Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ersöz G et al. | Effect of submaximal and incremental upper extremity exercise on platelet function and the role of blood shear stress. | 2002 | Thromb. Res. | pmid:12676189 |
Buchanan MR et al. | Aspirin inhibits platelet function independent of the acetylation of cyclo-oxygenase. | 1982 | Thromb. Res. | pmid:7071811 |
Umemura K et al. | Effect of dietary docosahexaenoic acid in the rat middle cerebral artery thrombosis model. | 1995 | Thromb. Res. | pmid:7660354 |
Küster LJ et al. | Mechanism of PAF-induced platelet aggregation in man. | 1986 | Thromb. Res. | pmid:3764802 |
Ali M et al. | Synthesis of prostaglandin D2 and thromboxane B2 by human platelets. | 1977 | Thromb. Res. | pmid:918907 |
Marasini B et al. | Cigarette smoking and platelet function. | 1986 | Thromb. Res. | pmid:3787563 |
Matsuo T et al. | A new thrombin inhibitor MD805 and thrombocytopenia encountered with heparin hemodialysis. | 1986 | Thromb. Res. | pmid:3787568 |
Neiman J et al. | Composition of platelet phosphatidylinositol and phosphatidylcholine after ethanol withdrawal. | 1987 | Thromb. Res. | pmid:3603426 |
Jørgensen KA et al. | The survival of pig to rabbit renal xenografts during inhibition of thromboxane synthesis. | 1983 | Thromb. Res. | pmid:6364449 |
Naran NH and Chetty N | The in vitro effect of ridogrel on platelet function in normocholesterolaemic and familial hypercholesterolaemic type IIa subjects. | 1997 | Thromb. Res. | pmid:9556227 |
Todd MH et al. | The involvement of prostaglandins and thromboxanes in the response to pulmonary embolism in anaesthetized rabbits and isolated perfused lungs. | 1983 | Thromb. Res. | pmid:6687961 |
Togna GI et al. | Cisplatin triggers platelet activation. | 2000 | Thromb. Res. | pmid:10973681 |
Vesterqvist O et al. | In vivo production of thromboxane in acute human myocardial infarction: a preliminary study. | 1985 | Thromb. Res. | pmid:3992528 |
Küster LJ and Frölich JC | PAF-induced platelet aggregation and TXB2 formation. | 1989 | Thromb. Res. | pmid:2922704 |
Han P et al. | Inhibition of platelet function of antiarrhythmic drugs, verapamil and disopyramide. | 1982 | Thromb. Haemost. | pmid:7101234 |
Miller KW and Keith JC | Effect of thromboxane synthetase inhibition on platelet function and morphology during ovine pregnancy-induced hypertension. | 1988 | Thromb. Haemost. | pmid:3238644 |
Teng CM et al. | ADP-mimicking platelet aggregation caused by rugosin E, an ellagitannin isolated from Rosa rugosa Thunb. | 1997 | Thromb. Haemost. | pmid:9066010 |
Santilli F et al. | Effects of high-amount-high-intensity exercise on in vivo platelet activation: modulation by lipid peroxidation and AGE/RAGE axis. | 2013 | Thromb. Haemost. | pmid:24030807 |
Joseph S et al. | Effect of the polyamine-spermine on agonist-induced human platelet activation--specific inhibition of "aggregation-independent" events induced by thrombin, but not by collagen, thromboxane mimetic, phorbol ester or calcium ionophore. | 1987 | Thromb. Haemost. | pmid:3110996 |
di Minno G et al. | Effects of any epoxymethano stable analogue of prostaglandin endoperoxides (U-46619) on human platelets. | 1981 | Thromb. Haemost. | pmid:6266066 |
Pampolina C and McNicol A | Streptococcus sanguis-induced platelet activation involves two waves of tyrosine phosphorylation mediated by FcgammaRIIA and alphaIIbbeta3. | 2005 | Thromb. Haemost. | pmid:15886812 |
Jilma-Stohlawetz P et al. | Impaired platelet function among platelet donors. | 2001 | Thromb. Haemost. | pmid:11583322 |
Dejana E et al. | Bleeding time in rats: a comparison of different experimental conditions. | 1982 | Thromb. Haemost. | pmid:6753230 |
Strano A et al. | Platelet sensitivity to prostacyclin and thromboxane production in hyperlipidemic patients. | 1982 | Thromb. Haemost. | pmid:6753232 |
Hansen JB et al. | The effect of lipopolysaccharides (LPS) on generation of thromboxane A2 and thromboplastin activity in whole blood of males, females and females on oral contraceptives. | 1989 | Thromb. Haemost. | pmid:2799762 |
Lepäntalo A et al. | Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. | 2006 | Thromb. Haemost. | pmid:16493486 |
