Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Durante W and Sunahara FA | Cardiovascular effects of high frequency ventilation--the possible involvement of thromboxane. | 1987 | Prostaglandins Leukot Med | pmid:3114767 |
Hamasaki Y et al. | Hypoxia stimulates prostacyclin generation by dog lung in vitro. | 1982 | Prostaglandins Leukot Med | pmid:7051045 |
Karmali RA et al. | Prostaglandin regulation of murine mammary tumor virus production: a basis for some of the glucocorticoid and prolactin actions on mammary tumor cell cultures. | 1982 | Prostaglandins Leukot Med | pmid:6296884 |
Karmali RA et al. | Macrophage production of prostaglandins: effects of fetal calf serum and diazepam. Use of an improved method for extracting 6-keto-PGF1 alpha. | 1982 | Prostaglandins Leukot Med | pmid:6955812 |
Mehta J et al. | Severe intracoronary thromboxane release preceding acute coronary artery occlusion. | 1982 | Prostaglandins Leukot Med | pmid:6955814 |
Jaweed MM et al. | Changes in thromboxane B2 and 6-keto-PGF1 alpha after direct electrical stimulation of the denervated rat gastrocnemius1,2. | 1982 | Prostaglandins Leukot Med | pmid:6956927 |
Taube C et al. | Enhanced thromboxane production in the aorta of spontaneously hypertensive rats in vitro. | 1982 | Prostaglandins Leukot Med | pmid:6960370 |
Merola AJ et al. | Prostaglandin response in the exercise conditioned rat. | 1984 | Prostaglandins Leukot Med | pmid:6377328 |
Sinzinger H et al. | Platelet function and prostaglandins in patients with peripheral vascular disease treated with calcium dobesilate. | 1987 | Prostaglandins Leukot Med | pmid:2959967 |
Pullen RH et al. | High performance liquid chromatographic determination of thromboxane B2 in human serum as a methoxime-panacylester derivative. | 1987 | Prostaglandins Leukot Med | pmid:3432306 |
Reeves WC et al. | The release of thromboxane A2 and prostacyclin following experimental acute pulmonary embolism. | 1983 | Prostaglandins Leukot Med | pmid:6348800 |
Mehta P et al. | Thromboxane and prostacyclin generation by intact human vessels in response to balloon catheter trauma. | 1982 | Prostaglandins Leukot Med | pmid:6217465 |
Kaar ML et al. | Prostacyclin and thromboxane in diabetic children. | 1983 | Prostaglandins Leukot Med | pmid:6351104 |
Dahl ML et al. | Sodium salicylate interferes with the inhibitory effects of aspirin and indomethacin on human platelets. | 1983 | Prostaglandins Leukot Med | pmid:6415666 |
Tremoli E et al. | In vitro effects of aspirin and non steroidal anti-inflammatory drugs on the formation of 12-hydroxyeicosatetraenoic acid by platelets. | 1986 | Prostaglandins Leukot Med | pmid:3094026 |
McDonald JW and Ali M | Recovery of cyclooxygenase activity after aspirin in populations of platelets separated on stractan density gradients. | 1983 | Prostaglandins Leukot Med | pmid:6419234 |
Morita I et al. | Effect of dietary protein level on platelet aggregation in rat. | 1985 | Prostaglandins Leukot Med | pmid:3892545 |
Simberg N | Maternal aspirin administration inhibits pulmonary arachidonic acid metabolism in fetal rabbits. | 1984 | Prostaglandins Leukot Med | pmid:6425868 |
Rao GH et al. | Enteric-coated aspirin, platelet cyclooxygenase activity and function. | 1984 | Prostaglandins Leukot Med | pmid:6425869 |
Brandt R et al. | Effect of propranolol, practolol and atenolol on human platelet thromboxane formation and plasma levels of prostaglandins 6-keto-F1 alpha and E2. | 1984 | Prostaglandins Leukot Med | pmid:6597450 |
Chiba S et al. | Sex and age-related differences in the urinary excretion of TXB2 in normal human subjects: a possible pathophysiological role of TXA2 in the aged kidney. | 1984 | Prostaglandins Leukot Med | pmid:6597456 |
Mahmud I et al. | Thromboxane synthesizing system in rat liver. | 1984 | Prostaglandins Leukot Med | pmid:6597457 |
Srivastava KC and Awasthi KK | A comparative study on the effect of cis (oleic, linoleic) and trans (elaidic, linoelaidic) fatty acids on the in vitro prostaglandin biosynthesis in human blood platelets from (1-14C) arachidonic acid. | 1982 | Prostaglandins Leukot Med | pmid:6818563 |
