Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

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Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Abortion, Habitual D000026 5 associated lipids
Acidosis D000138 13 associated lipids
Adenocarcinoma D000230 166 associated lipids
Agranulocytosis D000380 7 associated lipids
Airway Obstruction D000402 13 associated lipids
Albuminuria D000419 18 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Anaphylaxis D000707 35 associated lipids
Anemia D000740 21 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Angina Pectoris D000787 27 associated lipids
Angina Pectoris, Variant D000788 3 associated lipids
Angina, Unstable D000789 14 associated lipids
Hypoxia D000860 23 associated lipids
Aortic Aneurysm D001014 8 associated lipids
Aortic Arch Syndromes D001015 2 associated lipids
Aortic Rupture D001019 3 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Arthritis, Juvenile D001171 8 associated lipids
Arthus Reaction D001183 8 associated lipids
Ascites D001201 25 associated lipids
Asthenia D001247 5 associated lipids
Asthma D001249 52 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Bartter Syndrome D001477 5 associated lipids
Behcet Syndrome D001528 7 associated lipids
Biliary Tract Neoplasms D001661 7 associated lipids
Birth Weight D001724 23 associated lipids
Blister D001768 16 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Bluetongue D001819 1 associated lipids
Body Weight D001835 333 associated lipids
Bronchial Spasm D001986 18 associated lipids
Bronchitis D001991 6 associated lipids
Bronchopneumonia D001996 7 associated lipids
Bronchopulmonary Dysplasia D001997 4 associated lipids
Bronchopulmonary Sequestration D001998 3 associated lipids
Burns D002056 34 associated lipids
Byssinosis D002095 11 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Cat Diseases D002371 12 associated lipids
Cattle Diseases D002418 24 associated lipids
Celiac Disease D002446 16 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Intracranial Embolism and Thrombosis D002542 5 associated lipids
Cerebral Hemorrhage D002543 13 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Chediak-Higashi Syndrome D002609 4 associated lipids
Chest Pain D002637 4 associated lipids
Choline Deficiency D002796 16 associated lipids
Cleft Palate D002972 9 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Contusions D003288 3 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
Coronary Thrombosis D003328 7 associated lipids
Coronary Vasospasm D003329 9 associated lipids
Cough D003371 19 associated lipids
Death, Sudden D003645 12 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Diseases in Twins D004200 4 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
Drowning D004332 2 associated lipids
Ductus Arteriosus, Patent D004374 5 associated lipids
Edema D004487 152 associated lipids
Edema, Cardiac D004489 1 associated lipids
Embolism, Fat D004620 4 associated lipids
Endometriosis D004715 29 associated lipids
Enteritis D004751 8 associated lipids
Erythromelalgia D004916 1 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Eye Burns D005126 13 associated lipids
Facial Pain D005157 5 associated lipids
Fatty Liver D005234 48 associated lipids
Femoral Fractures D005264 7 associated lipids
Fetal Diseases D005315 8 associated lipids
Fever D005334 35 associated lipids
Fibromuscular Dysplasia D005352 2 associated lipids
Fibrosis D005355 23 associated lipids
Fistula D005402 8 associated lipids
Foot Rot D005535 1 associated lipids
Frostbite D005627 1 associated lipids
Per page 10 20 50 100 | Total 293

PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

Download all related citations
Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Wasserman MA and Griffin RL Thromboxane B2--comparative bronchoactivity in experimental systems. 1977 Eur. J. Pharmacol. pmid:590340
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Murota SI et al. The effects of thromboxane B2 and 6-ketoprostaglandin F1alpha on cultured fibroblasts. 1977 Biochim. Biophys. Acta pmid:911847
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Powell WS and Solomon S Biosynthesis of prostaglandins and thromboxane B2 by fetal lung homogenates. 1978 Prostaglandins pmid:635224
