Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Winter M et al. | Synthesis of thromboxane B2 in uraemia and the effects of dialysis. | 1983 | Thromb. Res. | pmid:6868024 |
Stegmeier K et al. | The pharmacological profile of the thromboxane A2 antagonist BM 13.177. A new anti-platelet and anti-thrombotic drug. | 1984 | Thromb. Res. | pmid:6385334 |
Gerrard JM et al. | Studies in patients with bleeding disorders show that platelet-vessel interaction is important for thromboxane formation in bleeding time wounds. | 1990 | Thromb. Res. | pmid:2278038 |
Wang JP et al. | Antiplatelet effect of capsaicin. | 1984 | Thromb. Res. | pmid:6528310 |
Buchanan MR et al. | The sex-related differences in aspirin pharmacokinetics in rabbits and man and its relationship to antiplatelet effects. | 1983 | Thromb. Res. | pmid:6221436 |
Best LC et al. | Mode of action of dipyridamole on human platelets. | 1979 | Thromb. Res. | pmid:229583 |
Maderna P et al. | Differential effects of oral administrations to human volunteers of acetylsalicylic acid, sodium salicylate and indomethacin on 12-hydroxyeicosatetraenoic acid formation by stimulated platelets. | 1988 | Thromb. Res. | pmid:3194896 |
Li C et al. | Aspirin response variability after major orthopedic surgery. | 2012 | Thromb. Res. | pmid:22575418 |
Pirich C et al. | Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. | 1999 | Thromb. Res. | pmid:10588465 |
De Caterina R et al. | Inhibition of platelet aggregation and thromboxane B2 production during aspirin treatment: dependence on the dose of the aggregating agent. | 1985 | Thromb. Res. | pmid:3975876 |
Worthington RE and Fuller GC | Dibutyryl cyclic guanosine monophosphate elevates bovine endothelial cell thromboxane production without affecting prostacyclin metabolism. | 1984 | Thromb. Res. | pmid:6322377 |
Yamaguchi A et al. | Effect of cetiedil on platelet aggregation and thromboxane synthesis. | 1985 | Thromb. Res. | pmid:2986312 |
Mogensen F et al. | Effect of specific thromboxane-synthetase inhibition on thromboxane and prostaglandin synthesis in stable angina induced by exercise test. | 1985 | Thromb. Res. | pmid:4038824 |
Lukaszyk A et al. | Does acute experimental pancreatitis affect blood platelet function? | 1989 | Thromb. Res. | pmid:2524119 |
Best LC et al. | The interrelationship between thromboxane biosynthesis, aggregation and 5-hydroxytryptamine secretion in human platelets in vitro. | 1980 | Thromb. Haemost. | pmid:6773171 |
Greer IA et al. | A comparative study of the effects of adrenoceptor antagonists on platelet aggregation and thromboxane generation. | 1985 | Thromb. Haemost. | pmid:2867620 |
Joseph S et al. | Effect of the polyamine-spermine on agonist-induced human platelet activation--specific inhibition of "aggregation-independent" events induced by thrombin, but not by collagen, thromboxane mimetic, phorbol ester or calcium ionophore. | 1987 | Thromb. Haemost. | pmid:3110996 |
di Minno G et al. | Effects of any epoxymethano stable analogue of prostaglandin endoperoxides (U-46619) on human platelets. | 1981 | Thromb. Haemost. | pmid:6266066 |
Pampolina C and McNicol A | Streptococcus sanguis-induced platelet activation involves two waves of tyrosine phosphorylation mediated by FcgammaRIIA and alphaIIbbeta3. | 2005 | Thromb. Haemost. | pmid:15886812 |
Strano A et al. | Platelet sensitivity to prostacyclin and thromboxane production in hyperlipidemic patients. | 1982 | Thromb. Haemost. | pmid:6753232 |
Hansen JB et al. | The effect of lipopolysaccharides (LPS) on generation of thromboxane A2 and thromboplastin activity in whole blood of males, females and females on oral contraceptives. | 1989 | Thromb. Haemost. | pmid:2799762 |
Swartz SL and Moore TJ | Effect of angiotensin II on collagen-induced platelet activation in normotensive subjects. | 1990 | Thromb. Haemost. | pmid:2339363 |
Siess W et al. | Stimulated platelet aggregation, thromboxane B2 formation and platelet sensitivity to prostacyclin - a critical evaluation. | 1981 | Thromb. Haemost. | pmid:7025338 |
Watanabe J et al. | Effect of vitamin E on platelet aggregation in diabetes mellitus. | 1984 | Thromb. Haemost. | pmid:6495252 |
Matsumoto M et al. | Thromboxane generation in patients with essential hypertension or cerebrovascular disease and effect of oral aspirin. | 1980 | Thromb. Haemost. | pmid:7423441 |
