Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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There are no associated biomedical information in the current reference collection.
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Lumley P et al. | Maximal blockade of TxA2 without compromised PGI2 formation; a superior profile of the TxA2 receptor blocking drug GR32191 over aspirin. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825385 |
Patrono C et al. | Thromboxane-dependent platelet activation as a transducer of enhanced risk of coronary and cerebral thrombosis. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825389 |
FitzGerald GA et al. | Thromboxane biosynthesis and antagonism in humans. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959047 |
Nowak J and FitzGerald GA | In vivo formation of prostacyclin and thromboxane A2 at the site of platelet-vascular interaction in humans. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959050 |
De Caterina R et al. | Characteristics of thromboxane production by the isolated-perfused rat heart. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959082 |
Samhoun MN et al. | Differential effect of vasoactive intestinal peptide on contractions induced by leukotriene D4, histamine, and acetylcholine in guinea pig lung parenchyma in vitro. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960144 |
Granström E and Kumlin M | Assay of thromboxane production in biological systems: reliability of TXB2 versus 11-dehydro-TXB2 as targets for measurement. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960161 |
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Tremoli E et al. | North Karelian study: changes in dietary fat reduce thromboxane B2 formation by platelets only in male subjects--preliminary report. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221594 |
Basso N et al. | Gastric mucosal prostaglandin generation in rats with stress ulcer. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221618 |
Foegh M et al. | Prostacyclin and thromboxane release from human peritoneal macrophages. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221630 |
Westwick J et al. | Inhibition of thromboxane formation prevents endotoxin-induced renal fibrin deposition in jaundiced rats. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221642 |
Mistry M and Nasjletti A | Role of TXA2 in the pathogenesis of severe angiotensin II-salt hypertension. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526469 |
Koshihara Y and Fukuda M | Appearance of metabolic activities for arachidonate during development of mouse embryos. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526512 |
Fuse I and Tai HH | Regulation of arachidonate release by G-proteins and protein kinase C in human platelets. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526540 |
Houtz P and Tai HH | Enzyme immunoassay of thromboxane B2 using immobilized hapten and enzyme amplification. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526560 |
Hayashi Y et al. | Radioimmunoassay of 11-dehydro-thromboxane B2 using monoclonal antibody. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526561 |
Knospe J et al. | Derivatization of prostaglandins to corresponding anilides and analysis by HPLC. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526562 |
Hadding U et al. | Peritoneal macrophages release prostaglandin E and thromboxane B2 in response to C3b. | 1982 | Adv. Exp. Med. Biol. | pmid:7158499 |
Novo S et al. | Platelet activity in relation to smoke and exercise in patients with chronic obstructive lung disease: effects of platelet antiaggregating drugs. | 1984 | Adv. Exp. Med. Biol. | pmid:6546467 |
Suchkova V | Prostanoid and anti-thrombin III levels in premature infants. | 1997 | Adv. Exp. Med. Biol. | pmid:9547655 |
Davì G et al. | Platelet function changes in acute myocardial infarction. | 1984 | Adv. Exp. Med. Biol. | pmid:6695571 |
Hori Y et al. | Interaction of endogenous kinins and prostaglandins in the plasma exudation of kaolin-induced pleurisy in rats. | 1989 | Adv. Exp. Med. Biol. | pmid:2481952 |
Yoshida T et al. | Improvement of renal function with selective thromboxane A2 synthetase inhibitor, DP-1904 in lupus nephritis. | 1997 | Adv. Exp. Med. Biol. | pmid:9561116 |
Müller M | In vivo measurement of interstitial TxB2-concentrations in skeletal muscle during ischemia and reperfusion. | 1997 | Adv. Exp. Med. Biol. | pmid:9561122 |
Arbogast E et al. | Intrauterine eicosanoid production in uncomplicated and hypertensive pregnancies: alterations of placental 12-hydroxyeicosatetraenoic acid. | 1997 | Adv. Exp. Med. Biol. | pmid:9561182 |
Moncada S and Whittle BJ | Biological actions of prostacyclin and its pharmacological use in platelet studies. | 1985 | Adv. Exp. Med. Biol. | pmid:3010671 |
Bourgeois N et al. | Effects of endotoxin on hemodynamics of isolated dog kidney. | 1987 | Adv. Exp. Med. Biol. | pmid:3303858 |
Flynn JT and Demling RH | Inhibition of endogenous thromboxane synthesis by exogenous prostacyclin during endotoxemia in conscious sheep. | 1982 | Adv Shock Res | pmid:6753534 |
Lefer AM and Crossley K | Mechanisms of the optimal protective effects of ibuprofen in acute myocardial ischemia. | 1980 | Adv Shock Res | pmid:7304314 |
Zamecnik J et al. | Concentrations of thromboxane B2 and 6-oxo-prostaglandin F1 alpha in amniotic fluid, decidual tissue, and placenta in the later stages of pregnancy in the rat. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6990719 |
Frame MH et al. | Inhibition of acid secretion from the rat-isolated gastric mucosa by arachidonic acid and identification of major metabolites. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6990724 |
Harris RH et al. | Relationship of TXB2 and 6-keto PGF1 alpha to the hemodynamic changes during baboon endotoxic shock. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6768234 |
Güllner HG et al. | The principal metabolites of arachidonic acid are overproduced in Bartter's syndrome. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6892749 |
Schlondorff D and Folkert VW | Prostaglandin synthesis in glomeruli from rats with unilateral ureteral obstruction. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369028 |
Van Praag D and Farber SJ | Prostaglandin biosynthesis in normal and ureteral obstructed rabbit kidney; formation of a novel metabolite. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369029 |
Lindgren JA et al. | Effects of platelet aggregation and adenosine 3':5'-monophosphate on the synthesis of thromboxane B2 in human platelets. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6247886 |
Kot PA et al. | Modification of the cardiovascular actions of prostaglandins by thromboxane B2. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369035 |
Gorman RR | Biochemical and pharmacological evaluation of thromboxane synthetase inhibitors. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6247892 |
Friedman LS et al. | Thromboxane B2 inhibits the pulmonary metabolism of PGE2 in the anesthetized dog. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369063 |
Bishai I and Coceani F | Metabolism of PGH2 in the feline brain. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7376980 |
Galli C et al. | Factors affecting brain prostaglandin formation. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7376983 |
Blotman F et al. | PGE2, PGF2 alpha, and TXB2 biosynthesis by human rheumatoid synovia. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377017 |
Katori M et al. | Changes of prostaglandin and thromboxane levels in pleural fluid of rat carrageenin-induced pleurisy. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377020 |
Crutchley DJ et al. | Potentiation of thromboxane B2 release from guinea pig lung during anaphylaxis following exposure to 100% O2. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377022 |
Morris HG and Sherman NA | Prostaglandin-like substances in urine of asthmatic patients. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377024 |
Schoene NW et al. | Effects of diets varying in fat and P/S ratio on arachidonic acid metabolism in human platelets. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377026 |
Patrono C et al. | Radioimmunoassay of serum thromboxane B2: a simple method of assessing pharmacologic effects on platelet function. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7386257 |
Langs DA et al. | Thromboxane molecules are not hairpin conformers. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7386281 |
Feinstein MB et al. | Serine-esterase (protease) inhibitors block stimulus-induced mobilization of arachidonate in platelets. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6770602 |