Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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There are no associated biomedical information in the current reference collection.
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Lumley P et al. | Maximal blockade of TxA2 without compromised PGI2 formation; a superior profile of the TxA2 receptor blocking drug GR32191 over aspirin. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825385 |
Patrono C et al. | Thromboxane-dependent platelet activation as a transducer of enhanced risk of coronary and cerebral thrombosis. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825389 |
Zhao Y et al. | Thromboxane and leukotriene generation by mononuclearcytes from cardiac transplant patients. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825392 |
Vial JH et al. | Rebound elevation in urinary thromboxane B2 and 6-keto-PGF1 alpha excretion after aspirin withdrawal. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825534 |
Ritter JM et al. | On the mechanism of the prolonged action in man of GR32191, a thromboxane receptor antagonist. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825568 |
Houtz P and Tai HH | Enzyme immunoassay of thromboxane B2 using immobilized hapten and enzyme amplification. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526560 |
Hayashi Y et al. | Radioimmunoassay of 11-dehydro-thromboxane B2 using monoclonal antibody. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526561 |
Knospe J et al. | Derivatization of prostaglandins to corresponding anilides and analysis by HPLC. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526562 |
De Caterina R et al. | Characteristics of thromboxane production by the isolated-perfused rat heart. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959082 |
Samhoun MN et al. | Differential effect of vasoactive intestinal peptide on contractions induced by leukotriene D4, histamine, and acetylcholine in guinea pig lung parenchyma in vitro. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960144 |
Granström E and Kumlin M | Assay of thromboxane production in biological systems: reliability of TXB2 versus 11-dehydro-TXB2 as targets for measurement. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960161 |
Lecompte T et al. | Radioimmunoassay for 11-dehydro-thromboxane B2 using an iodinated ligand: preliminary applications to human fluids. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960162 |
Catella F et al. | Analysis of multiple thromboxane metabolites in plasma and urine. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960166 |
Alessandrini P et al. | Eicosanoid biosynthesis in human diabetes mellitus. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960175 |
Nihei C et al. | Clinical study on effect of thromboxane A2 synthetase inhibitor (OKY-046) to clarify the regulation of cerebral blood flow in cerebral thrombosis. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960210 |
Miyazaki H et al. | Microdetermination of prostaglandins and thromboxane B2 by gas chromatography/high-resolution selected-ion monitoring. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936139 |
Kobayashi N et al. | Effect of changes in prostaglandin synthesis by platelets and vessel wall on the formation of arterial thrombosis in rabbits. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936159 |
Nishikawa K et al. | (E)-7-Phenyl-7-(3-pyridyl)-6-heptenoic acid (CV-4151): a potent, specific thromboxane A2 synthetase inhibitor. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936160 |
Takagi S and Den K | Prostacyclin and thromboxane A2 in preeclamptic umbilical circulation. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936183 |
Granström E et al. | Monitoring thromboxane production in vivo: metabolic and analytical aspects. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936194 |