Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Kumlin M et al. | Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics. | 1992 | Am. Rev. Respir. Dis. | pmid:1320824 |
Winther K et al. | Platelet function and fibrinolytic activity in cervical spinal cord injured patients. | 1992 | Thromb. Res. | pmid:1321515 |
Mantelli L et al. | Effects of thromboxane agonists on cardiac adrenergic neurotransmission. | 1992 | Eur. J. Pharmacol. | pmid:1323473 |
Coran AG et al. | Ibuprofen intervention in canine septic shock: reduction of pathophysiology without decreased cytokines. | 1992 | J. Surg. Res. | pmid:1326683 |
Nieminen MM et al. | Inhaled budesonide fails to inhibit the PAF-induced increase in plasma leukotriene B4 in man. | 1992 | Br J Clin Pharmacol | pmid:1327049 |
Landolfi R et al. | Increased thromboxane biosynthesis in patients with polycythemia vera: evidence for aspirin-suppressible platelet activation in vivo. | 1992 | Blood | pmid:1327286 |
Chen SC | [Plasma renin activity, angiotensin II, angiotensin converting enzyme, thromboxane A2 and prostacyclin I2 levels in pigs with severe hypoxia and hypercapnea and acidosis shock]. | 1992 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:1327548 |
Rathaus M et al. | Altered prostaglandin synthesis and impaired sodium conservation in the kidneys of old rats. | 1992 | Clin. Sci. | pmid:1327646 |
Ko FN et al. | PAF antagonism in vitro and in vivo by aglafoline from Aglaia elliptifolia Merr. | 1992 | Eur. J. Pharmacol. | pmid:1327822 |
Conroy DM et al. | Vasoactive intestinal peptide and helodermin inhibit the release of cyclo-oxygenase products induced by leukotriene D4 and bradykinin from guinea-pig perfused lung. | 1992 | Eur. J. Pharmacol. | pmid:1327827 |
Mackenzie R et al. | Down-regulation of cyclooxygenase product generation by human peritoneal macrophages. | 1992 | Immunology | pmid:1328041 |
Juergens UR et al. | Arachidonic acid metabolism in monocytes of aspirin-sensitive asthmatic patients before and after oral aspirin challenge. | 1992 | J. Allergy Clin. Immunol. | pmid:1328344 |
Paul-Eugene N et al. | Ligation of CD23 triggers cAMP generation and release of inflammatory mediators in human monocytes. | 1992 | J. Immunol. | pmid:1328391 |
Mori TA et al. | Plasma lipid levels and platelet and neutrophil function in patients with vascular disease following fish oil and olive oil supplementation. | 1992 | Metab. Clin. Exp. | pmid:1328817 |
Habib A and Maclouf J | Comparison of leukotriene A4 metabolism into leukotriene C4 by human platelets and endothelial cells. | 1992 | Arch. Biochem. Biophys. | pmid:1329661 |
Fritsche KL and Cassity NA | Dietary n-3 fatty acids reduce antibody-dependent cell cytotoxicity and alter eicosanoid release by chicken immune cells. | 1992 | Poult. Sci. | pmid:1333592 |
Kadiri C et al. | Guinea-pig treatment with pertussis toxin suppresses macrophage-dependent bronchoconstriction by fMLP and fails to inhibit the effects of PAF. | 1992 | Br. J. Pharmacol. | pmid:1334747 |
McMillan RM et al. | Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase. | 1992 | Br. J. Pharmacol. | pmid:1334748 |
Nagakawa J et al. | Protective effects of E3330, a novel quinone derivative, on galactosamine/tumor necrosis factor-alpha-induced hepatitis in mice. | 1992 | Eur. J. Pharmacol. | pmid:1335420 |
Smith IL and Smith EA | Inhibition of PAF-induced activation of human platelets by verapamil. | 1992 | Blood Coagul. Fibrinolysis | pmid:1336985 |
Honda A et al. | Manipulation of thromboxane synthesis by novel 26,27-dialkyl analogues of 1 alpha,25-dihydroxyvitamin D3 in human promyelocytic leukemia (HL-60) cells. | 1992 | Eur. J. Pharmacol. | pmid:1337046 |
Rostagno C et al. | Thromboxane and prostacyclin metabolites in pulmonary hypertension. | 1992 | N. Engl. J. Med. | pmid:1342789 |
Kapui Z et al. | The mechanism of cytoprotective effect of CHINOIN-127. | 1992 | Acta Physiol Hung | pmid:1345193 |
Weidenfeld J et al. | Role of the central adrenergic system in the regulation of prostaglandin biosynthesis in rat brain. | 1992 | J. Neurochem. | pmid:1345941 |
Bottje W et al. | Effect of diethyl maleate on glutathione, hepatic and renal cortical perfusion, and portal 6-ketoPGF1 alpha and TxB2 levels in swine. | 1992 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:1350957 |
Masumura H et al. | A thromboxane A2 synthetase inhibitor retards hypertensive rat diabetic nephropathy. | 1992 | Eur. J. Pharmacol. | pmid:1350991 |
