Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Vincent JE et al. | The formation of thromboxane B2, leukotriene B4 and 12-hydroxyeicosatetraenoic acid by alveolar macrophages after activation during tumor growth in the rat. | 1990 | Biochim. Biophys. Acta | pmid:2154265 |
Taylor L et al. | Prostaglandin production by type II alveolar epithelial cells. | 1979 | Biochim. Biophys. Acta | pmid:435506 |
Shaw JO et al. | Activation of rabbit platelet phospholipase and thromboxane synthesis by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor). | 1981 | Biochim. Biophys. Acta | pmid:7213765 |
Brouard C and Pascaud M | Effects of moderate dietary supplementations with n-3 fatty acids on macrophage and lymphocyte phospholipids and macrophage eicosanoid synthesis in the rat. | 1990 | Biochim. Biophys. Acta | pmid:2123401 |
Powell WS | Metabolism of prostaglandins, prostaglandin analogs and thromboxane B2 by lung and liver microsomes from pregnant rabbits. | 1979 | Biochim. Biophys. Acta | pmid:518891 |
Shaw JO and Lyons RM | Requirement for different Ca2+ pools in the activation of rabbit platelets II. Phospholipase activity. | 1982 | Biochim. Biophys. Acta | pmid:6800410 |
Blackwell GJ et al. | Prostacyclin prolongs viability of washed human platelets. | 1982 | Biochim. Biophys. Acta | pmid:6291622 |
Horton AA and Wood JM | Prevention of Ca(2+)-induced or thromboxane B2-induced hepatocyte plasma membrane bleb formation by thromboxane receptor antagonists. | 1991 | Biochim. Biophys. Acta | pmid:1836358 |
Fischer TH et al. | Kinetic evidence that arachidonate-induced calcium efflux from platelet microsomes involves a carrier-type ionophoric mechanism. | 1990 | Biochim. Biophys. Acta | pmid:2137712 |
Busshardt E et al. | Regulation of hepatic parenchymal and non-parenchymal cell function by the diadenine nucleotides Ap3A and Ap4A. | 1989 | Biochim. Biophys. Acta | pmid:2563228 |
Honda A et al. | Appearance of the arachidonic acid metabolic pathway in human promyelocytic leukemia (HL-60) cells during monocytic differentiation: enhancement of thromboxane synthesis by 1 alpha,25-dihydroxyvitamin D-3. | 1986 | Biochim. Biophys. Acta | pmid:3089289 |
Kloprogge E et al. | Stimulus-aggregation coupling in platelets activated with PAF-acether. | 1986 | Biochim. Biophys. Acta | pmid:3089297 |
Sekiya K and Okuda H | Inhibitory action of soluble elastin on thromboxane B2 formation in blood platelets. | 1984 | Biochim. Biophys. Acta | pmid:6320905 |
Roberts LJ et al. | Prostaglandin thromboxane, and 12-hydroxy-5,8,10,14-eicosatetraenoic acid production by ionophore-stimulated rat serosal mast cells. | 1979 | Biochim. Biophys. Acta | pmid:389290 |
Fitzpatrick FA and Gorman RR | A comparison of imidazole and 9,11-azoprosta-5,13-dienoic acid. Two selective thromboxane synthetase inhibitors. | 1978 | Biochim. Biophys. Acta | pmid:629996 |
Hrboticky N et al. | Linoleic acid esterified in low density lipoprotein serves as substrate for increased arachidonic acid synthesis in differentiating monocytic cells. | 1996 | Biochim. Biophys. Acta | pmid:8765140 |
de Waart DR et al. | Studies on the urinary excretion of thromboxane B2 in Zellweger patients and control subjects: evidence for a major role for peroxisomes in the beta-oxidative chain-shortening of thromboxane B2. | 1994 | Biochim. Biophys. Acta | pmid:8155738 |
Sato T et al. | Inhibition of platelet aggregation by unsaturated fatty acids through interference with a thromboxane-mediated process. | 1987 | Biochim. Biophys. Acta | pmid:3663714 |
VanRollins M et al. | Metabolism of 7,10,13,16-docosatetraenoic acid to dihomo-thromboxane, 14-hydroxy-7,10,12-nonadecatrienoic acid and hydroxy fatty acids by human platelets. | 1985 | Biochim. Biophys. Acta | pmid:3918572 |
