Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Vassar MJ et al. | Measurement of 6-keto-PGF1 alpha and thromboxane B2 levels in critically ill surgical patients. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:3174719 |
Al-Qattan KK et al. | Thromboxane-B2, prostaglandin-E2 and hypertension in the rat 2-kidney 1-clip model: a possible mechanism of the garlic induced hypotension. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161580 |
Beitz A et al. | Lipoproteins from normolipidemic and dyslipidemic subjects modify the thromboxane A2 generation by platelets in clotting human blood. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8341726 |
Pascual J et al. | TXB2: cardiostimulant effect that involves beta-adrenoceptor and Na+ + K+-ATPase activity. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2847200 |
Sullivan MH et al. | Equivalent inhibition of in vivo platelet function by low dose and high dose aspirin treatment. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2353031 |
Okita M et al. | Effect of arachidonic acid-rich oil on lipids and arachidonate metabolites in ethanol- treated rats. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418023 |
Wolfram R et al. | Daily prickly pear consumption improves platelet function. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878452 |
Urquhart P et al. | Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487303 |
Agnoli GC et al. | Renal function and urinary prostanoid excretions in salt-depleted women: comparative effects of enalapril and indomethacin treatments. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10328327 |
Chahine R et al. | The anti-thromboxane A2 synthetase activity of myocardial tissue and its variation during ischemia and reperfusion in isolated rabbit heart. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10328329 |
Peredo HA and Filinger EJ | Effect of dipyridamole on prostanoid production in rat isolated atria. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10328333 |
Dołegowska B et al. | Metabolism of eicosanoids and their action on renal function during ischaemia and reperfusion: the effect of alprostadil. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17011760 |
Ali M et al. | A potent thromboxane formation inhibitor in green tea leaves. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2274565 |
Bacman S et al. | Antilaminin IgG releases TXB2 through activation of the cholinergic system. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2274567 |
Ali M et al. | Antithrombotic activity of garlic: its inhibition of the synthesis of thromboxane-B2 during infusion of arachidonic acid and collagen in rabbits. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2274570 |
Schonwetter DJ et al. | Type A behavior and alcohol consumption: effects on resting and post-exercise bleeding time thromboxane and prostacyclin metabolites. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8446651 |
Engström K et al. | Effect of low-dose aspirin in combination with stable fish oil on whole blood production of eicosanoids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11427037 |
Leung S et al. | Isolation and purification of anticardiolipin antibody from plasma of a patient with antiphospholipid syndrome: induced generation of platelet thromboxane A2 synthesis. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014216 |
Vranic II et al. | Adenosine cardioprotection study in clinical setting of paroxysmal supraventricular tachycardia. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16682179 |
Bell JG et al. | Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9690713 |
van der Weiden RM et al. | Which prostanoid metabolites should be determined for the study of reproductive processes? | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610843 |
Beitz A | Influence of diet-modified lipoprotein fractions from rabbits on eicosanoid production and on proliferation of rabbit skin fibroblasts. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610847 |
Agnoli GC et al. | Effects of experimental salt depletion on urinary prostanoid excretions in normal women. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610848 |
Darlametsos IE et al. | Effect of nifedipine in cyclosporine-induced nephrotoxicity in rats: roles of the thromboxane and endothelin systems. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090252 |
Anfossi G et al. | Influence of propranolol on platelet aggregation and thromboxane B2 production from platelet-rich plasma and whole blood. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2525784 |
Karamouzis M et al. | The response of muscle interstitial prostaglandin E(2)(PGE(2)), prostacyclin I(2)(PGI(2)) and thromboxane A(2)(TXA(2)) levels during incremental dynamic exercise in humans determined by in vivo microdialysis. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418021 |
