Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Tagari P et al. | Measurement of canine urinary thromboxanes by GC-MS and HPLC-RIA. | 1994 | Prostaglandins | pmid:8041872 |
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Lin JS et al. | The change of penile blood thromboxane B2 and prostacyclin after intracavernous injection of vasoactive drugs for the treatment of arteriogenic impotence. | 1994 | Proc. Natl. Sci. Counc. Repub. China B | pmid:8029369 |
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Ding YA et al. | Effects of long-acting propranolol and verapamil on blood pressure, platelet function, metabolic and rheological properties in hypertension. | 1994 | J Hum Hypertens | pmid:8021907 |
Dodam JR et al. | Differential effects of tumor necrosis factor-alpha and platelet-activating factor on bovine pulmonary artery endothelial cells in vitro. | 1994 Mar-Apr | Exp. Lung Res. | pmid:8020428 |
Wu YZ | [Changes in plasma TxB2 and 6-keto-PGF1 alpha in patients with retinal vein occlusion]. | 1993 | Zhonghua Yan Ke Za Zhi | pmid:8020381 |
Whitman SC et al. | n-3 fatty acid incorporation into LDL particles renders them more susceptible to oxidation in vitro but not necessarily more atherogenic in vivo. | 1994 | Arterioscler. Thromb. | pmid:8018674 |
Pallapies D et al. | Effects on platelet functions and pharmacokinetics of azapropazone and ketorolac tromethamine given as single parenteral doses. | 1994 | Br J Clin Pharmacol | pmid:8018454 |
Hansen TN and Carpenter JF | The role of platelets in chilling-induced injury. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8017779 |
Barac G | [Does thromboxane B2 influence renal blood flow? (proceedings)]. | 1978 | Arch. Int. Physiol. Biochim. | pmid:80176 |
Keith JC et al. | Ridogrel improves maternal/fetal homeostasis in an ovine model of pregnancy-induced hypertension. | 1994 | Prostaglandins | pmid:8016393 |
Rubinger D et al. | Increased thromboxane mediates the adverse renal effects of interleukin-2 in rats. | 1994 | J. Am. Soc. Nephrol. | pmid:8011980 |
Fatimi J et al. | Synthesis and inhibitory effects of 1,4,5-trialkyl-2-thioimidazole derivatives on platelet aggregation. | 1994 | Boll Chim Farm | pmid:8011274 |
Xuan B et al. | Inhibitory effect of tetrahydroberberine on platelet aggregation and thrombosis. | 1994 | Zhongguo Yao Li Xue Bao | pmid:8010106 |
Xiao D et al. | Effects of quercetin on platelet and reperfusion-induced arrhythmias in rats. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8010047 |
Nassiri M et al. | Lymphoid organ production of immunomodulatory eicosanoids in mice resistant to neonatal tolerance induction. | 1994 | Transplantation | pmid:8009599 |
Nakae H et al. | Relationship between thromboxane B2 and 6-keto-prostaglandin F1 alpha in sepsis. | 1994 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:8008979 |
Sasaki Y et al. | Effects of thromboxane A2 synthetase inhibitor (CV-4151) on reperfused skeletal muscle in rats. | 1994 | Eur Surg Res | pmid:8005166 |
Jackman BR et al. | Comparison of the effects of ketoprofen and flunixin meglumine on the in vitro response of equine peripheral blood monocytes to bacterial endotoxin. | 1994 | Can. J. Vet. Res. | pmid:8004539 |
Kasjanovová D | [Functional status of thrombocytes in men and women in younger age groups]. | 1993 | Bratisl Lek Listy | pmid:8004501 |
Kitano A et al. | Increased 11-dehydrothromboxane B2 in migraine: platelet hyperfunction in patients with migraine during headache-free period. | 1994 | Headache | pmid:8002323 |
Fuse S and Kamiya T | Plasma thromboxane B2 concentration in pulmonary hypertension associated with congenital heart disease. | 1994 | Circulation | pmid:7994842 |
Magagna A et al. | Hemodynamic and humoral effects of low-dose aspirin in treated and untreated essential hypertensive patients. | 1994 | Blood Press. | pmid:7994448 |
Kurantsin-Mills J et al. | Elevated urinary levels of thromboxane and prostacyclin metabolities in sickle cell disease reflects activated platelets in the circulation. | 1994 | Br. J. Haematol. | pmid:7993800 |
Ishibashi M et al. | Analysis of 11-dehydrothromboxane B2 in human urine improved by use of gas chromatography/high-resolution selected ion monitoring with 18O2-labelled analogue as an internal standard. | 1994 | Biol. Mass Spectrom. | pmid:7986831 |
