Thromboxane b2
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
Cross Reference
Introduction
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thromboxane b2?
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
PubChem Associated disorders and diseases
What pathways are associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thromboxane b2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Thromboxane b2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Thromboxane b2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thromboxane b2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schuette AH et al. | Effect of lung thromboxane generation on regional blood flow during sheep bypass. | 1982 | Am. J. Physiol. | pmid:7065206 |
| Nishijima MK et al. | Effect of naloxone and ibuprofen on organ blood flow during endotoxic shock in pig. | 1988 | Am. J. Physiol. | pmid:3394818 |
| Katusić ZS et al. | Endothelium-dependent contractions to oxygen-derived free radicals in the canine basilar artery. | 1993 | Am. J. Physiol. | pmid:8456988 |
| Olson NC et al. | Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs. | 1993 | Am. J. Physiol. | pmid:8460710 |
| Chang SW and Ohara N | Increased pulmonary vascular permeability in rats with biliary cirrhosis: role of thromboxane A2. | 1993 | Am. J. Physiol. | pmid:8460713 |
| Stenmark KR et al. | Alveolar inflammation and arachidonate metabolism in monocrotaline-induced pulmonary hypertension. | 1985 | Am. J. Physiol. | pmid:3923843 |
| Benigni A et al. | Renal metabolism and urinary excretion of thromboxane B2 in the rat. | 1989 | Am. J. Physiol. | pmid:2750927 |
| Townsley MI et al. | Pulmonary embolism: analysis of endothelial pore sizes in canine lung. | 1988 | Am. J. Physiol. | pmid:3189571 |
| Himmelstein SI and Klotman PE | The role of thromboxane in two-kidney, one-clip Goldblatt hypertension in rats. | 1989 | Am. J. Physiol. | pmid:2527469 |
| Reinke M | Monitoring thromboxane in body fluids: a specific ELISA for 11-dehydrothromboxane B2 using a monoclonal antibody. | 1992 | Am. J. Physiol. | pmid:1590375 |
| Coceani F et al. | Prostaglandin E2 and thromboxane B2 in cerebrospinal fluid of afebrile and febrile cat. | 1983 | Am. J. Physiol. | pmid:6574712 |
| Stahl RA et al. | High protein intake stimulates glomerular prostaglandin formation in remnant kidneys. | 1987 | Am. J. Physiol. | pmid:3473940 |
| Lorenz RR and Vanhoutte PM | Prejunctional adrenergic inhibition by aggregating platelets in canine blood vessels. | 1985 | Am. J. Physiol. | pmid:4037113 |
| Raj JU and Chen P | Role of eicosanoids in hypoxic vasoconstriction in isolated lamb lungs. | 1987 | Am. J. Physiol. | pmid:2820247 |
| Yokoyama Y et al. | Role of thromboxane in producing portal hypertension following trauma-hemorrhage. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14613921 |
| Yokoyama Y et al. | Role of thromboxane A2 in early BDL-induced portal hypertension. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12431905 |
| Yang YY et al. | Roles of anandamide in the hepatic microcirculation in cirrhotic rats. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16407591 |
| Tanigawa T et al. | Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12958020 |
| Kleinbongard P et al. | Aspirate from human stented native coronary arteries vs. saphenous vein grafts: more endothelin but less particulate debris. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23934849 |
| Chen L et al. | Cyclooxygenase inhibitor blocks rebound response after NO inhalation in an endotoxin model. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12485821 |
| Lombard JH et al. | High-salt diet impairs vascular relaxation mechanisms in rat middle cerebral arteries. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12456391 |
| Ansari HR et al. | Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17921329 |
| Saito Y et al. | Disruption of group IVA cytosolic phospholipase A(2) attenuates myocardial ischemia-reperfusion injury partly through inhibition of TNF-α-mediated pathway. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22427514 |
| Gendron ME and Thorin E | A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17644574 |
| Stephenson AH et al. | Differential effects of 5,6-EET on segmental pulmonary vasoactivity in the rabbit. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12609822 |
