Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

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Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Abortion, Habitual D000026 5 associated lipids
Acidosis D000138 13 associated lipids
Adenocarcinoma D000230 166 associated lipids
Agranulocytosis D000380 7 associated lipids
Airway Obstruction D000402 13 associated lipids
Albuminuria D000419 18 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Anaphylaxis D000707 35 associated lipids
Anemia D000740 21 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Angina Pectoris D000787 27 associated lipids
Angina Pectoris, Variant D000788 3 associated lipids
Angina, Unstable D000789 14 associated lipids
Hypoxia D000860 23 associated lipids
Aortic Aneurysm D001014 8 associated lipids
Aortic Arch Syndromes D001015 2 associated lipids
Aortic Rupture D001019 3 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Arthritis, Juvenile D001171 8 associated lipids
Arthus Reaction D001183 8 associated lipids
Ascites D001201 25 associated lipids
Asthenia D001247 5 associated lipids
Asthma D001249 52 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Bartter Syndrome D001477 5 associated lipids
Behcet Syndrome D001528 7 associated lipids
Biliary Tract Neoplasms D001661 7 associated lipids
Birth Weight D001724 23 associated lipids
Blister D001768 16 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Bluetongue D001819 1 associated lipids
Body Weight D001835 333 associated lipids
Bronchial Spasm D001986 18 associated lipids
Bronchitis D001991 6 associated lipids
Bronchopneumonia D001996 7 associated lipids
Bronchopulmonary Dysplasia D001997 4 associated lipids
Bronchopulmonary Sequestration D001998 3 associated lipids
Burns D002056 34 associated lipids
Byssinosis D002095 11 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Cat Diseases D002371 12 associated lipids
Cattle Diseases D002418 24 associated lipids
Celiac Disease D002446 16 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Intracranial Embolism and Thrombosis D002542 5 associated lipids
Cerebral Hemorrhage D002543 13 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Chediak-Higashi Syndrome D002609 4 associated lipids
Chest Pain D002637 4 associated lipids
Choline Deficiency D002796 16 associated lipids
Cleft Palate D002972 9 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Contusions D003288 3 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
Coronary Thrombosis D003328 7 associated lipids
Coronary Vasospasm D003329 9 associated lipids
Cough D003371 19 associated lipids
Death, Sudden D003645 12 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Diseases in Twins D004200 4 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
Drowning D004332 2 associated lipids
Ductus Arteriosus, Patent D004374 5 associated lipids
Edema D004487 152 associated lipids
Edema, Cardiac D004489 1 associated lipids
Embolism, Fat D004620 4 associated lipids
Endometriosis D004715 29 associated lipids
Enteritis D004751 8 associated lipids
Erythromelalgia D004916 1 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Eye Burns D005126 13 associated lipids
Facial Pain D005157 5 associated lipids
Fatty Liver D005234 48 associated lipids
Femoral Fractures D005264 7 associated lipids
Fetal Diseases D005315 8 associated lipids
Fever D005334 35 associated lipids
Fibromuscular Dysplasia D005352 2 associated lipids
Fibrosis D005355 23 associated lipids
Fistula D005402 8 associated lipids
Foot Rot D005535 1 associated lipids
Frostbite D005627 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

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Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
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Parry MJ Effects of thromboxane synthetase inhibition on arachidonate metabolism and platelet behaviour. 1983 Br J Clin Pharmacol pmid:6401997
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FitzGerald GA et al. Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man. 1983 J. Clin. Invest. pmid:6355181
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Mehta J et al. Stimulation of vessel wall prostacyclin by selective thromboxane synthetase inhibitor OKY 1581. 1983 Prostaglandins Leukot Med pmid:6356153
Henriksen RA and Brotherton AF Evidence that activation of platelets and endothelium by thrombin involves distinct sites of interaction. Studies with the dysthrombin, Thrombin Quick I. 1983 J. Biol. Chem. pmid:6358210
Kaliman J et al. [Venous prostacycline synthesis and plasma thromboxane B2 after low-dose aspirin]. 1983 Wien. Klin. Wochenschr. pmid:6359724
Ylikorkala O et al. Prostacyclin and thromboxane in ovarian cancer: effect of cytostatics and prostaglandin synthesis inhibitors. 1983 Gynecol. Oncol. pmid:6360817
Krishnamurthi S et al. Paradoxical effects of indomethacin and trifluoperazine on Ca2+ ionophore A23187-induced human platelet aggregation, thromboxane B2 production, and dense granule release. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221559