Pönicke K et al. | Stimulation of aggregation and thromboxane A2 formation of human platelets by hypoxia. | 1987 | Prostaglandins Leukot Med | pmid:3478738 |
Henriksson P et al. | Increased aortic thromboxane production in experimental atherosclerosis. | 1987 | Prostaglandins Leukot Med | pmid:3478739 |
Ouwendijk RJ et al. | Raised plasma thromboxane B2 levels in alcoholic liver disease. | 1983 | Prostaglandins Leukot Med | pmid:6573682 |
Hornych A et al. | Thromboxane B2 in borderline and essential hypertensive patients. | 1983 | Prostaglandins Leukot Med | pmid:6573683 |
Wilson L and Lindsey R | Effects of progesterone withdrawal on uterine prostaglandin levels in the ovariectomized pregnant rat. | 1987 | Prostaglandins Leukot Med | pmid:3478741 |
Flynn JT et al. | Effects of anesthesia and surgery on prostanoid concentrations in plasma and pulmonary lymph. | 1983 | Prostaglandins Leukot Med | pmid:6573688 |
Patel K and Bakhle YS | Thromboxane B2 (TxB2) metabolism in rat isolated lung and its inhibition by drugs. | 1983 | Prostaglandins Leukot Med | pmid:6573689 |
Davì G et al. | Plasmatic TXB2 and 6-keto-PGF1 alpha levels during charcoal hemoperfusion in chronic renal failure patients. | 1983 | Prostaglandins Leukot Med | pmid:6573692 |
Lieb J et al. | Elevated levels of prostaglandin E2 and thromboxane B2 in depression. | 1983 | Prostaglandins Leukot Med | pmid:6574523 |
Viinikka L et al. | Effect of prolonged treatment with acetylsalicylic acid and dipyridamole on platelet thromboxane A2 production in atherosclerotic subjects. | 1983 | Prostaglandins Leukot Med | pmid:6576385 |
Fukumoto S and Tanaka K | Protective effects of thromboxane A2 synthetase inhibitors on endotoxin shock. | 1983 | Prostaglandins Leukot Med | pmid:6576388 |
Giani E et al. | Platelets from aged rats aggregate more, but are more sensitive to prostacyclin. | 1985 | Prostaglandins Leukot Med | pmid:3003760 |
Srivastava KC | Isolation and effects of some ginger components of platelet aggregation and eicosanoid biosynthesis. | 1986 | Prostaglandins Leukot Med | pmid:3103137 |
Shaala S et al. | Local effect of thromboxane B2 on the contractility of the human non pregnant uterus. | 1984 | Prostaglandins Leukot Med | pmid:6587408 |
Meydani M et al. | Effects of dietary methionine, methylmercury, and atrazine on ex-vivo synthesis of prostaglandin E1 and thromboxane B2. | 1984 | Prostaglandins Leukot Med | pmid:6588393 |
Bjøro K et al. | Formation of prostanoids in human umbilical vessels perfused in vitro. | 1986 | Prostaglandins | pmid:3523623 |
Lagente V et al. | Interference of the PAF-acether antagonist BN 52021 with passive anaphylaxis in the guinea-pig. | 1987 | Prostaglandins | pmid:2438723 |
Bjøro K | Prostacyclin and thromboxane formation in human umbilical arteries following stimulation with vasoactive autacoids. | 1986 | Prostaglandins | pmid:3523624 |
Förstermann U et al. | An increase in the ratio of thromboxane A2 to prostacyclin in association with increased blood pressure in patients on cyclosporine A. | 1989 | Prostaglandins | pmid:2662262 |
Leach CM and Thorburn GD | A comparative study of collagen induced thromboxane release from platelets of different species: implications for human atherosclerosis models. | 1982 | Prostaglandins | pmid:7122912 |
Mike I et al. | The differences in 12-hydroxyeicosatetraenoic acid and thromboxane B2 release from guinea pig platelets. | 1991 | Prostaglandins | pmid:1763200 |
Giani E et al. | Sex differences in platelet thromboxane and arterial prostacyclin production in control and n-6 fatty acid supplemented rats. | 1984 | Prostaglandins | pmid:6441187 |
Vesterqvist O and Gréen K | Urinary excretion of 2,3-dinor-thromboxane B2 in man under normal conditions, following drugs and during some pathological conditions. | 1984 | Prostaglandins | pmid:6539491 |
Hsueh W et al. | Identification of C3b as the major serum protein that stimulates prostaglandin and thromboxane synthesis by macrophages. | 1984 | Prostaglandins | pmid:6240667 |
Powell WS and Solomon S | Biosynthesis of prostaglandins and thromboxane B2 by fetal lung homogenates. | 1978 | Prostaglandins | pmid:635224 |
