Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Chen L et al. | Cyclooxygenase inhibition decreases nitric oxide synthase activity in human platelets. | 1997 | Am. J. Physiol. | pmid:9362253 |
Barton MH et al. | Effects of pentoxifylline infusion on response of horses to in vivo challenge exposure with endotoxin. | 1997 | Am. J. Vet. Res. | pmid:9361896 |
Baskett A et al. | Effect of pentoxifylline, flunixin meglumine, and their combination on a model of endotoxemia in horses. | 1997 | Am. J. Vet. Res. | pmid:9361895 |
Lahoz C et al. | Effects of dietary fat saturation on eicosanoid production, platelet aggregation and blood pressure. | 1997 | Eur. J. Clin. Invest. | pmid:9352251 |
Neupert W et al. | Effects of ibuprofen enantiomers and its coenzyme A thioesters on human prostaglandin endoperoxide synthases. | 1997 | Br. J. Pharmacol. | pmid:9351505 |
Supanz S et al. | Effects of the novel thromboxane (TXA2) receptor antagonist linotroban on inulin and para-aminohippuric acid clearances in the conscious male and female rat. | 1997 | Arzneimittelforschung | pmid:9342416 |
Zahavi M and Zahavi J | Concomitant in vitro platelet hypofunction and increased thromboxane B2 (TXB2) generation and enhanced in vivo platelet activation. A distinct syndrome in thrombosis? | 1997 | Eur. J. Haematol. | pmid:9338626 |
Chavali SR et al. | Decreased production of interleukin-1-beta, prostaglandin-E2 and thromboxane-B2, and elevated levels of interleukin-6 and -10 are associated with increased survival during endotoxic shock in mice consuming diets enriched with sesame seed oil supplemented with Quil-A saponin. | 1997 | Int. Arch. Allergy Immunol. | pmid:9338609 |
Hashimoto Y et al. | Characteristics of protein kinase C-independent exocytosis in human platelets. | 1997 | Thromb. Res. | pmid:9336873 |
Matrougui K et al. | Impaired nitric oxide- and prostaglandin-mediated responses to flow in resistance arteries of hypertensive rats. | 1997 | Hypertension | pmid:9336397 |
Moser L et al. | ACE inhibitor effects on platelet function in stages I-II hypertension. | 1997 | J. Cardiovasc. Pharmacol. | pmid:9335405 |
Uteshev DB and Uteshev BS | [Adhesive molecules as drugs and objects of pharmacological effect in myocardial ischemia and reperfusion]. | 1997 May-Jun | Eksp Klin Farmakol | pmid:9324410 |
Swails WS et al. | Effect of a fish oil structured lipid-based diet on prostaglandin release from mononuclear cells in cancer patients after surgery. | 1997 Sep-Oct | JPEN J Parenter Enteral Nutr | pmid:9323688 |
Berlin I et al. | [Comparison between effects of morning and evening administration of effervescent calcium carbasalate (equivalent of 160 mg aspirin) on the gastroduodenal mucosa in healthy volunteers]. | 1997 | Pathol. Biol. | pmid:9309270 |
Tanaka M et al. | Effects of a thromboxane synthetase inhibitor (OKY-046) in an ischemia-reperfusion model of intrauterine growth retardation in Sprague-Dawley rats. | 1997 | Biol. Neonate | pmid:9303217 |
Abate A et al. | Inhibition of mediator release from anaphylactic guinea pig hearts by the novel phospholipase A2 inhibitor 3-(4-octadecylbenzoyl) acrylic acid. | 1997 | Inflamm. Res. | pmid:9297549 |
Trang LE et al. | Levels of prostaglandins F2 alpha and E2 and thromboxane B2 in joint fluid in rheumatoid arthritis. | 1977 | Scand. J. Rheumatol. | pmid:929121 |
Cipollone F et al. | Differential suppression of thromboxane biosynthesis by indobufen and aspirin in patients with unstable angina. | 1997 | Circulation | pmid:9286937 |
