Thromboxane b2
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
Cross Reference
Introduction
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thromboxane b2?
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
PubChem Associated disorders and diseases
What pathways are associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thromboxane b2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Thromboxane b2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Thromboxane b2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thromboxane b2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zaitsu M et al. | Thromboxane synthesis is increased by upregulation of cytosolic phospholipase A2 and cyclooxygenase-2 in peripheral polymorphonuclear leukocytes during bacterial infection in childhood. | 2003 | Am. J. Hematol. | pmid:12555215 |
| Kirchheiner J et al. | Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans. | 2003 | Br J Clin Pharmacol | pmid:12534640 |
| von Aulock S et al. | Determination of the eicosanoid response to inflammatory stimuli in whole blood and its pharmacological modulation ex vivo. | 2003 | J. Immunol. Methods | pmid:12799039 |
| Cabrera DM et al. | A thromboxane A(2) system in the Atlantic stingray, Dasyatis sabina. | 2003 | Gen. Comp. Endocrinol. | pmid:12568793 |
| Yregård L et al. | Influence of local anaesthetics on inflammatory activity postburn. | 2003 | Burns | pmid:12781610 |
| Ersöz G et al. | Effect of sodium selenite treatment on platelet aggregation of streptozotocin-induced diabetic rats. | 2003 | Thromb. Res. | pmid:14698654 |
| Chen L et al. | Cyclooxygenase inhibitor blocks rebound response after NO inhalation in an endotoxin model. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12485821 |
| Zhuang HP et al. | [Effect of aspirin combined with perindopril on prostacyclin, thromboxone A2, and norepinephrine in the blood of arteriosclerosis rabbit models and the cardiac function]. | 2003 | Hunan Yi Ke Da Xue Xue Bao | pmid:12934393 |
| Castellani S et al. | Thromboxane inhibition improves renal perfusion and excretory function in severe congestive heart failure. | 2003 | J. Am. Coll. Cardiol. | pmid:12849673 |
| Pettus BJ et al. | Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. | 2003 | J. Biol. Chem. | pmid:12855693 |
| Shimada N et al. | Increased endothelin: nitric oxide ratio is associated with erythropoietin-induced hypertension in hemodialysis patients. | 2003 | Ren Fail | pmid:12911161 |
| Patrono C | Aspirin resistance: definition, mechanisms and clinical read-outs. | 2003 | J. Thromb. Haemost. | pmid:12911581 |
| Eder K et al. | Conjugated linoleic acids lower the release of eicosanoids and nitric oxide from human aortic endothelial cells. | 2003 | J. Nutr. | pmid:14652352 |
| Li JS et al. | [Change in intestinal free radical and prostaglandin metabolism in the aged rats with pneumococcus pneumonia]. | 2003 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:14552688 |
| Lombard JH et al. | High-salt diet impairs vascular relaxation mechanisms in rat middle cerebral arteries. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12456391 |
| De La Cruz JP et al. | Differences in the effects of extended-release aspirin and plain-formulated aspirin on prostanoids and nitric oxide in healthy volunteers. | 2003 | Fundam Clin Pharmacol | pmid:12803576 |
| Fujimoto Y et al. | Effects of endocrine disruptors on arachidonic acid metabolism in rabbit platelets. | 2003 | Toxicol. Appl. Pharmacol. | pmid:12781627 |
| Cipollone F et al. | Modulation of aspirin-insensitive eicosanoid biosynthesis by 6-methylprednisolone in unstable angina. | 2003 | Circulation | pmid:12515743 |
| Li ZG et al. | [Progress on study of experimental physico-chemical indexes related with ischemic stroke]. | 2003 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12764922 |
| Lei D et al. | Antioxidative and antiplatelet effects of aqueous inflorescence Piper betle extract. | 2003 | J. Agric. Food Chem. | pmid:12643677 |
| Park WH et al. | The antiplatelet activity of Geiji-Bokryung-Hwan, Korean traditional formulation, is mediated through inhibition of phospholipase C and inhibition of TxB(2) synthetase activity. | 2003 | Int. Immunopharmacol. | pmid:12810354 |
| Hou X et al. | Increased platelet-activating factor-induced periventricular brain microvascular constriction associated with immaturity. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12626359 |
