Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Crutchley DJ et al. | Enhanced thromboxane B2 release from challenged guinea pig lung after oxygen exposure. | 1980 | Am. Rev. Respir. Dis. | pmid:6155814 |
Güllner HG et al. | Correction of increased prostacyclin production in Bartter's syndrome by indomethacin. | 1980 | Trans. Assoc. Am. Physicians | pmid:7018063 |
Salmon JA | Analysis of arachidonic acid metabolites by radioimmunoassay and physicochemical methods. | 1980 | Mater Med Pol | pmid:7019588 |
Zamecnik J et al. | Concentrations of thromboxane B2 and 6-oxo-prostaglandin F1 alpha in amniotic fluid, decidual tissue, and placenta in the later stages of pregnancy in the rat. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6990719 |
Frame MH et al. | Inhibition of acid secretion from the rat-isolated gastric mucosa by arachidonic acid and identification of major metabolites. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6990724 |
Güllner HG et al. | The principal metabolites of arachidonic acid are overproduced in Bartter's syndrome. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6892749 |
Liggins GC et al. | Production rates of prostaglandin F, 6-keto-PGF1 alpha and thromboxane B2 by perifused human endometrium. | 1980 | Prostaglandins | pmid:6892962 |
Subbiah MT and Dietemeyer D | Altered synthesis of prostaglandins in platelet and aorta from spontaneously diabetic Wistar rats. | 1980 | Biochem Med | pmid:6893150 |
Ali M and McDonald JW | Synthesis of thromboxane B2 and 6-keto-prostaglandin F1 alpha by bovine gastric mucosal and muscle microsomes. | 1980 | Prostaglandins | pmid:6893365 |
Ohuchi K et al. | Prostaglandin production by minced carrageenin granuloma tissue of rats and its inhibition by dexamethasone and cycloheximide. | 1980 | Prostaglandins Med | pmid:6893750 |
Chiabrando C et al. | Quantitative determination of 6-keto-PGF1 alpha released by rat aorta: comparison of mass fragmentography and high resolution gas chromatography with electron capture detection. | 1980 | Prostaglandins | pmid:6894036 |
Powell WS | Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica. | 1980 | Prostaglandins | pmid:6258197 |
Crutchley DJ et al. | Potentiation of thromboxane B2 release from guinea pig lung during anaphylaxis following exposure to 100% O2. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377022 |
Morris HG and Sherman NA | Prostaglandin-like substances in urine of asthmatic patients. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377024 |
Schoene NW et al. | Effects of diets varying in fat and P/S ratio on arachidonic acid metabolism in human platelets. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377026 |
Smith EF et al. | Influence of thromboxane inhibition on the severity of myocardial ischemia in cats. | 1980 | Can. J. Physiol. Pharmacol. | pmid:7378931 |
Ellwood DA et al. | Specific changes in the in vitro production of prostanoids by the ovine cervix at parturition. | 1980 | Prostaglandins | pmid:7384553 |
Lagarde M et al. | Nicergoline, an anti-aggregating agent which inhibits release of arachidonic acid from human platelet phospholipids. | 1980 | Prostaglandins | pmid:7384555 |
Patrono C et al. | Radioimmunoassay of serum thromboxane B2: a simple method of assessing pharmacologic effects on platelet function. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7386257 |
Langs DA et al. | Thromboxane molecules are not hairpin conformers. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7386281 |
Lefer AM et al. | Dissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane A2, a stable analog of thromboxane A2. | 1980 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6929517 |
Bailey JM | Essential fatty acid requirements and metabolism of cells in tissue culture. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7386288 |
Moretti RL and Lin CY | Coronary vasoconstrictor extracted from blood plasma stimulates platelet lipoxidase activity. | 1980 | Prostaglandins | pmid:6770419 |
Maggi FM et al. | Prostaglandin synthetase activity in vascular tissue of male and female rats. | 1980 | Prostaglandins | pmid:6770422 |
