Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Singh D et al. | Evidence for the generation of hydroxyl radical during arachidonic acid metabolism by human platelets. | 1981 | Am. J. Hematol. | pmid:6274189 |
Sirois P et al. | Comparative effects of leukotriene B4, prostaglandins I2 and E2, 6-keto-PGF1 alpha thromboxane B2 and histamine on selected smooth muscle preparations. | 1981 | J. Pharm. Pharmacol. | pmid:6115037 |
Nordøy A | Lipids and thrombogenesis. | 1981 | Ann. Clin. Res. | pmid:7018362 |
Moncada S and Vane JR | Prostacyclin and blood coagulation. | 1981 | Drugs | pmid:7018874 |
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Hales CA et al. | Role of thromboxane and prostacyclin in pulmonary vasomotor changes after endotoxin in dogs. | 1981 | J. Clin. Invest. | pmid:7021593 |
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Baroody RA and Bito LZ | The impermeability of the basic cell membrane to thromboxane-B2' prostacyclin and 6-keto-PGF 1 alpha. | 1981 | Prostaglandins | pmid:7010455 |
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Ylikorkala O et al. | Effect of cytostatics on prostaglandin F2 alpha prostacyclin, and thromboxane in patients with gynecologic malignancies. | 1981 | Obstet Gynecol | pmid:7024882 |
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Araki H et al. | Mechanism of protection against arachidonate induced sudden death by glucocorticoid. | 1981 | Prostaglandins | pmid:7232764 |
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Tyler HM et al. | Administration to man of UK-37,248-01, a selective inhibitor of thromboxane synthetase. | 1981 | Lancet | pmid:6110861 |
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Feuerstein N et al. | 3-deazaadenosine, a transmethylase inhibitor, suppresses the effect of lipopolysaccharide on release of prostacyclin and thromboxane. | 1981 | J. Pharm. Pharmacol. | pmid:6115021 |
Foegh ML et al. | Urine i-TXB2 in renal allograft rejection. | 1981 | Lancet | pmid:6115199 |
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Kelly KL and Laychock SG | Prostaglandin synthesis and metabolism in isolated pancreatic islets of the rat. | 1981 | Prostaglandins | pmid:6803305 |
Matsumoto M et al. | Platelet aggregation induced by arachidonic acid and thromboxane generation in patients with hypertension or cerebrovascular disease. | 1981 | Prostaglandins Med | pmid:7323212 |
Smith MC and Dunn MJ | Impaired platelet thromboxane production in renal failure. | 1981 | Nephron | pmid:7329487 |
Lagarde M et al. | Inhibition of thrombin-induced platelet arachidonic acid release by 15-hydroperoxy-arachidonic acid. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7259783 |
Livio M et al. | Differential effects of itanoxone--a new hypolipidemic and hypouricemic drug--on platelet and vascular prostaglandin generation in rats. | 1981 | Atherosclerosis | pmid:7259827 |
Sterin-Borda L et al. | Stimulating effect of thromboxane B2 on isolated rat atria. | 1981 | Experientia | pmid:7262286 |
Roberts LJ et al. | Metabolism of thromboxane B2 in man. Identification of twenty urinary metabolites. | 1981 | J. Biol. Chem. | pmid:7263660 |
Zijlstra FJ and Vincent JE | Contractile characteristics of the rat stomach strip and the rabbit aorta and mesenteric artery. | 1981 | J Pharmacol Methods | pmid:7265989 |
Hirsh PD et al. | Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease. | 1981 | N. Engl. J. Med. | pmid:6894016 |
Allan G and Levi R | Thromboxane and prostacyclin release during cardiac immediate hypersensitivity reactions in vitro. | 1981 | J. Pharmacol. Exp. Ther. | pmid:6894166 |
Malemud CJ et al. | Prostaglandin biosynthesis by lapine articular chondrocytes in culture. | 1981 | Biochim. Biophys. Acta | pmid:6894251 |
Ohnishi H et al. | Effects of trapidil on thromboxane A2-induced aggregation of platelets, ischemic changes in heart and biosynthesis of thromboxane A2. | 1981 | Prostaglandins Med | pmid:6894333 |
Sobel M et al. | Circulating platelet products in unstable angina pectoris. | 1981 | Circulation | pmid:6450001 |
Defreyn G et al. | Familial bleeding tendency with partial platelet thromboxane synthetase deficiency: reorientation of cyclic endoperoxide metabolism. | 1981 | Br. J. Haematol. | pmid:6268139 |
Seitz M et al. | The influence of synovial fluid from patients with rheumatoid arthritis on the proliferation of peripheral blood lymphocytes and the prostanoid release from monocytes. | 1981 | Agents Actions | pmid:7340450 |
Catalano PM et al. | Platelet recovery from aspirin inhibition in vivo; differing patterns under various assay conditions. | 1981 | Blood | pmid:7448419 |
Agradi E et al. | In vitro effects of synthetic antioxidants and vitamin E on arachidonic acid metabolism and thromboxane formation in human platelets and on platelet aggregation. | 1981 | Prostaglandins | pmid:6794104 |
Russell NH et al. | Platelet adenine nucleotides and arachidonic acid metabolism in the myeloproliferative disorders. | 1981 | Thromb. Res. | pmid:6794179 |
Laviolette M et al. | Human alveolar macrophages: a lesion in arachidonic acid metabolism in cigarette smokers. | 1981 | Am. Rev. Respir. Dis. | pmid:6794395 |
Wonders TR et al. | Reduced plasma thromboxane elevation during partial cardiopulmonary bypass in thrombocytopenic sheep. | 1981 | Trans Am Soc Artif Intern Organs | pmid:7331082 |
Mezzano D et al. | Evidence that platelet buoyant density, but not size, correlates with platelet age in man. | 1981 | Am. J. Hematol. | pmid:7270546 |
Landgraf-Leurs MM et al. | Aggregation and thromboxane B2 formation in platelets and vascular prostacyclin production from genetically obese rats. | 1981 | Prostaglandins | pmid:6798637 |
Brox JH et al. | The effect of cod liver oil and corn oil on platelets and vessel wall in man. | 1981 | Thromb. Haemost. | pmid:7031981 |
Hirsh PD et al. | Prostaglandins and ischemic heart disease. | 1981 | Am. J. Med. | pmid:7032286 |
Dunham BM et al. | Role of prostaglandins in positive end-expiratory pressure-induced negative inotropism. | 1981 | Am. J. Physiol. | pmid:7034549 |
Strano A et al. | Thromboxane formation by platelets and platelet sensitivity to prostacyclin in patients with acute myocardial infarction. | 1981 | Thromb. Haemost. | pmid:7036402 |