Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

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Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Ulcer D014456 16 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Albuminuria D000419 18 associated lipids
Bronchial Spasm D001986 18 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Pregnancy Complications D011248 19 associated lipids
Cough D003371 19 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Peptic Ulcer D010437 19 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Nephritis D009393 19 associated lipids
Wounds and Injuries D014947 20 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Pleurisy D010998 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

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Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Mitchell MD et al. Thromboxane B-2 in the plasma and amniotic fluid of late pregnant and periparturient sheep. 1979 J. Reprod. Fertil. pmid:423152
Lefer AM et al. Protective effects of a novel thromboxane analog in lethal traumatic shock. 1979 Prostaglandins Med pmid:552102
Kanzaki Y et al. Thromboxane as possible trigger of liver regeneration. 1979 Cell Mol Biol Incl Cyto Enzymol pmid:535003
Lewy RI et al. Comparison of plasma concentrations of thromboxane B2 in Prinzmetal's variant angina and classical angina pectoris. 1979 Clin Cardiol pmid:544110
Best LC et al. Evidence that extracellular calcium ions inhibit thromboxane B2 biosynthesis by human platelets. 1979 Biochem. Biophys. Res. Commun. pmid:117802
Oelz O [The arachidonic acid metabolites (prostaglandins, thromboxanes, prostacyclin, leucotrienes):basics and clinical implications (author's transl)]. 1979 Ther Umsch pmid:119331
Robak J and Kasperczyk H [Prostaglandin synthetase components (author's transl)]. 1979 Postepy Biochem. pmid:120943
Tremoli E et al. Platelet thromboxanes and serum-cholesterol. 1979 Lancet pmid:84115
Makheia AN et al. Inhibition of platelet aggregation and thromboxane synthesis by onion and garlic. 1979 Lancet pmid:86023
Lewy RI et al. Intravenous heparin initiates in-vivo synthesis and release of thromboxane in angina pectoris. 1979 Lancet pmid:87990
Güllner HG et al. Prostacyclin overproduction in Bartter's syndrome. 1979 Lancet pmid:90861
Davis TM et al. Prostacyclin and thromboxane metabolites in diabetes. 1979 Lancet pmid:90875
Gorman RR et al. Independence of the cyclic AMP-lowering activity of thromboxane A2 from the platelet release reaction. 1979 Biochim. Biophys. Acta pmid:216409
Fitzpatrick FA and Gorman RR Regulatory role of cyclic adenosine 3',5'-monophosphate on the platelet cyclooxygenase and platelet function. 1979 Biochim. Biophys. Acta pmid:216415
Best LC et al. Mode of action of dipyridamole on human platelets. 1979 Thromb. Res. pmid:229583
Marcus AJ The role of prostaglandins in platelet function. 1979 Prog Hematol pmid:230534
Spagnuolo C et al. PGF2 alpha, thromboxane B2 and HETE levels in gerbil brain cortex after ligation of common carotid arteries and decapitation. 1979 Prostaglandins pmid:230539
Jonsson CE et al. Efflux of cyclic AMP, prostaglandin E2 and F2 alpha and thromboxane B2 in leg lymph of rabbits after scalding injury. 1979 Acta Physiol. Scand. pmid:232367
Karmazyn M and Dhalla NS Thromboxane B2: a cardiodepressant of isolated rat hearts and inhibitor of sarcolemma Na+ - K+ stimulated ATPase activity. 1979 Prostaglandins Med pmid:233217
Anhut H et al. Thromboxane B2 release and 3H-noradrenaline accumulation by a synaptosomal fraction of rat brain. 1979 Jul-Aug Pol J Pharmacol Pharm pmid:523340
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Best LC et al. The interrelationship between thromboxane biosynthesis, aggregation and 5-hydroxytryptamine secretion in human platelets in vitro. 1980 Thromb. Haemost. pmid:6773171
Olund A et al. Prostaglandins and thromboxanes in amniotic fluid during rivanol-induced abortion and labour. 1980 Prostaglandins pmid:6775353
