Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Jokela R et al. | Effect of in vitro stability of dietary fish oil on lipid peroxidation and prostanoids in vivo. | 1998 | Ups. J. Med. Sci. | pmid:10052110 |
Persico N et al. | Transdermal HRT and Doppler findings in normotensive and hypertensive postmenopausal patients. | 2005 | Ultrasound Obstet Gynecol | pmid:16184506 |
Komarevtseva IA et al. | [Change in prostanoid metabolism in cystic kidney lesion]. | 1997 Sep-Dec | Ukr. Biokhim. Zh. | pmid:9606841 |
Midttun M et al. | [Thrombocyte aggregation and serum thromboxane in patients with acute myocardial infarction]. | 1990 | Ugeskr. Laeg. | pmid:2275044 |
Lyck F et al. | [Thrombocyte aggregation and serum thromboxane B2 in patients with unstable angina pectoris treated with diltiazem or verapamil]. | 1992 | Ugeskr. Laeg. | pmid:1462402 |
Weir MR et al. | Acute effects of intravenous cyclosporine on blood pressure, renal hemodynamics, and urine prostaglandin production of healthy humans. | 1990 | Transplantation | pmid:2301025 |
Nassiri M et al. | Lymphoid organ production of immunomodulatory eicosanoids in mice resistant to neonatal tolerance induction. | 1994 | Transplantation | pmid:8009599 |
Coffman TM et al. | Effect of dietary fish oil supplementation on eicosanoid production by rat renal allografts. | 1988 | Transplantation | pmid:3125638 |
Ogata K et al. | Attenuation of ischemia and reperfusion injury of canine livers by inhibition of type II phospholipase A2 with LY329722. | 2001 | Transplantation | pmid:11374398 |
Lane NJ et al. | Inhibition of leukotriene B4 synthesis does not prevent development of acute renal failure following storage and transplantation. | 1994 | Transplantation | pmid:7809921 |
Ramos E et al. | The impact of arterialization on prostanoid generation after liver transplantation in the rat. | 1994 | Transplantation | pmid:8042232 |
Fan TP et al. | Mechanism of action of cyclosporine in preventing cardiac allograft rejection. II. Graft tissue levels of prostacyclin and thromboxane. | 1987 | Transplantation | pmid:3547787 |
Kawaguchi A et al. | Urinary thromboxane excretion in cardiac allograft rejection in immunosuppressed rats. | 1987 | Transplantation | pmid:3547788 |
Capitanio A et al. | Detection of circulating released platelets after renal transplantation. | 1982 | Transplantation | pmid:6461116 |
Gibbons CP et al. | Cortical and vascular prostaglandin synthesis during renal allograft rejection in the rat. | 1987 | Transplantation | pmid:3554639 |
Garvin PJ et al. | Evaluation of the thromboxane A2 synthetase inhibitor OKY-046 in a warm ischemia-reperfusion rat model. | 1996 | Transplantation | pmid:8633364 |
Balkhy HH et al. | Comparison of Eurocollins and University of Wisconsin solution in single flush preservation of the ischemic reperfused lung: an in vivo rabbit model. | 1995 | Transplantation | pmid:7732552 |
Markewitz A et al. | Reduction of cyclosporine-induced nephrotoxicity by cilastatin following clinical heart transplantation. | 1994 | Transplantation | pmid:8154033 |
Kim YI et al. | Hepatoprotection by a PGI2 analogue in complete warm ischemia of the pig liver. Prostanoid release from the reperfused liver. | 1994 | Transplantation | pmid:7940729 |
Khirabadi BS et al. | Urine immunoreactive thromboxane B2 in rat cardiac allograft rejection. | 1985 | Transplantation | pmid:3880966 |
Textor SC et al. | Systemic and renal hemodynamic differences between FK506 and cyclosporine in liver transplant recipients. | 1993 | Transplantation | pmid:7685934 |
Petric R et al. | Amelioration of experimental cyclosporine nephrotoxicity by calcium channel inhibition. | 1992 | Transplantation | pmid:1465778 |
Johnson BF et al. | Urinary thromboxane and 6-keto-prostaglandin F1 alpha are early markers of acute rejection in experimental pancreas transplantation. | 1994 | Transplantation | pmid:7518618 |
Smith SR et al. | Chronic thromboxane synthase inhibition with CGS 12970 in human cyclosporine nephrotoxicity. | 1993 | Transplantation | pmid:8279014 |
Johnson BF et al. | Thromboxane and prostacyclin synthesis in experimental pancreas transplantation. Changes in parenchymal and vascular prostanoids. | 1993 | Transplantation | pmid:8279018 |
