Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Izaki S et al. | Platelet-activating factor and arachidonic acid metabolites in psoriatic inflammation. | 1996 | Br. J. Dermatol. | pmid:8763425 |
Fuse I et al. | Vascular thromboxane formation in hemostasis mechanism: correlation between bleeding time and vascular TXB2 in a patient with congenital platelet cyclo-oxygenase deficiency. | 1996 | Int. J. Hematol. | pmid:8762815 |
Kuroiwa M et al. | Effects of granulocyte colony-stimulating factor on the hemostatic system in healthy volunteers. | 1996 | Int. J. Hematol. | pmid:8762814 |
Xiao J et al. | [Effects of platelet activating factor and platelet activating factor receptor antagonist on spinal cord blood flow after spinal cord injury]. | 1995 | Zhonghua Wai Ke Za Zhi | pmid:8762548 |
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Fimognari FL et al. | Associated daily biosynthesis of cortisol and thromboxane A2: a preliminary report. | 1996 | J. Lab. Clin. Med. | pmid:8759943 |
Hibi S et al. | Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase. | 1996 | J. Med. Chem. | pmid:8759636 |
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Gu YJ et al. | Leukocyte depletion results in improved lung function and reduced inflammatory response after cardiac surgery. | 1996 | J. Thorac. Cardiovasc. Surg. | pmid:8751518 |
Yokoyama I et al. | Liberation of vasoactive substances and its prevention with thromboxane A2 synthase inhibitor in pig liver transplantation. | 1996 | Transpl. Int. | pmid:8748415 |
Mathie RT et al. | The haemodynamic effects of the thromboxane A2 receptor antagonist GR32191B during cardiopulmonary bypass in the dog. | 1995 | Perfusion | pmid:8747897 |
Yoshida T et al. | Abnormal prostanoid metabolism in lupus nephritis and the effects of a thromboxane A2 synthetase inhibitor, DP-1904. | 1996 | Lupus | pmid:8743126 |
Yang JM et al. | Sodium nonivamide acetate: a non-pungently antinociceptive capsaicin derivative with unusual anti-inflammatory properties. | 1996 | Gen. Pharmacol. | pmid:8742512 |
Laffi G et al. | Defective aggregation in cirrhosis is independent of in vivo platelet activation. | 1996 | J. Hepatol. | pmid:8738730 |
Young JM et al. | Human whole blood assays for inhibition of prostaglandin G/H synthases-1 and -2 using A23187 and lipopolysaccharide stimulation of thromboxane B2 production. | 1996 | Inflamm. Res. | pmid:8737748 |
Ravn HB et al. | Magnesium inhibits human platelets. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735829 |
Lechi C et al. | In vitro study of the anti-aggregating activity of two nitroderivatives of acetylsalicylic acid. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735820 |
Jancinová V et al. | Inhibition of blood platelet functions by cationic amphiphilic drugs in relation to their physico-chemical properties. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735816 |
Cheng Z et al. | Pharmacokinetics and pharmacodynamics of phenylbutazone and oxyphenbutazone in the donkey. | 1996 | J. Vet. Pharmacol. Ther. | pmid:8735424 |
Li H | [Research on plasma TXA2, PGI2 levels, blood stasis syndrome and promoting blood circulation]. | 1995 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8732157 |
Liang-min LD et al. | [Effect of age on hemostasis and plasma level of TXB2 and 6-keto-PGF1 alpha]. | 1995 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8732148 |
Liang XC et al. | [Study on relationship of lipid peroxide in coronary heart disease with and without diabetes]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8732128 |
Xiong YL and Zhao HY | Experimental studies on preventive effects of API0134 on vessel reocclusion after thrombolysis. | 1995 | J. Tongji Med. Univ. | pmid:8731957 |
Xiong YL and Zhao HY | Effect of captopril on antithrombus function of endothelium. | 1995 | J. Tongji Med. Univ. | pmid:8731927 |
