Thromboxane b2
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
Cross Reference
Introduction
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thromboxane b2?
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
PubChem Associated disorders and diseases
What pathways are associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thromboxane b2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Thromboxane b2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Thromboxane b2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thromboxane b2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ward PS et al. | Excretion of metabolites of prostacyclin and thromboxane by rats with nephrotoxic nephritis: effects of interleukin-1. | 1991 | Br. J. Pharmacol. | pmid:1933130 |
| Carmo LG et al. | Platelet desensitization induced by arachidonic acid is not due to cyclo-oxygenase inactivation and involves the endoperoxide receptor. | 1985 | Br. J. Pharmacol. | pmid:2994786 |
| Conroy DM et al. | Effects of vasoactive intestinal peptide, helodermin and galanin on responses of guinea-pig lung parenchyma to histamine, acetylcholine and leukotriene D4. | 1991 | Br. J. Pharmacol. | pmid:1725762 |
| Juan H et al. | Effect of exogenous 5,8,11,14,17-eicosapentaenoic acid on cardiac anaphylaxis. | 1987 | Br. J. Pharmacol. | pmid:2881590 |
| Bakhle YS et al. | Differential release of eicosanoids by bradykinin, arachidonic acid and calcium ionophore A23187 in guinea-pig isolated perfused lung. | 1985 | Br. J. Pharmacol. | pmid:2996675 |
| Randon J et al. | Blockade by methylation inhibitors of the anaphylactic response of guinea-pig lung strips. | 1987 | Br. J. Pharmacol. | pmid:2447992 |
| Wainwright CL et al. | NCX4016 (NO-aspirin) reduces infarct size and suppresses arrhythmias following myocardial ischaemia/reperfusion in pigs. | 2002 | Br. J. Pharmacol. | pmid:11959790 |
| Provost P et al. | Platelets, neutrophils, and vasoconstriction after arterial injury by angioplasty in pigs: effects of MK-886, a leukotriene biosynthesis inhibitor. | 1998 | Br. J. Pharmacol. | pmid:9489613 |
| Hugli TE and Marceau F | Effects of the C5a anaphylatoxin and its relationship to cyclo-oxygenase metabolites in rabbit vascular strips. | 1985 | Br. J. Pharmacol. | pmid:3921089 |
| Giembycz MA et al. | Leukotriene D4 receptors are not negatively coupled to adenylyl cyclase in guinea-pig lung parenchyma. | 1993 | Br. J. Pharmacol. | pmid:8385538 |
| Zhang BL and Sassard J | Eicosanoid-dependence of responses of pre- but not postglomerular vessels to noradrenaline in rat isolated kidneys. | 1993 | Br. J. Pharmacol. | pmid:8220883 |
| Desquand S et al. | Interference of BN 52021, an antagonist of PAF, with different forms of active anaphylaxis in the guinea-pig: importance of the booster injection. | 1991 | Br. J. Pharmacol. | pmid:1285397 |
| De La Cruz JP et al. | Antiplatelet effect of the anaesthetic drug propofol: influence of red blood cells and leucocytes. | 1999 | Br. J. Pharmacol. | pmid:10602334 |
| Ritter JM | Prostanoid synthesis by aortic rings in human blood: selective increase of prostacyclin mediated by a serum factor. | 1984 | Br. J. Pharmacol. | pmid:6386089 |
| Gordon D et al. | Selective inhibition of thromboxane biosynthesis in human blood mononuclear cells and the effects of mitogen-stimulated lymphocyte proliferation. | 1981 | Br. J. Pharmacol. | pmid:7317694 |
| Dirig DM and Yaksh TL | In vitro prostanoid release from spinal cord following peripheral inflammation: effects of substance P, NMDA and capsaicin. | 1999 | Br. J. Pharmacol. | pmid:10217526 |