Tai HH et al. Transformation of arachidonate into 6-oxoprostaglandin F1 alpha, thromboxane B2 and prostaglandin E2 by sheep lung microsomal fraction. 1978 Biochem. J. pmid:637853
Murota SI et al. Transformation of arachidonic acid into thromboxane B2 by the homogenates of activated macrophages. 1978 Biochim. Biophys. Acta pmid:638172
Mallen DN et al. Structural verification of 15-oxo-13,14-dihydrothromboxane B2. 1978 Biomed. Mass Spectrom. pmid:678616
Morita I et al. Characterization of thromboxane B2 and 6-ketoprostaglandin F alpha by combined gas chromatography and chemical-ionization mass spectrometry. 1978 J. Chromatogr. pmid:681479
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Fitzpatrick FA et al. An antiserum against 9,11-azo-15-hydroxyprosta-5,13-dienoic acid recognises and binds prostaglandin endoperoxides. 1978 Nature pmid:652034
Cerskus AL et al. Effects of indomethacin and sulfinpyrazone on in vivo formation of thromboxane B2 and prostaglandin D2 during arachidonate infusion in rabbits. 1978 Thromb. Res. pmid:653641
Mitchell MD et al. Thromboxane B2 in amniotic fluid before and during labour. 1978 Br J Obstet Gynaecol pmid:656348
Raz A et al. Biosynthesis of thromboxane B2 and 12-L-hydroxy-5,8,10-heptadecatrienoic acid in human platelets. Evidence for a common enzymatic pathway. 1978 Eur. J. Biochem. pmid:658053
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Davidson EM et al. The release of thromboxane B2 by rabbit peritoneal polymorphonuclear leucocytes [proceedings]. 1978 Br. J. Pharmacol. pmid:667479
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Anhut H et al. Pharmacological modification of thromboxane and prostaglandin release in cardiac anaphylaxis. 1978 Prostaglandins pmid:704912
Nelson NA et al. Synthesis of thromboxane B2 metabolites. 1978 Prostaglandins pmid:704927
Marion J and Wolfe LS Increase in vivo of unesterified fatty acids, prostaglandin F2 alpha but not thromboxane B2 in rat brain during drug induced convulsions. 1978 Prostaglandins pmid:704928
Kitchen EA et al. Chemotactic activity of thromboxane B2, prostaglandins and their metabolites for polymorphonuclear leucocytes. 1978 Prostaglandins pmid:704931
Sors H et al. Analytical methods for thromboxane B2 measurement and validation of radioimmunoassay by gas liquid chromatography-mass spectrometry. 1978 Prostaglandins pmid:704933
Turk J et al. Fluorescent derivatives of prostaglandins and thromboxanes for liquid chromatography. 1978 Prostaglandins pmid:704934
Raz A and Aharony D Prostaglandin biosynthesis in platelets: demonstration and role of prostaglandin H2 leads to E2 isomerase. 1978 Res. Commun. Chem. Pathol. Pharmacol. pmid:705027
Chang WC et al. Inhibition of thromboxane B2 and 6-ketoprostaglandin F1 alpha formation by anti-inflammatory drugs in carrageenin-induced granuloma. 1978 Biochem. Pharmacol. pmid:619892
Goetzl EJ and Gorman RR Chemotactic and chemokinetic stimulation of human eosinophil and neutrophil polymorphonuclear leukocytes by 12-L-hydroxy-5,8,10-heptadecatrienoic acid (HHT). 1978 J. Immunol. pmid:621391
Mitchell MD et al. Thromboxane B2 and human parturition: concentrations in the plasma and production in vitro. 1978 J. Endocrinol. pmid:712300
Yoshimoto T et al. Selective inhibition of prostaglandin endoperoxide thromboxane isomerase by 1-carboxyalkylimidazoles. 1978 Prostaglandins pmid:725083
Anderson MW et al. Kinetic studies on the conversion of prostaglandin endoperoxide PGH2 by thromboxane synthase. 1978 Prostaglandins pmid:725086
Mitchell MD et al. Concentrations of thromboxane B2 in the maternal and foetal plasma of sheep during late pregnancy and induced parturition [proceedings]. 1978 J. Endocrinol. pmid:731165
Anhut H et al. Release of 15-keto-13, 14-dihydro-thromboxane B2 and prostaglandin D2 during anaphylaxis as measured by radioimmunoassay. 1978 Naunyn Schmiedebergs Arch. Pharmacol. pmid:740052
McMillan RM et al. Malonaldehyde formation in intact platelets is catalysed by thromboxane synthase. 1978 Biochem. J. pmid:743261
Chignard M et al. Synthesis of thromboxane B2 in incubates of dog platelet-rich plasma with arachidonic acid and its inhibition by different drugs. 1978 Biochem. Biophys. Res. Commun. pmid:743319
Mitchell MD and Robinson JS Concentrations of 6-oxo-prostaglandin F1 alpha and thromboxane B2 in the tracheal fluid of foetal sheep. 1978 J. Endocrinol. pmid:744937