| Tsuruta LR et al. | Characterization of 11-dehydro-thromboxane B2 recombinant antibody obtained by phage display technology. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12628223 |
| Nagase T et al. | A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12505870 |
| Davì G et al. | Platelet activation in obese women: role of inflammation and oxidant stress. | 2002 Oct 23-30 | JAMA | pmid:12387653 |
| Hayashi M et al. | Characterization of five marker levels of the hemostatic system and endothelial status in normotensive pregnancy and pre-eclampsia. | 2002 Nov-Dec | Eur. J. Haematol. | pmid:12460234 |
| Wolfram RM et al. | Effect of black tea on (iso-)prostaglandins and platelet aggregation in healthy volunteers. | 2002 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12144875 |
| Alarayyed NA et al. | Differential actions of naftopidil, doxazosin and nifedipine on platelet thromboxane generation and platelet-derived growth factor efflux in vitro. | 2002 Aug-Sep | Platelets | pmid:12189011 |
| Ersöz G et al. | Effect of submaximal and incremental upper extremity exercise on platelet function and the role of blood shear stress. | 2002 | Thromb. Res. | pmid:12676189 |
| Connolly E et al. | Cyclooxygenase isozyme expression and intimal hyperplasia in a rat model of balloon angioplasty. | 2002 | J. Pharmacol. Exp. Ther. | pmid:11805196 |
| Bermejo BP et al. | Sesquiterpenes from Jasonia glutinosa: in vitro anti-inflammatory activity. | 2002 | Biol. Pharm. Bull. | pmid:11824534 |
| Ersöz G et al. | The effect of submaximal exercise on platelet aggregation during late follicular and midluteal phases in women. | 2002 | Thromb. Res. | pmid:12590951 |
| Küsters S et al. | Effects of antihistamines on leukotriene and cytokine release from dispersed nasal polyp cells. | 2002 | Arzneimittelforschung | pmid:11878205 |
| Schelzig H et al. | Role of recombinant hirudin in a pig-to-human lung transplantation model. | 2002 | Transplant. Proc. | pmid:12270449 |
| Huang CG et al. | Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells. | 2002 | Thromb. Res. | pmid:12297129 |
| Lees P and Landoni MF | Pharmacodynamics and enantioselective pharmacokinetics of racemic carprofen in the horse. | 2002 | J. Vet. Pharmacol. Ther. | pmid:12485349 |
| Lassus P et al. | Pulmonary prostacyclin is associated with less severe respiratory distress in preterm infants. | 2002 | Early Hum. Dev. | pmid:11893431 |
| Venuto R et al. | Enhanced vascular effects of the Ca(2+) channel agonist Bay K 8644 in pregnant rabbits. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11893597 |
| Tang L et al. | [Relationship between cyclooxygenase-2 protein expression, prostaglandins levels and biologic behavior in ovarian carcinoma tissue]. | 2002 | Zhonghua Fu Chan Ke Za Zhi | pmid:12487927 |
| Wainwright CL et al. | NCX4016 (NO-aspirin) reduces infarct size and suppresses arrhythmias following myocardial ischaemia/reperfusion in pigs. | 2002 | Br. J. Pharmacol. | pmid:11959790 |
| Tuersun K and Huang Y | [Changes of blood vessel active substances in acute pulmonary embolism induced by echinococus granulous cyst in rabbits]. | 2002 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:12490126 |
| Sheu JR et al. | Mechanisms involved in the antiplatelet activity of midazolam in human platelets. | 2002 | Anesthesiology | pmid:11873041 |
| Horiguchi T et al. | Study on the usefulness of seratrodast in the treatment of chronic pulmonary emphysema. | 2002 | Arzneimittelforschung | pmid:12442639 |
| Zaitsu M et al. | Induction of thromboxane A2 synthesizing enzymes in DMSO-induced granulocytic differentiation of HL-60 cells. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468261 |
| Thomson M et al. | The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468270 |
| Sheu JR et al. | Mechanisms involved in the antiplatelet activity of magnesium in human platelets. | 2002 | Br. J. Haematol. | pmid:12472585 |
| Fiorucci S et al. | NCX-4016 (NO-aspirin) inhibits lipopolysaccharide-induced tissue factor expression in vivo: role of nitric oxide. | 2002 | Circulation | pmid:12473561 |
| Rouvier J et al. | Aspirin resistance. | 2002 | Circulation | pmid:12473569 |
| Miyataka M et al. | Nitric oxide, anti-inflammatory drugs on renal prostaglandins and cyclooxygenase-2. | 2002 | Hypertension | pmid:11897764 |