| Momen A et al. | Local prostaglandin blockade attenuates muscle mechanoreflex-mediated renal vasoconstriction during muscle stretch in humans. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18326807 |
| Cui J et al. | Cyclooxygenase inhibition attenuates sympathetic responses to muscle stretch in humans. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18441194 |
| Muscará MN et al. | Antihypertensive properties of a nitric oxide-releasing naproxen derivative in two-kidney, one-clip rats. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10924050 |
| Drew RC et al. | Healthy older humans exhibit augmented carotid-cardiac baroreflex sensitivity with aspirin during muscle mechanoreflex and metaboreflex activation. | 2015 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26371168 |
| Jones AE et al. | Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12639842 |
| Fike CD et al. | Arachidonic acid metabolites and an early stage of pulmonary hypertension in chronically hypoxic newborn pigs. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12388340 |
| Shinohara M et al. | Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. | 2014 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25217660 |
| Nagase T et al. | A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12505870 |
| Suliman HB et al. | Prevention of influenza-induced lung injury in mice overexpressing extracellular superoxide dismutase. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11133496 |
| Nørregaard R et al. | Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20147610 |
| Venuto R et al. | Enhanced vascular effects of the Ca(2+) channel agonist Bay K 8644 in pregnant rabbits. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11893597 |
| Yan Q et al. | Female ROMK null mice manifest more severe Bartter II phenotype on renal function and higher PGE2 production. | 2008 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:18579648 |
| Seta F et al. | Renal and cardiovascular characterization of COX-2 knockdown mice. | 2009 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:19357295 |
| Hou X et al. | Increased platelet-activating factor-induced periventricular brain microvascular constriction associated with immaturity. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12626359 |
| Salazar F et al. | Renal effects induced by prolonged mPGES1 inhibition. | 2014 | Am. J. Physiol. Renal Physiol. | pmid:24197070 |
| Llinás MT et al. | Role of COX-2-derived metabolites in regulation of the renal hemodynamic response to norepinephrine. | 2001 | Am. J. Physiol. Renal Physiol. | pmid:11592955 |
| Osmond DA et al. | Clopidogrel preserves whole kidney autoregulatory behavior in ANG II-induced hypertension. | 2014 | Am. J. Physiol. Renal Physiol. | pmid:24477682 |
| Francois H et al. | A role for the thromboxane receptor in L-NAME hypertension. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:18684890 |
| Bautista-Pérez R et al. | Involvement of neutral sphingomyelinase in the angiotensin II signaling pathway. | 2015 | Am. J. Physiol. Renal Physiol. | pmid:25354938 |
| Kawada N et al. | TP receptors regulate renal hemodynamics during angiotensin II slow pressor response. | 2004 | Am. J. Physiol. Renal Physiol. | pmid:15213069 |
| Edwin SS et al. | Cyclosporin A attenuates increased prostaglandin and thromboxane production in response to various stimuli in human decidua. | 1993 Sep-Oct | Am. J. Reprod. Immunol. | pmid:8311924 |
| Yoss EB et al. | Arachidonic acid metabolism in normal human alveolar macrophages: stimulus specificity for mediator release and phospholipid metabolism, and pharmacologic modulation in vitro and in vivo. | 1990 | Am. J. Respir. Cell Mol. Biol. | pmid:2155013 |
| Badesch DB et al. | Decreased arterial wall prostaglandin production in neonatal calves with severe chronic pulmonary hypertension. | 1989 | Am. J. Respir. Cell Mol. Biol. | pmid:2517777 |
| Sporn PH et al. | Complex effects of in vitro hyperoxia on alveolar macrophage arachidonic acid metabolism. | 1990 | Am. J. Respir. Cell Mol. Biol. | pmid:2155014 |
| Shellito J and Sniezek M | Altered release of eicosanoids by rat alveolar macrophages during granulomatous pulmonary inflammation. | 1990 | Am. J. Respir. Cell Mol. Biol. | pmid:2155633 |