Selg E et al. | Effects of selective and non-selective COX inhibitors on antigen-induced release of prostanoid mediators and bronchoconstriction in the isolated perfused and ventilated guinea pig lung. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18294831 |
Srivastava KC | Extracts from two frequently consumed spices--cumin (Cuminum cyminum) and turmeric (Curcuma longa)--inhibit platelet aggregation and alter eicosanoid biosynthesis in human blood platelets. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2503839 |
Nagase T et al. | Reduction of 15-hydroxyeicosatetraenoic acid (15-HETE) in tracheal fluid by high frequency oscillatory ventilation. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2402521 |
Peredo HA et al. | Prostanoid production in hypoxic rat isolated atria: influence of acute diabetes. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846089 |
Moon CH et al. | Mechanism for antiplatelet effect of onion: AA release inhibition, thromboxane A(2)synthase inhibition and TXA(2)/PGH(2)receptor blockade. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10883058 |
Neuer A et al. | The effect of zearalenone and 17 beta-estradiol on prostacyclin and thromboxane production in cell cultures from human umbilical cord veins. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846091 |
Lasserre B et al. | Modifications in the TXA(2) and PGI(2) plasma levels and some other biochemical parameters during the initiation and development of non-insulin-dependent diabetes mellitus (NIDDM) syndrome in the rabbit. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10883059 |
Norman JF and Miller CW | Prostacyclin, thromboxane A2, and atherosclerosis in young hypercholesterolemic swine. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846098 |
Bereczki C et al. | The roles of platelet function, thromboxane, blood lipids and nitric oxide in hypertension of children and adolescents. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10883060 |
Rizk M and Abdel-Rahman MS | Salicylamide reverses the aspirin-antagonistic effect of salicylic acid on rat platelet cyclooxygenase. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846108 |
Brunkwall JS et al. | Papaverine effects on PGI2 and TXA2 release from the canine vascular wall. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1508951 |
Arnold JH et al. | Production of platelet thromboxane A2 and arterial prostacyclin I2 from hypercholesterolemic rats. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1508954 |
Sciulli MG et al. | Platelet activation in patients with colorectal cancer. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15626589 |
Gajdos M et al. | Effective long-term inhibition of thromboxane production but not of serotonin release in patients with coronary heart disease by 30 mg/d acetylsalicylic acid dosage. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758203 |
Sanigorski AJ et al. | n-3 fatty acids reduce in vitro thromboxane production while having little effect on in vitro prostacyclin production in the rat. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8066095 |
Srivastava KC and Malhotra N | Acetyl eugenol, a component of oil of cloves (Syzygium aromaticum L.) inhibits aggregation and alters arachidonic acid metabolism in human blood platelets. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2011614 |
Nagai H et al. | The effect of three novel thromboxane A2 receptor antagonists (S-1452, AA-2414 and ONO-3708) on the increase in pulmonary pressure caused by Forssman anaphylaxis in guinea-pigs. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1534171 |
Tsuruta LR et al. | Characterization of 11-dehydro-thromboxane B2 recombinant antibody obtained by phage display technology. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12628223 |
Rao GH et al. | Effect of Amrinone, a cardiotonic drug, on hemodynamics and platelet function. | 1981 | Prostaglandins Med | pmid:6784136 |
Gullner HG et al. | Correction of increased prostacyclin synthesis in Bartter's syndrome by indomethacin treatment. | 1980 | Prostaglandins Med | pmid:6994153 |
Rao GH et al. | Modification of human platelet response to sodium arachidonate by membrane modulation. | 1981 | Prostaglandins Med | pmid:6261286 |
Makheja AN et al. | Effects of onion (Allium cepa) extract on platelet aggregation and thromboxane synthesis. | 1979 | Prostaglandins Med | pmid:552092 |
Lefer AM et al. | Protective effects of a novel thromboxane analog in lethal traumatic shock. | 1979 | Prostaglandins Med | pmid:552102 |
