Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Diczfalusy U et al. | Peroxisomal chain-shortening of thromboxane B2: evidence for impaired degradation of thromboxane B2 in Zellweger syndrome. | 1993 | J. Lipid Res. | pmid:8371058 |
Takasaki W et al. | Superiority of plasma 11-dehydro-TXB2 to TXB2 as an index of in vivo TX formation in rabbits after dosing of CS-518, a TX synthase inhibitor. | 1993 | Thromb. Res. | pmid:8367836 |
de la Cruz JP et al. | Antiplatelet effect of pentoxifylline in human whole blood. | 1993 | Gen. Pharmacol. | pmid:8365640 |
Mounier C et al. | Secretory phospholipase A2 is not required for arachidonic acid liberation during platelet activation. | 1993 | Eur. J. Biochem. | pmid:8365403 |
Gow JA et al. | The effect of regular and enteric-coated aspirin on bleeding time, thromboxane, and prostacyclin. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8361987 |
Sumiya T et al. | Effects of reactive oxygen species on arachidonic acid metabolism in rabbit platelets. | 1993 | Free Radic. Biol. Med. | pmid:8359708 |
Chu ZM and Beilin LJ | Mechanisms of vasodilatation in pregnancy: studies of the role of prostaglandins and nitric-oxide in changes of vascular reactivity in the in situ blood perfused mesentery of pregnant rats. | 1993 | Br. J. Pharmacol. | pmid:8358537 |
Aziz SM et al. | Intrinsic microbicidal activity and pulmonary hypertension in isolated newborn piglet lungs. | 1993 | Pediatr. Res. | pmid:8356015 |
Capaz FR et al. | Effect of active sensitization on the bronchopulmonary responses to tachykinins in the guinea pig. Modulation by peptidase inhibitors. | 1993 | J. Pharmacol. Exp. Ther. | pmid:8355211 |
Qu J and Thomas K | Prostaglandins stimulate the secretion of inhibin from human placental cells. | 1993 | J. Clin. Endocrinol. Metab. | pmid:8345062 |
Horgan PG et al. | Extracorporeal shock wave lithotripsy induces the release of prostaglandins which increase ureteric peristalsis. | 1993 | Br J Urol | pmid:8343888 |
Vissinger H et al. | Platelet-derived growth factor release and antiplatelet treatment with low-dose acetylsalicylic acid. | 1993 | Angiology | pmid:8342880 |
Beitz A et al. | Lipoproteins from normolipidemic and dyslipidemic subjects modify the thromboxane A2 generation by platelets in clotting human blood. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8341726 |
Ritter JM et al. | Thromboxane A2 receptor antagonism and synthase inhibition in essential hypertension. | 1993 | Hypertension | pmid:8340155 |
Loick HM et al. | Thromboxane receptor blockade with BM 13,177 following toxic airway damage by smoke inhalation in sheep. | 1993 | Eur. J. Pharmacol. | pmid:8339755 |
Tesson F et al. | Cell-associated and soluble phospholipases A2 increase during carrageenan and zymosan-induced pleurisy in rat. | 1993 | Eur. J. Pharmacol. | pmid:8339752 |
Keimowitz RM et al. | Transdermal modification of platelet function. A dermal aspirin preparation selectively inhibits platelet cyclooxygenase and preserves prostacyclin biosynthesis. | 1993 | Circulation | pmid:8339418 |
Wang SR et al. | [Experimental study on effects of 18 kinds of Chinese herbal medicine for synthesis of thromboxane A2 and PGI2]. | 1993 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8339039 |
Ford I et al. | Mechanisms of platelet aggregation by Streptococcus sanguis, a causative organism in infective endocarditis. | 1993 | Br. J. Haematol. | pmid:8338784 |