Feinstein MB et al. | Serine-esterase (protease) inhibitors block stimulus-induced mobilization of arachidonate in platelets. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6770602 |
Bolton HS et al. | Prostaglandin synthesis by adult heart myocytes. | 1980 | J. Mol. Cell. Cardiol. | pmid:7441771 |
Dejana E et al. | Impaired thromboxane production by newly formed platelets after aspirin administration to thrombocytopenic rats. | 1980 | Br. J. Haematol. | pmid:7448129 |
Ylikorkala O and Viinikka L | Thromboxane A2 in pregnancy and puerperium. | 1980 | Br Med J | pmid:7448530 |
Bone EA et al. | The effects of strontium and calcium ions on 5-hydroxytryptamine secretion and thromboxane B2 biosynthesis in washed human platelets. | 1980 | Biochem. Soc. Trans. | pmid:7450206 |
Mitchell MD | Prostaglandins at parturition and in the neonatal infant. | 1980 | Biochem. Soc. Trans. | pmid:7450282 |
Kent L et al. | Differential response of articular chondrocyte populations to thromboxane B2 and analogs of prostaglandin cyclic endoperoxides. | 1980 | Prostaglandins | pmid:7384546 |
Best LC et al. | The relationship between the production of thromboxane B2 and malondialdehyde by human blood platelets. | 1980 | Clin. Sci. | pmid:7190885 |
Heggers JP et al. | Histological demonstration of prostaglandins and thromboxanes in burned tissue. | 1980 | J. Surg. Res. | pmid:6987462 |
Kosaki G et al. | The mechanism of the inhibitory effect of protease inhibitors on platelet aggregation and cellular synthesis of prostaglandins. I. The effect on the release of arachidonic acid from phospholipids. | 1980 Dec 1-15 | Thromb. Res. | pmid:6785893 |
Patrono C et al. | Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects. | 1980 Feb 1-15 | Thromb. Res. | pmid:7368167 |
Koh H et al. | A radioimmunoassay of thromboxane B2 with thromboxane B2-125I-tyramide and its application to the study on the thromboxane B2 formation during platelet aggregation. | 1980 Feb 1-15 | Thromb. Res. | pmid:7368170 |
Boyd JA and Eling TE | Prostaglandin release and the interaction of platelets with the pulmonary vasculature of rat and guinea pig. | 1980 Jul 1-15 | Thromb. Res. | pmid:7003800 |
Bockman RS | Prostaglandin production by human blood monocytes and mouse peritoneal macrophages: synthesis dependent on in vitro culture conditions. | 1981 | Prostaglandins | pmid:6782622 |
Singh D et al. | Evidence for the generation of hydroxyl radical during arachidonic acid metabolism by human platelets. | 1981 | Am. J. Hematol. | pmid:6274189 |
Rittenhouse-Simmons S | Differential activation of platelet phospholipases by thrombin and ionophore A23187. | 1981 | J. Biol. Chem. | pmid:6783655 |
Galli C et al. | Differential effects of dietary fatty acids on the accumulation of arachidonic acid and its metabolic conversion through the cyclooxygenase and lipoxygenase in platelets and vascular tissue. | 1981 | Lipids | pmid:6783805 |
Rao GH et al. | Effect of Amrinone, a cardiotonic drug, on hemodynamics and platelet function. | 1981 | Prostaglandins Med | pmid:6784136 |
Smith EF and Lefer AM | Stabilization of cardiac lysosomal and cellular membranes in protection of ischemic myocardium due to coronary occlusion:efficacy of the nonsteroidal anti-inflammatory agent, naproxen. | 1981 | Am. Heart J. | pmid:7211667 |
Shaw JO et al. | Activation of rabbit platelet phospholipase and thromboxane synthesis by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor). | 1981 | Biochim. Biophys. Acta | pmid:7213765 |
Kass MA et al. | Prostaglandin and thromboxane synthesis by microsomes of inflamed rabbit ciliary body--iris. | 1981 | Invest. Ophthalmol. Vis. Sci. | pmid:7216665 |
Okamatsu S et al. | Effect of calcium channel blockers on arachidonate-induced sudden death in rabbits. | 1981 | Proc. Soc. Exp. Biol. Med. | pmid:6261265 |
Sakio H et al. | [Release of thromboxane A2 during hemorrhagic shock (author's transl)]. | 1981 | Masui | pmid:7218508 |
Rao GH et al. | Modification of human platelet response to sodium arachidonate by membrane modulation. | 1981 | Prostaglandins Med | pmid:6261286 |
Kawaguchi H et al. | Thromboxane B2 biosynthesis and phospholipids hydrolysis in platelets from hypercholesterolemic rabbits. | 1981 | Lipids | pmid:7219079 |