Santillan-Doherty P et al. | Plasma thromboxane B2 concentrations and pulmonary vascular resistance during lung reperfusion. | 1997 Jul-Aug | J Invest Surg | pmid:9284000 |
Freese R and Mutanen M | Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. | 1997 | Am. J. Clin. Nutr. | pmid:9280178 |
Berg J et al. | Isoenzyme-specific cyclooxygenase inhibitors: a whole cell assay system using the human erythroleukemic cell line HEL and the human monocytic cell line Mono Mac 6. | 1997 | J Pharmacol Toxicol Methods | pmid:9279772 |
Lewis K et al. | Effect of neuropeptide Y on bradykinin-induced release of prostacyclin and thromboxane from guinea pig perfused lung. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9276148 |
Xing X and Xia S | [The injury of liver sinusoidal endothelial cells in a rat's isolated liver perfusion (ILP) model for regional chemotherapy]. | 1996 | Zhonghua Wai Ke Za Zhi | pmid:9275689 |
Ku K et al. | Influences of dietary omega-3 polyunsaturated fatty acids on the recovery of cardiac and renal functions after preservation in hyperlipidemic rats. | 1997 | Transplantation | pmid:9275102 |
Azevedo I et al. | Increased spontaneous release of tumour necrosis factor-alpha by alveolar macrophages from wheezy infants. | 1997 | Eur. Respir. J. | pmid:9272917 |
Chang TS et al. | Thromboxane A2 synthase inhibition and thromboxane A2 receptor blockade by 2-[(4-cyanophenyl)amino]-3-chloro-1,4-naphthalenedione (NQ-Y15) in rat platelets. | 1997 | Biochem. Pharmacol. | pmid:9271330 |
Serebruany VL et al. | Could coenzyme Q10 affect hemostasis by inhibiting platelet vitronectin (CD51/CD61) receptor? | 1997 | Mol. Aspects Med. | pmid:9266521 |
De La Cruz JP et al. | Effects of S-adenosyl-L-methionine on platelet thromboxane and vascular prostacyclin. | 1997 | Biochem. Pharmacol. | pmid:9264331 |
Nanji AA et al. | Alterations in thromboxane synthase and thromboxane A2 receptors in experimental alcoholic liver disease. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9262373 |
Tulppala M et al. | Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production. | 1997 | Hum. Reprod. | pmid:9262298 |
Hishinuma T et al. | Microdetermination of the thromboxane B3 gas chromatography-selected-ion monitoring using [18O]thromboxane B3 as an internal standard. | 1997 | Prostaglandins | pmid:9261859 |
Slepko N et al. | Reorientation of prostanoid production accompanies "activation" of adult microglial cells in culture. | 1997 | J. Neurosci. Res. | pmid:9260740 |
Cenni E et al. | CD62, thromboxane B2, and beta-thromboglobulin: a comparison between different markers of platelet activation after contact with biomaterials. | 1997 | J. Biomed. Mater. Res. | pmid:9260099 |
van Kooten F et al. | Platelet activation and lipid peroxidation in patients with acute ischemic stroke. | 1997 | Stroke | pmid:9259748 |
Teng CM et al. | Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. | 1997 | J. Pharm. Pharmacol. | pmid:9255715 |
Brinkmann A et al. | The impact of prostanoids on pulmonary gas exchange during abdominal surgery with mesenteric traction. | 1997 | Anesth. Analg. | pmid:9249099 |
Kotuliaková K et al. | Human polymorphonuclear leukocytes: effect of chloroquine on aggregation, arachidonic acid liberation and thromboxane B2 generation. | 1996 | Gen. Physiol. Biophys. | pmid:9248834 |
González E et al. | Influence of nitric oxide synthase and kinin antagonists on metabolic parameters in chronic streptozotocin-induced diabetes mellitus. | 1997 | Prostaglandins | pmid:9247972 |
