| MeSH term | MeSH ID | Detail |
|---|---|---|
| Heart Defects, Congenital | D006330 | 20 associated lipids |
| Gastrointestinal Diseases | D005767 | 20 associated lipids |
| Myocardial Reperfusion Injury | D015428 | 20 associated lipids |
| Anemia | D000740 | 21 associated lipids |
| Myocardial Infarction | D009203 | 21 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Pulmonary Edema | D011654 | 23 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Cerebrovascular Disorders | D002561 | 25 associated lipids |
| Ascites | D001201 | 25 associated lipids |
| Hyperemia | D006940 | 25 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
Thromboxane b2
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
Cross Reference
Introduction
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thromboxane b2?
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
PubChem Associated disorders and diseases
What pathways are associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thromboxane b2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Thromboxane b2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Thromboxane b2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thromboxane b2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ushiyama S et al. | RS-5186, a novel thromboxane synthetase inhibitor with a potent and extended duration of action. | 1988 | Thromb. Res. | pmid:3175990 |
| Rogasi PG et al. | Radioimmunoassay of thromboxane B2 in plasma: methodological modifications. | 1988 | Thromb. Res. | pmid:3175991 |
| Schorer AE | Discordant effects on eicosanoids and fibrin degradation products in two murine models of antiphospholipid antibody. | 1997 | Thromb. Res. | pmid:9062953 |
| Kosaki G et al. | The mechanism of the inhibitory effect of protease inhibitors on platelet aggregation and cellular synthesis of prostaglandins. I. The effect on the release of arachidonic acid from phospholipids. | 1980 Dec 1-15 | Thromb. Res. | pmid:6785893 |
| Butler KD et al. | Prolongation of platelet survival in hypercholesterolaemic rabbits by CGS 12970 (3-methyl-2-(3-pyridyl)-1 indoleoctanoic acid) and dazoxiben. | 1987 | Thromb. Res. | pmid:3109067 |
| Anfossi G et al. | Studies on in vitro effect of picotamide on human platelet aggregation in platelet-rich plasma and whole blood. | 1995 | Thromb. Res. | pmid:7778055 |
| Carroll RC et al. | Post interventional cardiology urinary thromboxane correlates with PlateletMapping detected aspirin resistance. | 2010 | Thromb. Res. | pmid:19962724 |
| Lee GY et al. | Antiplatelet activity of BRX-018, (6aS,cis)-malonic acid 3-acetoxy-6a9-bis-(2-methoxycarbonyl-acetoxy)-6,6a,7,11b-tetrahydro-indeno[2,1-c]chromen-10-yl ester methylester. | 2005 | Thromb. Res. | pmid:15668191 |
| Ersöz G et al. | The effect of submaximal exercise on platelet aggregation during late follicular and midluteal phases in women. | 2002 | Thromb. Res. | pmid:12590951 |
| Mikashima H and Muramoto Y | Protective effect of Y-20811, a long-lasting thromboxane synthetase inhibitor, on endotoxin shock in rabbits. | 1990 | Thromb. Res. | pmid:2326771 |
| Agren JJ et al. | Dose responses in platelet fatty acid composition, aggregation and prostanoid metabolism during moderate freshwater fish diet. | 1990 | Thromb. Res. | pmid:2326774 |
| Ersöz G et al. | Effect of sodium selenite treatment on platelet aggregation of streptozotocin-induced diabetic rats. | 2003 | Thromb. Res. | pmid:14698654 |
| Huang CG et al. | Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells. | 2002 | Thromb. Res. | pmid:12297129 |
