Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Greer IA et al. | Inhibition of thromboxane and prostacyclin production in whole blood by adrenoceptor antagonists. | 1985 | Prostaglandins Leukot Med | pmid:2865745 |
Mikhailidis DP et al. | The effect of non-specific beta-blockade on metabolic and haemostatic variables during hypoglycaemia. | 1985 | Diabetes Res. | pmid:2866057 |
Mehta J et al. | Increase in human platelet alpha 2-adrenergic receptor affinity for agonist in unstable angina. | 1985 | J. Lab. Clin. Med. | pmid:2866219 |
Greer IA et al. | A comparative study of the effects of adrenoceptor antagonists on platelet aggregation and thromboxane generation. | 1985 | Thromb. Haemost. | pmid:2867620 |
Habenicht AJ et al. | Human platelet-derived growth factor stimulates prostaglandin synthesis by activation and by rapid de novo synthesis of cyclooxygenase. | 1985 | J. Clin. Invest. | pmid:3921570 |
Gragnoli G et al. | Effects of somatostatin on the behaviour of thromboxane B2 and beta-thromboglobulin in type I diabetes. | 1985 | Acta Endocrinol. | pmid:2408435 |
Yardumian DA et al. | Platelet hyperaggregability occurring during prolonged continuous intravenous infusions of prostacyclin analogue ZK 36374. | 1985 | Br. J. Haematol. | pmid:2408653 |
Patrassi GM et al. | Contact phase of coagulation in diabetes mellitus after aspirin administration. | 1985 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:2410343 |
Schlondorff D and Satriano JA | Interactions of vasopressin, cAMP, and prostaglandins in toad urinary bladder. | 1985 | Am. J. Physiol. | pmid:2579584 |
Lord A et al. | Leukotriene F4 and the release of arachidonic acid metabolites from perfused guinea pig lungs in vitro. | 1985 | Prostaglandins | pmid:3923570 |
Shorr RI et al. | In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis. | 1985 | Thromb. Res. | pmid:3923647 |
Francos GC et al. | Dialysis-induced hypoxemia: membrane dependent and membrane independent causes. | 1985 | Am. J. Kidney Dis. | pmid:3919574 |
Ylitalo P et al. | Inhibition of prostaglandin synthesis by indomethacin interacts with the antihypertensive effect of atenolol. | 1985 | Clin. Pharmacol. Ther. | pmid:3899459 |
Packham MA et al. | Duration of the effect of aspirin on the synthesis of thromboxane by density subpopulations of rabbit platelets stimulated with thrombin. | 1985 | Blood | pmid:3926022 |
Cattaneo M et al. | Human platelet aggregation and release reaction induced by platelet activating factor (PAF-acether)--effects of acetylsalicylic acid and external ionized calcium. | 1985 | Thromb. Haemost. | pmid:3927505 |
Mobley A and Tai HH | Synergistic stimulation of thromboxane biosynthesis by calcium ionophore and phorbol ester or thrombin in human platelets. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3927908 |
Jakubowski JA et al. | Cumulative antiplatelet effect of low-dose enteric coated aspirin. | 1985 | Br. J. Haematol. | pmid:3927970 |
Mehta J et al. | Influence of selective thromboxane synthetase blocker CGS-13080 on thromboxane and prostacyclin biosynthesis in whole blood: evidence for synthesis of prostacyclin by leukocytes from platelet-derived endoperoxides. | 1985 | J. Lab. Clin. Med. | pmid:3928780 |
Brown CG and Poyser NL | Further studies on prostaglandin and thromboxane production by the rat uterus during the oestrous cycle. | 1985 | J. Reprod. Fertil. | pmid:3857345 |
Callahan KS et al. | Enhancement of the antiaggregatory activity of prostacyclin by propranolol in human platelets. | 1985 | Circulation | pmid:2986877 |
Sawada M et al. | Enzyme-immunoassay of thromboxane B2 at the picogram level. | 1985 | Prostaglandins | pmid:3929333 |
De Caterina R et al. | Low-dose aspirin in patients recovering from myocardial infarction. Evidence for a selective inhibition of thromboxane-related platelet function. | 1985 | Eur. Heart J. | pmid:3930246 |
Beatty CH et al. | Metabolism of arachidonic acid by macaque platelets. Implications for studies on atherosclerosis. | 1985 | Atherosclerosis | pmid:3924062 |
Apprill P et al. | Cyclic blood flow variations induced by platelet-activating factor in stenosed canine coronary arteries despite inhibition of thromboxane synthetase, serotonin receptors, and alpha-adrenergic receptors. | 1985 | Circulation | pmid:2988822 |