Al-Madaney MM et al. | Effects of lipid-esterified conjugated linoleic acid isomers on platelet function: evidence for stimulation of platelet phospholipase activity. | 2003 | Biochim. Biophys. Acta | pmid:14729070 |
Murphy CT et al. | Comparison of the role of protein kinase C in platelet functional responses induced by three different mechanisms, PAF, ionomycin and arachidonic acid. | 1991 | Biochim. Biophys. Acta | pmid:1661165 |
Asbóth G et al. | The relation between thromboxane and prostaglandin synthesis in human decidua tissue: a comparison of eicosanoid synthesis in minced tissue with that in a cell-free preparation. | 1989 | Biochim. Biophys. Acta | pmid:2493805 |
Ko FN et al. | Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans. | 1990 | Biochim. Biophys. Acta | pmid:2162213 |
Croft KD et al. | Onset of changes in phospholipid fatty acid composition and prostaglandin synthesis following dietary manipulation with n-6 and n-3 fatty acids in the rat. | 1985 | Biochim. Biophys. Acta | pmid:3995069 |
Ko FN et al. | Inhibition on platelet activation by shikonin derivatives isolated from Arnebia euchroma. | 1995 | Biochim. Biophys. Acta | pmid:7548232 |
Horton AA and Wood JM | Prevention of thromboxane B2-induced hepatocyte plasma membrane bleb formation by certain prostaglandins and a proteinase inhibitor. | 1990 | Biochim. Biophys. Acta | pmid:2107870 |
Simon MF et al. | Selective inhibition of human platelet phospholipase A2 by buffering cytoplasmic calcium with the fluorescent indicator quin 2. Evidence for different calcium sensitivities of phospholipases A2 and C. | 1986 | Biochim. Biophys. Acta | pmid:3080024 |
Miller OV et al. | Acetyl glycerylphosphorylcholine inhibition of prostaglandin I2-stimulated adenosine 3',5'-cyclic monophosphate levels in human platelets. Evidence for thromboxane A2 dependence. | 1982 | Biochim. Biophys. Acta | pmid:6285985 |
Ko FN et al. | CIS-19, a novel platelet activating factor receptor antagonist: in vitro and in vivo studies. | 1993 | Biochim. Biophys. Acta | pmid:8380343 |
Teng CM et al. | Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng. | 1989 | Biochim. Biophys. Acta | pmid:2923911 |
Croft KD et al. | Differential inhibition of thromboxane B2 and leukotriene B4 biosynthesis by two naturally occurring acetylenic fatty acids. | 1987 | Biochim. Biophys. Acta | pmid:2822134 |
Hayashi Y et al. | Enzyme immunoassay of thromboxane B2. | 1983 | Biochim. Biophys. Acta | pmid:6407530 |
Nichols FC et al. | Prostaglandin E2, prostaglandin E1 and thromboxane B2 release from human monocytes treated with C3b or bacterial lipopolysaccharide. | 1987 | Biochim. Biophys. Acta | pmid:3101743 |
Asbóth G et al. | Conversion of arachidonic acid to prostanoids in the avian uterus. | 1983 | Biochim. Biophys. Acta | pmid:6402032 |
Wu CC et al. | Antiplatelet effects of clausine-D isolated from Clausena excavata. | 1994 | Biochim. Biophys. Acta | pmid:7918571 |
Malemud CJ et al. | Correlation of the biosynthesis of prostaglandin and cyclic AMP in monolayer cultures of rabbit articular chondrocytes. | 1982 | Biochim. Biophys. Acta | pmid:6280776 |
Caprani A et al. | Experimental evidence of a potentially increased thrombo-embolic disease risk by domestic electromagnetic field exposure. | 2004 | Bioelectromagnetics | pmid:15114641 |
Bartolini G et al. | Possible involvement of prostaglandin H synthase-1 induction in the differentiation of U-937 cells. | 1995 | Biofactors | pmid:7546213 |