Carter AJ et al. | A comparison of human pulmonary arterial and venous prostacyclin and thromboxane synthesis--effect of a thromboxane synthase inhibitor. | 1984 | Thromb. Haemost. | pmid:6377567 |
Spectre G et al. | Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications. | 2011 | Thromb. Haemost. | pmid:21800009 |
Honey AC et al. | Effect of indomethacin and dazoxiben on intravascular platelet aggregation in the anaesthetized rabbit. | 1986 | Thromb. Haemost. | pmid:3775692 |
Kyrle PA et al. | Investigation of the interaction of blood platelets with the coagulation system at the site of plug formation in vivo in man--effect of low-dose aspirin. | 1987 | Thromb. Haemost. | pmid:2954260 |
Krishnamurthi S et al. | Effect of pyridoxal 5'-phosphate (PALP) on human platelet aggregation, dense granule release and thromboxane B2 generation--role of Schiff base formation. | 1982 | Thromb. Haemost. | pmid:6891107 |
Essien EM et al. | Blood changes and enhanced thromboxane and 6-keto prostaglandin F1 alpha production in experimental acute Plasmodium bergei infection in hamsters. | 1984 | Thromb. Haemost. | pmid:6388013 |
Chen SL et al. | Chlorobutanol, a preservative of desmopressin, inhibits human platelet aggregation and release in vitro. | 1990 | Thromb. Haemost. | pmid:2096493 |
Martinuzzo ME et al. | Antiphospholipid antibodies enhance thrombin-induced platelet activation and thromboxane formation. | 1993 | Thromb. Haemost. | pmid:8115993 |
Kyrle PA et al. | Thromboxane A2 and prostacyclin generation in the microvasculature of patients with atherosclerosis--effect of low-dose aspirin. | 1989 | Thromb. Haemost. | pmid:2508252 |
Stratta P et al. | Warning: platelet factor 4, beta-thromboglobulin and thromboxane in donor's plasma units. | 1983 | Thromb. Haemost. | pmid:6189235 |
Larson MK et al. | Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects. | 2008 | Thromb. Haemost. | pmid:18841286 |
Wang WJ and Huang TF | A novel tetrameric venom protein, agglucetin from Agkistrodon acutus, acts as a glycoprotein Ib agonist. | 2001 | Thromb. Haemost. | pmid:11686327 |
Jackson C et al. | DN 9693: a phosphodiesterase inhibitor with a platelet membrane effect. | 1989 | Thromb. Haemost. | pmid:2546286 |
Davì G et al. | Increased thromboxane metabolites excretion in liver cirrhosis. | 1998 | Thromb. Haemost. | pmid:9569186 |
Sheu JR et al. | Mechanisms involved in the antiplatelet activity of Staphylococcus aureus lipoteichoic acid in human platelets. | 2000 | Thromb. Haemost. | pmid:10823277 |
Crescente M et al. | Gallic acid, a dietary polyphenolic component, blunts the inhibition of platelet COX-1 by aspirin: preliminary in-vitro findings. | 2007 | Thromb. Haemost. | pmid:17549313 |
Landolfi R et al. | Effects of unfractionated and low molecular weight heparins on platelet thromboxane biosynthesis "in vivo". | 1994 | Thromb. Haemost. | pmid:7740468 |
Undas A et al. | Lack of aspirin-induced decrease in thrombin formation in subjects resistant to aspirin. | 2007 | Thromb. Haemost. | pmid:17549314 |
Perneby C et al. | Dose- and time-dependent antiplatelet effects of aspirin. | 2006 | Thromb. Haemost. | pmid:16601836 |
Eldor A et al. | Effects of dipyrone on prostaglandin production by human platelets and cultured bovine aortic endothelial cells. | 1983 | Thromb. Haemost. | pmid:6346571 |
Menys VC and Davies JA | Selective inhibition of thromboxane synthetase with dazoxiben - basis of its inhibitory effect on platelet adhesion. | 1983 | Thromb. Haemost. | pmid:6346575 |
Hampton KK et al. | Coagulation, fibrinolytic and platelet function in patients on long-term therapy with aspirin 300 mg or 1,200 mg daily compared with placebo. | 1990 | Thromb. Haemost. | pmid:2073296 |
Vejar M et al. | Dissociation of platelet activation and spontaneous myocardial ischemia in unstable angina. | 1990 | Thromb. Haemost. | pmid:2363117 |
Foo LC et al. | Platelets of habitual smokers have reduced susceptibility to aggregating agent. | 1991 | Thromb. Haemost. | pmid:2048056 |
Dragani A et al. | Oxidative stress and platelet activation in subjects with moderate hyperhomocysteinaemia due to MTHFR 677 C→T polymorphism. | 2012 | Thromb. Haemost. | pmid:22782530 |
Gordge MP et al. | Platelet function and the bleeding time in progressive renal failure. | 1988 | Thromb. Haemost. | pmid:3187950 |