Fukuda Y | [Plasma prostaglandin and thromboxane levels in asthmatic children]. | 1985 | Arerugi | pmid:2992423 |
Gorczynska E et al. | [Effect of various stimulators on cyclooxygenase activity, platelet aggregation and TxB2 synthesis after using a platelet inhibitor (Aspro Clear) in vivo and in vitro]. | 1985 | Wiad. Lek. | pmid:3933184 |
Berman B et al. | Interferon enhancement of HLA-DR antigen expression on epidermal Langerhans cells. | 1985 | J. Invest. Dermatol. | pmid:2578172 |
Honda M et al. | Effects of purified hog pancreatic kallikrein on the kinin-prostaglandin system and renin-angiotensin-aldosterone system. | 1985 | Nephron | pmid:2993934 |
Shayevitz JR et al. | Inhalation anesthetics augment oxidant-induced pulmonary vasoconstriction: evidence for a membrane effect. | 1985 | Anesthesiology | pmid:3933385 |
Mehta P et al. | Plasma concentrations of thromboxane and prostacyclin metabolites in patients with bone tumors. | 1985 | Am J Pediatr Hematol Oncol | pmid:2994511 |
VanRollins M et al. | Metabolism of 7,10,13,16-docosatetraenoic acid to dihomo-thromboxane, 14-hydroxy-7,10,12-nonadecatrienoic acid and hydroxy fatty acids by human platelets. | 1985 | Biochim. Biophys. Acta | pmid:3918572 |
Baud L et al. | Lipoxygenase products mediate the attachment of rat macrophages to glomeruli in vitro. | 1985 | Kidney Int. | pmid:3927056 |
Benigni A et al. | Inhibition of human platelet aggregation by parathyroid hormone. Is cyclic AMP implicated? | 1985 | Am. J. Nephrol. | pmid:2996352 |
Leslie JB and Watkins WD | Eicosanoids in the central nervous system. | 1985 | J. Neurosurg. | pmid:2997413 |
Wilson TW and Tan LK | Low plasma renin activity in diabetes. Relation to urine prostaglandin excretion. | 1985 | Diabetes | pmid:3881302 |
Longenecker GL et al. | Kinetics of ibuprofen effect on platelet and endothelial prostanoid release. | 1985 | Clin. Pharmacol. Ther. | pmid:3882308 |
Mitchell JA et al. | Effects of high frequency oscillatory ventilation compared to conventional ventilation upon pulmonary vascular prostanoid production in neonatal piglets. | 1985 | Prostaglandins Leukot Med | pmid:3883366 |
Wenger H et al. | Pulmonary dysfunction secondary to soft-tissue endotoxin. | 1985 | Arch Surg | pmid:3883949 |
Schambelan M et al. | Increased prostaglandin production by glomeruli isolated from rats with streptozotocin-induced diabetes mellitus. | 1985 | J. Clin. Invest. | pmid:3156147 |
Schafer AI and Adelman B | Plasmin inhibition of platelet function and of arachidonic acid metabolism. | 1985 | J. Clin. Invest. | pmid:3156149 |
Sirois P et al. | Role of cyclooxygenase products in the lung action of leukotrienes A4, B4, C4, D4 and E4. | 1985 | Pharmacology | pmid:2997811 |
de Lorgeril M et al. | Acute influence of cigarette smoke in platelets, catecholamines and neurophysins in the normal conditions of daily life. | 1985 | Eur. Heart J. | pmid:2937635 |
Paajanen H and Kormano M | Prostacyclin (PGI2) and thromboxane (TXA2) levels during intravenous contrast medium administration in CT. | 1985 | Eur J Radiol | pmid:3896802 |
Yui Y et al. | A new stable prostacyclin analogue OP41483 (15-cyclopentyl-omega-pentanor-5(E)-carbacyclin). | 1985 | Jpn. Circ. J. | pmid:3897597 |
Túri S et al. | [Changes in serum prostaglandin metabolites in Schönlein-Henoch purpura]. | 1985 | Orv Hetil | pmid:3897944 |
Farias LR et al. | Effect of prostaglandin blockers on ascites fluid in pancreatitis. | 1985 | Surgery | pmid:3898455 |
Kubo K and Kobayashi T | Effects of OKY-046, a selective thromboxane synthetase inhibitor, on endotoxin-induced lung injury in unanesthetized sheep. | 1985 | Am. Rev. Respir. Dis. | pmid:3898941 |
Barst RJ and Stalcup SA | Endothelial function in clinical pulmonary hypertension. | 1985 | Chest | pmid:3899537 |
Pediconi M et al. | Effects of acute and chronic ethanol administration on thromboxane and prostacyclin levels and release in rat brain cortex. | 1985 | Prostaglandins | pmid:3901122 |
Neri Serneri GG et al. | Abnormal cardiocoronary thromboxane A2 production in patients with unstable angina. | 1985 | Am. Heart J. | pmid:3984828 |
