Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Nath KA et al. | Regulatory role of prostanoids in glomerular microcirculation of remnant nephrons. | 1987 | Am. J. Physiol. | pmid:3578532 |
Zipser RD and Martin K | Urinary excretion of arterial blood prostaglandins and thromboxanes in man. | 1982 | Am. J. Physiol. | pmid:6950668 |
Kruse-Elliott KT and Olson NC | CGS 8515 and indomethacin attenuate cytokine-induced cardiopulmonary dysfunction in pigs. | 1993 | Am. J. Physiol. | pmid:8386479 |
Schlondorff D and Satriano JA | Interactions of vasopressin, cAMP, and prostaglandins in toad urinary bladder. | 1985 | Am. J. Physiol. | pmid:2579584 |
Schrör K et al. | Preservation of ischemic myocardium by pinane thromboxane A2. | 1980 | Am. J. Physiol. | pmid:7356037 |
Lampugnani MG and de Gaetano G | Effects of metabolized and unmetabolized arachidonate on rat platelet shape change. | 1984 | Am. J. Physiol. | pmid:6433724 |
Murray MJ et al. | Select dietary fatty acids attenuate cardiopulmonary dysfunction during acute lung injury in pigs. | 1995 | Am. J. Physiol. | pmid:8594921 |
Wilkes BM et al. | Characterization of glomerular thromboxane receptor sites in the rat. | 1989 | Am. J. Physiol. | pmid:2525345 |
Kalichman MW et al. | Effects of cocaine on blood flow and prostaglandin metabolites in rat sciatic nerve. | 1994 | Am. J. Physiol. | pmid:8024013 |
Reyes AA and Klahr S | Bladder contributes to eicosanoids excreted in urine. | 1990 | Am. J. Physiol. | pmid:2240235 |
Wilkes BM et al. | Endothelin receptors in human placenta: relationship to vascular resistance and thromboxane release. | 1990 | Am. J. Physiol. | pmid:2159236 |
Beck N and Shaw JO | Thromboxane B2 and prostaglandin E2 in the K+-depleted rat kidney. | 1981 | Am. J. Physiol. | pmid:7468800 |
Reinke M | Monitoring thromboxane in body fluids: a specific ELISA for 11-dehydrothromboxane B2 using a monoclonal antibody. | 1992 | Am. J. Physiol. | pmid:1590375 |
Sirko S et al. | Prostaglandin formation in the hypothalamus in vivo: effect of pyrogens. | 1989 | Am. J. Physiol. | pmid:2784289 |
Yokoyama Y et al. | Role of thromboxane in producing portal hypertension following trauma-hemorrhage. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14613921 |
Yokoyama Y et al. | Role of thromboxane A2 in early BDL-induced portal hypertension. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12431905 |
Yang YY et al. | Roles of anandamide in the hepatic microcirculation in cirrhotic rats. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16407591 |
Tanigawa T et al. | Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12958020 |
Kleinbongard P et al. | Aspirate from human stented native coronary arteries vs. saphenous vein grafts: more endothelin but less particulate debris. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23934849 |
Chen L et al. | Cyclooxygenase inhibitor blocks rebound response after NO inhalation in an endotoxin model. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12485821 |
Lombard JH et al. | High-salt diet impairs vascular relaxation mechanisms in rat middle cerebral arteries. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12456391 |
Ansari HR et al. | Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17921329 |
Saito Y et al. | Disruption of group IVA cytosolic phospholipase A(2) attenuates myocardial ischemia-reperfusion injury partly through inhibition of TNF-α-mediated pathway. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22427514 |
Gendron ME and Thorin E | A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17644574 |
Stephenson AH et al. | Differential effects of 5,6-EET on segmental pulmonary vasoactivity in the rabbit. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12609822 |
Momen A et al. | Local prostaglandin blockade attenuates muscle mechanoreflex-mediated renal vasoconstriction during muscle stretch in humans. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18326807 |
Cui J et al. | Cyclooxygenase inhibition attenuates sympathetic responses to muscle stretch in humans. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18441194 |
Muscará MN et al. | Antihypertensive properties of a nitric oxide-releasing naproxen derivative in two-kidney, one-clip rats. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10924050 |
Drew RC et al. | Healthy older humans exhibit augmented carotid-cardiac baroreflex sensitivity with aspirin during muscle mechanoreflex and metaboreflex activation. | 2015 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26371168 |
Jones AE et al. | Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12639842 |
Fike CD et al. | Arachidonic acid metabolites and an early stage of pulmonary hypertension in chronically hypoxic newborn pigs. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12388340 |
Shinohara M et al. | Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. | 2014 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25217660 |
Nagase T et al. | A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12505870 |
Suliman HB et al. | Prevention of influenza-induced lung injury in mice overexpressing extracellular superoxide dismutase. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11133496 |
Nørregaard R et al. | Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20147610 |
Venuto R et al. | Enhanced vascular effects of the Ca(2+) channel agonist Bay K 8644 in pregnant rabbits. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11893597 |
Yan Q et al. | Female ROMK null mice manifest more severe Bartter II phenotype on renal function and higher PGE2 production. | 2008 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:18579648 |
Seta F et al. | Renal and cardiovascular characterization of COX-2 knockdown mice. | 2009 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:19357295 |
Hou X et al. | Increased platelet-activating factor-induced periventricular brain microvascular constriction associated with immaturity. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12626359 |
Salazar F et al. | Renal effects induced by prolonged mPGES1 inhibition. | 2014 | Am. J. Physiol. Renal Physiol. | pmid:24197070 |
Llinás MT et al. | Role of COX-2-derived metabolites in regulation of the renal hemodynamic response to norepinephrine. | 2001 | Am. J. Physiol. Renal Physiol. | pmid:11592955 |
Osmond DA et al. | Clopidogrel preserves whole kidney autoregulatory behavior in ANG II-induced hypertension. | 2014 | Am. J. Physiol. Renal Physiol. | pmid:24477682 |
Francois H et al. | A role for the thromboxane receptor in L-NAME hypertension. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:18684890 |
Bautista-Pérez R et al. | Involvement of neutral sphingomyelinase in the angiotensin II signaling pathway. | 2015 | Am. J. Physiol. Renal Physiol. | pmid:25354938 |
Kawada N et al. | TP receptors regulate renal hemodynamics during angiotensin II slow pressor response. | 2004 | Am. J. Physiol. Renal Physiol. | pmid:15213069 |
Edwin SS et al. | Cyclosporin A attenuates increased prostaglandin and thromboxane production in response to various stimuli in human decidua. | 1993 Sep-Oct | Am. J. Reprod. Immunol. | pmid:8311924 |
Yoss EB et al. | Arachidonic acid metabolism in normal human alveolar macrophages: stimulus specificity for mediator release and phospholipid metabolism, and pharmacologic modulation in vitro and in vivo. | 1990 | Am. J. Respir. Cell Mol. Biol. | pmid:2155013 |
Sporn PH et al. | Complex effects of in vitro hyperoxia on alveolar macrophage arachidonic acid metabolism. | 1990 | Am. J. Respir. Cell Mol. Biol. | pmid:2155014 |
Dent G et al. | Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9448055 |
Panos RJ et al. | Alterations in eicosanoid production by rat alveolar type II cells isolated after silica-induced lung injury. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1312852 |