di Minno G et al. | Effects of any epoxymethano stable analogue of prostaglandin endoperoxides (U-46619) on human platelets. | 1981 | Thromb. Haemost. | pmid:6266066 |
Handler JS | Vasopressin-prostaglandin interactions in the regulation of epithelial cell permeability to water. | 1981 | Kidney Int. | pmid:6267350 |
Sirois P et al. | Comparative effects of leukotriene B4, prostaglandins I2 and E2, 6-keto-PGF1 alpha thromboxane B2 and histamine on selected smooth muscle preparations. | 1981 | J. Pharm. Pharmacol. | pmid:6115037 |
Best LC et al. | Strontium ions induce production of thromboxane B2 and secretion of 5-hydroxytryptamine in washed human platelets. | 1981 | Biochem. Pharmacol. | pmid:6268118 |
Webb PJ et al. | Do prostacyclin and thromboxane play a role in endotoxic shock? | 1981 | Br J Surg | pmid:7025959 |
Parks WM et al. | Comparative effect of ibuprofen on endothelial and platelet prostaglandin synthesis. | 1981 | J. Pharmacol. Exp. Ther. | pmid:7026767 |
Roy AC et al. | Effect of intravenous infusion of OKY-1581 (sodium-(E)-3-[4-(3-pyridylmethyl)phenyl] -2-methylacrylate) on circulatory thromboxane A2 and prostacyclin levels in anaesthetized baboon. | 1981 | Prostaglandins Med | pmid:7029585 |
Stuart MJ | Effect of endotoxin on arachidonic acid release and thromboxane B2 production by human platelets. | 1981 | Am. J. Hematol. | pmid:7030066 |
Dembélé-Duchesne MJ et al. | Some new prospects in the mechanism of control of arachidonate metabolism in human placenta and amnion. | 1981 | Prostaglandins | pmid:6801732 |
Cook JA et al. | Sensitization of essential fatty acid-deficient rats to endotoxin by arachidonate pretreatment: role of thromboxane A2. | 1981 | Circ. Shock | pmid:7237685 |
Lorenz R et al. | Effects of very low versus standard dose acetyl salicylic acid, dipyridamole and sulfinpyrazone on platelet function and thromboxane formation in man. | 1981 | Eur. J. Pharmacol. | pmid:7238575 |
Polley MJ et al. | Human complement in the arachidonic acid transformation pathway in platelets. | 1981 | J. Exp. Med. | pmid:7241047 |
Greenberg S et al. | Pulmonary vascular smooth muscle function in porcine splanchnic arterial occlusion shock. | 1981 | Am. J. Physiol. | pmid:7246787 |
Townsend ER et al. | Preservation of platelets during extracorporeal circulation in sheep. A comparison between aspirin and sulfinpyrazone. | 1981 | Circ. Res. | pmid:7249281 |
McCann DS et al. | Radioimmunoassay for plasma thromboxane B2. | 1981 | Clin. Chem. | pmid:7273401 |
Coker SJ et al. | Aspirin inhibits the early myocardial release of thromboxane B2 and ventricular ectopic activity following acute coronary artery occlusion in dogs. | 1981 | Br. J. Pharmacol. | pmid:7284679 |
Mahoney DA et al. | Urinary thromboxane B2 on allograft rejection. | 1981 | Lancet | pmid:6118500 |
Allen JB et al. | Irradiation decreases vascular prostacyclin formation with no concomitant effect on platelet thromboxane production. | 1981 | Lancet | pmid:6118629 |
Rifkin BR and Tai HH | Elevated thromboxane B2 levels in periodontal disease. | 1981 | J. Periodont. Res. | pmid:6453981 |
Rubenstein MD et al. | Platelet activation in clinical coronary artery disease and spasm. | 1981 | Am. Heart J. | pmid:6455912 |
Kelly KL and Laychock SG | Prostaglandin synthesis and metabolism in isolated pancreatic islets of the rat. | 1981 | Prostaglandins | pmid:6803305 |
Gilani SH and Persaud TV | Embryopathic effects of thromboxane B2 in the chick. | 1981 | Prostaglandins Med | pmid:7267828 |
Anderson CB et al. | Thromboxane-B2 and renovascular resistance during hypothermic pulsatile perfusion. | 1981 | Transplant. Proc. | pmid:7268892 |
Coker SJ et al. | Thromboxane and prostacyclin release from ischaemic myocardium in relation to arrhythmias. | 1981 | Nature | pmid:6894485 |
Bishai I and Coceani F | Transformations of prostaglandin H2 in the cat brain. | 1981 | Biochim. Biophys. Acta | pmid:6894549 |
Drake TS et al. | Peritoneal fluid thromboxane B2 and 6-keto-prostaglandin F1 alpha in endometriosis. | 1981 | Am. J. Obstet. Gynecol. | pmid:6894667 |
