Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Bockman RS | Prostaglandin production by human blood monocytes and mouse peritoneal macrophages: synthesis dependent on in vitro culture conditions. | 1981 | Prostaglandins | pmid:6782622 |
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Smith EF and Lefer AM | Stabilization of cardiac lysosomal and cellular membranes in protection of ischemic myocardium due to coronary occlusion:efficacy of the nonsteroidal anti-inflammatory agent, naproxen. | 1981 | Am. Heart J. | pmid:7211667 |
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di Minno G et al. | Effects of any epoxymethano stable analogue of prostaglandin endoperoxides (U-46619) on human platelets. | 1981 | Thromb. Haemost. | pmid:6266066 |
Handler JS | Vasopressin-prostaglandin interactions in the regulation of epithelial cell permeability to water. | 1981 | Kidney Int. | pmid:6267350 |
Sirois P et al. | Comparative effects of leukotriene B4, prostaglandins I2 and E2, 6-keto-PGF1 alpha thromboxane B2 and histamine on selected smooth muscle preparations. | 1981 | J. Pharm. Pharmacol. | pmid:6115037 |
Best LC et al. | Strontium ions induce production of thromboxane B2 and secretion of 5-hydroxytryptamine in washed human platelets. | 1981 | Biochem. Pharmacol. | pmid:6268118 |
Parks WM et al. | Comparative effect of ibuprofen on endothelial and platelet prostaglandin synthesis. | 1981 | J. Pharmacol. Exp. Ther. | pmid:7026767 |
Roy AC et al. | Effect of intravenous infusion of OKY-1581 (sodium-(E)-3-[4-(3-pyridylmethyl)phenyl] -2-methylacrylate) on circulatory thromboxane A2 and prostacyclin levels in anaesthetized baboon. | 1981 | Prostaglandins Med | pmid:7029585 |
Stuart MJ | Effect of endotoxin on arachidonic acid release and thromboxane B2 production by human platelets. | 1981 | Am. J. Hematol. | pmid:7030066 |
Dembélé-Duchesne MJ et al. | Some new prospects in the mechanism of control of arachidonate metabolism in human placenta and amnion. | 1981 | Prostaglandins | pmid:6801732 |
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Townsend ER et al. | Preservation of platelets during extracorporeal circulation in sheep. A comparison between aspirin and sulfinpyrazone. | 1981 | Circ. Res. | pmid:7249281 |
McCann DS et al. | Radioimmunoassay for plasma thromboxane B2. | 1981 | Clin. Chem. | pmid:7273401 |
Coker SJ et al. | Aspirin inhibits the early myocardial release of thromboxane B2 and ventricular ectopic activity following acute coronary artery occlusion in dogs. | 1981 | Br. J. Pharmacol. | pmid:7284679 |
Allen JB et al. | Irradiation decreases vascular prostacyclin formation with no concomitant effect on platelet thromboxane production. | 1981 | Lancet | pmid:6118629 |
Anderson CB et al. | Thromboxane-B2 and renovascular resistance during hypothermic pulsatile perfusion. | 1981 | Transplant. Proc. | pmid:7268892 |
Coker SJ et al. | Thromboxane and prostacyclin release from ischaemic myocardium in relation to arrhythmias. | 1981 | Nature | pmid:6894485 |
Bishai I and Coceani F | Transformations of prostaglandin H2 in the cat brain. | 1981 | Biochim. Biophys. Acta | pmid:6894549 |
Drake TS et al. | Peritoneal fluid thromboxane B2 and 6-keto-prostaglandin F1 alpha in endometriosis. | 1981 | Am. J. Obstet. Gynecol. | pmid:6894667 |
Halushka PV et al. | Protective effects of aspirin in endotoxic shock. | 1981 | J. Pharmacol. Exp. Ther. | pmid:6894770 |
Feuerstein N et al. | Leukotrienes C4 and D4 induce prostaglandin and thromboxane release from rat peritoneal macrophages. | 1981 | Br. J. Pharmacol. | pmid:6894882 |
Karmazyn M et al. | Comparative effects of acetylsalicylic acid (ASA) and sulfinpyrazone on isoproterenol-induced heart damage. | 1981 | J. Pharmacol. Exp. Ther. | pmid:6894943 |
Morrison AR and Benabe JE | Prostaglandins in vascular tone in experimental obstructive nephropathy. | 1981 | Kidney Int. | pmid:6894950 |
Bombardieri S et al. | The synovial prostaglandin system in chronic inflammatory arthritis: differential effects of steroidal and nonsteroidal anti-inflammatory drugs. | 1981 | Br. J. Pharmacol. | pmid:6895043 |
Harms BA et al. | Prostaglandin release and altered microvascular integrity after burn injury. | 1981 | J. Surg. Res. | pmid:6895238 |
Ylikorkala O et al. | Amniotic fluid prostacyclin and thromboxane in normal, preeclamptic, and some other complicated pregnancies. | 1981 | Am. J. Obstet. Gynecol. | pmid:6895277 |
Ishihara Y et al. | [Effect of hypoxemia and pulmonary thromboembolism on plasma levels of 6-keto PGF 1 alpha, TxB, histamine and serotonin in anesthetized dogs (author's transl)]. | 1981 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:6895531 |
Defreyn G et al. | Familial bleeding tendency with partial platelet thromboxane synthetase deficiency: reorientation of cyclic endoperoxide metabolism. | 1981 | Br. J. Haematol. | pmid:6268139 |
Prancan A et al. | Platelet thromboxane production during endotoxin shock. | 1981 | Agents Actions | pmid:7340458 |
Hwang DH | Characteristics of the aggregation of platelets and the formation of prostaglandins (PGs) in rat. | 1981 | Prog. Lipid Res. | pmid:7342108 |
Agradi E et al. | In vitro effects of synthetic antioxidants and vitamin E on arachidonic acid metabolism and thromboxane formation in human platelets and on platelet aggregation. | 1981 | Prostaglandins | pmid:6794104 |
Halushka PV et al. | Increased platelet thromboxane synthesis in diabetes mellitus. | 1981 | J. Lab. Clin. Med. | pmid:7452084 |
Beck N and Shaw JO | Thromboxane B2 and prostaglandin E2 in the K+-depleted rat kidney. | 1981 | Am. J. Physiol. | pmid:7468800 |
Laviolette M et al. | Human alveolar macrophages: a lesion in arachidonic acid metabolism in cigarette smokers. | 1981 | Am. Rev. Respir. Dis. | pmid:6794395 |
Grimm LJ et al. | Inhibition of platelet thromboxane synthesis by 7-(1-imidazolyl) heptanoic acid: dissociation from inhibition of aggregation. | 1981 | Thromb. Res. | pmid:6801806 |
Honn KV and Meyer J | Thromboxanes and prostacyclin: positive and negative modulators of tumor growth. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6274330 |
Worthington RE and Nakeff A | Thromboxane synthesis in megakaryocytes isolated by centrifugal elutriation. | 1981 | Blood | pmid:6786393 |
Igarashi K et al. | Effect of polyamines on prostaglandin synthesis in various cell-free systems. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6800368 |
Landgraf-Leurs MM et al. | Aggregation and thromboxane B2 formation in platelets and vascular prostacyclin production from genetically obese rats. | 1981 | Prostaglandins | pmid:6798637 |