Wolfram RM et al. | Salivary isoprostanes indicate increased oxidation injury in periodontitis with additional tobacco abuse. | 2006 | Biofactors | pmid:17264390 |
Olszowski T et al. | The Effect of Cadmium on COX-1 and COX-2 Gene, Protein Expression, and Enzymatic Activity in THP-1 Macrophages. | 2015 | Biol Trace Elem Res | pmid:25645360 |
Korbecki J et al. | Cyclooxygenase-1 as the main source of proinflammatory factors after sodium orthovanadate treatment. | 2015 | Biol Trace Elem Res | pmid:25398544 |
Qu X et al. | Selenium deficiency-induced alterations in the vascular system of the rat. | 2000 | Biol Trace Elem Res | pmid:11051602 |
Knowles SO and Donaldson WE | Lead disrupts eicosanoid metabolism, macrophage function, and disease resistance in birds. | 1997 Oct-Nov | Biol Trace Elem Res | pmid:9404672 |
Tran-Thi TA et al. | Output and effects of thromboxane produced by the liver perfused with phorbol myristate acetate. | 1988 | Biol. Chem. Hoppe-Seyler | pmid:3242547 |
Redl H et al. | The elastase-inhibitor eglin has no effect in an ovine model of endotoxemia. | 1988 | Biol. Chem. Hoppe-Seyler | pmid:3060136 |
Ishibashi M et al. | Analysis of 11-dehydrothromboxane B2 in human urine improved by use of gas chromatography/high-resolution selected ion monitoring with 18O2-labelled analogue as an internal standard. | 1994 | Biol. Mass Spectrom. | pmid:7986831 |
Tanaka M et al. | Effects of a thromboxane synthetase inhibitor (OKY-046) in an ischemia-reperfusion model of intrauterine growth retardation in Sprague-Dawley rats. | 1997 | Biol. Neonate | pmid:9303217 |
Stuart MJ and Dusse J | In vitro comparison of the efficacy of cyclooxygenase inhibitors on the adult versus neonatal platelet. | 1985 | Biol. Neonate | pmid:4005330 |
Smalling WE et al. | Protective effect of pentoxifylline on volume-induced lung injury in newborn piglets. | 2004 | Biol. Neonate | pmid:14981352 |
Osiovich H et al. | Cardiopulmonary effects of tumor necrosis factor-alpha in the piglet: influence of cyclooxygenase inhibition. | 1995 | Biol. Neonate | pmid:8835089 |
Zheng NX et al. | Pharmacokinetic and pharmacodynamic studies of a thromboxane synthetase inhibitor, ozagrel, in rabbits. | 1995 | Biol. Pharm. Bull. | pmid:8787798 |
Kim YJ | Rhamnetin attenuates melanogenesis by suppressing oxidative stress and pro-inflammatory mediators. | 2013 | Biol. Pharm. Bull. | pmid:23739488 |
Bermejo BP et al. | Sesquiterpenes from Jasonia glutinosa: in vitro anti-inflammatory activity. | 2002 | Biol. Pharm. Bull. | pmid:11824534 |
Togna AR et al. | 4-Methylcoumarin derivatives with anti-inflammatory effects in activated microglial cells. | 2014 | Biol. Pharm. Bull. | pmid:24389482 |
Katoh M et al. | Inhibitory effects of TA-993 and its metabolite MB3 on platelet activation induced by collagen and U-46619 in human platelets. | 2001 | Biol. Pharm. Bull. | pmid:11379769 |
Hsiao G et al. | Antiplatelet action of 3',4'-diisovalerylkhellactone diester purified from Peucedanum japonicum Thunb. | 1998 | Biol. Pharm. Bull. | pmid:9703250 |
Akagi Y et al. | Influence of nonsteroidal anti-inflammatory drugs on the antiplatelet effects of aspirin in rats. | 2011 | Biol. Pharm. Bull. | pmid:21415533 |
Noguchi M et al. | Enzymologic and pharmacologic profile of loxoprofen sodium and its metabolites. | 2005 | Biol. Pharm. Bull. | pmid:16272692 |
Yokoyama H et al. | Theoretical investigation of aspirin dosage regimen to exhibit optimal antiplatelet effects and decrease risk of upper gastrointestinal lesions. | 2012 | Biol. Pharm. Bull. | pmid:23047244 |
Basselin M et al. | Chronic carbamazepine administration reduces N-methyl-D-aspartate receptor-initiated signaling via arachidonic acid in rat brain. | 2007 | Biol. Psychiatry | pmid:17628508 |
