Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kowalska MA et al. | Stromal cell-derived factor-1 and macrophage-derived chemokine: 2 chemokines that activate platelets. | 2000 | Blood | pmid:10891429 |
Bailey SR et al. | Differential activation of platelets from normal and allergic ponies by PAF and ADP. | 2000 | Inflamm. Res. | pmid:10893045 |
Rao AR and Prabhakar MC | Screening methods for antiasthmatic agents. | 2000 | Methods Find Exp Clin Pharmacol | pmid:10893704 |
Cayatte AJ et al. | The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E-deficient mice: evidence that eicosanoids other than thromboxane contribute to atherosclerosis. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10894809 |
Sugimoto KI et al. | Delayed hypotensive effect of the thromboxane A2/prostaglandin H2 receptor antagonist S-1452 in spontaneously hypertensive rats. | 2000 | Clin. Exp. Pharmacol. Physiol. | pmid:10901388 |
Köfeler HC et al. | Effect of cytochrome P-450 inhibitors econazole, bifonazole and clotrimazole on prostanoid formation. | 2000 | Br. J. Pharmacol. | pmid:10903961 |
Toft G et al. | Intravenously and topically applied magnesium in the prevention of arterial thrombosis. | 2000 | Thromb. Res. | pmid:10904104 |
Giedrojć J et al. | [Investigation of prostaglandins in supernatant of cultured monocytes]. | 2000 | Prz. Lek. | pmid:10907365 |
Momi S et al. | Involvement of platelets in experimental mouse trypanosomiasis: evidence of mouse platelet cytotoxicity against Trypanosoma equiperdum. | 2000 | Exp. Parasitol. | pmid:10910715 |
Ogura Y et al. | Chemoprevention of biliary carcinogenesis in syrian hamsters by the novel carboxamide derivative IS-741 after initiation with N-nitrosobis(2-oxopropyl)amine (BOP). | 2000 | Carcinogenesis | pmid:10910946 |
MalatyalioÄŸlu E et al. | Levels of stable metabolites of prostacyclin and thromboxane A2 and their ratio in normotensive and preeclamptic pregnant women during the antepartum and postpartum periods. | 2000 May-Jun | J Matern Fetal Med | pmid:10914626 |
Patrignani P et al. | Effects of vitamin E supplementation on F(2)-isoprostane and thromboxane biosynthesis in healthy cigarette smokers. | 2000 | Circulation | pmid:10920066 |
Dschietzig T et al. | Stimulation of pulmonary big endothelin-1 and endothelin-1 by antithrombin III: a rationale for combined application of antithrombin III and endothelin antagonists in sepsis-related acute respiratory distress syndrome? | 2000 | Crit. Care Med. | pmid:10921577 |
Muscará MN et al. | Antihypertensive properties of a nitric oxide-releasing naproxen derivative in two-kidney, one-clip rats. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10924050 |
Wang JS et al. | Effect of strenuous arm exercise on oxidized-LDL-potentiated platelet activation in individuals with spinal cord injury. | 2000 | Thromb. Haemost. | pmid:10928481 |
Kamata K et al. | Altered endothelium-dependent and -independent hyperpolarization and endothelium-dependent relaxation in carotid arteries isolated from streptozotocin-induced diabetic rats. | 2000 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:10935533 |
Kim WG et al. | Vasoconstrictive eicosanoid responses to extracorporeal circulation with or without an oxygenator in fetal lambs. | 2000 | Int J Artif Organs | pmid:10941636 |
Tsikas D et al. | Solid- and liquid-phase extraction for the gas chromatographic-tandem mass spectrometric quantification of 2,3-dinor-thromboxane B2 and 2,3-dinor-6-oxo-prostaglandin F1 alpha in human urine. | 2000 | J Chromatogr A | pmid:10941682 |
Porta C et al. | Amifostine, a reactive oxigen species scavenger with radiation- and chemo-protective properties, inhibits in vitro platelet activation induced by ADP, collagen or PAF. | 2000 | Haematologica | pmid:10942928 |
Sane S et al. | Eicosapentaenoic acid reduces pulmonary edema in endotoxemic rats. | 2000 | J. Surg. Res. | pmid:10945939 |
Krysztopik RJ et al. | Lazaroid and pentoxifylline suppress sepsis-induced increases in renal vascular resistance via altered arachidonic acid metabolism. | 2000 | J. Surg. Res. | pmid:10945946 |
Stanke-Labesque F et al. | Angiotensin II-induced contractions in human internal mammary artery: effects of cyclooxygenase and lipoxygenase inhibition. | 2000 | Cardiovasc. Res. | pmid:10946074 |