| Ochi T and Goto T | Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis. | 2002 | Br. J. Pharmacol. | pmid:11834626 |
| Sheu JR et al. | Expression of matrix metalloproteinase-9 in human platelets: regulation of platelet activation in in vitro and in vivo studies. | 2004 | Br. J. Pharmacol. | pmid:15289295 |
| Giuliano F and Warner TD | Ex vivo assay to determine the cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs. | 1999 | Br. J. Pharmacol. | pmid:10372826 |
| Failli P et al. | Effect of some cyclooxygenase inhibitors on the increase in guanosine 3':5'-cyclic monophosphate induced by NO-donors in human whole platelets. | 1998 | Br. J. Pharmacol. | pmid:9579743 |
| Franconi F et al. | Further insights into the anti-aggregating activity of NMDA in human platelets. | 1998 | Br. J. Pharmacol. | pmid:9630340 |
| Burka JF and Garland LG | A possible modulatory role for prostacyclin (PGI2) INIgGa-induced release of slow-reacting substance of anaphylaxis in rats. | 1977 | Br. J. Pharmacol. | pmid:339980 |
| Matz RL et al. | Vascular bed heterogeneity in age-related endothelial dysfunction with respect to NO and eicosanoids. | 2000 | Br. J. Pharmacol. | pmid:10991924 |
| Cano JP et al. | Molsidomine prevents post-ischaemic ventricular fibrillation in dogs. | 1986 | Br. J. Pharmacol. | pmid:3755634 |
| Higgs GA et al. | The source of thromboxane and prostaglandins in experimental inflammation. | 1983 | Br. J. Pharmacol. | pmid:6652359 |
| Rho MC et al. | Activation of rabbit platelets by Ca2+ influx and thromboxane A2 release in an external Ca(2+)-dependent manner by zooxanthellatoxin-A, a novel polyol. | 1995 | Br. J. Pharmacol. | pmid:7582454 |
| Sakai H et al. | E3040 sulphate, a novel thromboxane synthase inhibitor, blocks the Cl- secretion induced by platelet-activating factor in isolated rat colon. | 2002 | Br. J. Pharmacol. | pmid:12023941 |
| De Kimpe SJ et al. | Bovine polymorphonuclear leukocytes increase sensitivity to noradrenaline in isolated mesenteric arteries. | 1992 | Br. J. Pharmacol. | pmid:1628145 |
| Sheu JR et al. | The antiplatelet activity of PMC, a potent alpha-tocopherol analogue, is mediated through inhibition of cyclo-oxygenase. | 1999 | Br. J. Pharmacol. | pmid:10455267 |
| Yin K et al. | Study of mechanisms of glucocorticoid hypertension in rats: endothelial related changes and their amelioration by dietary fish oils. | 1992 | Br. J. Pharmacol. | pmid:1393269 |
| Jiménez R et al. | Involvement of thromboxane A2 in the endothelium-dependent contractions induced by myricetin in rat isolated aorta. | 1999 | Br. J. Pharmacol. | pmid:10455307 |
| Mallarkey G and Smith GM | In vivo platelet aggregation in the rat: dependence on extracellular divalent cation and inhibition by nonsteroidal anti-inflammatory drugs. | 1984 | Br. J. Pharmacol. | pmid:6423018 |
| Boukili MA et al. | Pharmacological modulation of the effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine in guinea-pigs: involvement of the arachidonic acid cascade. | 1986 | Br. J. Pharmacol. | pmid:3096407 |
| Chu ZM and Beilin LJ | Mechanisms of vasodilatation in pregnancy: studies of the role of prostaglandins and nitric-oxide in changes of vascular reactivity in the in situ blood perfused mesentery of pregnant rats. | 1993 | Br. J. Pharmacol. | pmid:8358537 |
| Riendeau D et al. | Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. | 1997 | Br. J. Pharmacol. | pmid:9146894 |