| Grauso F et al. | Effects of iloprost (ZK 36374), a prostacyclin derivative, on platelet function after ischaemic exercise in patients with stable angina pectoris. | 1987 | Thromb. Res. | pmid:2447664 |
| Udvardy M et al. | Plasma thromboxane and prostacyclin metabolite ratio in atherosclerosis and diabetes mellitus. | 1987 | Thromb. Res. | pmid:3116717 |
| GarcÃa Frade LJ et al. | Diabetes mellitus as a hypercoagulable state: its relationship with fibrin fragments and vascular damage. | 1987 | Thromb. Res. | pmid:3118498 |
| Chou TC and Li CY | Inhibitory mechanisms of dantrolene on platelet aggregation. | 1999 | Thromb. Res. | pmid:10593433 |
| Carter AJ et al. | Human pulmonary vessels obtained from necropsy produce less prostacyclin and thromboxane than fresh vessels obtained from operations. | 1984 | Thromb. Res. | pmid:6547546 |
| Rousson D et al. | Acute myocardial infarction: measurement of arachidonate end-products in whole blood as an index of platelet cyclo-oxygenase activity in vivo. | 1987 | Thromb. Res. | pmid:3122356 |
| Tsuboi T et al. | Effect of gliclazide on prostaglandin and thromboxane synthesis in guinea-pig platelets. | 1981 Jan 1-15 | Thromb. Res. | pmid:7233394 |
| Ditter H et al. | Effects of prostacyclin during cardiopulmonary bypass in men on plasma levels of beta-thromboglobulin, platelet factor 4, thromboxane B2, 6-keto-prostaglandin F1 alpha and heparin. | 1983 | Thromb. Res. | pmid:6197766 |
| Rostagno C et al. | In vitro effects of two novel calcium antagonists (nitrendipine and nisoldipine) on intraplatelet calcium redistribution, platelet aggregation and thromboxane A2 formation. Comparison with diltiazem, nifedipine and verapamil. | 1991 | Thromb. Res. | pmid:1754998 |
| Toivanen J et al. | Differential inhibition of platelet thromboxane and lung prostacyclin production by sulphinpyrazone, acetylsalicylic acid and indomethacin by human tissues in vitro. | 1985 | Thromb. Res. | pmid:3920778 |
| Stegmeier K et al. | The pharmacological profile of the thromboxane A2 antagonist BM 13.177. A new anti-platelet and anti-thrombotic drug. | 1984 | Thromb. Res. | pmid:6385334 |
| Mercer JB et al. | The effect of short-term cold exposure on risk factors for cardiovascular disease. | 1999 | Thromb. Res. | pmid:10418798 |
| Hall ER et al. | The reduction of platelet thrombi on damaged vessel wall by a thromboxane synthetase inhibitor in rabbits. | 1982 | Thromb. Res. | pmid:6891109 |
| Di Minno G et al. | Arachidonic acid induces human platelet-fibrin retraction: the role of platelet cyclic endoperoxides. | 1982 | Thromb. Res. | pmid:6803385 |
| Catella F and FitzGerald GA | Paired analysis of urinary thromboxane B2 metabolites in humans. | 1987 | Thromb. Res. | pmid:3686481 |
| Suehiro A et al. | The role of platelet hyperfunction in thrombus formation in hyperlipidemia. | 1982 | Thromb. Res. | pmid:6803387 |
| Vericel E et al. | Platelets and aging. I--Aggregation, arachidonate metabolism and antioxidant status. | 1988 | Thromb. Res. | pmid:3129819 |
| Arruzazabala ML et al. | Effects of Policosanol on platelet aggregation in rats. | 1993 | Thromb. Res. | pmid:8475481 |
| Wang JP et al. | Antiplatelet effect of capsaicin. | 1984 | Thromb. Res. | pmid:6528310 |
| Cattaneo M et al. | In vitro effects of picotamide on human platelet aggregation, the release reaction and thromboxane B2 production. | 1991 | Thromb. Res. | pmid:1926062 |
| Weide I et al. | Effects of cyclooxygenase inhibitors on ex vivo cysteinyl-leukotriene production by whole human blood allowed to clot spontaneously. Comparison to stimulated blood. | 1992 | Thromb. Res. | pmid:1440511 |