Thorwest M et al. | Dietary fish oil reduces microvascular thrombosis in a porcine experimental model. | 2000 | Thromb. Res. | pmid:10946095 |
McCann ME et al. | Effect of intravenous infusion of omega-3 and omega-6 lipid emulsions on equine monocyte fatty acid composition and inflammatory mediator production in vitro. | 2000 | Shock | pmid:10947170 |
Kelly JP et al. | Effect of inhibitors of arachidonic acid metabolism on mitogenesis in human lymphocytes: possible role of thromboxanes and products of the lipoxygenase pathway. | 1979 | J. Immunol. | pmid:109510 |
Belton O et al. | Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis. | 2000 | Circulation | pmid:10952950 |
Siler-Khodr TM et al. | Effect of ethanol on thromboxane and prostacyclin production in the human placenta. | 2000 | Alcohol | pmid:10963940 |
Arakida Y et al. | Effect of combined leukotriene D(4) and thromboxane A(2) receptor antagonist on mediator-controlled resistance in guinea pigs. | 2000 | Eur. J. Pharmacol. | pmid:10969159 |
Ohata T et al. | Role of nitric oxide in a temperature dependent regulation of systemic vascular resistance in cardiopulmonary bypass. | 2000 | Eur J Cardiothorac Surg | pmid:10973545 |
Togna GI et al. | Cisplatin triggers platelet activation. | 2000 | Thromb. Res. | pmid:10973681 |
Yuk DY et al. | Antithrombotic and antiplatelet activities of 2-chloro-3-[4-(ethylcarboxy)-phenyl]-amino-1,4-naphthoquinone (NQ12), a newly synthesized 1,4-naphthoquinone derivative. | 2000 | Biochem. Pharmacol. | pmid:10974210 |
Sabha M et al. | Transdermal nicotine mimics the smoking-induced endothelial dysfunction. | 2000 | Clin. Pharmacol. Ther. | pmid:10976548 |
van Haeringen NJ et al. | Flurbiprofen and enantiomers in ophthalmic solution tested as inhibitors of prostanoid synthesis in human blood. | 2000 | J Ocul Pharmacol Ther | pmid:10977130 |
Matz RL et al. | Vascular bed heterogeneity in age-related endothelial dysfunction with respect to NO and eicosanoids. | 2000 | Br. J. Pharmacol. | pmid:10991924 |
Boatman RJ et al. | Covalent protein adducts of hydroquinone in tissues from rats: quantitation of sulfhydryl-bound forms following single gavage or intraperitoneal administration or repetitive gavage administration. | 2000 | Chem. Res. Toxicol. | pmid:10995259 |
WÅ‚odarczyk Z et al. | Effects of pentoxifylline treatment on delayed graft function in cadaveric kidney recipients. | 2000 | Transplant. Proc. | pmid:10995988 |
de Jong CL et al. | Maternal thromboxane and prostacyclin levels in relation to fetal birth weight. | 2000 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:11000507 |
Tanaka H et al. | Effects of milrinone on platelet aggregation in swine with pulmonary hypertension. | 2000 | J Crit Care | pmid:11011824 |
Coppola A et al. | Homocysteine, coagulation, platelet function, and thrombosis. | 2000 | Semin. Thromb. Hemost. | pmid:11011842 |
Kim WG et al. | Is avoidance of air contact necessary for the in vitro evaluation of thrombogenicity in mechanical circulatory assist devices? | 2000 | Artif Organs | pmid:11012543 |
Jacoby RF et al. | The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis. | 2000 | Cancer Res. | pmid:11016626 |
Van Hecken A et al. | Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers. | 2000 | J Clin Pharmacol | pmid:11028250 |
Ciabattoni G et al. | In vivo lipid peroxidation and platelet activation in cystic fibrosis. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:11029317 |
Boyle JR et al. | Endovascular AAA repair attenuates the inflammatory and renal responses associated with conventional surgery. | 2000 | J. Endovasc. Ther. | pmid:11032254 |
Filipov NM et al. | Anti-inflammatory effects of ergotamine in steers. | 2000 | Proc. Soc. Exp. Biol. Med. | pmid:11044256 |
Parker CR et al. | Umbilical cord serum levels of thromboxane B2 in term infants of women who participated in a placebo-controlled trial of low-dose aspirin. | 2000 Jul-Aug | J Matern Fetal Med | pmid:11048830 |
Delemarre FM et al. | Urinary prostaglandin excretion in pregnancy: the effect of dietary sodium restriction. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11049696 |
Thomson M et al. | Thromboxane-B(2) levels in serum of rabbits receiving a single intravenous dose of aqueous extract of garlic and onion. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11049697 |
Qu X et al. | Selenium deficiency-induced alterations in the vascular system of the rat. | 2000 | Biol Trace Elem Res | pmid:11051602 |