Isozaki H et al. | Urinary thromboxane B2 as an indicator of acute rejection in human liver transplantation. | 1996 | Surg. Today | pmid:8727944 |
Grauer GF et al. | Effects of dietary n-3 fatty acid supplementation versus thromboxane synthetase inhibition on gentamicin-induced nephrotoxicosis in healthy male dogs. | 1996 | Am. J. Vet. Res. | pmid:8725828 |
Yanase T et al. | Dibutyryl cAMP improves systemic vasoconstriction caused by endotoxin in dogs. | 1996 | Shock | pmid:8721389 |
Kruse-Elliott KT et al. | Attenuation of endotoxin-induced pathophysiology by a new potent PAF receptor antagonist. | 1996 | Shock | pmid:8721386 |
Oláh L et al. | [Low doses of acetylsalicylic acid effectively inhibits thrombocyte aggregation after ischemic stroke]. | 1996 | Orv Hetil | pmid:8714038 |
Tishler M et al. | Salivary eicosanoid concentration in patients with Sjögren's syndrome. | 1996 | Ann. Rheum. Dis. | pmid:8712887 |
Herrick AL et al. | Von Willebrand factor, thrombomodulin, thromboxane, beta-thromboglobulin and markers of fibrinolysis in primary Raynaud's phenomenon and systemic sclerosis. | 1996 | Ann. Rheum. Dis. | pmid:8712862 |
Howarth SR et al. | Role of thromboxane A2 in the vasoconstrictor response to endothelin-1, angiotensin II and 5-hydroxytryptamine in human placental vessels. | 1995 | Placenta | pmid:8710799 |
Liu H et al. | [Effects of low dose aspirin on platelet function and prostaglandins metabolism in systemic and coronary circulation in patients with ischemia heart disease]. | 1995 | Zhonghua Nei Ke Za Zhi | pmid:8697924 |
Sun B et al. | [The experimental observation on the procedure of atherosclerotic restenosis following PTCA]. | 1995 | Zhonghua Nei Ke Za Zhi | pmid:8697911 |
Nosál R et al. | The H1-histamine antagonist Dithiaden inhibits human platelets in vitro. | 1996 | Inflamm. Res. | pmid:8696916 |
Jensen N et al. | Recovery of endothelial cells and prostanoid production in endothelial cell-seeded grafts. | 1996 | Eur J Vasc Endovasc Surg | pmid:8696898 |
Takase B et al. | Arachidonic acid metabolites in acute myocardial infarction. | 1996 | Angiology | pmid:8686958 |
Malý J et al. | Migraine--a haematological disorder? | 1995 | Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove | pmid:8685625 |
Taylor PM et al. | Pharmacodynamics and enantioselective pharmacokinetics of carprofen in the cat. | 1996 | Res. Vet. Sci. | pmid:8685536 |
Cervar M et al. | Altered release of endothelin-1,2 and thromboxane B2 from trophoblastic cells in pre-eclampsia. | 1996 | Eur. J. Clin. Invest. | pmid:8682152 |
Delatour P et al. | Pharmacodynamics and chiral pharmacokinetics of carprofen in calves. | 1996 | Br. Vet. J. | pmid:8680841 |
Tsunomori M et al. | 15-Hydroperoxyeicosapentaenoic acid inhibits arachidonic acid metabolism in rabbit platelets more potently than eicosapentaenoic acid. | 1996 | Biochim. Biophys. Acta | pmid:8679681 |
Myers SI et al. | Regulation of eicosanoid synthesis in fibroblasts from inflamed gallbladders. | 1995 | Mol. Cell. Endocrinol. | pmid:8674862 |
Stein CM et al. | Evidence of free radical-mediated injury (isoprostane overproduction) in scleroderma. | 1996 | Arthritis Rheum. | pmid:8670323 |
Saitta A et al. | Effects of gallopamil on epinephrine and norepinephrine plasmatic levels and on TxB2 and beta-tg release in patients with coronary artery disease during adrenergic stimulus with cold pressor test. | 1995 Jul-Aug | Pharmacol. Res. | pmid:8668647 |
Haimovich B et al. | The FcgammaRII receptor triggers pp125FAK phosphorylation in platelets. | 1996 | J. Biol. Chem. | pmid:8663117 |
Wahle KW and Peacock LI | Effects of isomeric cis and trans eighteen carbon monounsaturated fatty acids on porcine platelet function. | 1996 | Biochim. Biophys. Acta | pmid:8652649 |
Dehmlow C et al. | Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells. | 1996 | Life Sci. | pmid:8649189 |