Gu YJ et al. | Biocompatibility of leukocyte removal filters during leukocyte filtration of cardiopulmonary bypass perfusate. | 1993 | Artif Organs | pmid:8338443 |
Wetzka B et al. | Eicosanoid production by intrauterine tissues before and after labor in short-term tissue culture. | 1993 | Prostaglandins | pmid:8337416 |
Keith JC et al. | Effects of ridogrel on the prostacyclin-thromboxane ratio in nulliparous third trimester-pregnant rhesus monkeys. | 1993 | Prostaglandins | pmid:8337414 |
Myers SI et al. | Burn injury decreased splanchnic PGI2 release is restored by treatment with lazaroid. | 1993 | Prostaglandins | pmid:8337413 |
Mahmoud TZ et al. | Correlation between umbilical artery resistance index, 6 ketoprostaglandin F1 alpha and thromboxane B2 in the fetoplacental compartment in patients with pregnancy induced hypertension. | 1993 | Prostaglandins | pmid:8337411 |
Vollmar B et al. | Heparin-protamine reactions in pigs: role of oxygen-derived free radicals. | 1993 | J. Appl. Physiol. | pmid:8335575 |
Kraayenbrink AA et al. | Endothelial vasoactive mediators in preeclampsia. | 1993 | Am. J. Obstet. Gynecol. | pmid:8333445 |
Rouse DJ et al. | Midpregnancy serum thromboxane B2 determinations do not predict subsequent adverse pregnancy outcomes. | 1993 | Am. J. Obstet. Gynecol. | pmid:8333431 |
Weiss HJ and Lages B | Studies of thromboxane B2, platelet factor 4, and fibrinopeptide A in bleeding-time blood of patients deficient in von Willebrand factor, platelet glycoproteins Ib and IIb-IIIa, and storage granules. | 1993 | Blood | pmid:8329704 |
Patterson WR et al. | Aggregation of killer whale platelets. | 1993 | Thromb. Res. | pmid:8327987 |
Lemne C et al. | Plasma growth factor activity and cardiac wall thickness. | 1993 | J. Intern. Med. | pmid:8326295 |
Ohara N et al. | Tissue eicosanoids and vascular permeability in rats with chronic biliary obstruction. | 1993 | Hepatology | pmid:8325602 |
Chiabrando C et al. | Urinary excretion and origin of 11-dehydro-2,3-dinor-thromboxane B2 in man. | 1993 | Prostaglandins | pmid:8321910 |
Peredo HA and Enero MA | Effect of endothelium removal on basal and muscarinic cholinergic stimulated rat mesenteric vascular bed prostanoid synthesis. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8321873 |
van Pampus EC et al. | Influence of aspirin on human megakaryocyte prostaglandin synthesis. | 1993 | Eur. J. Haematol. | pmid:8319788 |
Olson RW et al. | Beneficial effects of combined thromboxane synthase inhibition/receptor blockade with CGS 22652 in a canine model of coronary thrombosis. | 1993 | Eur. J. Pharmacol. | pmid:8319746 |
Swaim SF et al. | The greyhound dog as a model for studying pressure ulcers. | 1993 | Decubitus | pmid:8318156 |
Li JX et al. | Capsular type-specific polysaccharide partially inhibits group B Streptococcus-induced pulmonary hypertension. | 1993 | Am. Rev. Respir. Dis. | pmid:8317791 |
Romero R et al. | The relationship between spontaneous rupture of membranes, labor, and microbial invasion of the amniotic cavity and amniotic fluid concentrations of prostaglandins and thromboxane B2 in term pregnancy. | 1993 | Am. J. Obstet. Gynecol. | pmid:8317506 |
Hudson N et al. | Effect of Helicobacter pylori colonisation on gastric mucosal eicosanoid synthesis in patients taking non-steroidal anti-inflammatory drugs. | 1993 | Gut | pmid:8314505 |
Schumacher WA et al. | Comparison of a thromboxane receptor antagonist and aspirin in experimental arterial thrombosis. | 1993 Jul-Aug | Haemostasis | pmid:8314172 |
Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction. The Ridogrel Versus Aspirin Patency Trial (RAPT). | 1994 | Circulation | pmid:8313547 | |
Yuan W | [Changes in renal cortical thromboxane A2, prostaglandin F1 alpha and effects of dazoxiben, chuan xiong on in situ immune complex glomerulonephritis in rats]. | 1993 | Zhonghua Yi Xue Za Zhi | pmid:8313194 |
Huang YS | [Thromboxane and prostacyclin imbalance in the pathogenesis of early damage after severe burns]. | 1993 | Zhonghua Yi Xue Za Zhi | pmid:8313186 |
Napolov IuK et al. | [The effect of x-ray contrast media on the amount of thromboxane and prostacyclin in the blood of man and rats in vivo and in vitro]. | 1993 Sep-Oct | Eksp Klin Farmakol | pmid:8312809 |
Wang XP et al. | [Therapeutic effects and mechanisms of tetramethylpyrazine on lung injury in acute haemorrhagic necrotizing pancreatitis in rats]. | 1993 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8312699 |
Edwin SS et al. | Cyclosporin A attenuates increased prostaglandin and thromboxane production in response to various stimuli in human decidua. | 1993 Sep-Oct | Am. J. Reprod. Immunol. | pmid:8311924 |
Bashakin NF et al. | [The functional characteristics of the prostacyclin-thromboxane system in newborn infants with a history of acute and chronic intrauterine hypoxia]. | 1993 | Akush Ginekol (Mosk) | pmid:8311150 |
Suckfüll MM et al. | The contribution of endothelial cells to hyperacute rejection in xenogeneic perfused working hearts. | 1994 | Transplantation | pmid:8310518 |
Foegh ML et al. | Urinary thromboxane A2 metabolites in patients presenting in the emergency room with acute chest pain. | 1994 | J. Intern. Med. | pmid:8308478 |
Schuster DP et al. | Thromboxane receptor stimulation/inhibition and perfusion redistribution after acute lung injury. | 1993 | J. Appl. Physiol. | pmid:8307861 |
Smith SR et al. | Effect of low-dose aspirin on thromboxane production and the antihypertensive effect of captopril. | 1993 | J. Am. Soc. Nephrol. | pmid:8305640 |
Nukina S et al. | Glycogenolytic effect of adenosine involves ATP from hepatocytes and eicosanoids from Kupffer cells. | 1994 | Am. J. Physiol. | pmid:8304463 |
van Kooten F et al. | Evidence for episodic platelet activation in acute ischemic stroke. | 1994 | Stroke | pmid:8303731 |
Hofmann D et al. | Evidence for sustained platelet activation in patients with early postinfarction angina. | 1993 | Thromb. Res. | pmid:8303651 |
Salerno F et al. | Effects of imidazole-salicylate on renal function and the diuretic action of furosemide in cirrhotic patients with ascites. | 1993 | J. Hepatol. | pmid:8301062 |
Furuzono T et al. | A novel biomaterial: poly(dimethylsiloxane)-polyamide multiblock copolymer I. Synthesis and evaluation of blood compatibility. | 1993 | J Biomater Sci Polym Ed | pmid:8297834 |
Rabinovici R et al. | Interleukin-2-induced lung injury. The role of complement. | 1994 | Circ. Res. | pmid:8293571 |
Semrad SD et al. | Pharmacokinetics and effects of repeated administration of phenylbutazone in neonatal calves. | 1993 | Am. J. Vet. Res. | pmid:8291771 |
Semrad SD et al. | Effects of concurrent administration of phenylbutazone and flunixin meglumine on pharmacokinetic variables and in vitro generation of thromboxane B2 in mares. | 1993 | Am. J. Vet. Res. | pmid:8291770 |
Iioka H et al. | Studies on placental inhibition of platelet aggregation: a comparison of human syncytiotrophoblast brush border and basal plasma membranes. | 1993 Sep-Oct | Placenta | pmid:8290492 |