| Leahy KM et al. | Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo. | 2002 | Cancer Res. | pmid:11830509 |
| Ozaki N et al. | Differential regulation of prostacyclin and thromboxane by dexamethasone and celecoxib during oxidative stress in newborn rabbits. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428679 |
| Ma LP et al. | Inhibition of platelet aggregation and expression of alpha granule membrane protein 140 and thromboxane B2 with pravastatin therapy for hypercholesterolemia. | 2002 | J Assoc Acad Minor Phys | pmid:11852667 |
| Ochi T and Goto T | Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis. | 2002 | Br. J. Pharmacol. | pmid:11834626 |
| De La Cruz JP et al. | Effects of the selective inhibition of platelet thromboxane synthesis on the platelet-subendothelium interaction. | 2002 | Br. J. Pharmacol. | pmid:12429581 |
| Bruno A et al. | Aspirin and urinary 11-dehydrothromboxane B(2) in African American stroke patients. | 2002 | Stroke | pmid:11779889 |
| Canbaz M et al. | Effects of tibolone on thromboxane B(2) levels in postmenopausal women. | 2002 | Gynecol. Obstet. Invest. | pmid:11803222 |
| Jeng JH et al. | Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase. | 2002 | Free Radic. Biol. Med. | pmid:11978487 |
| Streppa HK et al. | Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs in canine blood. | 2002 | Am. J. Vet. Res. | pmid:16206787 |
| Jiang Z et al. | [The changes of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha(6-keto-PGF1 alpha) in the lungs of rats drowned in hypothermic-sea-water]. | 2002 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:14694611 |
| Saareks V et al. | Opposite effects of nicotinic acid and pyridoxine on systemic prostacyclin, thromboxane and leukotriene production in man. | 2002 | Pharmacol. Toxicol. | pmid:12403056 |
| Kudolo GB et al. | Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and Type 2 diabetic subjects. | 2002 | Thromb. Res. | pmid:12590952 |
| Sinzinger H | Comments on "Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications". | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12445490 |
| Obase Y et al. | Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients. | 2002 | Chest | pmid:11796443 |
| Gordon SM et al. | Peripheral prostanoid levels and nonsteroidal anti-inflammatory drug analgesia: replicate clinical trials in a tissue injury model. | 2002 | Clin. Pharmacol. Ther. | pmid:12189364 |
| Van Hecken A et al. | Effects of enteric-coated, low-dose aspirin on parameters of platelet function. | 2002 | Aliment. Pharmacol. Ther. | pmid:12197849 |
| Gómez-Gaviro MV et al. | Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs. | 2002 | J. Biol. Chem. | pmid:12147693 |
| Khan AA et al. | In vivo selectivity of a selective cyclooxygenase 2 inhibitor in the oral surgery model. | 2002 | Clin. Pharmacol. Ther. | pmid:12152003 |
| Vecino AM et al. | Phospholipase A2 activity in platelets of patients with uremia. | 2002 | Platelets | pmid:12487789 |
| Kirchheiner J et al. | Enantiospecific effects of cytochrome P450 2C9 amino acid variants on ibuprofen pharmacokinetics and on the inhibition of cyclooxygenases 1 and 2. | 2002 | Clin. Pharmacol. Ther. | pmid:12152005 |
| Wang L et al. | Enhancement of human platelet activation by the combination of low concentrations of collagen and rabbit anticardiolipin antibodies. | 2002 | Br. J. Haematol. | pmid:12199800 |
| Park CH et al. | Investigations of new lead structures for the design of novel cyclooxygenase-2 inhibitors. | 2002 | Eur J Med Chem | pmid:12204472 |
| Cipollone F et al. | Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia: effects of statin therapy. | 2002 | Circulation | pmid:12135935 |
| Association between ibuprofen, aspirin therapy found. | 2002 | J Am Dent Assoc | pmid:12136787 | |
| Rinder HM et al. | Effects of meloxicam on platelet function in healthy adults: a randomized, double-blind, placebo-controlled trial. | 2002 | J Clin Pharmacol | pmid:12162470 |
| Wong DA et al. | Discrete role for cytosolic phospholipase A(2)alpha in platelets: studies using single and double mutant mice of cytosolic and group IIA secretory phospholipase A(2). | 2002 | J. Exp. Med. | pmid:12163563 |
| Kiemer AK et al. | Inhibition of cyclooxygenase-2 by natriuretic peptides. | 2002 | Endocrinology | pmid:11861506 |
| Huang K et al. | Role of selenium in cytoprotection against cholesterol oxide-induced vascular damage in rats. | 2002 | Atherosclerosis | pmid:11947907 |