Matsumoto M et al. | Thromboxane generation in patients with essential hypertension or cerebrovascular disease and effect of oral aspirin. | 1980 | Thromb. Haemost. | pmid:7423441 |
Carter AJ et al. | A comparison of human pulmonary arterial and venous prostacyclin and thromboxane synthesis--effect of a thromboxane synthase inhibitor. | 1984 | Thromb. Haemost. | pmid:6377567 |
Spectre G et al. | Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications. | 2011 | Thromb. Haemost. | pmid:21800009 |
Honey AC et al. | Effect of indomethacin and dazoxiben on intravascular platelet aggregation in the anaesthetized rabbit. | 1986 | Thromb. Haemost. | pmid:3775692 |
Gresele P et al. | Picotamide protects mice from death in a pulmonary embolism model by a mechanism independent from thromboxane suppression. | 1990 | Thromb. Haemost. | pmid:2274931 |
Krishnamurthi S et al. | Effect of pyridoxal 5'-phosphate (PALP) on human platelet aggregation, dense granule release and thromboxane B2 generation--role of Schiff base formation. | 1982 | Thromb. Haemost. | pmid:6891107 |
Chen SL et al. | Chlorobutanol, a preservative of desmopressin, inhibits human platelet aggregation and release in vitro. | 1990 | Thromb. Haemost. | pmid:2096493 |
Martinuzzo ME et al. | Antiphospholipid antibodies enhance thrombin-induced platelet activation and thromboxane formation. | 1993 | Thromb. Haemost. | pmid:8115993 |
Kyrle PA et al. | Thromboxane A2 and prostacyclin generation in the microvasculature of patients with atherosclerosis--effect of low-dose aspirin. | 1989 | Thromb. Haemost. | pmid:2508252 |
Stratta P et al. | Warning: platelet factor 4, beta-thromboglobulin and thromboxane in donor's plasma units. | 1983 | Thromb. Haemost. | pmid:6189235 |
Scharf RE | In vitro thromboxane synthesis of depleted blood platelets following renal transplantation. | 1990 | Thromb. Haemost. | pmid:2148845 |
Hoet B et al. | Ridogrel, a combined thromboxane synthase inhibitor and receptor blocker, decreases elevated plasma beta-thromboglobulin levels in patients with documented peripheral arterial disease. | 1990 | Thromb. Haemost. | pmid:2148849 |
Cattaneo M et al. | Human platelet aggregation and release reaction induced by platelet activating factor (PAF-acether)--effects of acetylsalicylic acid and external ionized calcium. | 1985 | Thromb. Haemost. | pmid:3927505 |
Wang WJ and Huang TF | A novel tetrameric venom protein, agglucetin from Agkistrodon acutus, acts as a glycoprotein Ib agonist. | 2001 | Thromb. Haemost. | pmid:11686327 |
Jackson C et al. | DN 9693: a phosphodiesterase inhibitor with a platelet membrane effect. | 1989 | Thromb. Haemost. | pmid:2546286 |
Davì G et al. | Increased thromboxane metabolites excretion in liver cirrhosis. | 1998 | Thromb. Haemost. | pmid:9569186 |
Sheu JR et al. | Mechanisms involved in the antiplatelet activity of Staphylococcus aureus lipoteichoic acid in human platelets. | 2000 | Thromb. Haemost. | pmid:10823277 |
Crescente M et al. | Gallic acid, a dietary polyphenolic component, blunts the inhibition of platelet COX-1 by aspirin: preliminary in-vitro findings. | 2007 | Thromb. Haemost. | pmid:17549313 |
Undas A et al. | Lack of aspirin-induced decrease in thrombin formation in subjects resistant to aspirin. | 2007 | Thromb. Haemost. | pmid:17549314 |
Homoncik M et al. | Monitoring of aspirin (ASA) pharmacodynamics with the platelet function analyzer PFA-100. | 2000 | Thromb. Haemost. | pmid:10739392 |
Perneby C et al. | Dose- and time-dependent antiplatelet effects of aspirin. | 2006 | Thromb. Haemost. | pmid:16601836 |
Eldor A et al. | Effects of dipyrone on prostaglandin production by human platelets and cultured bovine aortic endothelial cells. | 1983 | Thromb. Haemost. | pmid:6346571 |
Menys VC and Davies JA | Selective inhibition of thromboxane synthetase with dazoxiben - basis of its inhibitory effect on platelet adhesion. | 1983 | Thromb. Haemost. | pmid:6346575 |
Foo LC et al. | Platelets of habitual smokers have reduced susceptibility to aggregating agent. | 1991 | Thromb. Haemost. | pmid:2048056 |
Gordge MP et al. | Platelet function and the bleeding time in progressive renal failure. | 1988 | Thromb. Haemost. | pmid:3187950 |
