Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Oviedo PJ et al. | Progestogens reduce thromboxane production by cultured human endothelial cells. | 2011 | Climacteric | pmid:20443717 |
Sambu N et al. | Effect of clopidogrel withdrawal on platelet reactivity and vascular inflammatory biomarkers 1 year after drug-eluting stent implantation: results of the prospective, single-centre CESSATION study. | 2011 | Heart | pmid:21795297 |
Spectre G et al. | Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications. | 2011 | Thromb. Haemost. | pmid:21800009 |
Hoh CM et al. | Evaluation of effects of low-dose aspirin administration on urinary thromboxane metabolites in healthy dogs. | 2011 | Am. J. Vet. Res. | pmid:21801060 |
Dalli E et al. | Effects of hawthorn (Crataegus laevigata) on platelet aggregation in healthy volunteers. | 2011 | Thromb. Res. | pmid:21737127 |
Gao F et al. | Effect of polymorphism and type II diabetes on aspirin resistance in patients with unstable coronary artery disease. | 2011 | Chin. Med. J. | pmid:21740787 |
Lukasik M et al. | Aspirin treatment influences platelet-related inflammatory biomarkers in healthy individuals but not in acute stroke patients. | 2011 | Thromb. Res. | pmid:21788065 |
Shen L et al. | In vivo oxidation, platelet activation and simultaneous occurrence of natural immunity in atherosclerosis-prone mice. | 2011 | Isr. Med. Assoc. J. | pmid:21845968 |
Mattiello T et al. | Aspirin extrusion from human platelets through multidrug resistance protein-4-mediated transport: evidence of a reduced drug action in patients after coronary artery bypass grafting. | 2011 | J. Am. Coll. Cardiol. | pmid:21816313 |
Wójtowicz A et al. | Aspirin resistance may be associated with adverse pregnancy outcomes. | 2011 | Neuro Endocrinol. Lett. | pmid:21670728 |
Graziani F et al. | Thromboxane production in morbidly obese subjects. | 2011 | Am. J. Cardiol. | pmid:21439532 |
Cathcart MC et al. | Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer. | 2011 | Mol. Cancer | pmid:21388528 |
Oh SH et al. | Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients. | 2011 | Pharmacogenomics | pmid:21449675 |
Akagi Y et al. | Influence of nonsteroidal anti-inflammatory drugs on the antiplatelet effects of aspirin in rats. | 2011 | Biol. Pharm. Bull. | pmid:21415533 |
Capodanno D et al. | Pharmacodynamic effects of different aspirin dosing regimens in type 2 diabetes mellitus patients with coronary artery disease. | 2011 | Circ Cardiovasc Interv | pmid:21386092 |
Yan LG et al. | Injectable caltrop fruit saponin protects against ischemia-reperfusion injury in rat brain. | 2011 | Am. J. Chin. Med. | pmid:21476209 |
Liu JQ et al. | Effects of tanshinone IIA, a major component of Salvia miltiorrhiza, on platelet aggregation in healthy newborn piglets. | 2011 | J Ethnopharmacol | pmid:21453766 |
Halawani SH et al. | Aspirin failure in patients presenting with acute cerebrovascular ischaemia. | 2011 | Thromb. Haemost. | pmid:21544317 |
Gonçalves LH et al. | Urinary 11-dehydro thromboxane B₂ levels in type 2 diabetic patients before and during aspirin intake. | 2011 | Clin. Chim. Acta | pmid:21510926 |
Bauer J et al. | Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. | 2011 | Biochem. Pharmacol. | pmid:20933508 |
Basselin M et al. | Anti-inflammatory effects of chronic aspirin on brain arachidonic acid metabolites. | 2011 | Neurochem. Res. | pmid:20981485 |
Kleinbongard P et al. | Acute vasomotor paralysis and potential downstream effects of paclitaxel from stents implanted for saphenous vein aorto-coronary bypass stenosis. | 2011 | Basic Res. Cardiol. | pmid:21472462 |
Ceprnja M et al. | Oxidative stress markers in patients with post-traumatic stress disorder. | 2011 | Coll Antropol | pmid:22397253 |
Toliopoulos IK et al. | Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid. | 2011 | Indian J. Exp. Biol. | pmid:22403863 |
Lordkipanidzé M et al. | Heterogeneity in platelet cyclooxygenase inhibition by aspirin in coronary artery disease. | 2011 | Int. J. Cardiol. | pmid:20207433 |
Saihkay HN et al. | Validating 123I-metaiodobenzylguanidine as a platelet marker for non-invasive imaging in rabbits. | 2011 Jan-Feb | J Pharmacol Toxicol Methods | pmid:20646985 |