Lewy RI et al. | Detection of thromboxane B2 in peripheral blood of patients with Prinzmetal's angina. | 1979 | Prostaglandins Med | pmid:575861 |
Ohuchi K et al. | Prostaglandins E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 levels in carrageenin-induced inflammatory exudates in the rat air-pouch granuloma. | 1979 | Prostaglandins Med | pmid:583576 |
Roy AC et al. | Effect of intravenous infusion of OKY-1581 (sodium-(E)-3-[4-(3-pyridylmethyl)phenyl] -2-methylacrylate) on circulatory thromboxane A2 and prostacyclin levels in anaesthetized baboon. | 1981 | Prostaglandins Med | pmid:7029585 |
Hwang DH | Aggregation and inhibition of rat platelets, and the formation of endoperoxide metabolites. | 1980 | Prostaglandins Med | pmid:7413850 |
Uyama O et al. | Plasma concentrations of thromboxane B2 in patients with hypertension or cerebrovascular disease. | 1981 | Prostaglandins Med | pmid:7302001 |
Matsumoto M et al. | Platelet aggregation induced by arachidonic acid and thromboxane generation in patients with hypertension or cerebrovascular disease. | 1981 | Prostaglandins Med | pmid:7323212 |
Gilani SH and Persaud TV | Embryopathic effects of thromboxane B2 in the chick. | 1981 | Prostaglandins Med | pmid:7267828 |
Ohuchi K et al. | Prostaglandin production by minced carrageenin granuloma tissue of rats and its inhibition by dexamethasone and cycloheximide. | 1980 | Prostaglandins Med | pmid:6893750 |
Oka M and Manku MS | Spironolactone decreases the formation of prostaglandins and related substances from arachidonic acid in rat vascular rings and human platelets. | 1980 | Prostaglandins Med | pmid:7394062 |
Karmali RA et al. | Intrarenal growth of the Walker 256 tumour and renal vein concentrations of PGE2, PGF 2 alpha, and TXB2: effects of diazepam. | 1980 | Prostaglandins Med | pmid:7394064 |
Ohnishi H et al. | Effects of trapidil on thromboxane A2-induced aggregation of platelets, ischemic changes in heart and biosynthesis of thromboxane A2. | 1981 | Prostaglandins Med | pmid:6894333 |
Rao GH et al. | Influence of epinephrine on the aggregation response of aspirin-treated platelets. | 1980 | Prostaglandins Med | pmid:7403340 |
Hamberg M et al. | A method for measurement of platelet regeneration in man. | 1978 | Prostaglandins Med | pmid:104315 |
Kinney EL and Demers LM | Plasma 6 keto PGE1 alpha concentration in Raynaud's phenomenon. | 1981 | Prostaglandins Med | pmid:6895673 |
Karmazyn M and Dhalla NS | Thromboxane B2: a cardiodepressant of isolated rat hearts and inhibitor of sarcolemma Na+ - K+ stimulated ATPase activity. | 1979 | Prostaglandins Med | pmid:233217 |
Ali M et al. | Inhibition of human platelet cyclooxygenase by alpha-tocopherol. | 1980 | Prostaglandins Med | pmid:6771778 |
Hausman N et al. | Antenatal administration of celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, appears to improve placental perfusion in the pregnant rabbit. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:12611495 |
Suzuki N et al. | Quantitative liquid chromatography-tandem mass spectrometric analysis of 11-dehydro TXB2 in urine. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165035 |
Leclerc P et al. | Characterization of a human and murine mPGES-1 inhibitor and comparison to mPGES-1 genetic deletion in mouse models of inflammation. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:24045148 |
Ozaki N et al. | Differential regulation of prostacyclin and thromboxane by dexamethasone and celecoxib during oxidative stress in newborn rabbits. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428679 |
Ochi T and Goto T | Anti-inflammatory activity of a novel selective cyclooxygenase-2 inhibitor, FR140423, on type II collagen-induced arthritis in Lewis rats. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11785783 |
Harada Y et al. | Differing profiles of prostaglandin formation inhibition between selective prostaglandin H synthase-2 inhibitors and conventional NSAIDs in inflammatory and non-inflammatory sites of the rat. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9653772 |
Mizugaki M et al. | Monitoring of the thromboxane A2/prostacyclin ratio in the urine of patients with retinal vascular occlusion through the low-dose-aspirin therapy using the gas chromatography/selected ion monitoring method. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10593167 |
Hishinuma T et al. | Urinary thromboxane A2/prostacyclin balance reflects the pathological state of a diabetic. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10593168 |
Hoch B and Bernhard M | Reduced prostacyclin to thromboxane A2 ratio is correlated with central apneas in preterm infants. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10593170 |
John H et al. | Development and review of radioimmunoassay of 12-S-hydroxyheptadecatrienoic acid. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9785378 |
