Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Nassiri M et al. | Lymphoid organ production of immunomodulatory eicosanoids in mice resistant to neonatal tolerance induction. | 1994 | Transplantation | pmid:8009599 |
Ogata K et al. | Attenuation of ischemia and reperfusion injury of canine livers by inhibition of type II phospholipase A2 with LY329722. | 2001 | Transplantation | pmid:11374398 |
Lane NJ et al. | Inhibition of leukotriene B4 synthesis does not prevent development of acute renal failure following storage and transplantation. | 1994 | Transplantation | pmid:7809921 |
Ramos E et al. | The impact of arterialization on prostanoid generation after liver transplantation in the rat. | 1994 | Transplantation | pmid:8042232 |
Garvin PJ et al. | Evaluation of the thromboxane A2 synthetase inhibitor OKY-046 in a warm ischemia-reperfusion rat model. | 1996 | Transplantation | pmid:8633364 |
Khirabadi BS et al. | Urine immunoreactive thromboxane B2 in rat cardiac allograft rejection. | 1985 | Transplantation | pmid:3880966 |
Gladue RP and Newborg MF | The protective effects of the thromboxane synthetase inhibitor Dazmegrel on nephrotoxicity in cyclosporine-treated rats. | 1991 | Transplantation | pmid:1949170 |
Santillan-Doherty P et al. | Urinary thromboxane B2 as an indicator of acute rejection in lung allotransplantation. | 1988 | Transplantation | pmid:3285529 |
Ku K et al. | Influences of dietary omega-3 polyunsaturated fatty acids on the recovery of cardiac and renal functions after preservation in hyperlipidemic rats. | 1997 | Transplantation | pmid:9275102 |
Klassen DK et al. | Effects of cyclosporine on human renal allograft renin and prostaglandin production. | 1989 | Transplantation | pmid:2660347 |
Kawaguchi A et al. | Increase in urinary thromboxane B2 in rats caused by cyclosporine. | 1985 | Transplantation | pmid:4024243 |
Pfeiffer S et al. | Hyperacute lung rejection in the pig-to-human model. III. Platelet receptor inhibitors synergistically modulate complement activation and lung injury. | 2003 | Transplantation | pmid:12698079 |
Midttun M et al. | [Thrombocyte aggregation and serum thromboxane in patients with acute myocardial infarction]. | 1990 | Ugeskr. Laeg. | pmid:2275044 |
Lyck F et al. | [Thrombocyte aggregation and serum thromboxane B2 in patients with unstable angina pectoris treated with diltiazem or verapamil]. | 1992 | Ugeskr. Laeg. | pmid:1462402 |
Komarevtseva IA et al. | [Change in prostanoid metabolism in cystic kidney lesion]. | 1997 Sep-Dec | Ukr. Biokhim. Zh. | pmid:9606841 |
Persico N et al. | Transdermal HRT and Doppler findings in normotensive and hypertensive postmenopausal patients. | 2005 | Ultrasound Obstet Gynecol | pmid:16184506 |
Jokela R et al. | Effect of in vitro stability of dietary fish oil on lipid peroxidation and prostanoids in vivo. | 1998 | Ups. J. Med. Sci. | pmid:10052110 |
RogovyÄ IuE | [Beta 2-microglobulin as a criterion of dysfunction in the regulation of proximal tubular activity in mercuric chloride-induced nephropathy]. | 1998 May-Jun | Urol Nefrol (Mosk) | pmid:9644989 |
Frøkiaer J et al. | Renal blood flow and pelvic pressure after 4 weeks of total upper urinary tract obstruction in the pig. The effect of a TxA2 synthetase inhibitor on active preglomerular vasoconstriction. | 1988 | Urol. Res. | pmid:3413908 |
Ali M et al. | Urothelial synthesis of prostanoids in the ovine ureter. | 1998 | Urol. Res. | pmid:9694598 |
Greenstein A et al. | The role of oxygen free radicals and prostaglandins in reperfusion injury to warm ischemic kidneys. | 1991 | Urol. Res. | pmid:1759334 |
Rebrov BA | [Role of thromboxane A2 (B2) in the pathogenesis of stress proteinuria in healthy persons]. | 2001 Mar-Apr | Urologiia | pmid:11490711 |
Sinzinger H et al. | 20 mg aspirin daily--evidence for a clinical future of this extremely low-dose in arterial disease? | 1988 | VASA | pmid:3369232 |
Strobl-Jäger E et al. | Platelet half-life in comparison to other in-vivo platelet function parameters such as thromboxane B2, beta-thromboglobulin and platelet factor 4 in patients with atherosclerotic lesions with and without hyperlipoproteinemia. | 1986 | VASA | pmid:2948337 |
Ditter H and Matthias FR | Changes in thromboxane formation by platelets during and after a continuous endotoxin infusion into rabbits. | 1984 | VASA | pmid:6516562 |
Fitscha P et al. | Follow-up of in-vivo platelet function (platelet half-life, thromboxane B2) in patients with coronary heart disease. | 1984 | VASA | pmid:6516563 |