Omura Y et al. | Common factors contributing to intractable pain and medical problems with insufficient drug uptake in areas to be treated, and their pathogenesis and treatment: Part I. Combined use of medication with acupuncture, (+) Qi gong energy-stored material, soft laser or electrical stimulation. | 1992 | Acupunct Electrother Res | pmid:1353650 |
Tang Z et al. | [Influence of moxibustion on TXA2 and PGI2 in plasma of rat infected epidemic hemorrhagic fever virus (EHFV)]. | 1992 | Zhen Ci Yan Jiu | pmid:1356657 |
Amsterdam EA et al. | Contractile actions of C5a on isolated porcine myocardium. | 1992 | Am. J. Physiol. | pmid:1357981 |
Lee TK et al. | Dissociation of inhibitory effects of low-dose ASA on thromboxane production and platelet aggregation in ischemic stroke patients. | 1992 | J. Formos. Med. Assoc. | pmid:1363390 |
Tang Z | [Effect of moxibustion on humoral factors in the rat infected with epidemic hemorrhagic fever virus]. | 1992 | Zhen Ci Yan Jiu | pmid:1364109 |
Dai H et al. | Effects of diltiazem on platelet activation and cytosolic calcium during percutaneous transluminal coronary angioplasty. | 2003 | Postgrad Med J | pmid:13679549 |
Traber LD et al. | Pentafraction reduces the lung lymph response after endotoxin administration in the ovine model. | 1992 | Circ. Shock | pmid:1374688 |
Squadrito F et al. | Protective effects of G 619, a dual thromboxane synthase inhibitor and thromboxane A2 receptor antagonist, in splanchnic artery occlusion shock. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1375677 |
Terres W et al. | Residual platelet function under acetylsalicylic acid and the risk of restenosis after coronary angioplasty. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1376787 |
Berti F et al. | Protective activity of inhaled frusemide against immunological respiratory changes and mediator release in guinea-pigs. | 1992 | Pulm Pharmacol | pmid:1377065 |
Elias M et al. | Stabilization of standard platelet concentrates and minimization of the platelet storage lesion by a prostacyclin analogue. | 1992 | Ann. Hematol. | pmid:1379080 |
Pretolani M et al. | Effect of human recombinant interleukin-5 on in vitro responsiveness to PAF of lung from actively sensitized guinea-pigs. | 1992 | Br. J. Pharmacol. | pmid:1380388 |
Havel MP et al. | Aprotinin decreases release of 6-keto-prostaglandin F1 alpha and increases release of thromboxane B2 in cultured human umbilical vein endothelial cells. | 1992 | J. Thorac. Cardiovasc. Surg. | pmid:1381028 |
Wu G et al. | Inhibition effects of KRDS, a peptide derived from lactotransferrin, on platelet function and arterial thrombus formation in dogs. | 1992 | Haemostasis | pmid:1381697 |
Laffi G et al. | Thromboxane-receptor blockade increases water diuresis in cirrhotic patients with ascites. | 1992 | Gastroenterology | pmid:1386823 |
Wilkes BM et al. | Reduced glomerular thromboxane receptor sites and vasoconstrictor responses in diabetic rats. | 1992 | Kidney Int. | pmid:1387436 |
Douma S et al. | Effects of adrenaline infusion on serum thromboxane B2 and plasma beta-thromboglobulin levels in hypertensive and normotensive subjects. | 1992 | Nouv Rev Fr Hematol | pmid:1387933 |
Grauer GF et al. | Effects of a thromboxane synthetase inhibitor on established immune complex glomerulonephritis in dogs. | 1992 | Am. J. Vet. Res. | pmid:1388004 |
Lei ZM et al. | Expression of thromboxane A2 receptor gene and thromboxane A2 synthase in bovine corpora lutea. | 1992 | Biol. Reprod. | pmid:1391329 |
Burhop KE et al. | Effects of intravenous infusions of diaspirin cross-linked hemoglobin (DCLHb) on sheep. | 1992 | Biomater Artif Cells Immobilization Biotechnol | pmid:1391481 |
Uyama O et al. | Urinary 11-dehydro-thromboxane B2: a quantitative index of platelet activation in cerebral infarction. | 1992 | Intern. Med. | pmid:1392173 |
Takeda H et al. | Abnormalities in platelets and vascular endothelial cells induced by glycated lipoproteins. | 1992 | Intern. Med. | pmid:1392175 |
Ding Q | [Clinical study of qianxining in the treatment of 60 cases of yang hyperactivity due to yin deficiency type of hypertension]. | 1992 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:1392491 |
Zhou Q | [Experimental study of atherosclerosis and cholelithiasis with the same treatment. I. Effects of yiqi huoxue and shugan liqi agents in atherosclerosis of rabbit]. | 1992 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:1392494 |