Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Greer IA et al. | Inhibition of thromboxane and prostacyclin production in whole blood by adrenoceptor antagonists. | 1985 | Prostaglandins Leukot Med | pmid:2865745 |
Mikhailidis DP et al. | The effect of non-specific beta-blockade on metabolic and haemostatic variables during hypoglycaemia. | 1985 | Diabetes Res. | pmid:2866057 |
Mehta J et al. | Increase in human platelet alpha 2-adrenergic receptor affinity for agonist in unstable angina. | 1985 | J. Lab. Clin. Med. | pmid:2866219 |
Greer IA et al. | A comparative study of the effects of adrenoceptor antagonists on platelet aggregation and thromboxane generation. | 1985 | Thromb. Haemost. | pmid:2867620 |
Gragnoli G et al. | Effects of somatostatin on the behaviour of thromboxane B2 and beta-thromboglobulin in type I diabetes. | 1985 | Acta Endocrinol. | pmid:2408435 |
Yardumian DA et al. | Platelet hyperaggregability occurring during prolonged continuous intravenous infusions of prostacyclin analogue ZK 36374. | 1985 | Br. J. Haematol. | pmid:2408653 |
Patrassi GM et al. | Contact phase of coagulation in diabetes mellitus after aspirin administration. | 1985 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:2410343 |
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Francos GC et al. | Dialysis-induced hypoxemia: membrane dependent and membrane independent causes. | 1985 | Am. J. Kidney Dis. | pmid:3919574 |
Kobayashi H et al. | Effects of 6-keto-prostaglandin E1 on ascitic hepatoma-130 in vivo comparison with chemotherapeutic agents. | 1985 | Prostaglandins | pmid:3920729 |
Powell AM et al. | Menstrual-PGF2 alpha, PGE2 and TXA2 in normal and dysmenorrheic women and their temporal relationship to dysmenorrhea. | 1985 | Prostaglandins | pmid:3856904 |
Ylitalo P et al. | Inhibition of prostaglandin synthesis by indomethacin interacts with the antihypertensive effect of atenolol. | 1985 | Clin. Pharmacol. Ther. | pmid:3899459 |
Mobley A and Tai HH | Synergistic stimulation of thromboxane biosynthesis by calcium ionophore and phorbol ester or thrombin in human platelets. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3927908 |
Jakubowski JA et al. | Cumulative antiplatelet effect of low-dose enteric coated aspirin. | 1985 | Br. J. Haematol. | pmid:3927970 |
Mehta J et al. | Influence of selective thromboxane synthetase blocker CGS-13080 on thromboxane and prostacyclin biosynthesis in whole blood: evidence for synthesis of prostacyclin by leukocytes from platelet-derived endoperoxides. | 1985 | J. Lab. Clin. Med. | pmid:3928780 |
Sawada M et al. | Enzyme-immunoassay of thromboxane B2 at the picogram level. | 1985 | Prostaglandins | pmid:3929333 |
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Apprill P et al. | Cyclic blood flow variations induced by platelet-activating factor in stenosed canine coronary arteries despite inhibition of thromboxane synthetase, serotonin receptors, and alpha-adrenergic receptors. | 1985 | Circulation | pmid:2988822 |
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Gorczynska E et al. | [Effect of various stimulators on cyclooxygenase activity, platelet aggregation and TxB2 synthesis after using a platelet inhibitor (Aspro Clear) in vivo and in vitro]. | 1985 | Wiad. Lek. | pmid:3933184 |
Berman B et al. | Interferon enhancement of HLA-DR antigen expression on epidermal Langerhans cells. | 1985 | J. Invest. Dermatol. | pmid:2578172 |
Honda M et al. | Effects of purified hog pancreatic kallikrein on the kinin-prostaglandin system and renin-angiotensin-aldosterone system. | 1985 | Nephron | pmid:2993934 |
Shayevitz JR et al. | Inhalation anesthetics augment oxidant-induced pulmonary vasoconstriction: evidence for a membrane effect. | 1985 | Anesthesiology | pmid:3933385 |
Mehta P et al. | Plasma concentrations of thromboxane and prostacyclin metabolites in patients with bone tumors. | 1985 | Am J Pediatr Hematol Oncol | pmid:2994511 |
Patrono C et al. | Clinical pharmacology of platelet cyclooxygenase inhibition. | 1985 | Circulation | pmid:3933848 |