| Yeh CH et al. | Pharmacological characterization and antithrombotic effect of agkistin, a platelet glycoprotein Ib antagonist. | 2001 | Br. J. Pharmacol. | pmid:11181425 |
| Lees P et al. | Serum thromboxane in the horse and its inhibition by aspirin, phenylbutazone and flunixin. | 1987 Sep-Oct | Br. Vet. J. | pmid:3119142 |
| Delatour P et al. | Pharmacodynamics and chiral pharmacokinetics of carprofen in calves. | 1996 | Br. Vet. J. | pmid:8680841 |
| McKellar QA et al. | Serum thromboxane generation by platelets in several domestic animal species. | 1990 Sep-Oct | Br. Vet. J. | pmid:2224484 |
| Taylor PM et al. | Flunixin in the cat: a pharmacodynamic, pharmacokinetic and toxicological study. | 1994 May-Jun | Br. Vet. J. | pmid:8044665 |
| Lees P and Taylor PM | Pharmacodynamics and pharmacokinetics of flunixin in the cat. | 1991 Jul-Aug | Br. Vet. J. | pmid:1913126 |
| Nobutoki T et al. | Fluctuating hearing loss, episodic headache, and stroke with platelet hyperaggregability: coexistence of auditory neuropathy and cochlear hearing loss. | 2006 | Brain Dev. | pmid:16168600 |
| Patel PM et al. | Differential temperature sensitivity of ischemia-induced glutamate release and eicosanoid production in rats. | 1994 | Brain Res. | pmid:7953685 |
| Cach R et al. | Microvascular spasm is mediated by vasopressin fibers in the rat hippocampal slice. | 1989 | Brain Res. | pmid:2706515 |
| Busija DW et al. | Acetylcholine dramatically increases prostanoid synthesis in piglet parietal cortex. | 1988 | Brain Res. | pmid:3359178 |
| Petroni A et al. | Effects of hypoxia and recovery on brain eicosanoids and carbohydrate metabolites in rat brain cortex. | 1987 | Brain Res. | pmid:3607494 |
| Hynes N et al. | Leukotrienes in brain: natural occurrence and induced changes. | 1991 | Brain Res. | pmid:1933275 |
| Cach R et al. | Blood-borne factors regulating microvascular constriction in the rat hippocampal slice. | 1987 | Brain Res. | pmid:3620912 |
| Hartung HP et al. | Recombinant interleukin-1 beta stimulates eicosanoid production in rat primary culture astrocytes. | 1989 | Brain Res. | pmid:2501001 |
| Faden AI et al. | Effects of BW755C, a mixed cyclo-oxygenase-lipoxygenase inhibitor, following traumatic spinal cord injury in rats. | 1988 | Brain Res. | pmid:3143469 |
| Seregi A et al. | Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils. | 1984 | Brain Res. | pmid:6430471 |
| Pettigrew LC et al. | Delayed elevation of platelet activating factor in ischemic hippocampus. | 1995 | Brain Res. | pmid:8590061 |
| Constable AL et al. | Production of prostanoids by Lewis rat Schwann cells in vitro. | 1994 | Brain Res. | pmid:8173981 |
| Andrus PK et al. | Effects of the lipid peroxidation inhibitor tirilazad mesylate (U-74006F) on gerbil brain eicosanoid levels following ischemia and reperfusion. | 1994 | Brain Res. | pmid:7820653 |
| Ahmad M et al. | Prolonged opportunity for neuroprotection in experimental stroke with selective blockade of cyclooxygenase-2 activity. | 2009 | Brain Res. | pmid:19446533 |
| Aïd S and Bosetti F | Gene expression of cyclooxygenase-1 and Ca(2+)-independent phospholipase A(2) is altered in rat hippocampus during normal aging. | 2007 | Brain Res. Bull. | pmid:17499644 |
| Tuppo EE et al. | Sign of lipid peroxidation as measured in the urine of patients with probable Alzheimer's disease. | 2001 | Brain Res. Bull. | pmid:11397549 |
| Akarsu ES et al. | Effect of ciliary neurotrophic factor on body temperature and cerebrospinal fluid prostanoids in the cat. | 1998 | Brain Res. Bull. | pmid:9434196 |