Proppe DG et al. | Diagnostic value of urinary thromboxane B2 concentration in detection of initial acute rejection reactions in human renal allografts. | 1995 | Transplantation | pmid:7709445 |
Youngelman DF et al. | Effects of chronic cyclosporine administration on renal blood flow and intrarenal blood flow distribution. | 1991 | Transplantation | pmid:1994546 |
Elzinga L et al. | Modification of experimental nephrotoxicity with fish oil as the vehicle for cyclosporine. | 1987 | Transplantation | pmid:3810835 |
Coffman TM et al. | Evidence that renal prostaglandin and thromboxane production is stimulated in chronic cyclosporine nephrotoxicity. | 1987 | Transplantation | pmid:3810836 |
Gladue RP and Newborg MF | The protective effects of the thromboxane synthetase inhibitor Dazmegrel on nephrotoxicity in cyclosporine-treated rats. | 1991 | Transplantation | pmid:1949170 |
Santillan-Doherty P et al. | Urinary thromboxane B2 as an indicator of acute rejection in lung allotransplantation. | 1988 | Transplantation | pmid:3285529 |
Post S et al. | Rapid increase in the activity of enzymes of eicosanoid synthesis in hepatic and extrahepatic tissues after experimental liver transplantation. | 1991 | Transplantation | pmid:1903222 |
GarcÃa-Valdecasas JC et al. | Prostacyclin, thromboxane, and oxygen free radicals and postoperative liver function in human liver transplantation. | 1995 | Transplantation | pmid:7570973 |
Hotter G et al. | Nitric oxide and arachidonate metabolism in ischemia-reperfusion associated with pancreas transplantation. | 1995 | Transplantation | pmid:7871573 |
Moore TC et al. | Depression of peripheral lymph node lymphocyte traffic in sheep following central venous allogeneic whole-blood transfusion. | 1990 | Transplantation | pmid:1970202 |
Suckfüll MM et al. | The contribution of endothelial cells to hyperacute rejection in xenogeneic perfused working hearts. | 1994 | Transplantation | pmid:8310518 |
Post S et al. | Prostanoid release in experimental liver transplantation. | 1990 | Transplantation | pmid:2316009 |
Schnabel FR et al. | The relationship of urinary thromboxane excretion to cyclosporine nephrotoxicity. | 1991 | Transplantation | pmid:2006526 |
Ku K et al. | Influences of dietary omega-3 polyunsaturated fatty acids on the recovery of cardiac and renal functions after preservation in hyperlipidemic rats. | 1997 | Transplantation | pmid:9275102 |
Klassen DK et al. | Effects of cyclosporine on human renal allograft renin and prostaglandin production. | 1989 | Transplantation | pmid:2660347 |
Ruiz P et al. | Evidence that pretransplant donor blood transfusion prevents rat renal allograft dysfunction but not the in situ cellular alloimmune or morphologic manifestations of rejection. | 1988 | Transplantation | pmid:3276038 |
Kawaguchi A et al. | Increase in urinary thromboxane B2 in rats caused by cyclosporine. | 1985 | Transplantation | pmid:4024243 |
Pfeiffer S et al. | Hyperacute lung rejection in the pig-to-human model. III. Platelet receptor inhibitors synergistically modulate complement activation and lung injury. | 2003 | Transplantation | pmid:12698079 |
López-Boado MA et al. | Free radical ablation prevents ischemic injury after long periods of cold storage in rat pancreas transplantation. | 1990 | Transplant. Proc. | pmid:2219357 |
Shimizu Y et al. | Nafamostat mesilate prevents warm ischemia-reperfusion injury in canine pancreas autotransplantation. | 1995 | Transplant. Proc. | pmid:8539906 |
Odor-Morales A et al. | In vivo thromboxane production by different organs in the rat: its implication in organ transplant failure. | 1987 | Transplant. Proc. | pmid:3617213 |
Kasahara M et al. | Effect of FK3311 on ischemia-reperfusion injury in canine pulmonary models. | 2000 | Transplant. Proc. | pmid:11120230 |
Norio K et al. | Eicosanoids and delayed graft function in human renal transplantation. | 2001 | Transplant. Proc. | pmid:11406239 |
Nakache R et al. | Pancreatic juice immunoreactive thromboxane B2 in pancreas allograft rejection. | 1990 | Transplant. Proc. | pmid:1691546 |
Lim LK et al. | Fine needle aspiration biopsy, serum beta 2-microglobulin, and urine thromboxane in renal allografts. | 1989 | Transplant. Proc. | pmid:2669249 |