Vesterqvist O et al. | In vivo production of thromboxane in acute human myocardial infarction: a preliminary study. | 1985 | Thromb. Res. | pmid:3992528 |
O'Byrne PM et al. | Leukotriene B4 induces airway hyperresponsiveness in dogs. | 1985 | J. Appl. Physiol. | pmid:3001017 |
Mayfield RK et al. | Platelet function during continuous insulin infusion treatment in insulin-dependent diabetic patients. | 1985 | Diabetes | pmid:3930325 |
Tanaka M and Shibata Y | The different response of guinea pig peritoneal macrophages to various stimulators. | 1985 | Gen. Pharmacol. | pmid:3930344 |
Preud'homme Y et al. | Metabolism of arachidonic acid in rabbit iris and retina. | 1985 | Invest. Ophthalmol. Vis. Sci. | pmid:3930417 |
Zahavi J and Zahavi M | Enhanced platelet release reaction, shortened platelet survival time and increased platelet aggregation and plasma thromboxane B2 in chronic obstructive arterial disease. | 1985 | Thromb. Haemost. | pmid:3158092 |
Martin JL et al. | Effect of high dose aspirin on coronary hemodynamics during pacing-induced myocardial ischemia. | 1985 | J. Am. Coll. Cardiol. | pmid:3968305 |
Roy L et al. | Lack of efficacy of nafazatrom, a novel anti-thrombotic compound, in patients with coronary artery disease. | 1985 | Am. Heart J. | pmid:3158183 |
De Caterina R et al. | Inhibition of platelet aggregation and thromboxane B2 production during aspirin treatment: dependence on the dose of the aggregating agent. | 1985 | Thromb. Res. | pmid:3975876 |
Pedrinelli R et al. | The influence of selective and nonselective prostaglandin inhibition on renin. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159197 |
Cook JA et al. | Exchange transfusions in rats with a perfluorated blood substitute: effect on thromboxane B2 levels during endotoxemia. | 1985 | Circ. Shock | pmid:3978769 |
Reines HD et al. | Dazoxiben in human sepsis and adult respiratory distress syndrome. | 1985 | Clin. Pharmacol. Ther. | pmid:3979000 |
Greco NJ et al. | Action of platelet-activating factor on type 1 diabetic human platelets. | 1985 | J. Lab. Clin. Med. | pmid:3981054 |
Patterson GA et al. | Effects of imidazole and indomethacin on fluid balance in isolated sheep lungs. | 1985 | J. Appl. Physiol. | pmid:3884582 |
Kelley VE et al. | A fish oil diet rich in eicosapentaenoic acid reduces cyclooxygenase metabolites, and suppresses lupus in MRL-lpr mice. | 1985 | J. Immunol. | pmid:3918111 |
Schrör K et al. | [Inhibition of platelet aggregation and thromboxane formation by the calcium antagonist nisoldipine following a single oral dose of 10 mg. A double-blind study in healthy probands]. | 1985 | Klin. Wochenschr. | pmid:3838352 |
Bult H et al. | Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid. | 1985 | Br. J. Pharmacol. | pmid:3838489 |
Prosdocimi M et al. | Coronary and systemic 6-ketoprostaglandin F1 alpha and thromboxane B2 during myocardial ischemia in dog. | 1985 | Am. J. Physiol. | pmid:3838623 |
Krieger BP et al. | Mechanisms of interaction between oxygen and granulocytes in hyperoxic lung injury. | 1985 | J. Appl. Physiol. | pmid:3838744 |
Valentovic MA and Lubawy WC | Elevated glucose in vivo and in vitro adversely alters prostaglandin generation in rat aortas and platelets. | 1985 | Prostaglandins Leukot Med | pmid:3903777 |
Bergqvist D et al. | The effect of inhibition of thromboxane synthesis in experimental thrombosis and hemostasis. | 1985 | Thromb. Res. | pmid:3838828 |
Stuart MJ et al. | Prostanoids in hemolytic uremic syndrome. | 1985 | J. Pediatr. | pmid:3839015 |
Nigam S et al. | The concentrations of 6-keto-PGF1 alpha and TXB2 in plasma samples from patients with benign and malignant tumours of the breast. | 1985 | Prostaglandins | pmid:3839084 |
Hamilton TA et al. | gamma-Interferon enhances the secretion of arachidonic acid metabolites from murine peritoneal macrophages stimulated with phorbol diesters. | 1985 | J. Immunol. | pmid:3919102 |
Petroni A et al. | Differential effects of various vasoactive drugs on basal and stimulated levels of TXB2 and 6-keto-PGF1 alpha in rat brain. | 1985 | Prostaglandins | pmid:3839085 |