Rahman K and Billington D | Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans. | 2000 | J. Nutr. | pmid:11053504 |
De Somer F et al. | Phosphorylcholine coating of extracorporeal circuits provides natural protection against blood activation by the material surface. | 2000 | Eur J Cardiothorac Surg | pmid:11053824 |
Suzuki N et al. | Difference in urinary LTE4 and 11-dehydro-TXB2 excretion in asthmatic patients. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060902 |
Ferry DR et al. | A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints. | 2000 | Ann. Oncol. | pmid:11061613 |
Kawasaki K et al. | Inhibition of 12(S)-hydroxyeicosatetraenoic acid (12-HETE) production suppressed the intimal hyperplasia caused by poor-runoff conditions in the rabbit autologous vein grafts. | 2000 | J. Cardiovasc. Pharmacol. | pmid:11065214 |
Vazquez-Cruz B et al. | Increased renal vasoconstriction and gene expression of cyclooxygenase-1 in renovascular hypertension. | 2000 | J. Cardiovasc. Pharmacol. | pmid:11065217 |
Naito Y et al. | Increase in blood pressure with enhanced Na+, K+ -ATPase activity in stroke-prone spontaneously hypertensive rats after 4-weeks intake of rapeseed oil as the sole dietary fat. | 2000 | Pharmacol. Toxicol. | pmid:11068856 |
Praticò D et al. | Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis. | 2000 | Blood | pmid:11090066 |
Darlametsos IE et al. | Effect of nifedipine in cyclosporine-induced nephrotoxicity in rats: roles of the thromboxane and endothelin systems. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090252 |
Cruz MA et al. | Vascular reactivity to angiotensin II and eicosanoid production in the human placenta from term and preterm pregnancy. | 2000 | Gynecol. Obstet. Invest. | pmid:11093047 |
Basu S et al. | Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity. | 2000 | Clin. Sci. | pmid:11099394 |
Armstrong RA et al. | No effect of dietary trans isomers of alpha-linolenic acid on platelet aggregation and haemostatic factors in european healthy men. The TRANSLinE study. | 2000 | Thromb. Res. | pmid:11108899 |
De La Cruz JP et al. | Antithrombotic potential of olive oil administration in rabbits with elevated cholesterol. | 2000 | Thromb. Res. | pmid:11113274 |
Kasahara M et al. | Effect of FK3311 on ischemia-reperfusion injury in canine pulmonary models. | 2000 | Transplant. Proc. | pmid:11120230 |
Moosig F et al. | Opsonization of apoptotic neutrophils by anti-neutrophil cytoplasmic antibodies (ANCA) leads to enhanced uptake by macrophages and increased release of tumour necrosis factor-alpha (TNF-alpha). | 2000 | Clin. Exp. Immunol. | pmid:11122261 |
De Jong A et al. | Antiphospholipid antibodies and platelets. | 2000 | Curr Rheumatol Rep | pmid:11123065 |
Buccellati C et al. | Tramadol anti-inflammatory activity is not related to a direct inhibitory action on prostaglandin endoperoxide synthases. | 2000 | Eur J Pain | pmid:11124014 |
Suliman HB et al. | Prevention of influenza-induced lung injury in mice overexpressing extracellular superoxide dismutase. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11133496 |
Mizutani T et al. | Effects of a thromboxane receptor antagonist (NT-126) and a thromboxane synthase inhibitor (OKY-O46) on protamine-induced circulatory changes in dogs. | 2000 | J. Cardiothorac. Vasc. Anesth. | pmid:11139110 |
Whittle BJ | Prostaglandin synthetase inhibitors. Drugs which affect arachidonic acid metabolism. | 1979 | Acta Obstet Gynecol Scand Suppl | pmid:111464 |
Kitano T et al. | Unwashed shed blood infusion causes deterioration in right ventricular function after coronary artery surgery. | 2000 | Anaesth Intensive Care | pmid:11153289 |
Iuliano L et al. | Angioplasty increases coronary sinus F2-isoprostane formation: evidence for in vivo oxidative stress during PTCA. | 2001 | J. Am. Coll. Cardiol. | pmid:11153776 |
Qureshi AA et al. | Novel tocotrienols of rice bran suppress cholesterogenesis in hereditary hypercholesterolemic swine. | 2001 | J. Nutr. | pmid:11160537 |
Riendeau D et al. | Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11160644 |
Al-Qattan KK et al. | Thromboxane-B2, prostaglandin-E2 and hypertension in the rat 2-kidney 1-clip model: a possible mechanism of the garlic induced hypotension. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161580 |