| Petroni A et al. | Eicosanoid and inositol phosphate response to platelet-activating factor (PAF) and to a PAF antagonist in rat astroglial cells. | 1994 | Brain Res. Dev. Brain Res. | pmid:8026072 |
| Petrikova M et al. | Carvedilol--a beta-blocker with considerable antiaggregatory effect on human blood platelets. | 2005 | Bratisl Lek Listy | pmid:15869009 |
| Gajdos M et al. | [The effect of monotherapy with ciprofibrate and in combination with acetylsalicylic acid on the spectrum of lipids, thromboxane and fibrinogen in patients with atherosclerosis and hyperlipoproteinemia]. | 1999 | Bratisl Lek Listy | pmid:10645034 |
| Kasjanovová D and Baláz V | [Functional status of thrombocytes in men of various age groups]. | 1990 | Bratisl Lek Listy | pmid:2224554 |
| Rajec J et al. | Biochemical evaluation of the antiplatelet effect of aspirin in patients at different levels of cardiovascular risk. | 2008 | Bratisl Lek Listy | pmid:18814431 |
| Kasjanovová D | [Functional status of thrombocytes in men and women in younger age groups]. | 1993 | Bratisl Lek Listy | pmid:8004501 |
| Röth E | Effect of Ca-antagonists, beta-blockers and antioxidant during reperfusion period. | 1991 Mar-Apr | Bratisl Lek Listy | pmid:2029661 |
| Lamy M et al. | Biochemical pathways of acute lung injury. | 1985 May-Jun | Bull Eur Physiopathol Respir | pmid:3873973 |
| Sakanishi N et al. | Thromboxane A2 and hemodynamic-biochemical parameters in canine endotoxin shock. | 1983 | Bull. Tokyo Med. Dent. Univ. | pmid:6580966 |
| Huang YS et al. | Roles of thromboxane and its inhibitor anisodamine in burn shock. | 1990 | Burns | pmid:2257065 |
| Yregård L et al. | Influence of local anaesthetics on inflammatory activity postburn. | 2003 | Burns | pmid:12781610 |
| Huang YS et al. | Serial experimental and clinical studies on the pathogenesis of multiple organ dysfunction syndrome (MODS) in severe burns. | 1998 | Burns | pmid:9915670 |
| Huang YS et al. | Effect of smoke inhalation injury on thromboxane levels and platelet counts. | 1988 | Burns Incl Therm Inj | pmid:3250716 |
| Girotti MJ et al. | Comparison of regional pulmonary perfusion in lobar pneumonia during high frequency and conventional mechanical ventilation in sheep. | 1987 | Can J Anaesth | pmid:3581395 |
| Licker M et al. | Chronic angiotensin converting inhibition does not influence renal hemodynamic and function during cardiac surgery. | 1999 | Can J Anaesth | pmid:10442956 |
| Byrick RJ et al. | Corticosteroids do not inhibit acute pulmonary response to fat embolism. | 1990 | Can J Anaesth | pmid:2193732 |
| Byrick RJ et al. | Prostanoid production and pulmonary hypertension after fat embolism are not modified by methylprednisolone. | 1991 | Can J Anaesth | pmid:1934222 |
| Landymore RW et al. | Correlation between the effects of aspirin and dipyridamole on platelet function and prevention of intimal hyperplasia in autologous vein grafts. | 1988 Jan-Feb | Can J Cardiol | pmid:3359354 |
| Gerrard JM et al. | The structured interview elicits a differential prostacyclin response in A and B behaviour types. | 1991 | Can J Cardiol | pmid:2070285 |
| Klein RC et al. | Absence of differential inhibition of thromboxane A2 and prostacyclin by low and high dose aspirin in coronary artery disease. | 1987 | Can J Cardiol | pmid:3322532 |
| Shizukuda Y et al. | Effect of prednisolone on myocardial infarct healing: characteristics and comparison with indomethacin. | 1991 | Can J Cardiol | pmid:1768984 |
| Chou TZ et al. | Effect of felodipine-ER on blood pressure, platelet function, and rheological properties in hypertension. | 1993 | Can J Cardiol | pmid:8394193 |