Nagao T et al. | Effect of DP-1904, a thromboxane A2 synthetase inhibitor, on crescentic nephritis in rats. | 1994 | Eur. J. Pharmacol. | pmid:7982449 |
Imai T et al. | [Effects of platelet activating factor on release of thromboxane B2 from human granulocytes and platelets]. | 1994 | Arerugi | pmid:7980021 |
Cudd TA and Wood CE | Thromboxane A2 receptor antagonism prevents hormonal and cardiovascular responses to mineral acid infusion. | 1994 | Am. J. Physiol. | pmid:7977850 |
Blair IA et al. | Dietary stearic acid and thromboxane-prostacyclin biosynthesis in normal human subjects. | 1994 | Am. J. Clin. Nutr. | pmid:7977150 |
Nosál R et al. | Antihistaminic drug bromadryl and stimulated platelet aggregation. | 1994 | Agents Actions | pmid:7976789 |
Zhang QZ et al. | Effects of cyproheptadine on TXB2 and 6-keto-PGF1 alpha plasma levels in rabbits with hemorrhagic shock. | 1994 | Zhongguo Yao Li Xue Bao | pmid:7976376 |
Qiang WA et al. | [Antimetastatic action of polyactin A and its mechanism]. | 1994 | Yao Xue Xue Bao | pmid:7976351 |
Mazzarella G et al. | Protective effects of nedocromil sodium on cellular and biohumoral components present in the bronchial alveolar lavage fluid and in peripheral blood in atopic asthmatics. | 1994 | Respiration | pmid:7973106 |
Myers SI et al. | Increased intragallbladder pressure stimulates gallbladder eicosanoid release. | 1994 | Prostaglandins | pmid:7972880 |
Pape HC et al. | Does the reamer type influence the degree of lung dysfunction after femoral nailing following severe trauma? An animal study. | 1994 | J Orthop Trauma | pmid:7965291 |
Clinkenbeard KD et al. | Pasteurella haemolytica leukotoxin-induced synthesis of eicosanoids by bovine neutrophils in vitro. | 1994 | J. Leukoc. Biol. | pmid:7964171 |
Koike H et al. | [Studies on prostaglandin production relating to the mechanism of dysmenorrhea in endometriosis]. | 1994 | Nihon Naibunpi Gakkai Zasshi | pmid:7958083 |
van der Weiden RM et al. | Prostanoid levels in in vitro fertilization culture medium are not related to the likelihood of implantation. | 1994 | Fertil. Steril. | pmid:7957987 |
Kawamori R et al. | Platelet activation in diabetic patients with asymptomatic atherosclerosis. | 1994 | Diabetes Res. Clin. Pract. | pmid:7956714 |
Neiman J et al. | Increased urinary excretion of a major thromboxane metabolite in early alcohol withdrawal. | 1994 | Clin Physiol | pmid:7955938 |
Friedman M et al. | Parameters of pulmonary injury after total or partial cardiopulmonary bypass. | 1994 | Circulation | pmid:7955263 |
P'eng FK et al. | Pulmonary edema and rapid transfusion: the comparison between rapid intravenous and intraarterial infusion in the severely hemorrhagic anesthesized pigs. | 1994 | Zhonghua Yi Xue Za Zhi (Taipei) | pmid:7954050 |
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Imai Y et al. | Inflammatory chemical mediators during conventional ventilation and during high frequency oscillatory ventilation. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:7952613 |
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Shen D and Wang Y | Effects of hypoxia on platelet activation in pilots. | 1994 | Aviat Space Environ Med | pmid:7945133 |
Ito BR and Del Balzo U | Effect of platelet depletion and inhibition of platelet cyclooxygenase on C5a-mediated myocardial ischemia. | 1994 | Am. J. Physiol. | pmid:7943373 |
Geisel J et al. | Endotoxin tolerance is associated with decreased prostaglandin H synthases-1 and -2. | 1994 | Am. J. Physiol. | pmid:7943269 |
Monga M et al. | Cocaine alters placental production of thromboxane and prostacyclin. | 1994 | Am. J. Obstet. Gynecol. | pmid:7943110 |
Dabaghi SF et al. | Effects of low-dose aspirin on in vitro platelet aggregation in the early minutes after ingestion in normal subjects. | 1994 | Am. J. Cardiol. | pmid:7942533 |
Quereda C et al. | Urinary thromboxane B2 and cyclic AMP in cyclosporine-A-treated kidney transplantation. | 1994 | Transplant. Proc. | pmid:7940810 |
Kim YI et al. | Hepatoprotection by a PGI2 analogue in complete warm ischemia of the pig liver. Prostanoid release from the reperfused liver. | 1994 | Transplantation | pmid:7940729 |