Homo-Delarche F et al. | Thymic hormones and prostaglandins. II. Synergistic effect on mouse spontaneous rosette forming cells. | 1990 | Prostaglandins | pmid:2339201 |
Arima T et al. | Changes in urinary thromboxane level in man during cardiopulmonary bypass: effect of thromboxane on renal tubules. | 1990 | Prostaglandins | pmid:2339202 |
Rosenfeld J et al. | Extractive alkylation of prostaglandins. | 1981 | Prostaglandins | pmid:7010456 |
Tanaka M et al. | Increased prostacyclin synthesizing activity in human ripening uterine cervix. | 1981 | Prostaglandins | pmid:7010458 |
Tagari P et al. | Measurement of canine urinary thromboxanes by GC-MS and HPLC-RIA. | 1994 | Prostaglandins | pmid:8041872 |
Araki H et al. | Mechanism of protection against arachidonate induced sudden death by glucocorticoid. | 1981 | Prostaglandins | pmid:7232764 |
Goldsmith JC and Needleman SW | A comparative study of thromboxane and prostacyclin release from ex vivo and cultured bovine vascular endothelium. | 1982 | Prostaglandins | pmid:6815717 |
Lord A et al. | Leukotriene F4 and the release of arachidonic acid metabolites from perfused guinea pig lungs in vitro. | 1985 | Prostaglandins | pmid:3923570 |
Gorman RR et al. | Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate. | 1983 | Prostaglandins | pmid:6316421 |
Ogle CK et al. | The production of C3, PGE2 and TxB2 by splenic, alveolar, and peritoneal guinea pig macrophages. | 1988 | Prostaglandins | pmid:3237993 |
Ali M et al. | Synthesis of thromboxane B2 and prostaglandins by bovine gastric mucosal microsomes. | 1977 | Prostaglandins | pmid:594386 |
Stenson WF et al. | Metabolism of exogenous arachidonic acid by murine macrophage-like tumor cell lines. | 1981 | Prostaglandins | pmid:6803301 |
Kelly KL and Laychock SG | Prostaglandin synthesis and metabolism in isolated pancreatic islets of the rat. | 1981 | Prostaglandins | pmid:6803305 |
Yoshimoto T et al. | Selective inhibition of prostaglandin endoperoxide thromboxane isomerase by 1-carboxyalkylimidazoles. | 1978 | Prostaglandins | pmid:725083 |
Wilken C et al. | Increased production of ovarian thromboxane in gonadotropin-treated immature rats: relationship to the ovulatory process. | 1990 | Prostaglandins | pmid:2093939 |
Anderson MW et al. | Kinetic studies on the conversion of prostaglandin endoperoxide PGH2 by thromboxane synthase. | 1978 | Prostaglandins | pmid:725086 |
Chiabrando C et al. | Quantitative determination of 6-keto-PGF1 alpha released by rat aorta: comparison of mass fragmentography and high resolution gas chromatography with electron capture detection. | 1980 | Prostaglandins | pmid:6894036 |
Elliott GR et al. | Copper modulation of macrophage cyclooxygenase metabolite synthesis. | 1987 | Prostaglandins | pmid:3124217 |
Sadowitz PD et al. | The platelet cyclooxygenase metabolite 12-L-hydroxy-5, 8, 10-hepta-decatrienoic acid (HHT) may modulate primary hemostasis by stimulating prostacyclin production. | 1987 | Prostaglandins | pmid:3124219 |
Alanko J et al. | Catecholamines decrease leukotriene B4 and increase thromboxane B2 synthesis in A23187-stimulated human whole blood. | 1991 | Prostaglandins | pmid:1664115 |
Hubbard HL et al. | Extraction of thromboxane B2 from urine using an immobilized antibody column for subsequent analysis by gas chromatography-mass spectrometry. | 1987 | Prostaglandins | pmid:3588968 |
Yamanaka S et al. | 11-Dehydro thromboxane B2: a reliable parameter of thromboxane A2 production in dogs. | 1993 | Prostaglandins | pmid:8484010 |
Sawada M et al. | Enzyme-immunoassay of thromboxane B2 at the picogram level. | 1985 | Prostaglandins | pmid:3929333 |
Ellwood DA et al. | Specific changes in the in vitro production of prostanoids by the ovine cervix at parturition. | 1980 | Prostaglandins | pmid:7384553 |
Lagarde M et al. | Nicergoline, an anti-aggregating agent which inhibits release of arachidonic acid from human platelet phospholipids. | 1980 | Prostaglandins | pmid:7384555 |
Zhao Y et al. | Urinary thromboxane B2 in cardiac transplant patients as a screening method of rejection. | 1997 | Prostaglandins | pmid:9533183 |
Moretti RL and Lin CY | Coronary vasoconstrictor extracted from blood plasma stimulates platelet lipoxidase activity. | 1980 | Prostaglandins | pmid:6770419 |