Zhou Z et al. | Mechanisms underlying uridine adenosine tetraphosphate-induced vascular contraction in mouse aorta: Role of thromboxane and purinergic receptors. | 2015 | Vascul. Pharmacol. | pmid:25921923 |
Miyamoto A et al. | Ibuprofen or ozagrel increases NO release and l-nitro arginine induces TXA(2) release from cultured porcine basilar arterial endothelial cells. | 2007 | Vascul. Pharmacol. | pmid:17113355 |
González-Correa JA et al. | Gender differences in the effect of aspirin on retinal ischemia, prostanoid synthesis and nitric oxide production in experimental type 1-like diabetes. | 2007 Aug-Sep | Vascul. Pharmacol. | pmid:17581795 |
Park WH et al. | Anti-inflammatory effects of a traditional Korean herbal formulation, Silsosangami, consisting of seven medicinal herbs: effect on hemolysis, neutrophil function, and gene expressions of iNOS and COX-2. | 2004 | Vascul. Pharmacol. | pmid:15664882 |
Polkanov VS and Vinogradov AI | [The content of thromboxane B2 and 6-ketoprostaglandin F1 alpha of the blood plasma in patients with psoriasis and children with allergic dermatoses]. | 1989 | Vestn Dermatol Venerol | pmid:2718610 |
Brezitskaia ON and Sedov KR | [Status of the thrombocytic-vascular component of the hemostasis system in the population of the Far North]. | 1991 | Vestn. Akad. Med. Nauk SSSR | pmid:1801462 |
Dinev D and Andonova M | The effect of general anesthesia and abdominal surgery upon plasma thromboxane B concentrations in horses. | 2004 | Vet Anaesth Analg | pmid:15053753 |
Mullins KB et al. | Effects of carprofen, meloxicam and deracoxib on platelet function in dogs. | 2012 | Vet Anaesth Analg | pmid:22248445 |
Higgins AJ et al. | Actions of BW540C in an equine model of acute inflammation: a preliminary study. | 1987 | Vet Q | pmid:3039716 |
Moore RM et al. | Effect of platelet-activating factor antagonist L-691,880 on low-flow ischemia-reperfusion injury of the large colon in horses. | 1998 Jan-Feb | Vet Surg | pmid:9449176 |
Maddens BE et al. | Validation of immunoassays for the candidate renal markers C-reactive protein, immunoglobulin G, thromboxane B2 and retinol binding protein in canine urine. | 2010 | Vet. Immunol. Immunopathol. | pmid:19815297 |
Hall JA et al. | Dietary fish oil alters the lysophospholipid metabolomic profile and decreases urinary 11-dehydro thromboxane Bâ‚‚ concentration in healthy Beagles. | 2011 | Vet. Immunol. Immunopathol. | pmid:21925741 |
Sigel MM et al. | Phylogenetic studies on lymphokines. Fish lymphocytes respond to human IL-1 and epithelial cells produce an IL-1 like factor. | 1986 | Vet. Immunol. Immunopathol. | pmid:3490047 |
Peters SM et al. | In vivo characterization of inflammatory biomarkers in swine and the impact of flunixin meglumine administration. | 2012 | Vet. Immunol. Immunopathol. | pmid:22648045 |
Bailey SR et al. | Plasma concentrations of endotoxin and platelet activation in the developmental stage of oligofructose-induced laminitis. | 2009 | Vet. Immunol. Immunopathol. | pmid:19091426 |
Van de Weerdt ML et al. | Ketoprofen and phenylbutazone attenuation of PAF-induced lung inflammation in calves. | 1999 | Vet. J. | pmid:10030127 |
Lees P et al. | Pharmacodynamics and pharmacokinetics of tolfenamic acid in ruminating calves: evaluation in models of acute inflammation. | 1998 | Vet. J. | pmid:9638074 |
Giri SN et al. | Effects of endotoxin infusion on circulating levels of eicosanoids, progesterone, cortisol, glucose and lactic acid, and abortion in pregnant cows. | 1990 | Vet. Microbiol. | pmid:2407024 |
Cheng Z et al. | Pharmacokinetic and pharmacodynamic studies on phenylbutazone and oxyphenbutazone in goats. | 1997 | Vet. Rec. | pmid:9123796 |
Friton GM et al. | Clinical and anti-inflammatory effects of treating endotoxin-challenged pigs with meloxicam. | 2006 | Vet. Rec. | pmid:17056651 |
McKellar QA et al. | Flunixin pharmacokinetics and serum thromboxane inhibition in the dog. | 1989 | Vet. Rec. | pmid:2763429 |
Galbraith EA and McKellar QA | Pharmacokinetics and pharmacodynamics of piroxicam in dogs. | 1991 | Vet. Rec. | pmid:1887556 |
Mustonen K et al. | Dose-response investigation of oral ketoprofen in pigs challenged with Escherichia coli endotoxin. | 2012 | Vet. Rec. | pmid:22735989 |
Taylor PM et al. | Pharmacodynamics and pharmacokinetics of flunixin in the cat: a preliminary study. | 1991 | Vet. Rec. | pmid:2035219 |