Agradi E et al. Influence of short term dietary supplementation of different lipids on aggregation and arachidonic acid metabolism in rabbit platelets. 1978 Prostaglandins pmid:748984
Fitzpatrick FA and Gorman RR A comparison of imidazole and 9,11-azoprosta-5,13-dienoic acid. Two selective thromboxane synthetase inhibitors. 1978 Biochim. Biophys. Acta pmid:629996
Malik KU Prostaglandin-mediated inhibition of the vasoconstrictor responses of the isolated perfused art splenic vasculature to adrenergic stimuli. 1978 Circ. Res. pmid:27321
Hamberg M et al. A method for measurement of platelet regeneration in man. 1978 Prostaglandins Med pmid:104315
Roberts LJ et al. Metabolism of thromboxane B2 in the monkey. 1978 J. Biol. Chem. pmid:97291
Mitchell MD et al. Production of thromboxane B2 by the intra-uterine tissues from late pregnant Rhesus monkeys (Macaca mulatta) in vitro. 1978 J. Endocrinol. pmid:101641
Barac G [Does thromboxane B2 influence renal blood flow? (proceedings)]. 1978 Arch. Int. Physiol. Biochim. pmid:80176
Engineer DM et al. Modulation of slow-reacting substance of anaphylaxis and histamine release by prostacyclin and thromboxanes [proceedings]. 1978 J. Physiol. (Lond.) pmid:81301
Best LC et al. Dipyridamole and platelet function. 1978 Lancet pmid:81402
Adcock JJ et al. The mechanism of enhancement by fatty acid hydroperoxides of anaphylactic mediator release. 1978 Prostaglandins pmid:81495
Lagarde M et al. Impairment of platelet thromboxane A2 generation and of the platelet release reaction in two patients with congenital deficiency of platelet cyclo-oxygenase. 1978 Br. J. Haematol. pmid:205238
Crawford A et al. Rat osteogenic sarcoma cells: comparison of the effects of prostaglandins E1, E2, I2 (prostacyclin), 6-keto F1alpha and thromboxane B2 on cyclic AMP production and adenylate cyclase activity. 1978 Biochem. Biophys. Res. Commun. pmid:212039
Hyman AL et al. Prostaglandins and the lung. 1978 Am. Rev. Respir. Dis. pmid:339796
Boura AL and Murphy RD Thromboxane B2 inhibits prostaglandin E2 inactivation by the rat isolated perfused lung. 1978 Jul-Aug Clin. Exp. Pharmacol. Physiol. pmid:699382
Mitchell MD et al. Thromboxane B-2 in the plasma and amniotic fluid of late pregnant and periparturient sheep. 1979 J. Reprod. Fertil. pmid:423152
Tobelem G et al. Further studies on a specific platelet antibody found in Bernard-Soulier syndrome and its effects on normal platelet function. 1979 Br. J. Haematol. pmid:427045
Friedman LS et al. Cardiovascular and pulmonary effects of thromboxane B2 in the dog. 1979 Circ. Res. pmid:428069
Ciabattoni G et al. Characterization of furosemide-induced activation of the renal prostaglandin system. 1979 Eur. J. Pharmacol. pmid:393525
Svensson J Structure and quantitative determination of the major urinary metabolite of thromboxane B2 in the guinea pig. 1979 Prostaglandins pmid:472333
Langs DA et al. Thromboxane molecules do not adopt the prostaglandin hairpin conformation. 1979 Nature pmid:481594
Jonsson CE et al. Prostaglandins and thromboxanes in burn injury in man. 1979 Scand J Plast Reconstr Surg pmid:451477
Bailey JM et al. Anti-inflammatory drugs in experimental atherosclerosis. Part 4. Inhibition of atherosclerosis in vivo and thromboxane synthesis and platelet aggregation in vitro. 1979 Atherosclerosis pmid:454516
Makheja AN et al. Effects of onion (Allium cepa) extract on platelet aggregation and thromboxane synthesis. 1979 Prostaglandins Med pmid:552092
Lefer AM et al. Protective effects of a novel thromboxane analog in lethal traumatic shock. 1979 Prostaglandins Med pmid:552102
Russell NH et al. Thrombocytopathy in preleukaemia: association with a defect of thromboxane A2 activity. 1979 Br. J. Haematol. pmid:570847
Anhut H et al. Prostaglandin D2 is the prevailing prostaglandin in the acute inflammatory exudate of urate arthritis in the chicken. 1979 Br. J. Pharmacol. pmid:570865
Lewy RI et al. Detection of thromboxane B2 in peripheral blood of patients with Prinzmetal's angina. 1979 Prostaglandins Med pmid:575861
Ohuchi K et al. Prostaglandins E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 levels in carrageenin-induced inflammatory exudates in the rat air-pouch granuloma. 1979 Prostaglandins Med pmid:583576