Evans CA et al. | Gestational changes in prostanoid concentrations in intrauterine tissues and fetal fluids from pregnant sheep, and the relation to prostanoid output in vitro. | 1982 | Biol. Reprod. | pmid:6896829 |
Wilson L et al. | Alterations in reproductive tissue prostaglandins E and F, 6-keto-prostaglandin F1 alpha and thromboxane B2 with gestational age in the rat. | 1982 | Biol. Reprod. | pmid:6897617 |
Dubin NH et al. | Thromboxane production in the pregnant rat: differential recovery by platelets and uterus following aspirin administration. | 1983 | Biol. Reprod. | pmid:6626652 |
Miller JB et al. | Alterations in plasma and tissue prostaglandin levels in rabbits during luteal regression. | 1983 | Biol. Reprod. | pmid:6688954 |
Lei ZM et al. | Expression of thromboxane A2 receptor gene and thromboxane A2 synthase in bovine corpora lutea. | 1992 | Biol. Reprod. | pmid:1391329 |
Wilson L and Huang LS | Contributions of the fetoplacental unit to augmented uterine prostaglandin levels periparturition in the rat. | 1985 | Biol. Reprod. | pmid:3840391 |
Chou YI et al. | Correlations of platelet-derived microparticles with thromboxane B2, platelet-activating factor, endothelin-1, and neutrophil to lymphocyte ratio in patients with coronary intermediate lesions. | 2014 | Biomarkers | pmid:25391885 |
Lüdicke F et al. | A Japanese cross-sectional multicentre study of biomarkers associated with cardiovascular disease in smokers and non-smokers. | 2015 | Biomarkers | pmid:26616146 |
Burhop KE et al. | Effects of intravenous infusions of diaspirin cross-linked hemoglobin (DCLHb) on sheep. | 1992 | Biomater Artif Cells Immobilization Biotechnol | pmid:1391481 |
Hubbell JA and McIntire LV | Visualization and analysis of mural thrombogenesis on collagen, polyurethane and nylon. | 1986 | Biomaterials | pmid:3778995 |
Leake DL et al. | Comparative study of the thromboresistance of Dacron combined with various polyurethanes. | 1989 | Biomaterials | pmid:2529915 |
Cenni E et al. | Platelet and coagulation factor variations induced in vitro by polyethylene terephthalate (Dacron) coated with pyrolytic carbon. | 1995 | Biomaterials | pmid:8580259 |
Cenni E et al. | Numerical and functional modifications in platelets induced by polyester coated by a hydrophilic polymer. | 1993 | Biomaterials | pmid:8399951 |
Xie P et al. | Antithrombotic Effect and Mechanism of Radix Paeoniae Rubra. | 2017 | Biomed Res Int | pmid:28299338 |
Yan H et al. | Seawater Immersion Aggravates Burn Injury Causing Severe Blood Coagulation Dysfunction. | 2016 | Biomed Res Int | pmid:26885523 |
Abbas NA et al. | Thromboxane plasma level in kappa-carrageenin-induced acronecrosis of the tail in rats. | 1991 | Biomed. Biochim. Acta | pmid:1759973 |
Becker K et al. | Influence of the specific antagonist of PAF-acether, BN 52021, and of Ginkgo extract on the rejection of murine tail skin allografts and the PAF-acether mortality in mice in particular consideration of the role of TXB2. | 1988 | Biomed. Biochim. Acta | pmid:3073760 |
Ito T et al. | Selective thromboxane synthetase inhibitor and ischemic heart disease. | 1984 | Biomed. Biochim. Acta | pmid:6542777 |
Block HU et al. | Estimation of thromboxane B2 in the clotting human whole blood by gas chromatography. | 1984 | Biomed. Biochim. Acta | pmid:6517904 |
Beitz A et al. | Thromboxane B2 (TXB2) formation in clotting whole blood of healthy and diabetic humans in vitro. | 1984 | Biomed. Biochim. Acta | pmid:6517908 |
Schaper U et al. | Inhibition of lipoxygenase (LOX) or of cyclooxygenase (COX) improves survival of rats in endotoxin shock. | 1988 | Biomed. Biochim. Acta | pmid:3150270 |