| Tindall H et al. | Thrombin generation precedes platelet activation in native blood taken from the hand during multiple blood sampling following cold challenge. | 1987 | Thromb. Res. | pmid:3617016 |
| Mannucci L et al. | Indobufen is a potent inhibitor of whole blood aggregation in patients with a high atherosclerotic risk. | 1987 | Thromb. Res. | pmid:3445229 |
| Nosál' R et al. | Chloroquine: a multipotent inhibitor of human platelets in vitro. | 2000 | Thromb. Res. | pmid:10828481 |
| Winther K et al. | Platelet function and fibrinolytic activity in cervical spinal cord injured patients. | 1992 | Thromb. Res. | pmid:1321515 |
| Buchanan MR et al. | The sex-related differences in aspirin pharmacokinetics in rabbits and man and its relationship to antiplatelet effects. | 1983 | Thromb. Res. | pmid:6221436 |
| Randall MJ and Wilding RI | Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with thromboxane synthetase inhibitor dazoxiben hydrochloride, (UK-37, 248-01). | 1982 | Thromb. Res. | pmid:6897751 |
| Di Minno G and Violi F | Aspirin resistance and diabetic angiopathy: back to the future. | 2004 | Thromb. Res. | pmid:15115664 |
| Best LC et al. | Mode of action of dipyridamole on human platelets. | 1979 | Thromb. Res. | pmid:229583 |
| Jørgensen KA et al. | The survival of pig to rabbit renal xenografts during inhibition of thromboxane synthesis. | 1983 | Thromb. Res. | pmid:6364449 |
| Zijlstra FJ et al. | Thrombotic thrombocytopenic purpura and plasma thromboxane B2 levels. | 1983 | Thromb. Res. | pmid:6684333 |
| Altman R and Scazziota A | Synergistic actions of paf-acether and sodium arachidonate in human platelet aggregation. 2. Unexpected results after aspirin intake. | 1986 | Thromb. Res. | pmid:3088757 |
| Maderna P et al. | Differential effects of oral administrations to human volunteers of acetylsalicylic acid, sodium salicylate and indomethacin on 12-hydroxyeicosatetraenoic acid formation by stimulated platelets. | 1988 | Thromb. Res. | pmid:3194896 |
| Davì G et al. | Inhibition of platelet function by ticlopidine in arteriosclerosis obliterans of the lower limbs. | 1985 | Thromb. Res. | pmid:2933846 |
| Platelet function during long-term treatment with ketanserin of claudicating patients with peripheral atherosclerosis. A multi-center, double-blind, placebo-controlled trial. The PACK Trial Group. | 1989 | Thromb. Res. | pmid:2528841 | |
| Pattison A et al. | The in vitro effect of amrinone on thromboxane B2 synthesis in human whole blood. | 1986 | Thromb. Res. | pmid:3755259 |
| Hashimoto Y et al. | Characteristics of protein kinase C-independent exocytosis in human platelets. | 1997 | Thromb. Res. | pmid:9336873 |
| Yue TL et al. | Pharmacological profile of G619, a new platelet aggregation inhibitor. | 1992 | Thromb. Res. | pmid:1412200 |
| Thorwest M et al. | Dietary fish oil reduces microvascular thrombosis in a porcine experimental model. | 2000 | Thromb. Res. | pmid:10946095 |
| Di Minno MN et al. | Genotype-independent in vivo oxidative stress following a methionine loading test: maximal platelet activation in subjects with early-onset thrombosis. | 2011 | Thromb. Res. | pmid:21669453 |
| Ames PR et al. | Aspirin insensitive thromboxane generation is associated with oxidative stress in type 2 diabetes mellitus. | 2012 | Thromb. Res. | pmid:22521214 |
| Dupin JP et al. | In vitro antiaggregant activity of paracetamol and derivatives. | 1988 | Thromb. Res. | pmid:3134743 |
| Martin JF et al. | The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. | 1983 | Thromb. Res. | pmid:6658722 |
