Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kulkarni P and Payne S | Eicosanoids in bovine retinal microcirculation. | 1997 | J Ocul Pharmacol Ther | pmid:9090614 |
Best L et al. | Effect of glucose on platelet thromboxane biosynthesis. | 1979 | Lancet | pmid:90876 |
Yamamoto S et al. | Endothelin causes portal and pulmonary hypertension in porcine endotoxemic shock. | 1997 | Am. J. Physiol. | pmid:9087598 |
Davis TM et al. | Prostacyclin and thromboxane metabolites in diabetes. | 1979 | Lancet | pmid:90875 |
Güllner HG et al. | Prostacyclin overproduction in Bartter's syndrome. | 1979 | Lancet | pmid:90861 |
Stichtenoth DO et al. | Effects of meloxicam and indomethacin on cyclooxygenase pathways in healthy volunteers. | 1997 | J. Investig. Med. | pmid:9084574 |
Hsieh YZ and Kuo KL | Analysis of prostaglandins by micellar electrokinetic capillary chromatography. | 1997 | J Chromatogr A | pmid:9084156 |
Mori TA et al. | Interactions between dietary fat, fish, and fish oils and their effects on platelet function in men at risk of cardiovascular disease. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9081682 |
Bröijersén A et al. | No influence of simvastatin treatment on platelet function in vivo in patients with hypercholesterolemia. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9081681 |
Zheng NX et al. | Pharmacokinetic-pharmacodynamic modelling of DP-1904, a novel thromboxane synthetase inhibitor in rabbits, based on an indirect response model. | 1996 Oct-Dec | Eur J Drug Metab Pharmacokinet | pmid:9074892 |
Gomi T et al. | Protective effect of thromboxane synthetase inhibitor on hypertensive renal damage in Dahl salt-sensitive rats. | 1995 | Clin Exp Pharmacol Physiol Suppl | pmid:9072433 |
Fitzpatrick FA et al. | A radioimmunoassay for thromboxane B2. | 1977 | Anal. Biochem. | pmid:907115 |
Held HD et al. | Phosphodiesterase inhibitors prevent endothelin-1-induced vasoconstriction, bronchoconstriction, and thromboxane release in perfused rat lung. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070212 |
Tanabe K et al. | Erythrocyte magnesium and prostaglandin dynamics in chronic sleep deprivation. | 1997 | Clin Cardiol | pmid:9068914 |
Teng CM et al. | ADP-mimicking platelet aggregation caused by rugosin E, an ellagitannin isolated from Rosa rugosa Thunb. | 1997 | Thromb. Haemost. | pmid:9066010 |
van der Weiden RM et al. | Prostanoid excretion in incipient singleton and twin pregnancies. | 1996 | Am. J. Obstet. Gynecol. | pmid:9065139 |
Schorer AE | Discordant effects on eicosanoids and fibrin degradation products in two murine models of antiphospholipid antibody. | 1997 | Thromb. Res. | pmid:9062953 |
Feng J et al. | Effects of tetramethylpyrazine on the release of PGI2 and TXA2 in the hypoxic isolated rat heart. | 1997 | Mol. Cell. Biochem. | pmid:9059992 |
Yeh SL et al. | Effects of n-3 and n-6 fatty acids on plasma eicosanoids and liver antioxidant enzymes in rats receiving total parenteral nutrition. | 1997 | Nutrition | pmid:9058445 |
Serebruany VL et al. | Serial changes of the plasma prostanoids during myocardial ischemia-reperfusion in swine. Effects of magnesium, diltiazem, and a novel Mac-1 inhibitor. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9051723 |
Kadir A et al. | Phenylbutazone pharmacokinetics and bioavailability in the dromedary camel (Camelus dromedarius). | 1997 | J. Vet. Pharmacol. Ther. | pmid:9049950 |
Nanji AA et al. | Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat. | 1997 | Gastroenterology | pmid:9041257 |
Rodwell LT et al. | Effect of inhaled frusemide and oral indomethacin on the airway response to hypertonic saline challenge in asthmatic subjects. | 1997 | Thorax | pmid:9039247 |
Keen HL et al. | Thromboxane is required for full expression of angiotensin hypertension in rats. | 1997 | Hypertension | pmid:9039120 |
Alavi N and Singh A | Events that stimulate release of thromboxane B2 in passive heymann nephritis. | 1997 | Proc. Soc. Exp. Biol. Med. | pmid:9034135 |
