorylation on collagen-platelet interaction. | 1986 | Thromb. Res. | pmid:3810565 |
Serebruany VL and Gurbel PA | Assessment of platelet activity by measuring platelet-derived substances in plasma from patients with acute myocardial infarction: surprising lessons from the GUSTO-III Platelet Study. | 1999 | Thromb. Res. | pmid:10030832 |
Kelton JG et al. | A study of the bioavailability and platelet inhibitory effects of a new enteric-coated acetylsalicylic acid preparation. | 1984 | Thromb. Res. | pmid:6740573 |
Chou TC et al. | The inhibitory effect of 2-thienyl 2'-hydroxyphenyl ketone (C85) on platelet thromboxane formation. | 1996 | Thromb. Res. | pmid:8897698 |
Teng CM et al. | Antiplatelet actions of some coumarin compounds isolated from plant sources. | 1992 | Thromb. Res. | pmid:1523611 |
Preston FE et al. | Low-dose aspirin inhibits platelet and venous cyclo-oxygenase in man. | 1982 | Thromb. Res. | pmid:6815823 |
Knapp HR et al. | Effects of low-dose aspirin on endogenous eicosanoid formation in normal and atherosclerotic men. | 1988 | Thromb. Res. | pmid:3293263 |
Randall MJ et al. | UK-37, 248, a novel, selective thromboxane synthetase inhibitor with platelet anti-aggregatory and anti-thrombotic activity. | 1981 Jul 1-15 | Thromb. Res. | pmid:6795753 |
De Caterina R et al. | Inhibition of platelet aggregation and thromboxane B2 production during aspirin treatment: dependence on the dose of the aggregating agent. | 1985 | Thromb. Res. | pmid:3975876 |
Worthington RE and Fuller GC | Dibutyryl cyclic guanosine monophosphate elevates bovine endothelial cell thromboxane production without affecting prostacyclin metabolism. | 1984 | Thromb. Res. | pmid:6322377 |
Armstrong RA et al. | No effect of dietary trans isomers of alpha-linolenic acid on platelet aggregation and haemostatic factors in european healthy men. The TRANSLinE study. | 2000 | Thromb. Res. | pmid:11108899 |
De Caterina R et al. | Long-term maintenance of thromboxane inhibition by two different aspirin regimens in patients with unstable angina. | 1990 | Thromb. Res. | pmid:2126400 |
Bergqvist D et al. | The effect of inhibition of thromboxane synthesis in experimental thrombosis and hemostasis. | 1985 | Thromb. Res. | pmid:3838828 |
Kelton JG et al. | Sex-related differences in the efficacy of acetylsalicylic acid (ASA) : the absorption of ASA and its effect on collagen-induced thromboxane B2 generation. | 1981 Oct 1-15 | Thromb. Res. | pmid:7330835 |
De La Cruz JP et al. | Effect of DT-TX 30, a combined thromboxane synthase inhibitor and thromboxane receptor antagonist, on retinal vascularity in experimental diabetes mellitus. | 2000 | Thromb. Res. | pmid:10680643 |
Domoto DT et al. | Combined aspirin and sulfinpyrazone in the prevention of recurrent hemodialysis vascular access thrombosis. | 1991 | Thromb. Res. | pmid:1926064 |
Weber AA et al. | 40 mg of aspirin are not sufficient to inhibit platelet function under conditions of limited compliance. | 2000 | Thromb. Res. | pmid:10709913 |
Wu TM et al. | Inhibitory effect of hexapeptide (RGRHGD) on platelet aggregation. | 2000 | Thromb. Res. | pmid:10674405 |
Wang JP et al. | XC 386: a new antiplatelet agent. | 1984 | Thromb. Res. | pmid:6438827 |
Küster LJ and Frölich JC | PAF-induced platelet aggregation and TXB2 formation. | 1989 | Thromb. Res. | pmid:2922704 |
Driss F et al. | Inhibition of platelet aggregation and thromboxane synthesis after intake of small amount of icosapentaenoic acid. | 1984 | Thromb. Res. | pmid:6098051 |
Vila V et al. | Fibrinopeptide A release from intraplatelet fibrinogen is related to thrombin platelet activation. | 1997 | Thromb. Res. | pmid:9175247 |
Mogensen F et al. | Effect of specific thromboxane-synthetase inhibition on thromboxane and prostaglandin synthesis in stable angina induced by exercise test. | 1985 | Thromb. Res. | pmid:4038824 |
Tzeng SH et al. | Inhibition of platelet aggregation by some flavonoids. | 1991 | Thromb. Res. | pmid:1776142 |
Neiman J et al. | Platelet uptake of serotonin (5-HT) during ethanol withdrawal in male alcoholics. | 1987 | Thromb. Res. | pmid:2820078 |
Altman R et al. | Why single daily dose of aspirin may not prevent platelet aggregation. | 1988 | Thromb. Res. | pmid:3140408 |
Simmet T and Weide I | Thromboxane and cysteinyl-leukotriene formation are differentially activated in spontaneously clotting whole human blood in vitro. | 1991 | Thromb. Res. | pmid:1866709 |
Weigel G et al. | Regulation of eicosanoid release in human umbilical endothelial cells. | 1991 | Thromb. Res. | pmid:1656543 |
Delvos U et al. | Direct radioimmunological measurement of thromboxane B2 in plasma. | 1985 | Thromb. Res. | pmid:4082109 |
Ko FN et al. | Antiplatelet effects of protopine isolated from Corydalis tubers. | 1989 | Thromb. Res. | pmid:2559491 |
Grignani G et al. | Activation of platelet prostaglandin biosynthesis pathway during neoplastic cell-induced platelet aggregation. | 1984 | Thromb. Res. | pmid:6729776 |
Patterson WR et al. | Aggregation of killer whale platelets. | 1993 | Thromb. Res. | pmid:8327987 |