Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Powell WS | Metabolism of prostaglandins, prostaglandin analogs and thromboxane B2 by lung and liver microsomes from pregnant rabbits. | 1979 | Biochim. Biophys. Acta | pmid:518891 |
Spagnuolo C et al. | Differential effects of probenecid on the levels of endogenous PGF2 alpha and TXB2 in brain cortex. | 1979 | Prostaglandins | pmid:523683 |
Bennett A and Sanger GJ | Trimethoquinol selectively antagonises longitudinal muscle contractions of rat isolated gastric fundus to thromboxane B2 and epoxymethano analogues of PGH2 [proceedings]. | 1979 | Br. J. Pharmacol. | pmid:526738 |
Prancan AV et al. | L8027 and 1-nonyl-imidazole as non-selective inhibitors of thromboxane synthesis. | 1979 | Eur. J. Pharmacol. | pmid:527664 |
Makheja AN et al. | Effects of onion (Allium cepa) extract on platelet aggregation and thromboxane synthesis. | 1979 | Prostaglandins Med | pmid:552092 |
Whittle BJ | Prostaglandin synthetase inhibitors. Drugs which affect arachidonic acid metabolism. | 1979 | Acta Obstet Gynecol Scand Suppl | pmid:111464 |
Robinson JS et al. | Prostaglandin E, thromboxane B2 and 6-oxo-prostaglandin F1 alpha in amniotic fluid and maternal plasma of rhesus monkeys (Macaca mulatta) during the latter third of gestation. | 1979 | J. Endocrinol. | pmid:112214 |
Burch RM et al. | Vasopressin stimulates thromboxane synthesis in the toad urinary bladder: effects of imidazole. | 1979 | J. Pharmacol. Exp. Ther. | pmid:113526 |
Patrono C et al. | Inhibition of platelet cyclooxygenase by aspirin-like drugs: methods for in vitro and ex vivo assessment. | 1979 | Agents Actions Suppl. | pmid:115255 |
Wong PY and Cheung WY | Calmodulin stimulates human platelet phospholipase A2. | 1979 | Biochem. Biophys. Res. Commun. | pmid:116656 |
Okuma M and Uchino H | Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders. | 1979 | Blood | pmid:116695 |
Boura AL and Murphy RD | Thromboxane B2 inhibits prostaglandin E2 inactivation by the rat isolated perfused lung. | 1978 Jul-Aug | Clin. Exp. Pharmacol. Physiol. | pmid:699382 |
Davies GC et al. | Thromboxane B2 and fibrinopeptide A levels in platelet consumption and thrombosis. | 1978 | Surg Forum | pmid:401227 |
Mitchell MD et al. | Possible role for prostacyclin in human parturition. | 1978 | Prostaglandins | pmid:373020 |
Tai HH and Yuan B | Development of radioimmunoassay for thromboxane B2. | 1978 | Anal. Biochem. | pmid:567443 |
Murota S and Morita I | Effect of prostaglandin I2 and related compounds on vascular permeability response in granuloma tissues. | 1978 | Prostaglandins | pmid:635221 |
Powell WS and Solomon S | Biosynthesis of prostaglandins and thromboxane B2 by fetal lung homogenates. | 1978 | Prostaglandins | pmid:635224 |
Tai HH et al. | Transformation of arachidonate into 6-oxoprostaglandin F1 alpha, thromboxane B2 and prostaglandin E2 by sheep lung microsomal fraction. | 1978 | Biochem. J. | pmid:637853 |
Murota SI et al. | Transformation of arachidonic acid into thromboxane B2 by the homogenates of activated macrophages. | 1978 | Biochim. Biophys. Acta | pmid:638172 |
Mallen DN et al. | Structural verification of 15-oxo-13,14-dihydrothromboxane B2. | 1978 | Biomed. Mass Spectrom. | pmid:678616 |
Morita I et al. | Characterization of thromboxane B2 and 6-ketoprostaglandin F alpha by combined gas chromatography and chemical-ionization mass spectrometry. | 1978 | J. Chromatogr. | pmid:681479 |
Mitchell MD et al. | Production of thromboxane B2 by intra-uterine tissues from pregnant goats in vitro. | 1978 | J. Endocrinol. | pmid:681871 |
Fitzpatrick FA et al. | An antiserum against 9,11-azo-15-hydroxyprosta-5,13-dienoic acid recognises and binds prostaglandin endoperoxides. | 1978 | Nature | pmid:652034 |
Cerskus AL et al. | Effects of indomethacin and sulfinpyrazone on in vivo formation of thromboxane B2 and prostaglandin D2 during arachidonate infusion in rabbits. | 1978 | Thromb. Res. | pmid:653641 |
Mitchell MD et al. | Thromboxane B2 in amniotic fluid before and during labour. | 1978 | Br J Obstet Gynaecol | pmid:656348 |
