Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Qvist R and Larkins RG | Diminished production of thromboxane B2 and prostaglandin E by stimulated polymorphonuclear leukocytes from insulin-treated diabetic subjects. | 1983 | Diabetes | pmid:6345241 |
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Eldor A et al. | Effects of dipyrone on prostaglandin production by human platelets and cultured bovine aortic endothelial cells. | 1983 | Thromb. Haemost. | pmid:6346571 |
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Aznavoorian SA et al. | Prostacyclin inhibits 5-hydroxytryptamine release but stimulates thromboxane synthesis during cardiopulmonary bypass. | 1983 | Prostaglandins | pmid:6348886 |
Buchanan MR et al. | The sex-related differences in aspirin pharmacokinetics in rabbits and man and its relationship to antiplatelet effects. | 1983 | Thromb. Res. | pmid:6221436 |
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Kawaguchi H | Thromboxane synthesis in hypercholesterolemic platelets--on the mechanism of increased thromboxane synthesis. | 1983 | Hokkaido Igaku Zasshi | pmid:6618425 |
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FitzGerald GA et al. | Aspirin inhibits endogenous prostacyclin and thromboxane biosynthesis in man. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221534 |
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van der Giessen WJ et al. | Acute effect of cigarette smoking on cardiac prostaglandin synthesis and platelet behavior in patients with coronary heart disease. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221546 |
Nuotto E et al. | Effect of acetylsalicylic acid on plasma thromboxane B2 and platelet aggregation in man. | 1983 | Eur. J. Clin. Pharmacol. | pmid:6628518 |
Bach MK et al. | In vivo and in vitro actions of a new selective inhibitor of leukotriene C and D synthesis. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221551 |
Grose JH et al. | Imbalanced prostacyclin and thromboxane A2 production in essential hypertension. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221555 |
Hornych A et al. | Thromboxane B2 in borderline and essential hypertension. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221556 |
MacIntyre DE et al. | Role of endogenous arachidonate metabolites in phospholipid-induced human platelet activation. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221557 |
Kiff PS et al. | Haemodynamic and metabolic effects of dazoxiben at rest and during atrial pacing. | 1983 | Br J Clin Pharmacol | pmid:6681708 |
Hutton I et al. | Effects of dazoxiben on transcardiac thromboxane levels and haemodynamics in coronary heart disease. | 1983 | Br J Clin Pharmacol | pmid:6681709 |
Zijlstra FJ et al. | Thrombotic thrombocytopenic purpura and plasma thromboxane B2 levels. | 1983 | Thromb. Res. | pmid:6684333 |
Abiko Y et al. | The stimulation of macrophage prostaglandin E2 and thromboxane B2 secretion by Streptococcus mutans insoluble glucans. | 1983 | FEBS Lett. | pmid:6403385 |
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Gordon PR et al. | Platelet arachidonate metabolism and platelet function in zinc-deficient rats. | 1983 | J. Nutr. | pmid:6403678 |
Okegawa T et al. | Endotoxin induces chronic prostaglandin and thromboxane synthesis from ureter-obstructed kidneys: role of inflammatory cells. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6403696 |
Han P et al. | Verapamil and collagen-induced platelet reactions--evidence for a role for intracellular calcium in platelet activation. | 1983 | Thromb. Haemost. | pmid:6415847 |
Barnhart MI et al. | DDAVP: does the drug have a direct effect on the vessel wall? | 1983 | Thromb. Res. | pmid:6415852 |
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Gurtner GH et al. | Oxidant- and lipid-induced pulmonary vasoconstriction mediated by arachidonic acid metabolites. | 1983 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6688802 |
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McDonald JW and Ali M | Recovery of cyclooxygenase activity after aspirin in populations of platelets separated on stractan density gradients. | 1983 | Prostaglandins Leukot Med | pmid:6419234 |
Zijlstra FJ and Vincent JE | Comparison of the determination of thromboxane A2 by bioassay on the rabbit mesenteric artery and in the form of TxB2 by radioimmunoassay. | 1983 | J Pharmacol Methods | pmid:6632924 |
Bryant RW and Hwang DH | Development of a radioimmunoassay for 15-HETE and its application to 15-HETE production by reticulocytes. | 1983 | Prostaglandins | pmid:6419285 |
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Chong KP et al. | Vasopressin stimulates thromboxane synthesis in isolated hamster hepatocytes: relation to hepatocyte calcium content. | 1983 | Prostaglandins | pmid:6419286 |
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Zipser RD et al. | Urinary thromboxane B2 and prostaglandin E2 in the hepatorenal syndrome: evidence for increased vasoconstrictor and decreased vasodilator factors. | 1983 | Gastroenterology | pmid:6572162 |
Schenkelaars EJ and Bonta IL | Effect of leukotriene C4 on the release of secretory products by elicited populations of rat peritoneal macrophages. | 1983 | Eur. J. Pharmacol. | pmid:6572592 |
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Ouwendijk RJ et al. | Raised plasma thromboxane B2 levels in alcoholic liver disease. | 1983 | Prostaglandins Leukot Med | pmid:6573682 |
Hornych A et al. | Thromboxane B2 in borderline and essential hypertensive patients. | 1983 | Prostaglandins Leukot Med | pmid:6573683 |
Flynn JT et al. | Effects of anesthesia and surgery on prostanoid concentrations in plasma and pulmonary lymph. | 1983 | Prostaglandins Leukot Med | pmid:6573688 |
Patel K and Bakhle YS | Thromboxane B2 (TxB2) metabolism in rat isolated lung and its inhibition by drugs. | 1983 | Prostaglandins Leukot Med | pmid:6573689 |
Davì G et al. | Plasmatic TXB2 and 6-keto-PGF1 alpha levels during charcoal hemoperfusion in chronic renal failure patients. | 1983 | Prostaglandins Leukot Med | pmid:6573692 |
Lieb J et al. | Elevated levels of prostaglandin E2 and thromboxane B2 in depression. | 1983 | Prostaglandins Leukot Med | pmid:6574523 |
Okahara T et al. | Zonal heterogeneity of prostaglandin and thromboxane release in the dog kidney. | 1983 | Prostaglandins | pmid:6575405 |
Hoult JR and Robinson C | Selective inhibition of thromboxane B2 accumulation and metabolism in perfused guinea-pig lung. | 1983 | Br. J. Pharmacol. | pmid:6824820 |
Hirsh PD et al. | Effects of provocation on transcardiac thromboxane in patients with coronary artery disease. | 1983 | Am. J. Cardiol. | pmid:6829431 |
Walinsky P et al. | Beneficial effects of ibuprofen in pacing-induced myocardial ischemia. | 1983 | Am. J. Cardiol. | pmid:6829434 |
Gimenez T et al. | Fetal-maternal secretion of prostaglandins in the cow. | 1983 | Prostaglandins | pmid:6576447 |
Butler RR et al. | Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6339712 |
Laitinen O et al. | Plasma levels and urinary excretion of prostaglandins in patients with rheumatoid arthritis. | 1983 | Clin. Rheumatol. | pmid:6589104 |
Ouwendijk RJ et al. | Raised plasma levels of thromboxane B2 in systemic mastocytosis. | 1983 | Eur. J. Clin. Invest. | pmid:6409646 |
Snapper JR et al. | Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep. | 1983 | J. Clin. Invest. | pmid:6409930 |