| Moreno A et al. | Prostacyclin-thromboxane balance and retinal vascular pattern in rats with experimentally induced diabetes. | 1995 | Can. J. Ophthalmol. | pmid:7627895 |
| Tosaki A et al. | Effect of cicletanine on reperfusion-induced arrhythmias and its relation to 6-keto-PGF1 alpha and thromboxane B2 release. | 1991 | Can. J. Physiol. Pharmacol. | pmid:2059911 |
| Datar S et al. | Effect of cyclooxygenase and thromboxane synthetase inhibition on furosemide-stimulated plasma renin activity. | 1987 | Can. J. Physiol. Pharmacol. | pmid:3105853 |
| Rodrigue ME et al. | Cyclooxygenase inhibition with acetylsalicylic acid unmasks a role for prostacyclin in erythropoietin-induced hypertension in uremic rats. | 2005 | Can. J. Physiol. Pharmacol. | pmid:16049546 |
| Gerrard JM | Measurements of 6-keto-prostaglandin F1 alpha and thromboxane B2 in bleeding time blood: relation to bleeding and vascular disorders? | 1989 | Can. J. Physiol. Pharmacol. | pmid:2688855 |
| Kitamura R et al. | Thiopental enhances human platelet aggregation by increasing arachidonic acid release. | 2001 | Can. J. Physiol. Pharmacol. | pmid:11697744 |
| Kaushal RD and Wilson TW | Effect of furegrelate on renal plasma flow after angiotensin II infusion. | 1990 | Can. J. Physiol. Pharmacol. | pmid:2328452 |
| Liao CH et al. | Antiplatelet effect of demethyldiisoeugenol. | 1996 | Can. J. Physiol. Pharmacol. | pmid:9022830 |
| Jancar S et al. | Mechanism of action of platelet-activating factor on guinea-pig lung parenchyma strips. | 1988 | Can. J. Physiol. Pharmacol. | pmid:3146431 |
| Smith EF et al. | Influence of thromboxane inhibition on the severity of myocardial ischemia in cats. | 1980 | Can. J. Physiol. Pharmacol. | pmid:7378931 |
| Jiang J et al. | Endothelin-1 blockade prevents COX2 induction and TXA2 production in the fructose hypertensive rat. | 2007 Mar-Apr | Can. J. Physiol. Pharmacol. | pmid:17612651 |
| Carvalho C et al. | Inhibition of airway hyperreactivity, edema, and lung cell infiltration by compound U-83836E in sensitized guinea pigs. | 1998 Jul-Aug | Can. J. Physiol. Pharmacol. | pmid:10030451 |
| Lewis K et al. | Effect of neuropeptide Y on bradykinin-induced release of prostacyclin and thromboxane from guinea pig perfused lung. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9276148 |
| Jenkins DK et al. | Effects of albumin on fatty acid, protein, and eicosanoid levels in rat mesenteric arterial bed perfusions. | 1988 | Can. J. Physiol. Pharmacol. | pmid:3167681 |
| Gibb W et al. | Cyclooxygenase products formed by primary cultures of cells from human chorion laeve: influence of steroids. | 1988 | Can. J. Physiol. Pharmacol. | pmid:3167693 |
| Riendeau D et al. | Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9365818 |
| Jackman BR et al. | Comparison of the effects of ketoprofen and flunixin meglumine on the in vitro response of equine peripheral blood monocytes to bacterial endotoxin. | 1994 | Can. J. Vet. Res. | pmid:8004539 |
| King JN | The use of intradermal carrageenan in calves to estimate the dose of oxindanac, a nonsteroidal anti-inflammatory drug. | 1993 | Can. J. Vet. Res. | pmid:8269358 |
| Yamamura S et al. | Prostaglandin levels of primary bone tumor tissues correlate with peritumoral edema demonstrated by magnetic resonance imaging. | 1997 | Cancer | pmid:9010098 |
| Klausner JM et al. | Interleukin-2-induced lung permeability is mediated by leukotriene B4. | 1990 | Cancer | pmid:2173970 |