Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Chavali SR et al. | Increased production of TNF-alpha and decreased levels of dienoic eicosanoids, IL-6 and IL-10 in mice fed menhaden oil and juniper oil diets in response to an intraperitoneal lethal dose of LPS. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9774171 |
Chen MF et al. | Vitamin E supplementation attenuates myointimal proliferation of the abdominal aorta after balloon injury in diet-induced hypercholesterolemic rabbits. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9777654 |
Lindström T et al. | The effect of unreamed and reamed intramedullary nailing on the urinary excretion of prostacyclin and thromboxane A2 metabolites in patients with tibial shaft fractures. | 1998 | J Trauma | pmid:9783614 |
John H et al. | Development and review of radioimmunoassay of 12-S-hydroxyheptadecatrienoic acid. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9785378 |
Thomson M et al. | Prostanoid synthesis in whole blood cells from fish of the Arabian Gulf. | 1998 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9787758 |
Smith CJ et al. | Pharmacological analysis of cyclooxygenase-1 in inflammation. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9789085 |
Sheu JR et al. | Mechanisms involved in the antiplatelet activity of Escherichia coli lipopolysaccharide in human platelets. | 1998 | Br. J. Haematol. | pmid:9792285 |
Obase Y et al. | Effects of cysteinyl-leukotriene receptor antagonist, thromboxane A2 receptor antagonist, and thromboxane A2 synthetase inhibitor on antigen-induced bronchoconstriction in patients with asthma. | 1998 | Chest | pmid:9792572 |
Turpeinen AM et al. | Replacement of dietary saturated by unsaturated fatty acids: effects of platelet protein kinase C activity, urinary content of 2,3-dinor-TXB2 and in vitro platelet aggregation in healthy man. | 1998 | Thromb. Haemost. | pmid:9798986 |
Huszár E et al. | Elevated circulating adenosine level potentiates antigen-induced immediate bronchospasm and bronchoconstrictor mediator release in sensitized guinea pigs. | 1998 | J. Allergy Clin. Immunol. | pmid:9802380 |
Cullen L et al. | Selective cyclooxygenase-2 inhibition by nimesulide in man. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9808683 |
Hellyer PW et al. | The effects of hyperoxia on the biosynthesis of cyclooxygenase products and haemodynamic response to nitric oxide synthase inhibition with L-NAME in endotoxaemic pigs. | 1998 | J. Vet. Pharmacol. Ther. | pmid:9811434 |
Dobner P and Engelmann B | Low-density lipoproteins supply phospholipid-bound arachidonic acid for platelet eicosanoid production. | 1998 | Am. J. Physiol. | pmid:9814996 |
Jiang XW et al. | Effects of low-dose Beraprost sodium, a stable prostaglandin I2 analogue, on reperfusion injury to rabbit lungs. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9817723 |
Menè P et al. | Eicosanoid synthesis in peripheral blood monocytes: a marker of disease activity in lupus nephritis. | 1998 | Am. J. Kidney Dis. | pmid:9820447 |
Saitta A et al. | Effects of picotamide on release of endothelin-1, thromboxane and prostacycline after treadmill stress in patients with peripheral artery disease. | 1998 | Angiology | pmid:9822043 |
Hauth J et al. | Maternal serum thromboxane B2 concentrations do not predict improved outcomes in high-risk pregnancies in a low-dose aspirin trial. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medical Units. | 1998 | Am. J. Obstet. Gynecol. | pmid:9822499 |
Kalgutkar AS et al. | Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators. | 1998 | J. Med. Chem. | pmid:9822550 |
Schmeck J et al. | Endothelin-1 and thromboxane A2 increase pulmonary vascular resistance in granulocyte-mediated lung injury. | 1998 | Crit. Care Med. | pmid:9824081 |
Henry A et al. | Inhibition of platelet activation by the Alzheimer's disease amyloid precursor protein. | 1998 | Br. J. Haematol. | pmid:9827912 |