Textor SC et al. | Systemic and renal effects of nifedipine in cyclosporine-associated hypertension. | 1994 | Hypertension | pmid:8282363 |
Szczapa J et al. | [Effect of intraventricular hemorrhage in newborns on levels of certain prostanoids in blood plasma]. | 1993 | Ginekol. Pol. | pmid:8282238 |
Li Q et al. | Suppression of S-antigen-induced experimental autoimmune uveoretinitis in Lewis rats by oral administration with CGS-13080, a thromboxane synthetase inhibitor. | 1993 | Exp. Eye Res. | pmid:8282047 |
Mück AO et al. | The effect of 17 beta-estradiol and endothelin 1 on prostacyclin and thromboxane production in human endothelial cell cultures. | 1993 | Clin Exp Obstet Gynecol | pmid:8281701 |
Johnson BF et al. | Thromboxane and prostacyclin synthesis in experimental pancreas transplantation. Changes in parenchymal and vascular prostanoids. | 1993 | Transplantation | pmid:8279018 |
Smith SR et al. | Chronic thromboxane synthase inhibition with CGS 12970 in human cyclosporine nephrotoxicity. | 1993 | Transplantation | pmid:8279014 |
Zhou W et al. | Lipid mediator production in acute and chronic pancreatitis in the rat. | 1994 | J. Surg. Res. | pmid:8277767 |
Heasman PA et al. | Flurbiprofen in the prevention and treatment of experimental gingivitis. | 1993 | J. Clin. Periodontol. | pmid:8276984 |
Uematsu T et al. | Changes in plasma and urinary 11-dehydrothromboxane B2 in healthy subjects produced by oral CS-518, a novel thromboxane synthase inhibitor. | 1993 | Eur. J. Clin. Pharmacol. | pmid:8276056 |
Lee M et al. | Dose effects of aspirin on gastric prostaglandins and stomach mucosal injury. | 1994 | Ann. Intern. Med. | pmid:8273981 |
Yavin E et al. | Gangliosides stimulate synthesis of prostaglandin E2 and prostacyclin in fetal rat brain hemispheres after episodes of global intrauterine ischemia. | 1993 | J. Neurosci. Res. | pmid:8271317 |
Wang S | [The effect of captopril on hemodynamics in patients of chronic obstructive pulmonary disease with pulmonary hypertension]. | 1993 | Zhonghua Nei Ke Za Zhi | pmid:8269786 |
Jin L et al. | [The effect of low dose aspirin on the platelet function in patients with acute myocardial infarction]. | 1993 | Zhonghua Nei Ke Za Zhi | pmid:8269785 |
King JN | The use of intradermal carrageenan in calves to estimate the dose of oxindanac, a nonsteroidal anti-inflammatory drug. | 1993 | Can. J. Vet. Res. | pmid:8269358 |
Fukuoka T et al. | Platelet-activating factor as a vasodepressive mediator of liver ischemia. | 1993 | Transplant. Proc. | pmid:8266523 |
Nakazawa I et al. | Some features in prostaglandin synthesis of the cancer cells which metastasized into liver from intestinal cancer lesions. | 1993 | Tohoku J. Exp. Med. | pmid:8266326 |
Yang B et al. | Dietary fish oil supplementation attenuates myocardial dysfunction and injury caused by global ischemia and reperfusion in isolated rat hearts. | 1993 | J. Nutr. | pmid:8263599 |
Chen G et al. | Prostacyclin, thromboxane and antioxidant levels in pregnancy-induced hypertension. | 1993 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:8262302 |
Zhang BL et al. | Effects of naftidrofuryl on isolated perfused kidneys of spontaneously hypertensive rats. | 1993 | Clin. Exp. Pharmacol. Physiol. | pmid:8261661 |
Falcon CR et al. | The in vitro production of thromboxane B2 by platelets of diabetic patients is normal at physiological concentrations of ionized calcium. | 1993 | Thromb. Haemost. | pmid:8259535 |