VanRollins M et al. | Metabolism of 7,10,13,16-docosatetraenoic acid to dihomo-thromboxane, 14-hydroxy-7,10,12-nonadecatrienoic acid and hydroxy fatty acids by human platelets. | 1985 | Biochim. Biophys. Acta | pmid:3918572 |
Benigni A et al. | Inhibition of human platelet aggregation by parathyroid hormone. Is cyclic AMP implicated? | 1985 | Am. J. Nephrol. | pmid:2996352 |
Leslie JB and Watkins WD | Eicosanoids in the central nervous system. | 1985 | J. Neurosurg. | pmid:2997413 |
Darius H et al. | Beneficial effects of a new potent and specific thromboxane receptor antagonist (SQ-29,548) in vitro and in vivo. | 1985 | J. Pharmacol. Exp. Ther. | pmid:2997428 |
Zavagli G et al. | Platelet aggregation and evaluation of the ratio thromboxane B2/6-keto-prostaglandin F1 alpha in the plasma of patients on long term cimetidine treatment. | 1985 | Prostaglandins Leukot Med | pmid:2997804 |
Longenecker GL et al. | Kinetics of ibuprofen effect on platelet and endothelial prostanoid release. | 1985 | Clin. Pharmacol. Ther. | pmid:3882308 |
Mitchell JA et al. | Effects of high frequency oscillatory ventilation compared to conventional ventilation upon pulmonary vascular prostanoid production in neonatal piglets. | 1985 | Prostaglandins Leukot Med | pmid:3883366 |
Sinzinger H | Double blind study of the influence of co-dergocrine on platelet parameters in healthy volunteers. | 1985 | Eur. J. Clin. Pharmacol. | pmid:2998802 |
Wenger H et al. | Pulmonary dysfunction secondary to soft-tissue endotoxin. | 1985 | Arch Surg | pmid:3883949 |
Schambelan M et al. | Increased prostaglandin production by glomeruli isolated from rats with streptozotocin-induced diabetes mellitus. | 1985 | J. Clin. Invest. | pmid:3156147 |
Velardo B and Lagarde M | Differential effect of external calcium on the oxygenated metabolism of endogenous and exogenous arachidonic acid in platelets. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3927915 |
Schafer AI and Adelman B | Plasmin inhibition of platelet function and of arachidonic acid metabolism. | 1985 | J. Clin. Invest. | pmid:3156149 |
Klotman PE et al. | Captopril enhances aminoglycoside nephrotoxicity in potassium-depleted rats. | 1985 | Kidney Int. | pmid:2422431 |
Yui Y et al. | A new stable prostacyclin analogue OP41483 (15-cyclopentyl-omega-pentanor-5(E)-carbacyclin). | 1985 | Jpn. Circ. J. | pmid:3897597 |
Túri S et al. | [Changes in serum prostaglandin metabolites in Schönlein-Henoch purpura]. | 1985 | Orv Hetil | pmid:3897944 |
Farias LR et al. | Effect of prostaglandin blockers on ascites fluid in pancreatitis. | 1985 | Surgery | pmid:3898455 |
Kubo K and Kobayashi T | Effects of OKY-046, a selective thromboxane synthetase inhibitor, on endotoxin-induced lung injury in unanesthetized sheep. | 1985 | Am. Rev. Respir. Dis. | pmid:3898941 |
Barst RJ and Stalcup SA | Endothelial function in clinical pulmonary hypertension. | 1985 | Chest | pmid:3899537 |
Pediconi M et al. | Effects of acute and chronic ethanol administration on thromboxane and prostacyclin levels and release in rat brain cortex. | 1985 | Prostaglandins | pmid:3901122 |
Neri Serneri GG et al. | Abnormal cardiocoronary thromboxane A2 production in patients with unstable angina. | 1985 | Am. Heart J. | pmid:3984828 |
Vesterqvist O et al. | In vivo production of thromboxane in acute human myocardial infarction: a preliminary study. | 1985 | Thromb. Res. | pmid:3992528 |
Wirthumer-Hoche C and Sinzinger H | [Protein binding of thromboxane--one of the sources of error in thromboxane determination]. | 1985 | Wien. Klin. Wochenschr. | pmid:3993037 |
Croft KD et al. | Onset of changes in phospholipid fatty acid composition and prostaglandin synthesis following dietary manipulation with n-6 and n-3 fatty acids in the rat. | 1985 | Biochim. Biophys. Acta | pmid:3995069 |
Eldor A et al. | Platelet interaction with subendothelial extracellular matrix: platelet-fibrinogen interactions are essential for platelet aggregation but not for the matrix-induced release reaction. | 1985 | Blood | pmid:3995180 |
Mayfield RK et al. | Platelet function during continuous insulin infusion treatment in insulin-dependent diabetic patients. | 1985 | Diabetes | pmid:3930325 |
