Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Friedman LS et al. | Cardiovascular and pulmonary effects of thromboxane B2 in the dog. | 1979 | Circ. Res. | pmid:428069 |
Ciabattoni G et al. | Characterization of furosemide-induced activation of the renal prostaglandin system. | 1979 | Eur. J. Pharmacol. | pmid:393525 |
Svensson J | Structure and quantitative determination of the major urinary metabolite of thromboxane B2 in the guinea pig. | 1979 | Prostaglandins | pmid:472333 |
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Jonsson CE et al. | Prostaglandins and thromboxanes in burn injury in man. | 1979 | Scand J Plast Reconstr Surg | pmid:451477 |
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Ohuchi K et al. | Prostaglandins E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 levels in carrageenin-induced inflammatory exudates in the rat air-pouch granuloma. | 1979 | Prostaglandins Med | pmid:583576 |
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Jarabak J and Fried J | Comparison of substrate specificities of the human placental NAD- and NADP-linked 15-hydroxyprostaglandin dehydrogenases. | 1979 | Prostaglandins | pmid:42948 |
Miura Y and Fukui N | Prostaglandins as possible triggers for liver regeneration after partial hepatectomy. A review. | 1979 | Cell Mol Biol Incl Cyto Enzymol | pmid:44483 |
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Le Breton GC et al. | 13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor. | 1979 | Proc. Natl. Acad. Sci. U.S.A. | pmid:291066 |
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Peskar BA and Holland A | Plasma levels of immunoreactive 15-keto-13,14-dihydro-thromboxane B2 in guinea pigs during anaphylaxis and after histamine injection. | 1979 | Agents Actions Suppl. | pmid:294148 |
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Stuart MJ et al. | The influence of albumin and calcium on human platelet arachidonic acid metabolism. | 1980 | Blood | pmid:6766753 |
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Poyser NL and Scott FM | Prostaglandin and thromboxane production by the rat uterus and ovary in vitro during the oestrous cycle. | 1980 | J. Reprod. Fertil. | pmid:7001011 |
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Ali AE et al. | Prostaglandin and thromboxane production by fibroblasts and vascular endothelial cells. | 1980 | Prostaglandins | pmid:7008090 |
Ohtsu E and Matsuzawa T | Metabolic alterations in the endogenous formation of 6 keto-prostaglandin F1 alpha, thromboxane B2 and prostaglandin E2 in the brain-stem of stroke-resistant spontaneously hypertensive rats. | 1980 | J. Nutr. Sci. Vitaminol. | pmid:7229740 |
Vargaftig BB et al. | Activation of guinea-pig platelets induced by convulxin, a substance extracted from the venom of Crotalus durissus cascavella. | 1980 | Eur. J. Pharmacol. | pmid:7009169 |
Giri SN and Krishna GA | Development of a dual isotopes techniques and two-stage column chromatography to characterize the prostaglandin F2alpha, E2 and Thromboxane B2 formed by the guinea pig lung. | 1980 | J Pharmacol Methods | pmid:7009992 |
Zapol WM et al. | Plasma thromboxane and prostacyclin metabolites in sheep partial cardiopulmonary bypass. | 1980 | Trans Am Soc Artif Intern Organs | pmid:7018060 |
Güllner HG et al. | Correction of increased prostacyclin production in Bartter's syndrome by indomethacin. | 1980 | Trans. Assoc. Am. Physicians | pmid:7018063 |
Heggers JP et al. | Evaluation of burn blister fluid. | 1980 | Plast. Reconstr. Surg. | pmid:6770396 |
Wise WC et al. | Protective effects of thromboxane synthetase inhibitors in rats in endotoxic shock. | 1980 | Circ. Res. | pmid:7189697 |
Salmon JA | Analysis of arachidonic acid metabolites by radioimmunoassay and physicochemical methods. | 1980 | Mater Med Pol | pmid:7019588 |
Zamecnik J et al. | Concentrations of thromboxane B2 and 6-oxo-prostaglandin F1 alpha in amniotic fluid, decidual tissue, and placenta in the later stages of pregnancy in the rat. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6990719 |
Mathé AA et al. | Increased content of immunoreactive prostaglandin E in cerebrospinal fluid of patients with schizophrenia. | 1980 | Lancet | pmid:6101355 |
Frame MH et al. | Inhibition of acid secretion from the rat-isolated gastric mucosa by arachidonic acid and identification of major metabolites. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6990724 |
Mestel F et al. | Severe bleeding associated with defective thromboxane synthetase. | 1980 | Lancet | pmid:6101498 |
Pareti FI et al. | Platelets and the vessel wall: how much aspirin? | 1980 | Lancet | pmid:6101829 |