| Sayers BC et al. | Role of cyclooxygenase-2 in exacerbation of allergen-induced airway remodeling by multiwalled carbon nanotubes. | 2013 | Am. J. Respir. Cell Mol. Biol. | pmid:23642096 |
| Dent G et al. | Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9448055 |
| Panos RJ et al. | Alterations in eicosanoid production by rat alveolar type II cells isolated after silica-induced lung injury. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1312852 |
| Ciabattoni G et al. | In vivo lipid peroxidation and platelet activation in cystic fibrosis. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:11029317 |
| Mitra A et al. | Thromboxane-mediated alveolar responses to acute obstruction of the pulmonary vasculature. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9117035 |
| Vass G et al. | Comparison of nasal and oral inhalation during exhaled breath condensate collection. | 2003 | Am. J. Respir. Crit. Care Med. | pmid:12493648 |
| Okazawa A et al. | 8-Epi-PGF2alpha induces airflow obstruction and airway plasma exudation in vivo. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9032175 |
| Pavord ID et al. | Induced sputum eicosanoid concentrations in asthma. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10588604 |
| Kataoka M et al. | A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:16192456 |
| Snapper JR et al. | Role of endothelin in endotoxin-induced sustained pulmonary hypertension in sheep. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9445282 |
| Chen CR et al. | Platelet-activating factor potentiates protamine-induced lung edema. Role of eicosanoids. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8111595 |
| Jankov RP et al. | Thromboxane A(2) receptors mediate pulmonary hypertension in 60% oxygen-exposed newborn rats by a cyclooxygenase-independent mechanism. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:12119234 |
| Gust R et al. | Role of cyclooxygenase-2 in oleic acid-induced acute lung injury. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10508803 |
| Mayer K et al. | Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids. | 2009 | Am. J. Respir. Crit. Care Med. | pmid:19136374 |
| Gust R et al. | Synergistic hemodynamic effects of low-dose endotoxin and acute lung injury. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9620928 |
| O'Connor BJ et al. | Inhibitory effect of UK,74505, a potent and specific oral platelet activating factor (PAF) receptor antagonist, on airway and systemic responses to inhaled PAF in humans. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8025768 |
| Davì G et al. | Enhanced thromboxane biosynthesis in patients with chronic obstructive pulmonary disease. The Chronic Obstructive Bronchitis and Haemostasis Study Group. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9412557 |
| Jiang XW et al. | Effects of low-dose Beraprost sodium, a stable prostaglandin I2 analogue, on reperfusion injury to rabbit lungs. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9817723 |
| Praticò D et al. | Chronic obstructive pulmonary disease is associated with an increase in urinary levels of isoprostane F2alpha-III, an index of oxidant stress. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9847257 |
| Gust R et al. | Response to inhaled nitric oxide in acute lung injury depends on distribution of pulmonary blood flow prior to its administration. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:9927374 |
| Imai Y et al. | Inflammatory chemical mediators during conventional ventilation and during high frequency oscillatory ventilation. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:7952613 |
| Degges RD et al. | Pulmonary hypertensive effect of heparin and protamine interaction: evidence for thromboxane B2 release from the lung. | 1987 | Am. J. Surg. | pmid:3425821 |
| Myers SI and Hernandez R | Leukotriene C4 regulation of splanchnic blood flow during ischemia. | 1994 | Am. J. Surg. | pmid:8209929 |
| O'Neill PA et al. | Role of renal sympathetic nerve activity in renal failure associated with obstructive jaundice in the rat. | 1991 | Am. J. Surg. | pmid:1862825 |
| Tanowitz HB et al. | Enhanced platelet adherence and aggregation in Chagas' disease: a potential pathogenic mechanism for cardiomyopathy. | 1990 | Am. J. Trop. Med. Hyg. | pmid:2121055 |