Preud'homme Y et al. | Metabolism of arachidonic acid in rabbit iris and retina. | 1985 | Invest. Ophthalmol. Vis. Sci. | pmid:3930417 |
Zahavi J and Zahavi M | Enhanced platelet release reaction, shortened platelet survival time and increased platelet aggregation and plasma thromboxane B2 in chronic obstructive arterial disease. | 1985 | Thromb. Haemost. | pmid:3158092 |
Roy L et al. | Lack of efficacy of nafazatrom, a novel anti-thrombotic compound, in patients with coronary artery disease. | 1985 | Am. Heart J. | pmid:3158183 |
Pedrinelli R et al. | The influence of selective and nonselective prostaglandin inhibition on renin. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159197 |
Ezra D et al. | Effects of platelet-activating factor on coronary hemodynamics and coronary venous plasma levels of TXB2, 6-keto-PGF1 alpha, and leukotriene C4 immunoreactivity in the intact domestic pig heart. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159202 |
Gensini GF et al. | Effects of dipyridamole infusion on local platelet aggregation and local formation of thromboxane A2 in patients with pulmonary hypertension. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159209 |
Reines HD et al. | Dazoxiben in human sepsis and adult respiratory distress syndrome. | 1985 | Clin. Pharmacol. Ther. | pmid:3979000 |
Greco NJ et al. | Action of platelet-activating factor on type 1 diabetic human platelets. | 1985 | J. Lab. Clin. Med. | pmid:3981054 |
Rajtar G et al. | Prostaglandins and human platelet aggregation. Implications for the anti-aggregating activity of thromboxane-synthase inhibitors. | 1985 | Biochem. Pharmacol. | pmid:3918536 |
Patterson GA et al. | Effects of imidazole and indomethacin on fluid balance in isolated sheep lungs. | 1985 | J. Appl. Physiol. | pmid:3884582 |
Kelley VE et al. | A fish oil diet rich in eicosapentaenoic acid reduces cyclooxygenase metabolites, and suppresses lupus in MRL-lpr mice. | 1985 | J. Immunol. | pmid:3918111 |
Prosdocimi M et al. | Coronary and systemic 6-ketoprostaglandin F1 alpha and thromboxane B2 during myocardial ischemia in dog. | 1985 | Am. J. Physiol. | pmid:3838623 |
Krieger BP et al. | Mechanisms of interaction between oxygen and granulocytes in hyperoxic lung injury. | 1985 | J. Appl. Physiol. | pmid:3838744 |
Valentovic MA and Lubawy WC | Elevated glucose in vivo and in vitro adversely alters prostaglandin generation in rat aortas and platelets. | 1985 | Prostaglandins Leukot Med | pmid:3903777 |
Bergqvist D et al. | The effect of inhibition of thromboxane synthesis in experimental thrombosis and hemostasis. | 1985 | Thromb. Res. | pmid:3838828 |
Stuart MJ et al. | Prostanoids in hemolytic uremic syndrome. | 1985 | J. Pediatr. | pmid:3839015 |
Nigam S et al. | The concentrations of 6-keto-PGF1 alpha and TXB2 in plasma samples from patients with benign and malignant tumours of the breast. | 1985 | Prostaglandins | pmid:3839084 |
Hamilton TA et al. | gamma-Interferon enhances the secretion of arachidonic acid metabolites from murine peritoneal macrophages stimulated with phorbol diesters. | 1985 | J. Immunol. | pmid:3919102 |
Petroni A et al. | Differential effects of various vasoactive drugs on basal and stimulated levels of TXB2 and 6-keto-PGF1 alpha in rat brain. | 1985 | Prostaglandins | pmid:3839085 |
Zipser RD | Effects of selective inhibition of thromboxane synthesis on renal function in humans. | 1985 | Am. J. Physiol. | pmid:3839111 |
Elliott GR et al. | Differential regulation of the cyclooxygenase pathway in starch elicited rat peritoneal macrophages by prostaglandin E2, U-44069, a stable endoperoxide analogue and dibutyryl-cyclic AMP. | 1985 | Eur. J. Pharmacol. | pmid:2995076 |
Weisman SM et al. | Platelet-activating factor is a potent stimulus for renal prostaglandin synthesis: possible significance in unilateral ureteral obstruction. | 1985 | J. Pharmacol. Exp. Ther. | pmid:3862805 |
Fink MP et al. | Low-dose dopamine preserves renal blood flow in endotoxin shocked dogs treated with ibuprofen. | 1985 | J. Surg. Res. | pmid:3839278 |