Zipser RD | Effects of selective inhibition of thromboxane synthesis on renal function in humans. | 1985 | Am. J. Physiol. | pmid:3839111 |
Kimura Y et al. | Effects of stilbene derivatives on arachidonate metabolism in leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:3931689 |
Wargovich T et al. | Reduction in blood flow in normal and narrowed coronary arteries of dogs by leukotriene C4. | 1985 | J. Am. Coll. Cardiol. | pmid:4045029 |
Cerletti C et al. | Aspirin kinetics and inhibition of platelet thromboxane generation-relevance for a solution of the "aspirin dilemma". | 1985 | Thromb. Haemost. | pmid:4049312 |
Dejana E et al. | Differential salicylate-aspirin interaction on vascular prostacyclin and platelet thromboxane synthesis in patients undergoing saphenectomy. | 1985 | Proc. Soc. Exp. Biol. Med. | pmid:3841210 |
Hillbom M et al. | Platelet thromboxane formation and bleeding time is influenced by ethanol withdrawal but not by cigarette smoking. | 1985 | Thromb. Haemost. | pmid:4049313 |
Gairola C and Tai HH | Selective inhibition of leukotriene B4 biosynthesis in rat pulmonary alveolar macrophages by dietary selenium deficiency. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2998361 |
Fiedler VB et al. | The effects of nafazatrom in an acute occlusion-reperfusion model of canine myocardial injury. | 1985 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3841382 |
Aviram M et al. | Plasma lipoproteins affect platelet malondialdehyde and thromboxane B2 production. | 1985 | Biochem Med | pmid:4052061 |
Simmet T et al. | Modulation of eicosanoid release from anaphylactic guinea-pig heart with 5-benzoyl-a-methyl-2-thiophene acetic acid (tiaprofenic acid). | 1985 | Arch Int Pharmacodyn Ther | pmid:3841634 |
Rinaldo JE and Dauber JH | Effect of methylprednisolone and of ibuprofen, a nonsteroidal antiinflammatory agent, on bronchoalveolar inflammation following endotoxemia. | 1985 | Circ. Shock | pmid:4053294 |
Shingu T | [Prostaglandin metabolism in ischemic brain edema]. | 1985 | Nihon Geka Hokan | pmid:3841635 |
Leffler CW and Busija DW | Prostanoids in cortical subarachnoid cerebrospinal fluid and pial arterial diameter in newborn pigs. | 1985 | Circ. Res. | pmid:4053302 |
Tobian L et al. | Prostaglandin alterations in barely hypertensive Dahl S rats. | 1985 | Trans. Assoc. Am. Physicians | pmid:3842205 |
Ment LR et al. | Beagle puppy model of perinatal cerebral infarction. Acute changes in regional cerebral prostaglandins during hemorrhagic hypotension. | 1985 | J. Neurosurg. | pmid:4056903 |
Di Minno G et al. | Platelet dysfunction in uremia. Multifaceted defect partially corrected by dialysis. | 1985 | Am. J. Med. | pmid:3933340 |
Numano F et al. | Coronary spasm, prostaglandin and HLA factors. | 1985 | Jpn. Circ. J. | pmid:3855470 |
Purkerson ML et al. | Inhibition of thromboxane synthesis ameliorates the progressive kidney disease of rats with subtotal renal ablation. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3855542 |
Dempsey RJ et al. | Polyamine and prostaglandin markers in focal cerebral ischemia. | 1985 | Neurosurgery | pmid:3864030 |
Dahl ML and Uotila P | Sodium salicylate does not prevent the inhibitory effect of indomethacin on thromboxane formation in human blood ex vivo. | 1985 | Prostaglandins Leukot Med | pmid:3856282 |
Kääpä P | Immunoreactive thromboxane B2 and 6-keto-prostaglandin F1 alpha in neonatal hyperbilirubinemia. | 1985 | Prostaglandins Leukot Med | pmid:3856285 |
Mallarkey G and Smith GM | A comparative study of the involvement of the prostaglandin H2/thromboxane A2 pathway in intravascular platelet aggregation in guinea-pigs and rats. | 1985 | Br. J. Pharmacol. | pmid:3156648 |
Salmon JA et al. | Evaluation of inhibitors of eicosanoid synthesis in leukocytes: possible pitfall of using the calcium ionophore A23187 to stimulate 5' lipoxygenase. | 1985 | Prostaglandins | pmid:2988019 |
Murphy RC et al. | Surgical delay and arachidonic acid metabolites: evidence for an inflammatory mechanism: an experimental study in rats. | 1985 | Br J Plast Surg | pmid:3921087 |
Sterk PJ et al. | Limited maximal airway narrowing in nonasthmatic subjects. Role of neural control and prostaglandin release. | 1985 | Am. Rev. Respir. Dis. | pmid:2864892 |