| Bottoms GD et al. | Thromboxane, prostaglandin I2 (epoprostenol), and the hemodynamic changes in equine endotoxin shock. | 1982 | Am. J. Vet. Res. | pmid:7049018 |
| Brideau C et al. | In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats. | 2001 | Am. J. Vet. Res. | pmid:11703020 |
| Giraudel JM et al. | Development of in vitro assays for the evaluation of cyclooxygenase inhibitors and predicting selectivity of nonsteroidal anti-inflammatory drugs in cats. | 2005 | Am. J. Vet. Res. | pmid:15900953 |
| Emau P et al. | Function of prostaglandins, thromboxane A2, and histamine in hypersensitivity reaction to experimental bluetongue disease in calves. | 1984 | Am. J. Vet. Res. | pmid:6093650 |
| Grauer GF et al. | Effects of dietary n-3 fatty acid supplementation versus thromboxane synthetase inhibition on gentamicin-induced nephrotoxicosis in healthy male dogs. | 1996 | Am. J. Vet. Res. | pmid:8725828 |
| Baltzer WI et al. | Measurement of urinary 11-dehydro-thromboxane B2 excretion in dogs with gastric dilatation-volvulus. | 2006 | Am. J. Vet. Res. | pmid:16426215 |
| Morris DD et al. | Proadifen-induced production of prostacyclin by equine peritoneal macrophages. | 1989 | Am. J. Vet. Res. | pmid:2499232 |
| Morris DD et al. | Endotoxin-induced changes in plasma concentrations of thromboxane and prostacyclin in neonatal calves given antiserum to a mutant Escherichia coli (J-5). | 1986 | Am. J. Vet. Res. | pmid:3541703 |
| Hoh CM et al. | Evaluation of effects of low-dose aspirin administration on urinary thromboxane metabolites in healthy dogs. | 2011 | Am. J. Vet. Res. | pmid:21801060 |
| Semrad SD et al. | Hypertension in bulls and steers anesthetized with guaifenesin-thiobarbiturate-halothane combination. | 1986 | Am. J. Vet. Res. | pmid:3740628 |
| Streppa HK et al. | Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs in canine blood. | 2002 | Am. J. Vet. Res. | pmid:16206787 |
| Longhofer SL et al. | Effects of a specific thromboxane synthetase inhibitor on thromboxane generation and excretion in healthy dogs. | 1990 | Am. J. Vet. Res. | pmid:2240799 |
| Pratt HL et al. | Platelet aggregation, storage pool deficiency, and protein phosphorylation in mice with Chediak-Higashi syndrome. | 1991 | Am. J. Vet. Res. | pmid:1652907 |
| Ward DS et al. | Equine endotoxemia: cardiovascular, eicosanoid, hematologic, blood chemical, and plasma enzyme alterations. | 1987 | Am. J. Vet. Res. | pmid:3307560 |
| Davidson MG et al. | Vascular permeability and coagulation during Rickettsia rickettsii infection in dogs. | 1990 | Am. J. Vet. Res. | pmid:2105679 |
| Gershwin LJ and Giri SN | Effects of allergen challenge on plasma concentrations of prostaglandins, thromboxane B2, and histamine in calves infected with bovine respiratory syncytial virus. | 1992 | Am. J. Vet. Res. | pmid:1416375 |
| Semrad SD et al. | Effects of concurrent administration of phenylbutazone and flunixin meglumine on pharmacokinetic variables and in vitro generation of thromboxane B2 in mares. | 1993 | Am. J. Vet. Res. | pmid:8291770 |
| Wooten JG et al. | Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs. | 2008 | Am. J. Vet. Res. | pmid:18380576 |
| Swaim SF et al. | Evaluation of the dermal effects of cast padding in coaptation casts on dogs. | 1992 | Am. J. Vet. Res. | pmid:1497201 |
| Cargile JL et al. | Effects of tumor necrosis factor blockade on interleukin 6, lactate, thromboxane, and prostacyclin responses in miniature horses given endotoxin. | 1995 | Am. J. Vet. Res. | pmid:8585654 |
| Jones CJ et al. | In vivo effects of meloxicam and aspirin on blood, gastric mucosal, and synovial fluid prostanoid synthesis in dogs. | 2002 | Am. J. Vet. Res. | pmid:12428662 |
| Semrad SD et al. | Flunixin meglumine given in small doses: pharmacokinetics and prostaglandin inhibition in healthy horses. | 1985 | Am. J. Vet. Res. | pmid:4083579 |
| Templeton CB et al. | Hemodynamics, plasma eicosanoid concentrations, and plasma biochemical changes in calves given multiple injections of Escherichia coli endotoxin. | 1988 | Am. J. Vet. Res. | pmid:3281526 |
| Cook VL et al. | Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum. | 2009 | Am. J. Vet. Res. | pmid:19645580 |
| Arifah AK et al. | Pharmacodynamics and pharmacokinetics of ketoprofen enantiomers in sheep. | 2001 | Am. J. Vet. Res. | pmid:11197566 |