Daniel EE et al. Prostaglandins and myogenic control of tension in lower esophageal sphincter in vitro. 1979 Prostaglandins pmid:379920
Kanzaki Y et al. Thromboxane as possible trigger of liver regeneration. 1979 Cell Mol Biol Incl Cyto Enzymol pmid:535003
Lewy RI et al. Comparison of plasma concentrations of thromboxane B2 in Prinzmetal's variant angina and classical angina pectoris. 1979 Clin Cardiol pmid:544110
Russell FA and Deykin D The use of high pressure liquid chromatography (HPLC) for the separation of radiolabeled arachidonic acid and its metabolities produced by thrombin-treated human platelets. I. The validation of the technique. 1979 Prostaglandins pmid:523671
Wong PY and Cheung WY Calmodulin stimulates human platelet phospholipase A2. 1979 Biochem. Biophys. Res. Commun. pmid:116656
Okuma M and Uchino H Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders. 1979 Blood pmid:116695
Best LC et al. Evidence that extracellular calcium ions inhibit thromboxane B2 biosynthesis by human platelets. 1979 Biochem. Biophys. Res. Commun. pmid:117802
Oelz O [The arachidonic acid metabolites (prostaglandins, thromboxanes, prostacyclin, leucotrienes):basics and clinical implications (author's transl)]. 1979 Ther Umsch pmid:119331
Robak J and Kasperczyk H [Prostaglandin synthetase components (author's transl)]. 1979 Postepy Biochem. pmid:120943
Tremoli E et al. Platelet thromboxanes and serum-cholesterol. 1979 Lancet pmid:84115
Makheia AN et al. Inhibition of platelet aggregation and thromboxane synthesis by onion and garlic. 1979 Lancet pmid:86023
Lewy RI et al. Intravenous heparin initiates in-vivo synthesis and release of thromboxane in angina pectoris. 1979 Lancet pmid:87990
Güllner HG et al. Prostacyclin overproduction in Bartter's syndrome. 1979 Lancet pmid:90861
Davis TM et al. Prostacyclin and thromboxane metabolites in diabetes. 1979 Lancet pmid:90875
Best L et al. Effect of glucose on platelet thromboxane biosynthesis. 1979 Lancet pmid:90876
Jarabak J and Fried J Comparison of substrate specificities of the human placental NAD- and NADP-linked 15-hydroxyprostaglandin dehydrogenases. 1979 Prostaglandins pmid:42948
Miura Y and Fukui N Prostaglandins as possible triggers for liver regeneration after partial hepatectomy. A review. 1979 Cell Mol Biol Incl Cyto Enzymol pmid:44483
Ford-Hutchinson AW et al. The aggregation of rat neutrophils by arachidonic acid: a possible bioassay for lipoxygenase activity. 1979 J. Pharm. Pharmacol. pmid:43380
Gorman RR et al. Independence of the cyclic AMP-lowering activity of thromboxane A2 from the platelet release reaction. 1979 Biochim. Biophys. Acta pmid:216409
Fitzpatrick FA and Gorman RR Regulatory role of cyclic adenosine 3',5'-monophosphate on the platelet cyclooxygenase and platelet function. 1979 Biochim. Biophys. Acta pmid:216415
Best LC et al. Mode of action of dipyridamole on human platelets. 1979 Thromb. Res. pmid:229583
Marcus AJ The role of prostaglandins in platelet function. 1979 Prog Hematol pmid:230534
Spagnuolo C et al. PGF2 alpha, thromboxane B2 and HETE levels in gerbil brain cortex after ligation of common carotid arteries and decapitation. 1979 Prostaglandins pmid:230539
Jonsson CE et al. Efflux of cyclic AMP, prostaglandin E2 and F2 alpha and thromboxane B2 in leg lymph of rabbits after scalding injury. 1979 Acta Physiol. Scand. pmid:232367
Karmazyn M and Dhalla NS Thromboxane B2: a cardiodepressant of isolated rat hearts and inhibitor of sarcolemma Na+ - K+ stimulated ATPase activity. 1979 Prostaglandins Med pmid:233217
Hassid A et al. Prostaglandin synthesis in isolated rat kidney glomeruli. 1979 Proc. Natl. Acad. Sci. U.S.A. pmid:286300
Le Breton GC et al. 13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor. 1979 Proc. Natl. Acad. Sci. U.S.A. pmid:291066
Chignard M et al. Arachidonate-mediated bronchoconstriction and platelet activation are inhibited by microgram doses of compound L8027 which are not selective for thromboxane synthetase. 1979 Agents Actions Suppl. pmid:291306
Peskar BA and Holland A Plasma levels of immunoreactive 15-keto-13,14-dihydro-thromboxane B2 in guinea pigs during anaphylaxis and after histamine injection. 1979 Agents Actions Suppl. pmid:294148
Kass MA and Holmberg NJ Prostaglandin and thromboxane synthesis by microsomes of rabbit ocular tissues. 1979 Invest. Ophthalmol. Vis. Sci. pmid:761971