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Hardisty RM et al. A new congenital defect of platelet secretion: impaired responsiveness of the platelets to cytoplasmic free calcium. 1983 Br. J. Haematol. pmid:6830700
Lecompte T et al. Interference of transmethylation inhibitors with thromboxane synthesis in rat platelets: evidence for the requirement of a methyl transfer reaction in platelet activation. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221560
Patrono C et al. Evidence for a renal origin of urinary thromboxane B2 in health and disease. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221569
Fletcher JR et al. Thromboxane inhibition in gram-negative sepsis fails to improve survival. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221586
Jørgensen KA et al. The survival of pig to rabbit renal xenografts during inhibition of thromboxane synthesis. 1983 Thromb. Res. pmid:6364449
Socini A et al. Fish oil administration lowers prostacyclin production and the antiaggregatory activity of aortic walls more effectively than platelet aggregation and thromboxane in the rat. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221591
Hornstra G et al. Dietary-fat-induced changes in the formation of prostanoids of the 2 and 3 series in relation to arterial thrombosis (rat) and atherosclerosis (rabbit). 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221593
Mandrovnaia NV et al. [Age-related changes in prostacyclin and thromboxane B2 biosynthesis under normal conditions and in arterial hypertension]. 1983 Kardiologiia pmid:6366325
Tremoli E et al. North Karelian study: changes in dietary fat reduce thromboxane B2 formation by platelets only in male subjects--preliminary report. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221594
Wynalda MA et al. Sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate (U-63557A), a new, selective thromboxane synthase inhibitor: intravenous and oral pharmacokinetics in dogs and correlations with ex situ thromboxane B2 production. 1983 Prostaglandins pmid:6685888
Basso N et al. Gastric mucosal prostaglandin generation in rats with stress ulcer. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221618
McDonald JW et al. Thromboxane synthesis by sources other than platelets in association with complement-induced pulmonary leukostasis and pulmonary hypertension in sheep. 1983 Circ. Res. pmid:6687354
Randall MJ and Wilding RI Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with dazoxiben hydrochloride (UK 37,248-01). 1983 Br J Clin Pharmacol pmid:6687429
Foegh M et al. Prostacyclin and thromboxane release from human peritoneal macrophages. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221630
Bruckner G et al. Dietary trilinoelaidate: effects on hematological parameters, serum eicosanoids and tissue fatty acid composition in rats. 1983 J. Nutr. pmid:6687476
Westwick J et al. Inhibition of thromboxane formation prevents endotoxin-induced renal fibrin deposition in jaundiced rats. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221642
Bessin P et al. Acute circulatory collapse caused by platelet-activating factor (PAF-acether) in dogs. 1983 Eur. J. Pharmacol. pmid:6687572
Ingerman-Wojenski CM et al. Early morphological changes in the endothelium of a peripheral artery of rabbits fed an atherogenic diet. 1983 Exp. Mol. Pathol. pmid:6687574
Schumacher WA and Lucchesi BR Effect of the thromboxane synthetase inhibitor UK-37,248 (dazoxiben) upon platelet aggregation, coronary artery thrombosis and vascular reactivity. 1983 J. Pharmacol. Exp. Ther. pmid:6418881
Sakamoto T [Studies on platelet function in toxemia of pregnancy]. 1983 Nippon Sanka Fujinka Gakkai Zasshi pmid:6223964
Hartung HP and Toyka KV Tuftsin stimulates the release of oxygen radicals and thromboxane from macrophages. 1983 Immunol. Lett. pmid:6687720
Winchester JF et al. Early indicators of renal allograft rejection. 1983 Kidney Int. Suppl. pmid:6224041
D'Angelo A et al. Effect of des-amino-D-arginine vasopressin (DDAVP) on plasma levels of platelet and endothelial cell release products. 1983 Thromb. Haemost. pmid:6687766
Westwick J et al. Platelet activation during steady state sickle cell disease. 1983 J Med pmid:6224876
Ku EC et al. Characterization of imidazo[1,5-a]pyridine-5-hexanoic acid (CGS 13080) as a selective thromboxane synthetase inhibitor using in vitro and in vivo biochemical models. 1983 Biochem. Biophys. Res. Commun. pmid:6687803
Anderegg K et al. Effects of a pyridine derivative thromboxane synthetase inhibitor and its inactive isomer in endotoxic shock in the rat. 1983 Br. J. Pharmacol. pmid:6687819
Todd MH et al. The involvement of prostaglandins and thromboxanes in the response to pulmonary embolism in anaesthetized rabbits and isolated perfused lungs. 1983 Thromb. Res. pmid:6687961
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Tsukatani E Etiology of EPH-gestosis from the viewpoint of dynamics of vasoactive prostanoid, lipid peroxides and vitamin E. 1983 Nippon Sanka Fujinka Gakkai Zasshi pmid:6688085