| Hu X et al. | [The influence of nasal continual positive airway pressure on some vasoactive substances in patients with obstructive sleep apnea syndrome]. | 2002 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:11953098 |
| Burleigh ME et al. | Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. | 2002 | Circulation | pmid:11956125 |
| Jankov RP et al. | Thromboxane A(2) receptors mediate pulmonary hypertension in 60% oxygen-exposed newborn rats by a cyclooxygenase-independent mechanism. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:12119234 |
| Signorello MG et al. | Effect of homocysteine on arachidonic acid release in human platelets. | 2002 | Eur. J. Clin. Invest. | pmid:11952814 |
| Leese PT et al. | Valdecoxib does not impair platelet function. | 2002 | Am J Emerg Med | pmid:12098171 |
| Tsukamoto H et al. | Simultaneous quantification of prostaglandins, isoprostane and thromboxane in cell-cultured medium using gas chromatography-mass spectrometry. | 2002 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:12076690 |
| Sakai H et al. | E3040 sulphate, a novel thromboxane synthase inhibitor, blocks the Cl- secretion induced by platelet-activating factor in isolated rat colon. | 2002 | Br. J. Pharmacol. | pmid:12023941 |
| Jung K et al. | The effect of dietary intervention through the modification of fatty acids composition and antioxidant vitamin intake on plasma TXB(2) level in Korean postmenopausal women with hypercholesterolemia. | 2002 | J. Korean Med. Sci. | pmid:12068132 |
| Jung YS et al. | Antithrombotic effect of onion in streptozotocin-induced diabetic rat. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12054917 |
| van Kraaij DJ et al. | A comparison of the effects of nabumetone vs meloxicam on serum thromboxane B2 and platelet function in healthy volunteers. | 2002 | Br J Clin Pharmacol | pmid:12047490 |
| Appleyard CB et al. | Temporal changes in colonic vascular architecture and inflammatory mediator levels in animal models of colitis. | 2002 | Dig. Dis. Sci. | pmid:12353846 |
| Saldeen P et al. | Structural, functional and circulatory placental changes associated with impaired glucose metabolism. | 2002 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:12381475 |
| Zhang H et al. | [Perioperative lung injury in ventricular septal defect with severe pulmonary hypertension, a clinical study of 31 cases]. | 2002 | Zhonghua Yi Xue Za Zhi | pmid:12425808 |
| Jones CJ et al. | In vivo effects of meloxicam and aspirin on blood, gastric mucosal, and synovial fluid prostanoid synthesis in dogs. | 2002 | Am. J. Vet. Res. | pmid:12428662 |
| Buluç M et al. | Effect of misoprostol and indomethacin on cyclooxygenase induction and eicosanoid production in carrageenan-induced air pouch inflammation in rats. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428691 |
| Gray PA et al. | Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors. | 2002 | Br. J. Pharmacol. | pmid:12429575 |
| Valeri CR et al. | Circulation and hemostatic function of autologous fresh, liquid-preserved, and cryopreserved baboon platelets transfused to correct an aspirin-induced thrombocytopathy. | 2002 | Transfusion | pmid:12430680 |
| Wilner KD et al. | Celecoxib does not affect the antiplatelet activity of aspirin in healthy volunteers. | 2002 | J Clin Pharmacol | pmid:12211219 |
| Molina V et al. | D-003, a potential antithrombotic compound isolated from sugar cane wax with effects on arachidonic acid metabolites. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12213431 |
| Koizumi T et al. | Inhibition of endogenous nitric oxide during endotoxemia in awake sheep - effects of Nomega-nitro-l-arginine on the distribution of pulmonary vascular resistance and prostanoid products. | 2002 | Exp. Lung Res. | pmid:12217213 |
| Khan I et al. | Altered expression of Na(+)/H(+) exchanger isoforms 1 and 3 in clipped and unclipped kidneys of a 2-kidney-1-clip Goldblatt model of hypertension. | 2002 | Nephron | pmid:12218313 |
| Vaughan JE and Walsh SW | Oxidative stress reproduces placental abnormalities of preeclampsia. | 2002 | Hypertens Pregnancy | pmid:12517328 |
| Ferlito M et al. | Implication of Galpha i proteins and Src tyrosine kinases in endotoxin-induced signal transduction events and mediator production. | 2002 | J. Endotoxin Res. | pmid:12701623 |