Giessler C et al. | An enzyme-linked immunoassay for thromboxane B2 and 6-oxo-PGF1 alpha using peroxidase as label. | 1988 | Biomed. Biochim. Acta | pmid:3248100 |
Heinroth-Hoffmann I et al. | Effects of trapidil and trapidil derivatives on arachidonic acid and prostaglandin endoperoxide analogue U 46619-induced blood pressure changes in rats. | 1988 | Biomed. Biochim. Acta | pmid:3248102 |
Vapaatalo H et al. | Plasma catecholamines and production of thromboxane B2 by platelets after psychological and physical tests in normotensive and mild hypertensive subjects. | 1988 | Biomed. Biochim. Acta | pmid:3248115 |
Lamers JM et al. | Dietary fish oil reduces intimal proliferation of the coronary artery caused by implantation of a constrictor in pigs. | 1988 | Biomed. Biochim. Acta | pmid:3248119 |
Shindo N et al. | Rapid quantification of 11 prostanoids by combined capillary column gas chromatography and negative ion chemical ionization mass spectrometry: application to prostanoids released from normal human embryonic lung fibroblasts WI38 in a culture medium. | 1988 | Biomed. Environ. Mass Spectrom. | pmid:3349205 |
Voyksner RD et al. | Derivatization to improve thermospray HPLC/MS sensitivity for the determination of prostaglandins and thromboxane B2. | 1987 | Biomed. Environ. Mass Spectrom. | pmid:2960399 |
Ishibashi M et al. | Dimethylisopropylsilyl ether derivative in gas chromatography/mass spectrometry of 11-dehydrothromboxane B2. | 1988 | Biomed. Environ. Mass Spectrom. | pmid:3191252 |
Li D et al. | Diet rich in saturated fat decreases the ratio of thromboxane/prostacyclin in healthy men. | 2003 | Biomed. Environ. Sci. | pmid:15011964 |
Mallen DN et al. | Structural verification of 15-oxo-13,14-dihydrothromboxane B2. | 1978 | Biomed. Mass Spectrom. | pmid:678616 |
Roselló J et al. | Quantitative profiling of the metabolic cascade of arachidonic acid by capillary gas chromatography mass spectrometry. | 1981 | Biomed. Mass Spectrom. | pmid:7236862 |
Meese CO et al. | Measurement of thromboxane B2 in human urine by isotope dilution and negative ion chemical ionization mass spectrometry. | 1985 | Biomed. Mass Spectrom. | pmid:2932184 |
Nocun M et al. | French maritime pine bark extract Pycnogenol reduces thromboxane generation in blood from diabetic male rats. | 2008 | Biomed. Pharmacother. | pmid:17698319 |
Milani M et al. | Effects of two different HMG-CoA reductase inhibitors on thromboxane production in type IIA hypercholesterolemia. | 1996 | Biomed. Pharmacother. | pmid:8952866 |
Faure P et al. | Influence of a long-term zinc-deficient diet on rat platelet function and fatty acid composition. | 1995 | Biometals | pmid:7865995 |
Sadovskaia VL et al. | [Study of prostaglandins and thromboxanes B2 using mass-spectrometry of secondary ions]. | 1986 | Bioorg. Khim. | pmid:3768052 |
Vigorita MG et al. | Chiral 3,3'-(1,2-ethanediyl)-bis[2-(3,4-dimethoxyphenyl)-4-thiazolidinones] with anti-inflammatory activity. Part 11: evaluation of COX-2 selectivity and modelling. | 2003 | Bioorg. Med. Chem. | pmid:12614885 |
Mayer AM et al. | Marine sponge Hymeniacidon sp. amphilectane metabolites potently inhibit rat brain microglia thromboxane B2 generation. | 2012 | Bioorg. Med. Chem. | pmid:22153874 |
Takeuchi K et al. | Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition--I. Synthesis, structure-activity relationship, and evaluation of substituted omega-phenyl-omega-(3-pyridyl)alkenoic acids. | 1994 | Bioorg. Med. Chem. | pmid:7894968 |
Hu MK et al. | Synthesis and evaluation of backbone/amide-modified analogs of leualacin. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10098664 |