Brainard BM et al. | Effects of clopidogrel and aspirin on platelet aggregation, thromboxane production, and serotonin secretion in horses. | 2011 Jan-Feb | J. Vet. Intern. Med. | pmid:21143302 |
Alcott CJ et al. | Clinical and immunomodulating effects of ketamine in horses with experimental endotoxemia. | 2011 Jul-Aug | J. Vet. Intern. Med. | pmid:21745244 |
Chakroun T et al. | The cyclooxygenase-1 C50T polymorphism is not associated with aspirin responsiveness status in stable coronary artery disease in Tunisian patients. | 2011 Jul-Aug | Genet Test Mol Biomarkers | pmid:21434767 |
Thomason J et al. | Platelet cyclooxygenase expression in normal dogs. | 2011 Sep-Oct | J. Vet. Intern. Med. | pmid:21985141 |
Ramadan E et al. | Lamotrigine blocks NMDA receptor-initiated arachidonic acid signalling in rat brain: implications for its efficacy in bipolar disorder. | 2012 | Int. J. Neuropsychopharmacol. | pmid:21733229 |
Barberà -Cremades M et al. | P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release. | 2012 | FASEB J. | pmid:22490780 |
Su CL et al. | Inducible cyclooxygenase expression mediating hypoxia/reoxygenation-induced pulmonary vasoconstriction is attenuated by a cyclooxygenase inhibitor in rats. | 2012 | Transplant. Proc. | pmid:22564588 |
Ames PR et al. | Aspirin insensitive thromboxane generation is associated with oxidative stress in type 2 diabetes mellitus. | 2012 | Thromb. Res. | pmid:22521214 |
Andersson T et al. | Evaluation of the pharmacodynamics of acetylsalicylic acid 81 mg with or without esomeprazole 20 mg in healthy volunteers. | 2012 | Am J Cardiovasc Drugs | pmid:22631032 |
Wang JW et al. | [Effects of puerarin on the vascular active factor related to cerebral vasospasm after aneurysm subarachnoid hemorrhage]. | 2012 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:22574584 |
Li C et al. | Aspirin response variability after major orthopedic surgery. | 2012 | Thromb. Res. | pmid:22575418 |
Sakai H et al. | Cardiopulmonary hemodynamic responses to the small injection of hemoglobin vesicles (artificial oxygen carriers) in miniature pigs. | 2012 | J Biomed Mater Res A | pmid:22615268 |
Santostefano MJ et al. | Off-target platelet activation in macaques unique to a therapeutic monoclonal antibody. | 2012 | Toxicol Pathol | pmid:22552394 |
Ledwidge MT et al. | In vivo impact of prodrug isosorbide-5-nicotinate-2-aspirinate on lipids and prostaglandin D2: is this a new immediate-release therapeutic option for niacin? | 2012 | Atherosclerosis | pmid:22326030 |
Yang D et al. | Effects of short- and long-term hypercholesterolemia on contrast-induced acute kidney injury. | 2012 | Am. J. Nephrol. | pmid:22189165 |
Mustonen K et al. | Dose-response investigation of oral ketoprofen in pigs challenged with Escherichia coli endotoxin. | 2012 | Vet. Rec. | pmid:22735989 |
Zhao Y et al. | [Effects of the effective components group of xiaoshuantongluo formula on rat acute blood stasis model]. | 2012 | Yao Xue Xue Bao | pmid:22812003 |
Khandelwal AR et al. | Resveratrol and quercetin interact to inhibit neointimal hyperplasia in mice with a carotid injury. | 2012 | J. Nutr. | pmid:22718033 |
Guo S et al. | Gastric mucosal damage in water immersion stress: mechanism and prevention with GHRP-6. | 2012 | World J. Gastroenterol. | pmid:22791951 |
Wei X et al. | [Study of dahuangzhechong pills on anti-arterial thrombosis with the orthogonal design]. | 2012 | Zhong Yao Cai | pmid:22734422 |
Qu C et al. | Effect of fenofibrate on the secretion of endothelium-derived contracting factors in hypertensive rats. | 2012 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:22776656 |
Kaiser A et al. | [Effects of two different extracts of total saponins from Cicer arietinum on kidney of T2DM rats]. | 2012 | Yao Xue Xue Bao | pmid:22799041 |
Macaluso M et al. | How biomarkers will change psychiatry. Part II: Biomarker selection and potential inflammatory markers of depression. | 2012 | J Psychiatr Pract | pmid:22805902 |
Shih CY and Chou TC | The antiplatelet activity of magnolol is mediated by PPAR-β/γ. | 2012 | Biochem. Pharmacol. | pmid:22750553 |