Halushka PV et al. | Protective effects of aspirin in endotoxic shock. | 1981 | J. Pharmacol. Exp. Ther. | pmid:6894770 |
Feuerstein N et al. | Leukotrienes C4 and D4 induce prostaglandin and thromboxane release from rat peritoneal macrophages. | 1981 | Br. J. Pharmacol. | pmid:6894882 |
Karmazyn M et al. | Comparative effects of acetylsalicylic acid (ASA) and sulfinpyrazone on isoproterenol-induced heart damage. | 1981 | J. Pharmacol. Exp. Ther. | pmid:6894943 |
Morrison AR and Benabe JE | Prostaglandins in vascular tone in experimental obstructive nephropathy. | 1981 | Kidney Int. | pmid:6894950 |
Bombardieri S et al. | The synovial prostaglandin system in chronic inflammatory arthritis: differential effects of steroidal and nonsteroidal anti-inflammatory drugs. | 1981 | Br. J. Pharmacol. | pmid:6895043 |
Harms BA et al. | Prostaglandin release and altered microvascular integrity after burn injury. | 1981 | J. Surg. Res. | pmid:6895238 |
Ylikorkala O et al. | Amniotic fluid prostacyclin and thromboxane in normal, preeclamptic, and some other complicated pregnancies. | 1981 | Am. J. Obstet. Gynecol. | pmid:6895277 |
Ishihara Y et al. | [Effect of hypoxemia and pulmonary thromboembolism on plasma levels of 6-keto PGF 1 alpha, TxB, histamine and serotonin in anesthetized dogs (author's transl)]. | 1981 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:6895531 |
Kinney EL and Demers LM | Plasma 6 keto PGE1 alpha concentration in Raynaud's phenomenon. | 1981 | Prostaglandins Med | pmid:6895673 |
Defreyn G et al. | Familial bleeding tendency with partial platelet thromboxane synthetase deficiency: reorientation of cyclic endoperoxide metabolism. | 1981 | Br. J. Haematol. | pmid:6268139 |
Barnett AH et al. | Circulating prostanoid levels, both basal and during the chlorpropamide alcohol flush, in non-insulin dependent diabetes. | 1981 | Clin. Endocrinol. (Oxf) | pmid:6895721 |
Seitz M et al. | The influence of synovial fluid from patients with rheumatoid arthritis on the proliferation of peripheral blood lymphocytes and the prostanoid release from monocytes. | 1981 | Agents Actions | pmid:7340450 |
Prancan A et al. | Platelet thromboxane production during endotoxin shock. | 1981 | Agents Actions | pmid:7340458 |
Hwang DH | Characteristics of the aggregation of platelets and the formation of prostaglandins (PGs) in rat. | 1981 | Prog. Lipid Res. | pmid:7342108 |
Agradi E et al. | In vitro effects of synthetic antioxidants and vitamin E on arachidonic acid metabolism and thromboxane formation in human platelets and on platelet aggregation. | 1981 | Prostaglandins | pmid:6794104 |
Halushka PV et al. | Increased platelet thromboxane synthesis in diabetes mellitus. | 1981 | J. Lab. Clin. Med. | pmid:7452084 |
Russell NH et al. | Platelet adenine nucleotides and arachidonic acid metabolism in the myeloproliferative disorders. | 1981 | Thromb. Res. | pmid:6794179 |
Beck N and Shaw JO | Thromboxane B2 and prostaglandin E2 in the K+-depleted rat kidney. | 1981 | Am. J. Physiol. | pmid:7468800 |
Laviolette M et al. | Human alveolar macrophages: a lesion in arachidonic acid metabolism in cigarette smokers. | 1981 | Am. Rev. Respir. Dis. | pmid:6794395 |
Grimm LJ et al. | Inhibition of platelet thromboxane synthesis by 7-(1-imidazolyl) heptanoic acid: dissociation from inhibition of aggregation. | 1981 | Thromb. Res. | pmid:6801806 |
Honn KV and Meyer J | Thromboxanes and prostacyclin: positive and negative modulators of tumor growth. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6274330 |
Worthington RE and Nakeff A | Thromboxane synthesis in megakaryocytes isolated by centrifugal elutriation. | 1981 | Blood | pmid:6786393 |
Hwang DH et al. | In vitro and in vivo effects of ethanol on the formation of endoperoxide metabolites in rat platelets. | 1981 | Lipids | pmid:6792442 |
Igarashi K et al. | Effect of polyamines on prostaglandin synthesis in various cell-free systems. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6800368 |
Landgraf-Leurs MM et al. | Aggregation and thromboxane B2 formation in platelets and vascular prostacyclin production from genetically obese rats. | 1981 | Prostaglandins | pmid:6798637 |