Boeri N et al. | Influence of a 12-hour, 22 degrees C holding period for buffy coats on the preparation of platelet concentrates stored in plasma. | 1994 | Transfusion | pmid:7940660 |
Hanazaki K et al. | Protective effect of the thromboxane A2 receptor antagonist ONO 3708 on ischemia-reperfusion injury in the dog liver. | 1994 | Surgery | pmid:7940195 |
Chiabrando C et al. | Urinary excretion of 2,3-dinor-thromboxane B1, a major metabolite of thromboxane B2 in the rat. | 1994 | Prostaglandins | pmid:7938613 |
Turi S et al. | Laser aggregometer studies, ATP release and thromboxane B2 release and cAMP concentration of the platelets in nephrotic syndrome. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7938102 |
Yanagisawa H et al. | Dietary protein restriction in isolated glomeruli from rats with bilateral ureteral obstruction. | 1994 | Kidney Int. | pmid:7933843 |
King JN | Correlation between the pharmacokinetics of oxindanac and inhibition of serum thromboxane B2 in calves. | 1994 | J. Vet. Pharmacol. Ther. | pmid:7933057 |
King JN et al. | High performance liquid chromatography and pharmacokinetics of the non-steroidal anti-inflammatory drug oxindanac in calves. | 1994 | J. Vet. Pharmacol. Ther. | pmid:7933056 |
Cozzi P et al. | Agents combining thromboxane receptor antagonism with thromboxane synthase inhibition: [[[2-(1H-imidazol-1-yl)ethylidene]amino]oxy]alkanoic acids. | 1994 | J. Med. Chem. | pmid:7932586 |
Walmrath D et al. | Endotoxin "priming" potentiates lung vascular abnormalities in response to Escherichia coli hemolysin: an example of synergism between endo- and exotoxin. | 1994 | J. Exp. Med. | pmid:7931076 |
Földes-Filep E et al. | Pulmonary surfactant lipids inhibit prostanoid production of guinea pig alveolar macrophages. | 1994 | J. Leukoc. Biol. | pmid:7930944 |
Clohisy JC et al. | Prostanoid-induced expression of matrix metalloproteinase-1 messenger ribonucleic acid in rat osteosarcoma cells. | 1994 | Endocrinology | pmid:7925106 |
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Tohjima T et al. | In vitro effects of trapidil on fatty acid and prostaglandin metabolism in platelets. | 1994 May-Jun | Clin Ther | pmid:7923307 |
Wu CC et al. | Antiplatelet effects of clausine-D isolated from Clausena excavata. | 1994 | Biochim. Biophys. Acta | pmid:7918571 |
Chiang MT et al. | Lipoprotein, lecithin:cholesterol acyl transferase and acetyl CoA carboxylase in stroke-prone spontaneously hypertensive rats fed a diet high in eicosapentaenoic acid. | 1994 | Atherosclerosis | pmid:7912508 |
Arimura A et al. | Contribution of thromboxane A2 to the antigen-induced immediate asthmatic response mediated by IgG1 antibody by augmentation of bronchial responsiveness in guinea-pigs. | 1994 | Br. J. Pharmacol. | pmid:7912155 |
D'Argenio G et al. | Butyrate, mesalamine, and factor XIII in experimental colitis in the rat: effects on transglutaminase activity. | 1994 | Gastroenterology | pmid:7905450 |
Fletcher MP et al. | C5a-induced myocardial ischemia: role for CD18-dependent PMN localization and PMN-platelet interactions. | 1993 | Am. J. Physiol. | pmid:7902015 |
Saldeen P et al. | Lack of association between Doppler velocimetry and synthesis of prostacyclin and thromboxane in umbilical cord vessels from growth retarded fetuses. | 1995 | Acta Obstet Gynecol Scand | pmid:7900504 |
Takeuchi K et al. | Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition--I. Synthesis, structure-activity relationship, and evaluation of substituted omega-phenyl-omega-(3-pyridyl)alkenoic acids. | 1994 | Bioorg. Med. Chem. | pmid:7894968 |
Stratton MD et al. | The effect of Clostridium difficile toxin on colonocyte prostanoid activity. | 1994 | Prostaglandins | pmid:7892508 |
Hsyu PH et al. | Pharmacokinetics and cyclooxygenase inhibition of itazigrel in normal volunteers after single oral doses. | 1994 | J Pharm Sci | pmid:7891305 |
Haugen G et al. | Effect of phenazone (antipyrine) on the prostanoid formation in human umbilical arteries perfused in vitro. | 1995 | Gynecol. Obstet. Invest. | pmid:7890260 |
Hatori N et al. | Biocompatibility of heparin-coated membrane oxygenator during cardiopulmonary bypass. | 1994 | Artif Organs | pmid:7887827 |
Singh HP et al. | Prostacyclin and thromboxane levels in pleural space fluid during cardiopulmonary bypass. | 1995 | Ann. Thorac. Surg. | pmid:7887705 |