Vezza R et al. | Antivasoconstrictor and antiaggregatory activities of picotamide unrelated to thromboxane A2 antagonism. | 1997 | Thromb. Haemost. | pmid:9408024 |
Lessiani G et al. | Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of iloprost. | 2011 | Thromb. Haemost. | pmid:21103664 |
Greer IA et al. | Platelet activation in allergic asthma. | 1985 | Thromb. Haemost. | pmid:2931855 |
Hohlfeld T et al. | Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia. | 1994 | Thromb. Haemost. | pmid:7513092 |
Han P et al. | Verapamil and collagen-induced platelet reactions--evidence for a role for intracellular calcium in platelet activation. | 1983 | Thromb. Haemost. | pmid:6415847 |
Turpeinen AM et al. | Replacement of dietary saturated by unsaturated fatty acids: effects of platelet protein kinase C activity, urinary content of 2,3-dinor-TXB2 and in vitro platelet aggregation in healthy man. | 1998 | Thromb. Haemost. | pmid:9798986 |
Guthikonda S et al. | Increased platelet sensitivity among individuals with aspirin resistance - platelet aggregation to submaximal concentration of arachidonic acid predicts response to antiplatelet therapy. | 2008 | Thromb. Haemost. | pmid:18612542 |
Gresele P et al. | Platelet activation markers in patients with peripheral arterial disease--a prospective comparison of different platelet function tests. | 1997 | Thromb. Haemost. | pmid:9423790 |
Naesh O et al. | Platelet function in surgical stress. | 1985 | Thromb. Haemost. | pmid:2935969 |
Davì G et al. | The effect of two low doses of aspirin on whole blood thromboxane and prostacyclin generation in healthy subjects. | 1983 | Thromb. Haemost. | pmid:6417815 |
Dale J et al. | The effect of a thromboxane synthetase inhibitor, dazoxiben, and acetylsalicylic acid on platelet function and prostaglandin metabolism. | 1983 | Thromb. Haemost. | pmid:6689091 |
Hornby EJ et al. | The inhibitory effect of GR32191, a thromboxane receptor blocking drug, on human platelet aggregation, adhesion and secretion. | 1989 | Thromb. Haemost. | pmid:2529661 |
Bar J et al. | The regulation of platelet aggregation in vitro by interleukin-1beta and tumor necrosis factor-alpha: changes in pregnancy and in pre-eclampsia. | 1997 | Thromb. Haemost. | pmid:9364994 |
Husted SE et al. | Intravenous acetylsalicylic acid--dose-related effects on platelet function and fibrinolysis in healthy males. | 1992 | Thromb. Haemost. | pmid:1412171 |
Subbiah MT et al. | Studies of aggregation and thromboxane B2 synthesis in avian thrombocytes: comparison between atherosclerosis-susceptible and resistant breeds. | 1980 | Thromb. Haemost. | pmid:7455983 |
Zahavi M et al. | Abnormal typical pattern of platelet function and thromboxane generation in unstable angina. | 1989 | Thromb. Haemost. | pmid:2531938 |
Barrett PA and Butler KD | Shortening of platelet survival by induced hypercholesterolaemia in rabbits and its prolongation by anagrelide. | 1983 | Thromb. Haemost. | pmid:6648889 |
Szczeklik A et al. | Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever. | 1986 | Thromb. Haemost. | pmid:3563961 |
Falcon CR et al. | The in vitro production of thromboxane B2 by platelets of diabetic patients is normal at physiological concentrations of ionized calcium. | 1993 | Thromb. Haemost. | pmid:8259535 |
Larsen SB et al. | Increased platelet aggregation and serum thromboxane levels in aspirin-treated patients with prior myocardial infarction. | 2012 | Thromb. Haemost. | pmid:22534977 |
Cattaneo M et al. | Conditions influencing the interaction of asialo von Willebrand factor with human platelets--the effects of external ionized calcium concentration and the role of arachidonate pathway. | 1988 | Thromb. Haemost. | pmid:3146144 |
Fimognari FL et al. | Nocturnal rise of urinary thromboxane B 2 in patients with coronary artery disease. | 2005 | Thromb. Haemost. | pmid:15735822 |
De Caterina R et al. | Organic nitrates: direct antiplatelet effects and synergism with prostacyclin. Antiplatelet effects of organic nitrates. | 1988 | Thromb. Haemost. | pmid:3291182 |
Teng CM and Ko FN | Comparison of the platelet aggregation induced by three thrombin-like enzymes of snake venoms and thrombin. | 1988 | Thromb. Haemost. | pmid:3291184 |