D'Angelo A et al. | Effect of des-amino-D-arginine vasopressin (DDAVP) on plasma levels of platelet and endothelial cell release products. | 1983 | Thromb. Haemost. | pmid:6687766 |
Vezza R et al. | Antivasoconstrictor and antiaggregatory activities of picotamide unrelated to thromboxane A2 antagonism. | 1997 | Thromb. Haemost. | pmid:9408024 |
Lessiani G et al. | Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of iloprost. | 2011 | Thromb. Haemost. | pmid:21103664 |
Greer IA et al. | Platelet activation in allergic asthma. | 1985 | Thromb. Haemost. | pmid:2931855 |
Hohlfeld T et al. | Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia. | 1994 | Thromb. Haemost. | pmid:7513092 |
Han P et al. | Verapamil and collagen-induced platelet reactions--evidence for a role for intracellular calcium in platelet activation. | 1983 | Thromb. Haemost. | pmid:6415847 |
Guthikonda S et al. | Increased platelet sensitivity among individuals with aspirin resistance - platelet aggregation to submaximal concentration of arachidonic acid predicts response to antiplatelet therapy. | 2008 | Thromb. Haemost. | pmid:18612542 |
Gresele P et al. | Platelet activation markers in patients with peripheral arterial disease--a prospective comparison of different platelet function tests. | 1997 | Thromb. Haemost. | pmid:9423790 |
Naesh O et al. | Platelet function in surgical stress. | 1985 | Thromb. Haemost. | pmid:2935969 |
Davì G et al. | The effect of two low doses of aspirin on whole blood thromboxane and prostacyclin generation in healthy subjects. | 1983 | Thromb. Haemost. | pmid:6417815 |
Michelson AD et al. | Reversible inhibition of human platelet activation by hypothermia in vivo and in vitro. | 1994 | Thromb. Haemost. | pmid:7522354 |
Dale J et al. | The effect of a thromboxane synthetase inhibitor, dazoxiben, and acetylsalicylic acid on platelet function and prostaglandin metabolism. | 1983 | Thromb. Haemost. | pmid:6689091 |
Bar J et al. | The regulation of platelet aggregation in vitro by interleukin-1beta and tumor necrosis factor-alpha: changes in pregnancy and in pre-eclampsia. | 1997 | Thromb. Haemost. | pmid:9364994 |
Wang JS et al. | Effect of strenuous arm exercise on oxidized-LDL-potentiated platelet activation in individuals with spinal cord injury. | 2000 | Thromb. Haemost. | pmid:10928481 |
Subbiah MT et al. | Studies of aggregation and thromboxane B2 synthesis in avian thrombocytes: comparison between atherosclerosis-susceptible and resistant breeds. | 1980 | Thromb. Haemost. | pmid:7455983 |
Zahavi M et al. | Abnormal typical pattern of platelet function and thromboxane generation in unstable angina. | 1989 | Thromb. Haemost. | pmid:2531938 |
Halawani SH et al. | Aspirin failure in patients presenting with acute cerebrovascular ischaemia. | 2011 | Thromb. Haemost. | pmid:21544317 |
Connellan JM et al. | Investigation of alternative mechanisms of collagen-induced platelet activation by using monoclonal antibodies to glycoprotein IIb-IIIa and fibrinogen. | 1986 | Thromb. Haemost. | pmid:2940722 |
Patrono C et al. | Characterization of biochemical and functional effects of antiplatelet drugs as a key to their clinical development. | 1995 | Thromb. Haemost. | pmid:8578493 |
Cortellaro M et al. | Transcoronary platelet thromboxane A2 formation without platelet trapping in patients with coronary stenosis-effect of sulphinpyrazone treatment. | 1983 | Thromb. Haemost. | pmid:6665767 |
Falcon CR et al. | The in vitro production of thromboxane B2 by platelets of diabetic patients is normal at physiological concentrations of ionized calcium. | 1993 | Thromb. Haemost. | pmid:8259535 |
Larsen SB et al. | Increased platelet aggregation and serum thromboxane levels in aspirin-treated patients with prior myocardial infarction. | 2012 | Thromb. Haemost. | pmid:22534977 |
Fruzzetti F et al. | Platelet-vessel wall interactions with third-generation oral contraceptives: no evidence of detrimental effects. | 1999 | Thromb. Haemost. | pmid:10494782 |
Fimognari FL et al. | Nocturnal rise of urinary thromboxane B 2 in patients with coronary artery disease. | 2005 | Thromb. Haemost. | pmid:15735822 |
de Castellarnau C et al. | Prostacyclin and thromboxane production by autogenous femoral veins grafted into the arterial circulation of the dog. | 1989 | Thromb. Haemost. | pmid:2665174 |