Szebeni J et al. | Complement activation and thromboxane secretion by liposome-encapsulated hemoglobin in rats in vivo: inhibition by soluble complement receptor type 1. | 1997 | Artif Cells Blood Substit Immobil Biotechnol | pmid:9242930 |
Johnson RD et al. | Aspirin induces increased expression of both prostaglandin H synthase-1 and prostaglandin H synthase-2 in cultured human placental trophoblast. | 1997 | Am. J. Obstet. Gynecol. | pmid:9240586 |
Davì G et al. | Diabetes mellitus, hypercholesterolemia, and hypertension but not vascular disease per se are associated with persistent platelet activation in vivo. Evidence derived from the study of peripheral arterial disease. | 1997 | Circulation | pmid:9236419 |
Rautanen M et al. | Experimental fat embolism induces urine 2,3-dinor-6-ketoprostaglandin F1alpha and 11-dehydrothromboxane B2 excretion in pigs. | 1997 | Crit. Care Med. | pmid:9233750 |
Desideri N et al. | N-omega-carbethoxypentyl-4-quinolones: a new class of leukotriene biosynthesis inhibitors. | 1997 | Arch. Pharm. (Weinheim) | pmid:9230527 |
Calzada C et al. | Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation. | 1997 | Biochem. J. | pmid:9230133 |
Hansen TN and Brockbank KG | Increased platelet aggregation due to chilling to 20 degrees C is not related to increased sensitivity to agonists. | 1997 | Transfusion | pmid:9225932 |
Inui Y et al. | Platelet volume and urinary prostanoid metabolites in non-insulin-dependent diabetes mellitus. | 1994 | J. Atheroscler. Thromb. | pmid:9222878 |
Matsumata T et al. | Urinary excretion of prostaglandins and renal function after hepatic resection. | 1997 May-Jun | Hepatogastroenterology | pmid:9222688 |
De la Cruz JP et al. | Effect of erythrocytes and prostacyclin production in the effect of fructose and sorbitol on platelet activation in human whole blood in vitro. | 1997 | Thromb. Res. | pmid:9219331 |
Fenner H | Differentiating among nonsteroidal antiinflammatory drugs by pharmacokinetic and pharmacodynamic profiles. | 1997 | Semin. Arthritis Rheum. | pmid:9219317 |
Ansley DM et al. | Platelet activating factor and thromboxane B2 production after cardiopulmonary bypass. | 1997 May-Jun | J Invest Surg | pmid:9219083 |
Malini PL et al. | Thromboxane antagonism and cough induced by angiotensin-converting-enzyme inhibitor. | 1997 | Lancet | pmid:9217714 |
Nanji AA et al. | Cholesterol supplementation prevents necrosis and inflammation but enhances fibrosis in alcoholic liver disease in the rat. | 1997 | Hepatology | pmid:9214456 |
Yan Y et al. | [Study on mechanism of eye-signs in blood stasis syndrome]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9206243 |
Hellyer PW et al. | Effect of NG-nitro-L-arginine-methyl-ester on cardiopulmonary function and biosynthesis of cyclooxygenase products during porcine endotoxemia. | 1997 | Crit. Care Med. | pmid:9201060 |
Carty TJ et al. | Tenidap inhibits 5-lipoxygenase product formation in vitro, but this activity is not observed in three animal models. | 1997 | Inflamm. Res. | pmid:9197987 |
Hato T et al. | Outside-in signaling from integrin alpha IIb beta 3 into platelets in the absence of agonist-induced signaling. | 1997 | Int. J. Hematol. | pmid:9195778 |
Cook ME et al. | Comparative effects of nabumetone, sulindac, and ibuprofen on renal function. | 1997 | J. Rheumatol. | pmid:9195523 |
Fujinishi A et al. | Effects of nisoldipine on cytosolic calcium, platelet aggregation, and coagulation/fibrinolysis in patients with coronary artery disease. | 1997 | Angiology | pmid:9194537 |