De Caterina R et al. | n-3 fatty acids reduce proteinuria in patients with chronic glomerular disease. | 1993 | Kidney Int. | pmid:8258959 |
Balteskard L et al. | Thromboxane production in the blood of women increases after menopause whereas tumor necrosis factor is reduced in women compared with men. | 1993 | Atherosclerosis | pmid:8257457 |
Reshetnikov O | Chronic gastritis, prostaglandins and Helicobacter pylori. | 1993 | Z Gastroenterol | pmid:8256482 |
Berger JI et al. | Effect of amrinone during group B Streptococcus-induced pulmonary hypertension in piglets. | 1993 | Pediatr. Pulmonol. | pmid:8255635 |
Williams B and Schrier RW | Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells. | 1993 | J. Clin. Invest. | pmid:8254044 |
Fink MP et al. | A novel leukotriene B4-receptor antagonist in endotoxin shock: a prospective, controlled trial in a porcine model. | 1993 | Crit. Care Med. | pmid:8252886 |
Djurup R et al. | Rapid, direct enzyme immunoassay of 11-keto-thromboxane B2 in urine, validated by immunoaffinity/gas chromatography-mass spectrometry. | 1993 | Clin. Chem. | pmid:8252718 |
Jin YQ and Li XQ | [Pathophysiological basis of 3 subtypes in ganfeng neidong syndrome]. | 1993 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8251718 |
Huang TF et al. | Antiplatelet protease, kistomin, selectively cleaves human platelet glycoprotein Ib. | 1993 | Biochim. Biophys. Acta | pmid:8251530 |
Du ZY and Huang YH | Effects of tetrandrine on production of leukotriene B4 and thromboxane B2 in rabbit blood. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8249626 |
Matsuo Y et al. | Effect of a novel thromboxane A2 receptor antagonist, S-1452, on postischemic brain injury in rats. | 1993 | Stroke | pmid:8248988 |
Siler-Khodr TM and Forman J | Effect of IGF-1 on placental prostanoid production. | 1993 | Prostaglandins | pmid:8248549 |
Eskew ML et al. | Increased thromboxane A2 synthesis by rat lung neutrophils during selenium deficiency. | 1993 | Prostaglandins | pmid:8248545 |
Arruzazabala ML et al. | Effect of policosanol on cerebral ischemia in Mongolian gerbils: role of prostacyclin and thromboxane A2. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8248276 |
Bell JG et al. | Dietary sunflower, linseed and fish oils affect phospholipid fatty acid composition, development of cardiac lesions, phospholipase activity and eicosanoid production in Atlantic salmon (Salmo salar). | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8248271 |
Stengel PW et al. | Bronchopulmonary actions of 1-(1,2,3,4-tetrahydro-1-naphthylenyl)-1H-imidazole, nitric acid salt (LY150310), a substituted imidazole, in the guinea pig. | 1993 | J. Pharmacol. Exp. Ther. | pmid:8246133 |
Zemel D et al. | Relationship of TNF-alpha, interleukin-6, and prostaglandins to peritoneal permeability for macromolecules during longitudinal follow-up of peritonitis in continuous ambulatory peritoneal dialysis. | 1993 | J. Lab. Clin. Med. | pmid:8245688 |
Zhou S et al. | [The changes in free radical and prostaglandin metabolism in newborn infants with asphyxia]. | 1993 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:8244309 |
Püschel GP et al. | Increase in prostanoid formation in rat liver macrophages (Kupffer cells) by human anaphylatoxin C3a. | 1993 | Hepatology | pmid:8244278 |
Myers SI et al. | Acute cholecystitis potentiates bradykinin stimulated fibroblast prostanoid release in the rabbit. | 1993 | Mol. Cell. Endocrinol. | pmid:8243803 |