| Li C et al. | Aspirin response variability after major orthopedic surgery. | 2012 | Thromb. Res. | pmid:22575418 |
| Serebruany VL and Gurbel PA | Assessment of platelet activity by measuring platelet-derived substances in plasma from patients with acute myocardial infarction: surprising lessons from the GUSTO-III Platelet Study. | 1999 | Thromb. Res. | pmid:10030832 |
| Kelton JG et al. | A study of the bioavailability and platelet inhibitory effects of a new enteric-coated acetylsalicylic acid preparation. | 1984 | Thromb. Res. | pmid:6740573 |
| Weide I et al. | Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens. | 1993 | Thromb. Res. | pmid:8122190 |
| Uyama O et al. | Plasma concentrations of 6-keto-prostaglandin F1 alpha in patients with hypertension, cerebrovascular disease or Takayasu's arteritis. | 1982 Jan 1-15 | Thromb. Res. | pmid:6121391 |
| Voss R et al. | In vitro and ex vivo effects of aspirin in patients on a low-dose aspirin therapy. | 1993 | Thromb. Res. | pmid:8122187 |
| Croft KD and Beilin LJ | Platelet and neutrophil function and eicosanoid release in a subject with abetalipoproteinaemia. | 1993 | Thromb. Res. | pmid:8385810 |
| Chou TC et al. | The inhibitory effect of 2-thienyl 2'-hydroxyphenyl ketone (C85) on platelet thromboxane formation. | 1996 | Thromb. Res. | pmid:8897698 |
| Takasaki W et al. | Enzyme immunoassay of human plasma 11-dehydrothromboxane B2. | 1991 | Thromb. Res. | pmid:1957275 |
| Korth R et al. | Unsaturated platelet-activating factor: influence on aggregation, serotonin release and thromboxane synthesis of human thrombocytes. | 1986 | Thromb. Res. | pmid:3961742 |
| Preston FE et al. | Low-dose aspirin inhibits platelet and venous cyclo-oxygenase in man. | 1982 | Thromb. Res. | pmid:6815823 |
| Sinzinger H et al. | Response of thromboxane B2, malondialdehyde and platelet sensitivity to 3 weeks low-dose aspirin (ASA) in healthy volunteers. | 1989 | Thromb. Res. | pmid:2497545 |
| Pinto S et al. | No signs of increased thrombin generation in menopause. | 1990 | Thromb. Res. | pmid:2201101 |
| Riess H et al. | Thromboxane receptor blockade versus cyclooxigenase inhibition: antiplatelet effects in patients. | 1986 | Thromb. Res. | pmid:3012819 |
| Pirich C et al. | Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. | 1999 | Thromb. Res. | pmid:10588465 |
| De Caterina R et al. | Inhibition of platelet aggregation and thromboxane B2 production during aspirin treatment: dependence on the dose of the aggregating agent. | 1985 | Thromb. Res. | pmid:3975876 |
| Altman R et al. | Synergistic actions of PAF-acether and sodium arachidonate in human platelet aggregation. 1. Studies in normal human platelet rich plasma. | 1986 | Thromb. Res. | pmid:3014677 |
| Worthington RE and Fuller GC | Dibutyryl cyclic guanosine monophosphate elevates bovine endothelial cell thromboxane production without affecting prostacyclin metabolism. | 1984 | Thromb. Res. | pmid:6322377 |
| Teng CM et al. | Platelet aggregation induced by equinatoxin. | 1988 | Thromb. Res. | pmid:2906181 |
| Kelton JG et al. | Sex-related differences in the efficacy of acetylsalicylic acid (ASA) : the absorption of ASA and its effect on collagen-induced thromboxane B2 generation. | 1981 Oct 1-15 | Thromb. Res. | pmid:7330835 |
| Yamaguchi A et al. | Effect of cetiedil on platelet aggregation and thromboxane synthesis. | 1985 | Thromb. Res. | pmid:2986312 |
| De La Cruz JP et al. | Effect of DT-TX 30, a combined thromboxane synthase inhibitor and thromboxane receptor antagonist, on retinal vascularity in experimental diabetes mellitus. | 2000 | Thromb. Res. | pmid:10680643 |
