Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

Cross Reference

Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Airway Obstruction D000402 13 associated lipids
Uremia D014511 33 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Ovarian Neoplasms D010051 10 associated lipids
Pain D010146 64 associated lipids
Contusions D003288 3 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
Burns D002056 34 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Cattle Diseases D002418 24 associated lipids
Fatty Liver D005234 48 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Gastritis D005756 27 associated lipids
Heart Failure D006333 36 associated lipids
Pulmonary Edema D011654 23 associated lipids
Pulmonary Embolism D011655 5 associated lipids
Coronary Disease D003327 70 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Hypothyroidism D007037 32 associated lipids
Rhinitis D012220 10 associated lipids
Hypercapnia D006935 5 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Pain, Postoperative D010149 13 associated lipids
Asthma D001249 52 associated lipids
Kidney Diseases D007674 29 associated lipids
Femoral Fractures D005264 7 associated lipids
Weight Gain D015430 101 associated lipids
Hyperemia D006940 25 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Acidosis D000138 13 associated lipids
Glioma D005910 112 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Ulcer D014456 16 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Endometriosis D004715 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Myocardial Infarction D009203 21 associated lipids
Proteinuria D011507 30 associated lipids
Arteriosclerosis D001161 86 associated lipids
Magnesium Deficiency D008275 9 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Fibrosis D005355 23 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Fetal Diseases D005315 8 associated lipids
Glomerulonephritis D005921 35 associated lipids
Cerebral Hemorrhage D002543 13 associated lipids
Sepsis D018805 11 associated lipids
Leukopenia D007970 9 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Liver Cirrhosis, Biliary D008105 12 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hyperlipoproteinemia Type IV D006953 6 associated lipids
Nephrotic Syndrome D009404 11 associated lipids
Brain Ischemia D002545 89 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Seizures D012640 87 associated lipids
Peptic Ulcer D010437 19 associated lipids
Birth Weight D001724 23 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Glomerulosclerosis, Focal Segmental D005923 4 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Thromboembolism D013923 6 associated lipids
Nasal Polyps D009298 26 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Per page 10 20 50 100 | Total 293

PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

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Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
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Abdel-Halim MS et al. Identification of prostaglandin D2 as a major prostaglandin in homogenates of rat brain. 1977 Prostaglandins pmid:594367
Williams KI and Downing I Prostaglandin and thromboxane production by rat decidual microsomes. 1977 Prostaglandins pmid:594385
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Chang WC et al. Inhibition of thromboxane B2 and 6-ketoprostaglandin F1 alpha formation by anti-inflammatory drugs in carrageenin-induced granuloma. 1978 Biochem. Pharmacol. pmid:619892
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Anhut H et al. Release of 15-keto-13, 14-dihydro-thromboxane B2 and prostaglandin D2 during anaphylaxis as measured by radioimmunoassay. 1978 Naunyn Schmiedebergs Arch. Pharmacol. pmid:740052
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Agradi E et al. Influence of short term dietary supplementation of different lipids on aggregation and arachidonic acid metabolism in rabbit platelets. 1978 Prostaglandins pmid:748984
Fitzpatrick FA and Gorman RR A comparison of imidazole and 9,11-azoprosta-5,13-dienoic acid. Two selective thromboxane synthetase inhibitors. 1978 Biochim. Biophys. Acta pmid:629996
Malik KU Prostaglandin-mediated inhibition of the vasoconstrictor responses of the isolated perfused art splenic vasculature to adrenergic stimuli. 1978 Circ. Res. pmid:27321
Hamberg M et al. A method for measurement of platelet regeneration in man. 1978 Prostaglandins Med pmid:104315
Roberts LJ et al. Metabolism of thromboxane B2 in the monkey. 1978 J. Biol. Chem. pmid:97291
Mitchell MD et al. Production of thromboxane B2 by the intra-uterine tissues from late pregnant Rhesus monkeys (Macaca mulatta) in vitro. 1978 J. Endocrinol. pmid:101641
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Engineer DM et al. Modulation of slow-reacting substance of anaphylaxis and histamine release by prostacyclin and thromboxanes [proceedings]. 1978 J. Physiol. (Lond.) pmid:81301
Best LC et al. Dipyridamole and platelet function. 1978 Lancet pmid:81402
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Lagarde M et al. Impairment of platelet thromboxane A2 generation and of the platelet release reaction in two patients with congenital deficiency of platelet cyclo-oxygenase. 1978 Br. J. Haematol. pmid:205238
Crawford A et al. Rat osteogenic sarcoma cells: comparison of the effects of prostaglandins E1, E2, I2 (prostacyclin), 6-keto F1alpha and thromboxane B2 on cyclic AMP production and adenylate cyclase activity. 1978 Biochem. Biophys. Res. Commun. pmid:212039
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Boura AL and Murphy RD Thromboxane B2 inhibits prostaglandin E2 inactivation by the rat isolated perfused lung. 1978 Jul-Aug Clin. Exp. Pharmacol. Physiol. pmid:699382
Ciabattoni G et al. Characterization of furosemide-induced activation of the renal prostaglandin system. 1979 Eur. J. Pharmacol. pmid:393525
Svensson J Structure and quantitative determination of the major urinary metabolite of thromboxane B2 in the guinea pig. 1979 Prostaglandins pmid:472333
Langs DA et al. Thromboxane molecules do not adopt the prostaglandin hairpin conformation. 1979 Nature pmid:481594
Jonsson CE et al. Prostaglandins and thromboxanes in burn injury in man. 1979 Scand J Plast Reconstr Surg pmid:451477
Bailey JM et al. Anti-inflammatory drugs in experimental atherosclerosis. Part 4. Inhibition of atherosclerosis in vivo and thromboxane synthesis and platelet aggregation in vitro. 1979 Atherosclerosis pmid:454516
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Parker CW et al. Formation of thromboxane B2 and hydroxyarachidonic acids in purified human lymphocytes in the presence and absence of PHA. 1979 J. Immunol. pmid:448099
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Robinson JS et al. Prostaglandin E, thromboxane B2 and 6-oxo-prostaglandin F1 alpha in amniotic fluid and maternal plasma of rhesus monkeys (Macaca mulatta) during the latter third of gestation. 1979 J. Endocrinol. pmid:112214
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Patrono C et al. Inhibition of platelet cyclooxygenase by aspirin-like drugs: methods for in vitro and ex vivo assessment. 1979 Agents Actions Suppl. pmid:115255
Wong PY and Cheung WY Calmodulin stimulates human platelet phospholipase A2. 1979 Biochem. Biophys. Res. Commun. pmid:116656
Okuma M and Uchino H Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders. 1979 Blood pmid:116695
Best LC et al. Evidence that extracellular calcium ions inhibit thromboxane B2 biosynthesis by human platelets. 1979 Biochem. Biophys. Res. Commun. pmid:117802
Jarabak J and Fried J Comparison of substrate specificities of the human placental NAD- and NADP-linked 15-hydroxyprostaglandin dehydrogenases. 1979 Prostaglandins pmid:42948
Miura Y and Fukui N Prostaglandins as possible triggers for liver regeneration after partial hepatectomy. A review. 1979 Cell Mol Biol Incl Cyto Enzymol pmid:44483
Ford-Hutchinson AW et al. The aggregation of rat neutrophils by arachidonic acid: a possible bioassay for lipoxygenase activity. 1979 J. Pharm. Pharmacol. pmid:43380
Dembińska-Kièć A et al. Prostacyclin-dependent differences in TXA2 formation by platelets from normal and atherosclerotic rabbits. 1979 Atherosclerosis pmid:224890
Hassid A et al. Prostaglandin synthesis in isolated rat kidney glomeruli. 1979 Proc. Natl. Acad. Sci. U.S.A. pmid:286300
Le Breton GC et al. 13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor. 1979 Proc. Natl. Acad. Sci. U.S.A. pmid:291066
Chignard M et al. Arachidonate-mediated bronchoconstriction and platelet activation are inhibited by microgram doses of compound L8027 which are not selective for thromboxane synthetase. 1979 Agents Actions Suppl. pmid:291306
Peskar BA and Holland A Plasma levels of immunoreactive 15-keto-13,14-dihydro-thromboxane B2 in guinea pigs during anaphylaxis and after histamine injection. 1979 Agents Actions Suppl. pmid:294148
Kass MA and Holmberg NJ Prostaglandin and thromboxane synthesis by microsomes of rabbit ocular tissues. 1979 Invest. Ophthalmol. Vis. Sci. pmid:761971