Bisordi JE et al. Interaction of vasopressin and prostaglandins in the toad urinary bladder. 1980 J. Clin. Invest. pmid:6777397
Burch RM and Halushka PV Thromboxane and stable prostaglandin endoperoxide analogs stimulate water permeability in the toad urinary bladder. 1980 J. Clin. Invest. pmid:6777398
Challis JR and Patrick JE The production of prostaglandins and thromboxanes in the feto-placental unit and their effects on the developing fetus. 1980 Semin. Perinatol. pmid:6992278
Ahnfelt-Rønne I et al. Macrophages from adjuvent arthritic rats preferentially synthetize prostacyclin. 1980 Agents Actions pmid:6992544
Gullner HG et al. Correction of increased prostacyclin synthesis in Bartter's syndrome by indomethacin treatment. 1980 Prostaglandins Med pmid:6994153
Crutchley DJ et al. Enhanced thromboxane B2 release from challenged guinea pig lung after oxygen exposure. 1980 Am. Rev. Respir. Dis. pmid:6155814
Brodie MJ et al. Is prostacyclin in the major pro-inflammatory prostanoid in joint fluid? 1980 Life Sci. pmid:6999274
Cella G et al. In vivo platelet release reaction in patients with heart valve prosthesis. 1980 Haemostasis pmid:6157609
Silver MJ et al. A model system for studying initial events in atherosclerosis. 1980 Artery pmid:7000044
Best LC et al. Lanthanum stimulates the accumulation of cyclic AMP and inhibits secretion and thromboxane B2 formation in human platelets. 1980 Biochim. Biophys. Acta pmid:6251913
Harris RH et al. Relationship of TXB2 and 6-keto PGF1 alpha to the hemodynamic changes during baboon endotoxic shock. 1980 Adv Prostaglandin Thromboxane Res pmid:6768234
Galli C et al. Effects of 8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxy carboxyl methoxy coumarin (AD6) on aggregation, arachidonic acid metabolism and thromboxane B2 formation in human platelets. 1980 Pharmacol Res Commun pmid:7393988
Oka M and Manku MS Spironolactone decreases the formation of prostaglandins and related substances from arachidonic acid in rat vascular rings and human platelets. 1980 Prostaglandins Med pmid:7394062
Karmali RA et al. Intrarenal growth of the Walker 256 tumour and renal vein concentrations of PGE2, PGF 2 alpha, and TXB2: effects of diazepam. 1980 Prostaglandins Med pmid:7394064
Cooper JD et al. Prostaglandin production associated with the pulmonary vascular response to complement activation. 1980 Surgery pmid:7394704
Dupont J et al. Effects of dietary essential fatty acid concentration upon prostanoid synthesis in rats. 1980 J. Nutr. pmid:7400858
Langs DA et al. Thromboxane molecules are not hairpin conformers. 1980 Adv Prostaglandin Thromboxane Res pmid:7386281
Bailey JM Essential fatty acid requirements and metabolism of cells in tissue culture. 1980 Adv Prostaglandin Thromboxane Res pmid:7386288
Cook JA et al. Elevated thromboxane levels in the rat during endotoxic shock: protective effects of imidazole, 13-azaprostanoic acid, or essential fatty acid deficiency. 1980 J. Clin. Invest. pmid:7350199
Stuart MJ et al. Effect of cholesterol on production of thromboxane b2 by platelets in vitro. 1980 N. Engl. J. Med. pmid:7350406
Wise WC et al. Ibuprofen improves survival from endotoxic shock in the rat. 1980 J. Pharmacol. Exp. Ther. pmid:7452480
Subbiah MT et al. Studies of aggregation and thromboxane B2 synthesis in avian thrombocytes: comparison between atherosclerosis-susceptible and resistant breeds. 1980 Thromb. Haemost. pmid:7455983
Pace-Asciak CR and Edwards NS Tetranor thromboxane B2 is the principal urinary catabolite formed after i.v. infusion of thromboxane B2 in the rat. 1980 Biochem. Biophys. Res. Commun. pmid:7458943
Vanderhoek JY et al. 15-hydroxy-5,8,11,13-eicosatetraenoic acid: A potent and selective inhibitor of platelet lipoxygenase. 1980 J. Biol. Chem. pmid:6771259
Ali M et al. Inhibition of human platelet cyclooxygenase by alpha-tocopherol. 1980 Prostaglandins Med pmid:6771778