Sunose Y et al. | Effects of FK3311 on pulmonary ischemia-reperfusion injury in a canine model. | 2001 | J. Surg. Res. | pmid:11162041 |
Grace RF et al. | Effects of diclofenac in the rat tail ischaemia--reperfusion injury model of acute hyperalgesia. | 2001 | Pain | pmid:11166467 |
Shah AA et al. | Selective inhibition of COX-2 in humans is associated with less gastrointestinal injury: a comparison of nimesulide and naproxen. | 2001 | Gut | pmid:11171823 |
Fujimoto Y et al. | Tetrahydrobiopterin attenuates modulation of platelet 12-lipoxygenase and cyclooxygenase activities by nitric oxide. | 2001 | Nitric Oxide | pmid:11178940 |
Yeh CH et al. | Pharmacological characterization and antithrombotic effect of agkistin, a platelet glycoprotein Ib antagonist. | 2001 | Br. J. Pharmacol. | pmid:11181425 |
Moreno JJ | Antiflammin-2 prevents HL-60 adhesion to endothelial cells and prostanoid production induced by lipopolysaccharides. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11181920 |
Greenberg HE et al. | A new cyclooxygenase-2 inhibitor, rofecoxib (VIOXX), did not alter the antiplatelet effects of low-dose aspirin in healthy volunteers. | 2000 | J Clin Pharmacol | pmid:11185674 |
Laguna MS et al. | [Thromboxane B2 and platelet derived growth factor in essential thrombocythemia treated with anagrelide]. | 2000 | Medicina (B Aires) | pmid:11188949 |
Li G et al. | Ischemic preconditioning enhances donor lung preservation in canine lung transplantation. | 1998 | Chin. Med. J. | pmid:11189228 |
Guo Q et al. | [Influence of moderate hypothermia on the contents of 6-KETO-PGF1 alpha and TXB2 in brain tissues after cardiac arrest and resuscitation in dogs]. | 1998 | Hunan Yi Ke Da Xue Xue Bao | pmid:11189396 |
Feldman M et al. | A comparison of every-third-day versus daily low-dose aspirin therapy on serum thromboxane concentrations in healthy men and women. | 2001 | Clin. Appl. Thromb. Hemost. | pmid:11190906 |
Sunose Y et al. | The effect of cyclooxygenase-2 inhibitor FK3311 on ischemia-reperfusion injury in a canine total hepatic vascular exclusion model. | 2001 | J. Am. Coll. Surg. | pmid:11192923 |
Arifah AK et al. | Pharmacodynamics and pharmacokinetics of ketoprofen enantiomers in sheep. | 2001 | Am. J. Vet. Res. | pmid:11197566 |
Giedrojć J et al. | [Interaction of platelets with monocytes with regard to arachidonic acid metabolites]. | 2000 | Prz. Lek. | pmid:11199865 |
Ames PR et al. | Antioxidant susceptibility of pathogenic pathways in subjects with antiphospholipid antibodies: a pilot study. | 2000 | Lupus | pmid:11199924 |
Wang ZG et al. | Can endothelial seeding enhance patency and inhibit neointimal hyperplasia? Experimental studies and clinical trial of endothelial seeded venous prostheses. | 2000 | Int Angiol | pmid:11201596 |
MacKay RJ et al. | Effect of eltenac in horses with induced endotoxaemia. | 2000 | Equine Vet J Suppl | pmid:11202378 |
Alric L et al. | Reactive oxygen intermediates and eicosanoid production by kupffer cells and infiltrated macrophages in acute and chronic liver injury induced in rats by CCl4. | 2000 | Inflamm. Res. | pmid:11211921 |
Demasi M et al. | Assay of cyclooxygenase-1 and 2 in human monocytes. | 2000 | Inflamm. Res. | pmid:11211927 |
Yang G et al. | Effects of prostaglandins and leukotrienes on hypoxic pulmonary vasoconstriction in rats. | 2000 | J. Tongji Med. Univ. | pmid:11215045 |
Vagnoni KE et al. | The influence of the phase of the estrous cycle on sheep endometrial tissue response to lipopolysaccharide. | 2001 | J. Anim. Sci. | pmid:11219456 |
Robinson JS et al. | Prostaglandin E, thromboxane B2 and 6-oxo-prostaglandin F1 alpha in amniotic fluid and maternal plasma of rhesus monkeys (Macaca mulatta) during the latter third of gestation. | 1979 | J. Endocrinol. | pmid:112214 |
Kawaguchi A et al. | Preventive effect of platelet-activating factor antagonist, Y-24180, against cyclosporine-induced acute nephrotoxicity. | 2001 | Life Sci. | pmid:11228102 |
Seno K et al. | Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11229777 |
Wight NJ et al. | Rofecoxib, a COX-2 inhibitor, does not inhibit human gastric mucosal prostaglandin production. | 2001 | Gastroenterology | pmid:11231941 |
Li G et al. | Cardiac ischemic preconditioning improves lung preservation in valve replacement operations. | 2001 | Ann. Thorac. Surg. | pmid:11235719 |