Sanger GJ and Bennett A | Trimethoquinol selectively antagonizes contractions of rat gastric fundus to TXB2 and epoxymethano analogs of PGH2. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6103666 |
Zahavi J et al. | Enhanced in-vivo platelet release reaction, increased thromboxane synthesis, and decreased prostacyclin release after tourniquet ischaemia. | 1980 | Lancet | pmid:6106784 |
Jécsai G and Bagdány S | Quantitative determination of thromboxane synthesis in blood samples by video-densitometry. | 1980 | Acta Biochim. Biophys. Acad. Sci. Hung. | pmid:7282294 |
Hwang DH | Aggregation and inhibition of rat platelets, and the formation of endoperoxide metabolites. | 1980 | Prostaglandins Med | pmid:7413850 |
Cerskus AL et al. | Thromboxane B2 and 6-keto-prostaglandin F1 alpha synthesis during infusion of collagen and arachidonic acid in rabbits: inhibition by aspirin and sulfinpyrazone. | 1980 | Thromb. Res. | pmid:7414555 |
Tada M et al. | Significance of thromboxane A2 in myocardial ischemia in patients with coronary artery disease. | 1980 | Adv Myocardiol | pmid:7423053 |
Matsumoto M et al. | Thromboxane generation in patients with essential hypertension or cerebrovascular disease and effect of oral aspirin. | 1980 | Thromb. Haemost. | pmid:7423441 |
Davies GC et al. | Elevated plasma fibrinopeptide A and thromboxane B2 levels during cardiopulmonary bypass. | 1980 | Circulation | pmid:6965618 |
Kennedy MS et al. | In vitro synthesis of prostaglandins and related lipids by populations of human peripheral blood mononuclear cells. | 1980 | Prostaglandins | pmid:6967616 |
Galli C et al. | Modulation of prostaglandin production in tissues by dietary essential fatty acids. | 1980 | Acta Med. Scand. Suppl. | pmid:6935943 |
Wong PY et al. | The role of calmodulin in prostaglandin metabolism. | 1980 | Ann. N. Y. Acad. Sci. | pmid:6940495 |
Lefer AM and Crossley K | Mechanisms of the optimal protective effects of ibuprofen in acute myocardial ischemia. | 1980 | Adv Shock Res | pmid:7304314 |
Güllner HG et al. | The principal metabolites of arachidonic acid are overproduced in Bartter's syndrome. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6892749 |
Liggins GC et al. | Production rates of prostaglandin F, 6-keto-PGF1 alpha and thromboxane B2 by perifused human endometrium. | 1980 | Prostaglandins | pmid:6892962 |
Subbiah MT and Dietemeyer D | Altered synthesis of prostaglandins in platelet and aorta from spontaneously diabetic Wistar rats. | 1980 | Biochem Med | pmid:6893150 |
Ali M and McDonald JW | Synthesis of thromboxane B2 and 6-keto-prostaglandin F1 alpha by bovine gastric mucosal and muscle microsomes. | 1980 | Prostaglandins | pmid:6893365 |
Ohuchi K et al. | Prostaglandin production by minced carrageenin granuloma tissue of rats and its inhibition by dexamethasone and cycloheximide. | 1980 | Prostaglandins Med | pmid:6893750 |
Chiabrando C et al. | Quantitative determination of 6-keto-PGF1 alpha released by rat aorta: comparison of mass fragmentography and high resolution gas chromatography with electron capture detection. | 1980 | Prostaglandins | pmid:6894036 |
Schrör K et al. | Preservation of ischemic myocardium by pinane thromboxane A2. | 1980 | Am. J. Physiol. | pmid:7356037 |
Hassid A and Dunn MJ | Microsomal prostaglandin biosynthesis of human kidney. | 1980 | J. Biol. Chem. | pmid:7358683 |
Kadowitz PJ and Hyman AL | Comparative effects of thromboxane B2 on the canine and feline pulmonary vascular bed. | 1980 | J. Pharmacol. Exp. Ther. | pmid:7365689 |
Schlondorff D and Folkert VW | Prostaglandin synthesis in glomeruli from rats with unilateral ureteral obstruction. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369028 |
Van Praag D and Farber SJ | Prostaglandin biosynthesis in normal and ureteral obstructed rabbit kidney; formation of a novel metabolite. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369029 |
Lindgren JA et al. | Effects of platelet aggregation and adenosine 3':5'-monophosphate on the synthesis of thromboxane B2 in human platelets. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6247886 |
Kot PA et al. | Modification of the cardiovascular actions of prostaglandins by thromboxane B2. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369035 |
Gorman RR | Biochemical and pharmacological evaluation of thromboxane synthetase inhibitors. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6247892 |
Friedman LS et al. | Thromboxane B2 inhibits the pulmonary metabolism of PGE2 in the anesthetized dog. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369063 |
Garfield RE et al. | Gap junction formation in myometrium: control by estrogens, progesterone, and prostaglandins. | 1980 | Am. J. Physiol. | pmid:7369350 |