de Castellarnau C et al. | Prostacyclin and thromboxane production by autogenous femoral veins grafted into the arterial circulation of the dog. | 1989 | Thromb. Haemost. | pmid:2665174 |
Davì G et al. | Demonstration of Rickettsia Conorii-induced coagulative and platelet activation in vivo in patients with Mediterranean spotted fever. | 1995 | Thromb. Haemost. | pmid:8584998 |
Habib A et al. | Increased expression of inducible cyclooxygenase-2 in human endothelial cells by antiphospholipid antibodies. | 1995 | Thromb. Haemost. | pmid:8585020 |
Evangelista V et al. | Defibrotide inhibits platelet activation by cathepsin G released from stimulated polymorphonuclear leukocytes. | 1992 | Thromb. Haemost. | pmid:1509406 |
Rocca B et al. | Increased thromboxane biosynthesis in essential thrombocythemia. | 1995 | Thromb. Haemost. | pmid:8607099 |
Korbut R et al. | On the mechanism of thrombolytic action of thromboxane synthetase inhibitors. | 1987 | Thromb. Haemost. | pmid:3324381 |
Huang TF et al. | Mechanism of action of a potent antiplatelet peptide, triflavin from Trimeresurus flavoviridis snake venom. | 1991 | Thromb. Haemost. | pmid:1665595 |
Totani L et al. | Prasugrel inhibits platelet-leukocyte interaction and reduces inflammatory markers in a model of endotoxic shock in the mouse. | 2012 | Thromb. Haemost. | pmid:22436970 |
Véricel E et al. | Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. | 2015 | Thromb. Haemost. | pmid:25832443 |
Spowart K et al. | Haemostatic effects of ketorolac with and without concomitant heparin in normal volunteers. | 1988 | Thromb. Haemost. | pmid:3266379 |
Cerletti C et al. | Aspirin kinetics and inhibition of platelet thromboxane generation-relevance for a solution of the "aspirin dilemma". | 1985 | Thromb. Haemost. | pmid:4049312 |
Aoki T et al. | Difference of (Ca2+)i movements in platelets stimulated by thrombin and TRAP: the involvement of alpha(IIb)beta3-mediated TXA2 synthesis. | 1998 | Thromb. Haemost. | pmid:9657446 |
Larsen SB et al. | Reduced antiplatelet effect of aspirin is associated with low-grade inflammation in patients with coronary artery disease. | 2013 | Thromb. Haemost. | pmid:23407706 |
Dotevall A et al. | Cigarette smoking increases thromboxane A2 formation without affecting platelet survival in young healthy females. | 1992 | Thromb. Haemost. | pmid:1455405 |
De Caterina R et al. | Benefit/risk profile of combined antiplatelet therapy with ticlopidine and aspirin. | 1991 | Thromb. Haemost. | pmid:1871711 |
de Boer A et al. | Interaction study between Org 10172, a low molecular weight heparinoid, and acetylsalicylic acid in healthy male volunteers. | 1991 | Thromb. Haemost. | pmid:1722918 |
De Caterina R et al. | Equal antiplatelet effects of aspirin 50 or 324 mg/day in patients after acute myocardial infarction. | 1985 | Thromb. Haemost. | pmid:4082090 |
Davì G et al. | Influence of metabolic control on thromboxane biosynthesis and plasma plasminogen activator inhibitor type-1 in non-insulin-dependent diabetes mellitus. | 1996 | Thromb. Haemost. | pmid:8819248 |
Ding YA et al. | Potentiation of adrenaline-induced platelet aggregation by angiotensin II. | 1985 | Thromb. Haemost. | pmid:4089801 |
Blais N et al. | Response to aspirin in healthy individuals. Cross-comparison of light transmission aggregometry, VerifyNow system, platelet count drop, thromboelastography (TEG) and urinary 11-dehydrothromboxane B(2). | 2009 | Thromb. Haemost. | pmid:19652893 |
Holme S et al. | The effect of albumin bound polyunsaturated fatty acids on human platelets. | 1984 | Thromb. Haemost. | pmid:6719386 |
Carter AJ and Hanley SP | The effect of platelet number and haematocrit on whole blood thromboxane synthesis. | 1985 | Thromb. Haemost. | pmid:4024033 |
Brox JH et al. | The effect of cod liver oil and corn oil on platelets and vessel wall in man. | 1981 | Thromb. Haemost. | pmid:7031981 |
Strano A et al. | Thromboxane formation by platelets and platelet sensitivity to prostacyclin in patients with acute myocardial infarction. | 1981 | Thromb. Haemost. | pmid:7036402 |
Butler KD et al. | The effects of modulation of prostanoid metabolism on the thoracic platelet accumulation induced by intravenous administration of collagen in the guinea-pig. | 1986 | Thromb. Haemost. | pmid:3105104 |