Fischer S et al. In vivo and in vitro effects of nafazatrom (Bay g 6575), an antithrombotic compound, on arachidonic acid metabolism in platelets and vascular tissue. 1983 Biochem. Pharmacol. pmid:6688182
Bailey IA et al. Effects of vascular trauma and transient myocardial ischaemia on coronary venous prostaglandin levels in the dog. 1983 Cardiovasc. Res. pmid:6688202
Mathieson MA et al. Ischemia of the limb stimulates thromboxane production and myocardial depression. 1983 Surg Gynecol Obstet pmid:6648769
Barrett PA and Butler KD Shortening of platelet survival by induced hypercholesterolaemia in rabbits and its prolongation by anagrelide. 1983 Thromb. Haemost. pmid:6648889
Robinson C and Hoult JR Thromboxane A2 analogues inhibit the metabolism of thromboxane B2 in perfused guinea-pig lung. 1983 Biochim. Biophys. Acta pmid:6652102
Higgs GA et al. The source of thromboxane and prostaglandins in experimental inflammation. 1983 Br. J. Pharmacol. pmid:6652359
Anton RF et al. In vivo regional levels of PGE and thromboxane in mouse brain: effect of decapitation, focused microwave fixation, and indomethacin. 1983 Prostaglandins pmid:6658001
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Cohen RA et al. 5-Hydroxytryptamine can mediate endothelium-dependent relaxation of coronary arteries. 1983 Am. J. Physiol. pmid:6660308
Cortellaro M et al. Transcoronary platelet thromboxane A2 formation without platelet trapping in patients with coronary stenosis-effect of sulphinpyrazone treatment. 1983 Thromb. Haemost. pmid:6665767
De Caterina R et al. Antiplatelet effects of isosorbide dinitrate in man. 1983 Z Kardiol pmid:6666233
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Moonen P et al. An improved method for separation of thromboxane B2 by reversed phase liquid chromatography. 1983 Prostaglandins pmid:6669711
Socini A et al. Fish oil administration as a supplement to a corn oil containing diet affects arterial prostacyclin production more than platelet thromboxane formation in the rat. 1983 Prostaglandins pmid:6310702
Gethmann U et al. Effect of catecholestrogens on prostaglandin release by rat pituitaries superfused in vitro. 1983 Arch. Gynecol. pmid:6320749
Lieb J et al. Elevated levels of prostaglandin E2 and thromboxane B2 in depression. 1983 Prostaglandins Leukot Med pmid:6574523
Coceani F et al. Prostaglandin E2 and thromboxane B2 in cerebrospinal fluid of afebrile and febrile cat. 1983 Am. J. Physiol. pmid:6574712
Viinikka L et al. Effect of prolonged treatment with acetylsalicylic acid and dipyridamole on platelet thromboxane A2 production in atherosclerotic subjects. 1983 Prostaglandins Leukot Med pmid:6576385
Fukumoto S and Tanaka K Protective effects of thromboxane A2 synthetase inhibitors on endotoxin shock. 1983 Prostaglandins Leukot Med pmid:6576388
Kinney EL et al. Mechanism of action of amrinone: role of thromboxane synthetase inhibition. 1983 Prostaglandins Leukot Med pmid:6576389
Hawkey CJ et al. Imbalance of prostacyclin and thromboxane synthesis in Crohn's disease. 1983 Gut pmid:6578172
Zijlstra FJ et al. Separation of the two components of the contractile activity of leukotriene C4 on the guinea pig lung parenchymal strip. 1983 Prostaglandins Leukot Med pmid:6578519
Roy L et al. Increased plasma concentrations of prostacyclin metabolite 6-keto-PGF1 alpha in essential hypertension. Influence of therapy with labetalol. 1983 Am. J. Cardiol. pmid:6823861
Reuben SR et al. Effects of dazoxiben on exercise performance in chronic stable angina. 1983 Br J Clin Pharmacol pmid:6402000
Mahoney DP et al. Radioimmunoassay of prostaglandins and thromboxane B2 in extracted and unextracted urine and serum using an iodinated ligand. 1983 Prostaglandins Leukot Med pmid:6579570
Güllner HG et al. Renal thromboxane excretion in Brattleboro rats with hereditary hypothalamic diabetes insipidus. Effect of vasopressin treatment. 1983 Prostaglandins Leukot Med pmid:6580653
Rojas J et al. Effects of cyclooxygenase inhibition on the response to group B streptococcal toxin in sheep. 1983 Pediatr. Res. pmid:6402752
Sakanishi N et al. Thromboxane A2 and hemodynamic-biochemical parameters in canine endotoxin shock. 1983 Bull. Tokyo Med. Dent. Univ. pmid:6580966
Förster W and Pönicke K Influence of sympathomimetic drugs (1-phenyl-2-amino-ethan-1-ol derivatives) on the biosynthesis of prostaglandins and thromboxane B2. 1983 Br. J. Pharmacol. pmid:6403094
Orlandi M et al. Normal plasma thromboxane B2 (TXB2) and 6-keto-PGF1 alpha levels in childhood diabetes. 1983 Prostaglandins Leukot Med pmid:6583712
Männistö J and Uotila P Cigarette smoke ventilation decreases thromboxane B2 metabolism in isolated rat lungs. 1983 Prostaglandins Leukot Med pmid:6583713
Sharon P et al. Prostanoid synthesis by cultured gastric and duodenal mucosa: Possible role in the pathogenesis of duodenal ulcer. 1983 Scand. J. Gastroenterol. pmid:6584967
Asbóth G et al. Conversion of arachidonic acid to prostanoids in the avian uterus. 1983 Biochim. Biophys. Acta pmid:6402032