Lynch CM et al. | The role of thromboxane A(2) in the pathogenesis of intrauterine growth restriction associated with maternal smoking in pregnancy. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21723954 |
Beck-Speier I et al. | Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518563 |
Hasan J et al. | Early postnatal ibuprofen and indomethacin effects in suckling and weanling rat kidneys. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18096423 |
Moussa O et al. | Urinary thromboxane B2 and thromboxane receptors in bladder cancer: opportunity for detection and monitoring. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21983220 |
Nishimaki S and Seki K | An imbalance between prostacyclin and thromboxane in relation to cerebral blood flow in neonates with maternal preeclampsia. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10482286 |
Brivio I et al. | The pulmonary pharmacology of [4-methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide] (2NTX-99), an anti-atherotrombotic compound with therapeutic potential in pathological conditions that target lung vasculature. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22342851 |
Cherdon C et al. | BM-573 inhibits the development of early atherosclerotic lesions in Apo E deficient mice by blocking TP receptors and thromboxane synthase. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21397034 |
Buluç M et al. | Effect of misoprostol and indomethacin on cyclooxygenase induction and eicosanoid production in carrageenan-induced air pouch inflammation in rats. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428691 |
Yao X et al. | Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: A targeted metabolomic approach. | Prostaglandins Other Lipid Mediat. | pmid:25841349 | |
Suzuki N et al. | Difference in urinary LTE4 and 11-dehydro-TXB2 excretion in asthmatic patients. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060902 |
Chen MF et al. | Vitamin E supplementation attenuates myointimal proliferation of the abdominal aorta after balloon injury in diet-induced hypercholesterolemic rabbits. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9777654 |
Daza L et al. | Captopril effect on prostaglandin E2, thromboxane B2 and proteinuria in lupus nephritis patients. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16303616 |
Dawood MY and Khan-Dawood FS | Differential suppression of menstrual fluid prostaglandin F2a, prostaglandin E2, 6-keto prostaglandin F1a and thromboxane B2 by suprofen in women with primary dysmenorrhea. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259081 |
Giedrojć J et al. | [Investigation of prostaglandins in supernatant of cultured monocytes]. | 2000 | Prz. Lek. | pmid:10907365 |
Zielonka TM et al. | [Concentration of thromboxane B2 in bronchoalveolar lavage fluid in selected interstitial pulmonary diseases]. | 1995 | Prz. Lek. | pmid:7568987 |
Giedrojć J et al. | [Interaction of platelets with monocytes with regard to arachidonic acid metabolites]. | 2000 | Prz. Lek. | pmid:11199865 |
Bruce EC et al. | Platelet thromboxane A2 secretion in patients with major depression responsive to electroconvulsive therapy. | 2008 | Psychosom Med | pmid:18378867 |
Shemesh E et al. | Symptoms of posttraumatic stress disorder in patients who have had a myocardial infarction. | 2006 May-Jun | Psychosomatics | pmid:16684940 |
Aritzi S et al. | Hostile personality characteristics and prostaglandins in essential hypertension. | 1989 | Psychother Psychosom | pmid:2486875 |
Berti F et al. | Protective activity of inhaled frusemide against immunological respiratory changes and mediator release in guinea-pigs. | 1992 | Pulm Pharmacol | pmid:1377065 |
Pelé JP et al. | Secretion of thromboxane B2 and prostaglandin E2 by guinea-pig lung cells isolated by centrifugal elutriation and by macrophages obtained by bronchoalveolar lavage. | 1989 | Pulm Pharmacol | pmid:2485200 |
Rossoni G et al. | Positive interaction of the novel beta2-agonist carmoterol and tiotropium bromide in the control of airway changes induced by different challenges in guinea-pigs. | 2007 | Pulm Pharmacol Ther | pmid:16533614 |
Lessa A et al. | The effect of pentoxifylline on the pulmonary response to high tidal volume ventilation in rats. | 2008 | Pulm Pharmacol Ther | pmid:17251044 |
Dreesen RG and Becker GJ | Effects of streptokinase in thrombolytic therapy: a radiology research project. | 1987 Jan-Feb | Radiol Technol | pmid:3823412 |
Ishibashi M et al. | Identification of 11-dehydro-2,3-dinorthromboxane B3 in human urine based on the mass spectral properties of 11-dehydrothromboxane B3 and related compounds. | 1995 | Rapid Commun. Mass Spectrom. | pmid:8829476 |