Okazawa A et al. | 8-Epi-PGF2alpha induces airflow obstruction and airway plasma exudation in vivo. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9032175 |
Zingarelli B et al. | The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity. | 1997 | Br. J. Pharmacol. | pmid:9031736 |
Israels SJ et al. | Deficient thromboxane synthesis and response in platelets from premature infants. | 1997 | Pediatr. Res. | pmid:9029642 |
Cervar M et al. | Drug actions in preeclampsia: aspirin, but not magnesium chloride or dihydralazine, differentially inhibits cultured human trophoblast release of thromboxane and prostacyclin without affecting angiotensin II, endothelin-1, or leukotriene B4 secretion. | 1997 | Am. J. Obstet. Gynecol. | pmid:9024091 |
Cheng JB et al. | The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9023272 |
Liao CH et al. | Antiplatelet effect of demethyldiisoeugenol. | 1996 | Can. J. Physiol. Pharmacol. | pmid:9022830 |
Ringdahl BE et al. | Effect of nicotine on arachidonic acid metabolites and epithelial parameters in rat oral mucosa. | 1997 | J. Oral Pathol. Med. | pmid:9021551 |
Matsumoto H et al. | Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9020023 |
Sheu JR et al. | Mechanism of inhibition of platelet aggregation by rutaecarpine, an alkaloid isolated from Evodia rutaecarpa. | 1996 | Eur. J. Pharmacol. | pmid:9016940 |
Liu CZ and Huang TF | Crovidisin, a collagen-binding protein isolated from snake venom of Crotalus viridis, prevents platelet-collagen interaction. | 1997 | Arch. Biochem. Biophys. | pmid:9016825 |
Leung S et al. | Isolation and purification of anticardiolipin antibody from plasma of a patient with antiphospholipid syndrome: induced generation of platelet thromboxane A2 synthesis. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014216 |
Lewis DA et al. | Production of endothelium-derived factors from sodded expanded polytetrafluoroethylene grafts. | 1997 | J. Vasc. Surg. | pmid:9013924 |
Watanabe A et al. | Effect of TYB-2285 on lung anaphylaxis in actively sensitized rats. | 1997 | Gen. Pharmacol. | pmid:9013209 |
Yamamura S et al. | Prostaglandin levels of primary bone tumor tissues correlate with peritumoral edema demonstrated by magnetic resonance imaging. | 1997 | Cancer | pmid:9010098 |
Pacchiarini L et al. | In vitro effect of reduced glutathione on platelet function. | 1996 Nov-Dec | Haematologica | pmid:9009436 |
Belisario MA et al. | In vitro effect of avarone and avarol, a quinone/hydroquinone couple of marine origin, on platelet aggregation. | 1996 | Pharmacol. Toxicol. | pmid:9000256 |
Prié S et al. | Eosinophils and neutrophils modify arachidonic acid-induced relaxation of guinea-pig trachea. | 1996 | Eur. J. Pharmacol. | pmid:8997620 |
Isenring P et al. | Eicosanoid modulation of the norepinephrine effect on blood pressure and renal hemodynamics in humans. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8992495 |
Nagao T et al. | Effect of DP-1904, a thromboxane A2 synthase inhibitor, on passive Heymann nephritis in rats. | 1996 | Eur. J. Pharmacol. | pmid:8982653 |
Santini G et al. | Effects of flurbiprofen and flurbinitroxybutylester on prostaglandin endoperoxide synthases. | 1996 | Eur. J. Pharmacol. | pmid:8982652 |
Dayal S et al. | Increased ratio of thromboxane B2 and 6-keto PGF1 alpha in patients of hepatic venous outflow obstruction. | 1996 | Eur. J. Haematol. | pmid:8982298 |
Pregnolato P et al. | Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981629 |
Fritsche KL and Cassity NA | Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981628 |
Matsumoto K et al. | Role of thromboxane-A2 and cholinergic mechanisms in bronchoconstriction induced by cigarette smoke in guinea-pigs. | 1996 | Eur. Respir. J. | pmid:8980955 |
Miyahara T et al. | Specific neutrophil elastase inhibitor does not attenuate acute lung injury induced by air embolism in awake sheep. | 1996 Nov-Dec | Exp. Lung Res. | pmid:8979046 |