Ali M et al. | Synthesis of prostaglandin D2 and thromboxane B2 by human platelets. | 1977 | Thromb. Res. | pmid:918907 |
Oosaki R et al. | Urinary leukotriene E4 and 11-dehydrothromboxane B2 in patients with aspirin-sensitive asthma. | 1997 | Allergy | pmid:9188934 |
Murthy S et al. | Ischemia/reperfusion injury in the rat colon. | 1997 | Inflammation | pmid:9187961 |
Bräutigam R et al. | Arachidonic acid of platelet phospholipids is decreased after extracorporeal removal of plasma low density lipoproteins in patients with familial hypercholesterolemia. | 1997 | Atherosclerosis | pmid:9180250 |
Vila V et al. | Fibrinopeptide A release from intraplatelet fibrinogen is related to thrombin platelet activation. | 1997 | Thromb. Res. | pmid:9175247 |
Barbieri B et al. | p-Aminobenzoic acid, but not its metabolite p-acetamidobenzoic acid, inhibits thrombin induced thromboxane formation in human platelets in a non NSAID like manner. | 1997 | Thromb. Res. | pmid:9175234 |
Oguogho A et al. | Chloroquine minimizes sampling artefacts for radioimmunological determination of thromboxane B2 in plasma. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9175176 |
Klosterhalfen B et al. | The influence of heat shock protein 70 induction on hemodynamic variables in a porcine model of recurrent endotoxemia. | 1997 | Shock | pmid:9165671 |
Low-dose aspirin in polycythaemia vera: a pilot study. Gruppo Italiano Studio Policitemia (GISP). | 1997 | Br. J. Haematol. | pmid:9163613 | |
Shimada Y et al. | Role of platelets in myocardial ischemia-reperfusion injury in dogs. | 1997 | Jpn. Circ. J. | pmid:9152773 |
Closa D et al. | Prostanoids and free radicals in Cl4C-induced hepatotoxicity in rats: effect of astilbin. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9150380 |
Sinzinger H et al. | PGE1-induced arterial thromboresistance is a vascular property as identified by cross-perfusion technique. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9150379 |
Zhang T et al. | Effects of the incubation of long-chain polyunsaturated fatty acids on platelet lipids and thromboxane release. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9150370 |
Kraft M et al. | The effect of salmeterol on nocturnal symptoms, airway function, and inflammation in asthma. | 1997 | Chest | pmid:9149578 |
Roberts LJ et al. | Metabolism of thromboxane B2 in man. Identification of the major urinary metabolite. | 1977 | J. Biol. Chem. | pmid:914816 |
Bishop-Bailey D et al. | Characterization of the induction of nitric oxide synthase and cyclo-oxygenase in rat aorta in organ culture. | 1997 | Br. J. Pharmacol. | pmid:9146896 |
Riendeau D et al. | Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. | 1997 | Br. J. Pharmacol. | pmid:9146894 |
Henrion D et al. | Alteration of flow-induced dilatation in mesenteric resistance arteries of L-NAME treated rats and its partial association with induction of cyclo-oxygenase-2. | 1997 | Br. J. Pharmacol. | pmid:9146891 |
Todd MK et al. | Comparison of methods for evaluating exercise-induced changes in thromboxane B2 and beta-thromboglobulin. | 1997 | Med Sci Sports Exerc | pmid:9140910 |
Olson KR et al. | Cardiovascular effects of homologous bradykinin in rainbow trout. | 1997 | Am. J. Physiol. | pmid:9140009 |
Oelkers R et al. | Disposition and effects of flurbiprofen enantiomers in human serum and blister fluid. | 1997 | Br J Clin Pharmacol | pmid:9131946 |
He CF et al. | Postural vasoregulation and mediators of reperfusion injury in venous ulceration. | 1997 | J. Vasc. Surg. | pmid:9129619 |