| Ding YA et al. | Antiplatelet actions of 2-(4-[1-(2-chlorophenyl) piperazinyl]) methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one compound. | 1995 | Thromb. Res. | pmid:7740521 |
| Prosdocimi M et al. | Inhibition by AD6 (8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxycarbonyl methoxy coumarin) of platelet aggregation in dog stenosed coronary artery. | 1985 | Thromb. Res. | pmid:3840290 |
| Vila V et al. | Fibrinopeptide A release from intraplatelet fibrinogen is related to thrombin platelet activation. | 1997 | Thromb. Res. | pmid:9175247 |
| Carter AJ and Jones EW | The effect of the degree of diabetic control on thromboxane synthesis in clotted whole blood. | 1986 | Thromb. Res. | pmid:3515613 |
| Mogensen F et al. | Effect of specific thromboxane-synthetase inhibition on thromboxane and prostaglandin synthesis in stable angina induced by exercise test. | 1985 | Thromb. Res. | pmid:4038824 |
| Tzeng SH et al. | Inhibition of platelet aggregation by some flavonoids. | 1991 | Thromb. Res. | pmid:1776142 |
| Antonino MJ et al. | Antiplatelet effects of aspirin with phytosterols: comparison with non-enteric coated aspirin alone. | 2010 | Thromb. Res. | pmid:19446864 |
| Neiman J et al. | Platelet responses to platelet-activating factor are inhibited in alcoholics undergoing alcohol withdrawal. | 1989 | Thromb. Res. | pmid:2617478 |
| Neiman J et al. | Platelet uptake of serotonin (5-HT) during ethanol withdrawal in male alcoholics. | 1987 | Thromb. Res. | pmid:2820078 |
| Altman R et al. | Why single daily dose of aspirin may not prevent platelet aggregation. | 1988 | Thromb. Res. | pmid:3140408 |
| Zahavi M et al. | Enhanced platelet release reaction and increased thromboxane generation in esophageal achalasia and selective in vitro inhibition of arachidonic acid induced platelet aggregation by vasoactive intestinal peptide. | 1990 | Thromb. Res. | pmid:2146767 |
| Simmet T and Weide I | Thromboxane and cysteinyl-leukotriene formation are differentially activated in spontaneously clotting whole human blood in vitro. | 1991 | Thromb. Res. | pmid:1866709 |
| Lukaszyk A et al. | Does acute experimental pancreatitis affect blood platelet function? | 1989 | Thromb. Res. | pmid:2524119 |
| Weigel G et al. | Regulation of eicosanoid release in human umbilical endothelial cells. | 1991 | Thromb. Res. | pmid:1656543 |
| Ko FN et al. | Antiplatelet effects of protopine isolated from Corydalis tubers. | 1989 | Thromb. Res. | pmid:2559491 |
| Ito T et al. | Role of activated platelets in endotoxin-induced DIC in rats. | 1990 | Thromb. Res. | pmid:2080492 |
| Alessandrini P et al. | Physiologic variables affecting thromboxane B2 production in human whole blood. | 1985 | Thromb. Res. | pmid:3983893 |
| Lukaszyk A et al. | Blood platelet function in canine acute pancreatitis with reference to treatment with Nafamostat mesilate (FUT-175). | 1992 | Thromb. Res. | pmid:1579898 |
| Meyers KM et al. | An evaluation of the arachidonate pathway of platelets from companion and food-producing animals, mink, and man. | 1980 | Thromb. Res. | pmid:7209869 |
| Grignani G et al. | Activation of platelet prostaglandin biosynthesis pathway during neoplastic cell-induced platelet aggregation. | 1984 | Thromb. Res. | pmid:6729776 |
| Patterson WR et al. | Aggregation of killer whale platelets. | 1993 | Thromb. Res. | pmid:8327987 |
| Barbieri B et al. | p-Aminobenzoic acid, but not its metabolite p-acetamidobenzoic acid, inhibits thrombin induced thromboxane formation in human platelets in a non NSAID like manner. | 1997 | Thromb. Res. | pmid:9175234 |