Raz A et al. | Biosynthesis of thromboxane B2 and 12-L-hydroxy-5,8,10-heptadecatrienoic acid in human platelets. Evidence for a common enzymatic pathway. | 1978 | Eur. J. Biochem. | pmid:658053 |
Salmon JA | A radioimmunoassay for 6-keto-prostaglandin F1alpha. | 1978 | Prostaglandins | pmid:663275 |
Davidson EM et al. | The release of thromboxane B2 by rabbit peritoneal polymorphonuclear leucocytes [proceedings]. | 1978 | Br. J. Pharmacol. | pmid:667479 |
Goldstein IM et al. | Thromboxane generation by human peripheral blood polymorphonuclear leukocytes. | 1978 | J. Exp. Med. | pmid:702055 |
Anhut H et al. | Pharmacological modification of thromboxane and prostaglandin release in cardiac anaphylaxis. | 1978 | Prostaglandins | pmid:704912 |
Nelson NA et al. | Synthesis of thromboxane B2 metabolites. | 1978 | Prostaglandins | pmid:704927 |
Mitchell MD et al. | Thromboxane B2 and human parturition: concentrations in the plasma and production in vitro. | 1978 | J. Endocrinol. | pmid:712300 |
Yoshimoto T et al. | Selective inhibition of prostaglandin endoperoxide thromboxane isomerase by 1-carboxyalkylimidazoles. | 1978 | Prostaglandins | pmid:725083 |
Anderson MW et al. | Kinetic studies on the conversion of prostaglandin endoperoxide PGH2 by thromboxane synthase. | 1978 | Prostaglandins | pmid:725086 |
Mitchell MD et al. | Concentrations of thromboxane B2 in the maternal and foetal plasma of sheep during late pregnancy and induced parturition [proceedings]. | 1978 | J. Endocrinol. | pmid:731165 |
Anhut H et al. | Release of 15-keto-13, 14-dihydro-thromboxane B2 and prostaglandin D2 during anaphylaxis as measured by radioimmunoassay. | 1978 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:740052 |
McMillan RM et al. | Malonaldehyde formation in intact platelets is catalysed by thromboxane synthase. | 1978 | Biochem. J. | pmid:743261 |
Chignard M et al. | Synthesis of thromboxane B2 in incubates of dog platelet-rich plasma with arachidonic acid and its inhibition by different drugs. | 1978 | Biochem. Biophys. Res. Commun. | pmid:743319 |
Mitchell MD and Robinson JS | Concentrations of 6-oxo-prostaglandin F1 alpha and thromboxane B2 in the tracheal fluid of foetal sheep. | 1978 | J. Endocrinol. | pmid:744937 |
Agradi E et al. | Influence of short term dietary supplementation of different lipids on aggregation and arachidonic acid metabolism in rabbit platelets. | 1978 | Prostaglandins | pmid:748984 |
Fitzpatrick FA and Gorman RR | A comparison of imidazole and 9,11-azoprosta-5,13-dienoic acid. Two selective thromboxane synthetase inhibitors. | 1978 | Biochim. Biophys. Acta | pmid:629996 |
Malik KU | Prostaglandin-mediated inhibition of the vasoconstrictor responses of the isolated perfused art splenic vasculature to adrenergic stimuli. | 1978 | Circ. Res. | pmid:27321 |
Roberts LJ et al. | Metabolism of thromboxane B2 in the monkey. | 1978 | J. Biol. Chem. | pmid:97291 |
Mitchell MD et al. | Production of thromboxane B2 by the intra-uterine tissues from late pregnant Rhesus monkeys (Macaca mulatta) in vitro. | 1978 | J. Endocrinol. | pmid:101641 |
Barac G | [Does thromboxane B2 influence renal blood flow? (proceedings)]. | 1978 | Arch. Int. Physiol. Biochim. | pmid:80176 |
Engineer DM et al. | Modulation of slow-reacting substance of anaphylaxis and histamine release by prostacyclin and thromboxanes [proceedings]. | 1978 | J. Physiol. (Lond.) | pmid:81301 |
Best LC et al. | Dipyridamole and platelet function. | 1978 | Lancet | pmid:81402 |
Adcock JJ et al. | The mechanism of enhancement by fatty acid hydroperoxides of anaphylactic mediator release. | 1978 | Prostaglandins | pmid:81495 |
Crawford A et al. | Rat osteogenic sarcoma cells: comparison of the effects of prostaglandins E1, E2, I2 (prostacyclin), 6-keto F1alpha and thromboxane B2 on cyclic AMP production and adenylate cyclase activity. | 1978 | Biochem. Biophys. Res. Commun. | pmid:212039 |
Hyman AL et al. | Prostaglandins and the lung. | 1978 | Am. Rev. Respir. Dis. | pmid:339796 |