Bornman MS et al. | Elevated thromboxane B2 levels during erection. | 1985 | S. Afr. Med. J. | pmid:3839322 |
Steinhauer HB et al. | Stimulation of peritoneal synthesis of vasoactive prostaglandins during peritonitis in patients on continuous ambulatory peritoneal dialysis. | 1985 | Eur. J. Clin. Invest. | pmid:3921379 |
Hillbom M et al. | Platelet thromboxane formation and bleeding time is influenced by ethanol withdrawal but not by cigarette smoking. | 1985 | Thromb. Haemost. | pmid:4049313 |
Gairola C and Tai HH | Selective inhibition of leukotriene B4 biosynthesis in rat pulmonary alveolar macrophages by dietary selenium deficiency. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2998361 |
Aviram M et al. | Plasma lipoproteins affect platelet malondialdehyde and thromboxane B2 production. | 1985 | Biochem Med | pmid:4052061 |
Simmet T et al. | Modulation of eicosanoid release from anaphylactic guinea-pig heart with 5-benzoyl-a-methyl-2-thiophene acetic acid (tiaprofenic acid). | 1985 | Arch Int Pharmacodyn Ther | pmid:3841634 |
Rinaldo JE and Dauber JH | Effect of methylprednisolone and of ibuprofen, a nonsteroidal antiinflammatory agent, on bronchoalveolar inflammation following endotoxemia. | 1985 | Circ. Shock | pmid:4053294 |
Shingu T | [Prostaglandin metabolism in ischemic brain edema]. | 1985 | Nihon Geka Hokan | pmid:3841635 |
Leffler CW and Busija DW | Prostanoids in cortical subarachnoid cerebrospinal fluid and pial arterial diameter in newborn pigs. | 1985 | Circ. Res. | pmid:4053302 |
Tobian L et al. | Prostaglandin alterations in barely hypertensive Dahl S rats. | 1985 | Trans. Assoc. Am. Physicians | pmid:3842205 |
Ment LR et al. | Beagle puppy model of perinatal cerebral infarction. Acute changes in regional cerebral prostaglandins during hemorrhagic hypotension. | 1985 | J. Neurosurg. | pmid:4056903 |
Wong C et al. | Effect of hydroxyl radical scavenging on endotoxin-induced lung injury. | 1985 | Surgery | pmid:2983450 |
Di Minno G et al. | Platelet dysfunction in uremia. Multifaceted defect partially corrected by dialysis. | 1985 | Am. J. Med. | pmid:3933340 |
Numano F et al. | Coronary spasm, prostaglandin and HLA factors. | 1985 | Jpn. Circ. J. | pmid:3855470 |
Katoh K et al. | [Serial changes in plasma thromboxane and complement in ARDS--effect of the thromboxane synthetase inhibitor]. | 1985 | Masui | pmid:4057547 |
Purkerson ML et al. | Inhibition of thromboxane synthesis ameliorates the progressive kidney disease of rats with subtotal renal ablation. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3855542 |
Jackson EK | Effects of thromboxane synthase inhibition on vascular responsiveness in the in vivo rat mesentery. | 1985 | J. Clin. Invest. | pmid:4077980 |
Dempsey RJ et al. | Polyamine and prostaglandin markers in focal cerebral ischemia. | 1985 | Neurosurgery | pmid:3864030 |
Dahl ML and Uotila P | Sodium salicylate does not prevent the inhibitory effect of indomethacin on thromboxane formation in human blood ex vivo. | 1985 | Prostaglandins Leukot Med | pmid:3856282 |
Kääpä P | Immunoreactive thromboxane B2 and 6-keto-prostaglandin F1 alpha in neonatal hyperbilirubinemia. | 1985 | Prostaglandins Leukot Med | pmid:3856285 |
Mallarkey G and Smith GM | A comparative study of the involvement of the prostaglandin H2/thromboxane A2 pathway in intravascular platelet aggregation in guinea-pigs and rats. | 1985 | Br. J. Pharmacol. | pmid:3156648 |
Zijlstra FJ and Vincent JE | Leukotriene D4 and phospholipase A2 release thromboxane A2 of different origin in the guinea pig lung parenchymal strip. | 1985 | Prostaglandins Leukot Med | pmid:3857642 |
Salmon JA et al. | Evaluation of inhibitors of eicosanoid synthesis in leukocytes: possible pitfall of using the calcium ionophore A23187 to stimulate 5' lipoxygenase. | 1985 | Prostaglandins | pmid:2988019 |
Hutchison AA et al. | Plasma 6-keto prostaglandin F1 alpha and thromboxane B2 in sick preterm neonates. | 1985 | Prostaglandins Leukot Med | pmid:3859877 |
Sterk PJ et al. | Limited maximal airway narrowing in nonasthmatic subjects. Role of neural control and prostaglandin release. | 1985 | Am. Rev. Respir. Dis. | pmid:2864892 |