Davì G et al. | Demonstration of Rickettsia Conorii-induced coagulative and platelet activation in vivo in patients with Mediterranean spotted fever. | 1995 | Thromb. Haemost. | pmid:8584998 |
Habib A et al. | Increased expression of inducible cyclooxygenase-2 in human endothelial cells by antiphospholipid antibodies. | 1995 | Thromb. Haemost. | pmid:8585020 |
Zahavi J and Zahavi M | Enhanced platelet release reaction, shortened platelet survival time and increased platelet aggregation and plasma thromboxane B2 in chronic obstructive arterial disease. | 1985 | Thromb. Haemost. | pmid:3158092 |
Evangelista V et al. | Defibrotide inhibits platelet activation by cathepsin G released from stimulated polymorphonuclear leukocytes. | 1992 | Thromb. Haemost. | pmid:1509406 |
Etulain J et al. | Acidosis downregulates platelet haemostatic functions and promotes neutrophil proinflammatory responses mediated by platelets. | 2012 | Thromb. Haemost. | pmid:22159527 |
Rocca B et al. | Increased thromboxane biosynthesis in essential thrombocythemia. | 1995 | Thromb. Haemost. | pmid:8607099 |
Pettinella C et al. | Cyclooxygenase-1 haplotype C50T/A-842G does not affect platelet response to aspirin. | 2009 | Thromb. Haemost. | pmid:19350112 |
Korbut R et al. | On the mechanism of thrombolytic action of thromboxane synthetase inhibitors. | 1987 | Thromb. Haemost. | pmid:3324381 |
Huang TF et al. | Mechanism of action of a potent antiplatelet peptide, triflavin from Trimeresurus flavoviridis snake venom. | 1991 | Thromb. Haemost. | pmid:1665595 |
Totani L et al. | Prasugrel inhibits platelet-leukocyte interaction and reduces inflammatory markers in a model of endotoxic shock in the mouse. | 2012 | Thromb. Haemost. | pmid:22436970 |
Véricel E et al. | Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. | 2015 | Thromb. Haemost. | pmid:25832443 |
Kyrle PA et al. | Evidence for an increased generation of prostacyclin in the microvasculature and an impairment of the platelet alpha-granule release in chronic renal failure. | 1988 | Thromb. Haemost. | pmid:2975407 |
Hillbom M et al. | Platelet thromboxane formation and bleeding time is influenced by ethanol withdrawal but not by cigarette smoking. | 1985 | Thromb. Haemost. | pmid:4049313 |
Aoki T et al. | Difference of (Ca2+)i movements in platelets stimulated by thrombin and TRAP: the involvement of alpha(IIb)beta3-mediated TXA2 synthesis. | 1998 | Thromb. Haemost. | pmid:9657446 |
McMahon GS et al. | Transient heparin-induced platelet activation linked to generation of platelet 12-lipoxygenase. Findings from a randomised controlled trial. | 2013 | Thromb. Haemost. | pmid:23494053 |
Larsen SB et al. | Reduced antiplatelet effect of aspirin is associated with low-grade inflammation in patients with coronary artery disease. | 2013 | Thromb. Haemost. | pmid:23407706 |
Dotevall A et al. | Cigarette smoking increases thromboxane A2 formation without affecting platelet survival in young healthy females. | 1992 | Thromb. Haemost. | pmid:1455405 |
De Caterina R et al. | Benefit/risk profile of combined antiplatelet therapy with ticlopidine and aspirin. | 1991 | Thromb. Haemost. | pmid:1871711 |
De Caterina R et al. | Equal antiplatelet effects of aspirin 50 or 324 mg/day in patients after acute myocardial infarction. | 1985 | Thromb. Haemost. | pmid:4082090 |
Davì G et al. | Influence of metabolic control on thromboxane biosynthesis and plasma plasminogen activator inhibitor type-1 in non-insulin-dependent diabetes mellitus. | 1996 | Thromb. Haemost. | pmid:8819248 |
Ding YA et al. | Potentiation of adrenaline-induced platelet aggregation by angiotensin II. | 1985 | Thromb. Haemost. | pmid:4089801 |
Forastiero R et al. | Anti-beta2 glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: association with increased excretion of platelet-derived thromboxane urinary metabolites. | 1998 | Thromb. Haemost. | pmid:9459320 |
Carter AJ and Hanley SP | The effect of platelet number and haematocrit on whole blood thromboxane synthesis. | 1985 | Thromb. Haemost. | pmid:4024033 |
Butler KD et al. | The effects of modulation of prostanoid metabolism on the thoracic platelet accumulation induced by intravenous administration of collagen in the guinea-pig. | 1986 | Thromb. Haemost. | pmid:3105104 |