Maggi FM et al. | Prostaglandin synthetase activity in vascular tissue of male and female rats. | 1980 | Prostaglandins | pmid:6770422 |
Neulen J et al. | Arachidonic acid metabolism and prostaglandin production by primate preimplantation blastocysts. | 1991 | Prostaglandins | pmid:1775634 |
Myers SI et al. | Burn injury decreased splanchnic PGI2 release is restored by treatment with lazaroid. | 1993 | Prostaglandins | pmid:8337413 |
Kane GC et al. | Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor. | 1995 | Prostaglandins | pmid:8588068 |
Wetzka B et al. | Eicosanoid production by intrauterine tissues before and after labor in short-term tissue culture. | 1993 | Prostaglandins | pmid:8337416 |
Feddersen CO et al. | Leukotriene E4 causes pulmonary vasoconstriction, not inhibited by meclofenamate. | 1983 | Prostaglandins | pmid:6098932 |
Spagnuolo C et al. | PGF2 alpha, thromboxane B2 and HETE levels in gerbil brain cortex after ligation of common carotid arteries and decapitation. | 1979 | Prostaglandins | pmid:230539 |
She HS et al. | Metabolism of prostaglandin endoperoxide by microsomes from cat lung. | 1981 | Prostaglandins | pmid:6894797 |
Redfern JS et al. | Gastroduodenal ulceration following active immunization with prostaglandin E2 in dogs. Role of gastric acid secretion. | 1987 | Prostaglandins | pmid:3481091 |
Siler-Khodr TM et al. | The effect of dexamethasone on CRH and prostanoid production from human term placenta. | 1997 | Prostaglandins | pmid:9373879 |
Agradi E et al. | In vitro effects of synthetic antioxidants and vitamin E on arachidonic acid metabolism and thromboxane formation in human platelets and on platelet aggregation. | 1981 | Prostaglandins | pmid:6794104 |
Anton RF et al. | In vivo regional levels of PGE and thromboxane in mouse brain: effect of decapitation, focused microwave fixation, and indomethacin. | 1983 | Prostaglandins | pmid:6658001 |
Mahoney D et al. | Influence of dietary polyunsaturated fatty acids on renal & aortic prostaglandin synthesis in 1 kidney 1 clip Goldblatt hypertensive rats. | 1983 | Prostaglandins | pmid:6658002 |
Pediconi M et al. | Effects of acute and chronic ethanol administration on thromboxane and prostacyclin levels and release in rat brain cortex. | 1985 | Prostaglandins | pmid:3901122 |
Chong KP et al. | Vasopressin stimulates thromboxane synthesis in isolated hamster hepatocytes: relation to hepatocyte calcium content. | 1983 | Prostaglandins | pmid:6419286 |
Miller RF et al. | Meclofenamate blocks the pulmonary arterial vasopressor effects of leukotriene B4 in awake sheep. | 1988 | Prostaglandins | pmid:2853421 |
Aitokallio-Tallberg A | Prostacyclin and thromboxane synthesis by endometrial cancer and leiomyomas. | 1990 | Prostaglandins | pmid:2111034 |
Slama H et al. | Metabolism of arachidonic acid by caruncular and allantochorionic tissues in cows with retained fetal membranes (RFM). | 1993 | Prostaglandins | pmid:8380936 |
Datar S et al. | Testing the "redirection hypothesis" of prostaglandin metabolism in the kidney. | 1987 | Prostaglandins | pmid:3296006 |
Chiabrando C et al. | Urinary excretion and origin of 11-dehydro-2,3-dinor-thromboxane B2 in man. | 1993 | Prostaglandins | pmid:8321910 |
Nigam S et al. | The concentrations of 6-keto-PGF1 alpha and TXB2 in plasma samples from patients with benign and malignant tumours of the breast. | 1985 | Prostaglandins | pmid:3839084 |
Farker K et al. | Measurements of urinary prostaglandins in young ovulatory women during the menstrual cycle and in postmenopausal women. | 1997 | Prostaglandins | pmid:9373880 |
Sullivan MH et al. | Effects of a thromboxane synthetase inhibitor on platelet function; possible risks of use in pregnancy. | 1993 | Prostaglandins | pmid:8378539 |
Westlund P et al. | Circulating and urinary thromboxane B2 metabolites in the rabbit: 11-dehydro-thromboxane B2 as parameter of thromboxane production. | 1986 | Prostaglandins | pmid:3520685 |
Chiabrando C et al. | Urinary excretion of 2,3-dinor-thromboxane B1, a major metabolite of thromboxane B2 in the rat. | 1994 | Prostaglandins | pmid:7938613 |