Cheng Z et al. | Pharmacokinetic and pharmacodynamic studies on phenylbutazone and oxyphenbutazone in goats. | 1997 | Vet. Rec. | pmid:9123796 |
Yagi T et al. | Hepatropic soluble vitamin E derivative EPC-K1 prevents warm ischemia/reperfusion injury of non-heart-beating donor liver transplantation in pigs. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123352 |
Suehiro T et al. | Value of caval effluent in predicting early graft function after orthotopic liver transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123086 |
Ishine N et al. | Hemodynamic analysis of post-reperfusion syndrome and the effect of preventing this syndrome using thromboxane A2 synthetase inhibitor (OKY-046) in swine liver transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123045 |
Teraoka S et al. | Multicenter trial of the therapeutic effect of a newly developed antiplatelet agent, satigrel, on biopsy-proven chronic rejection after kidney transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9122990 |
Shinohara M et al. | [Responses to surgical stress in blood coagulation and fibrinolysis, platelet counts and thromboxane B2 after esophageal cancer operation]. | 1997 | Rinsho Byori | pmid:9121003 |
Aibiki M and Cook JA | Ulinastatin, a human trypsin inhibitor, inhibits endotoxin-induced thromboxane B2 production in human monocytes. | 1997 | Crit. Care Med. | pmid:9118658 |
Murota SI et al. | The effects of thromboxane B2 and 6-ketoprostaglandin F1alpha on cultured fibroblasts. | 1977 | Biochim. Biophys. Acta | pmid:911847 |
Cambridge H et al. | Plasma thromboxane B2 levels in horses experimentally infected with Strongylus vulgaris. | 1989 | Equine Vet J Suppl | pmid:9118097 |
Mitra A et al. | Thromboxane-mediated alveolar responses to acute obstruction of the pulmonary vasculature. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9117035 |
Hayball PJ et al. | The influence of renal function on the enantioselective pharmacokinetics and pharmacodynamics of ketoprofen in patients with rheumatoid arthritis. | 1993 | Br J Clin Pharmacol | pmid:9114902 |
Brus F et al. | Number and activation of circulating polymorphonuclear leukocytes and platelets are associated with neonatal respiratory distress syndrome severity. | 1997 | Pediatrics | pmid:9113943 |
Barry MC et al. | Immunological and physiological responses to aortic surgery: effect of reperfusion on neutrophil and monocyte activation and pulmonary function. | 1997 | Br J Surg | pmid:9112905 |
Zeltsman D et al. | Pathophysiologic plasma levels of leukotriene C4 in relation to the hemodynamic dysfunction and mediator release of graded bacteremia. | 1997 | Shock | pmid:9110414 |
Tomas-Barberan S et al. | Effect of diclofenac on prostaglandin liberation in the rabbit after photorefractive keratectomy. | 1997 Mar-Apr | J Refract Surg | pmid:9109071 |
Yasui K et al. | Involvement of thromboxane A2 in antigen-induced nasal blockage in guinea pigs. | 1997 | Int. Arch. Allergy Immunol. | pmid:9104797 |
Cueto SM et al. | beta-Carotene attenuates peroxide-induced vasoconstriction in the human placenta. | 1997 Mar-Apr | J. Soc. Gynecol. Investig. | pmid:9101463 |
Shellhaas CS et al. | Intravillous eicosanoid compartmentalization and regulation of placental blood flow. | 1997 Mar-Apr | J. Soc. Gynecol. Investig. | pmid:9101462 |
Rocha FA et al. | PAF modulates eicosanoids and TNF release in immune-complex arthritis in rats. | 1997 | J Lipid Mediat Cell Signal | pmid:9101418 |
Kume S | [Evaluation and problems on platelet function tests]. | 1997 | Nippon Rinsho | pmid:9097565 |