Lewy RI | Effect of elevated plasma-free fatty acids on thromboxane release in patients with coronary artery disease. | 1980 | Haemostasis | pmid:7372200 |
Bishai I and Coceani F | Metabolism of PGH2 in the feline brain. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7376980 |
Galli C et al. | Factors affecting brain prostaglandin formation. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7376983 |
Blotman F et al. | PGE2, PGF2 alpha, and TXB2 biosynthesis by human rheumatoid synovia. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377017 |
Powell WS | Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica. | 1980 | Prostaglandins | pmid:6258197 |
Katori M et al. | Changes of prostaglandin and thromboxane levels in pleural fluid of rat carrageenin-induced pleurisy. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377020 |
Crutchley DJ et al. | Potentiation of thromboxane B2 release from guinea pig lung during anaphylaxis following exposure to 100% O2. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377022 |
Morris HG and Sherman NA | Prostaglandin-like substances in urine of asthmatic patients. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377024 |
Schoene NW et al. | Effects of diets varying in fat and P/S ratio on arachidonic acid metabolism in human platelets. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377026 |
Smith EF et al. | Influence of thromboxane inhibition on the severity of myocardial ischemia in cats. | 1980 | Can. J. Physiol. Pharmacol. | pmid:7378931 |
Ellwood DA et al. | Specific changes in the in vitro production of prostanoids by the ovine cervix at parturition. | 1980 | Prostaglandins | pmid:7384553 |
Lagarde M et al. | Nicergoline, an anti-aggregating agent which inhibits release of arachidonic acid from human platelet phospholipids. | 1980 | Prostaglandins | pmid:7384555 |
Lefer AM et al. | Dissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane A2, a stable analog of thromboxane A2. | 1980 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6929517 |
Moretti RL and Lin CY | Coronary vasoconstrictor extracted from blood plasma stimulates platelet lipoxidase activity. | 1980 | Prostaglandins | pmid:6770419 |
Maggi FM et al. | Prostaglandin synthetase activity in vascular tissue of male and female rats. | 1980 | Prostaglandins | pmid:6770422 |
Maclouf J et al. | Interactions of prostaglandin H2 and thromboxane A2 with human serum albumin. | 1980 | Eur. J. Biochem. | pmid:7408901 |
Hwang DW et al. | Species variation in serum levels of prostaglandins and their precursor acids. | 1980 | Lipids | pmid:7432104 |
Bolton HS et al. | Prostaglandin synthesis by adult heart myocytes. | 1980 | J. Mol. Cell. Cardiol. | pmid:7441771 |
Dejana E et al. | Impaired thromboxane production by newly formed platelets after aspirin administration to thrombocytopenic rats. | 1980 | Br. J. Haematol. | pmid:7448129 |
Ylikorkala O and Viinikka L | Thromboxane A2 in pregnancy and puerperium. | 1980 | Br Med J | pmid:7448530 |
Bone EA et al. | The effects of strontium and calcium ions on 5-hydroxytryptamine secretion and thromboxane B2 biosynthesis in washed human platelets. | 1980 | Biochem. Soc. Trans. | pmid:7450206 |
Mitchell MD | Prostaglandins at parturition and in the neonatal infant. | 1980 | Biochem. Soc. Trans. | pmid:7450282 |
Kent L et al. | Differential response of articular chondrocyte populations to thromboxane B2 and analogs of prostaglandin cyclic endoperoxides. | 1980 | Prostaglandins | pmid:7384546 |
Viinikka L and Ylikorkala O | Measurement of thromboxane B2 in human plasma or serum by radioimmunoassay. | 1980 | Prostaglandins | pmid:7465865 |
Lagarde M et al. | Increase of platelet thromboxane A2 formation and of its plasmatic half-life in diabetes mellitus. | 1980 | Thromb. Res. | pmid:7466751 |
Lewy RI et al. | Thromboxane release during pacing-induced angina pectoris: possible vasoconstrictor influence on the coronary vasculature. | 1980 | Circulation | pmid:7371128 |
McManus LM et al. | Thromboxane B2 (TxB2) release during IgE anaphylaxis in the rabbit. | 1980 | J. Immunol. | pmid:7430618 |
Best LC et al. | The relationship between the production of thromboxane B2 and malondialdehyde by human blood platelets. | 1980 | Clin. Sci. | pmid:7190885 |
Heggers JP et al. | Histological demonstration of prostaglandins and thromboxanes in burned tissue. | 1980 | J. Surg. Res. | pmid:6987462 |
Meyers KM et al. | An evaluation of the arachidonate pathway of platelets from companion and food-producing animals, mink, and man. | 1980 | Thromb. Res. | pmid:7209869 |