Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Salonen JT et al. | Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo-controlled, double-blind trial in men with low antioxidant status. | 1991 | Am. J. Clin. Nutr. | pmid:1826987 |
Prakash C et al. | Decreased systemic thromboxane A2 biosynthesis in normal human subjects fed a salmon-rich diet. | 1994 | Am. J. Clin. Nutr. | pmid:8074067 |
Gonzalez-Crussi F et al. | Prostaglandins in histiocytosis-X. PG synthesis by histiocytosis-X cells. | 1981 | Am. J. Clin. Pathol. | pmid:6970520 |
Hyman PE et al. | Enhanced urinary immunoreactive thromboxane in neonatal necrotizing enterocolitis. A diagnostic indicator of thrombotic activity. | 1987 | Am. J. Dis. Child. | pmid:2953236 |
Hammerman C et al. | Hypoxic vs septic pulmonary hypertension. Selective role of thromboxane mediation. | 1988 | Am. J. Dis. Child. | pmid:3278589 |
Singh D et al. | Evidence for the generation of hydroxyl radical during arachidonic acid metabolism by human platelets. | 1981 | Am. J. Hematol. | pmid:6274189 |
Zaitsu M et al. | Thromboxane synthesis is increased by upregulation of cytosolic phospholipase A2 and cyclooxygenase-2 in peripheral polymorphonuclear leukocytes during bacterial infection in childhood. | 2003 | Am. J. Hematol. | pmid:12555215 |
Wu X et al. | Zileuton, a 5-lipoxygenase inhibitor, increases production of thromboxane A2 and platelet aggregation in patients with asthma. | 2003 | Am. J. Hematol. | pmid:12949886 |
Stuart MJ | Effect of endotoxin on arachidonic acid release and thromboxane B2 production by human platelets. | 1981 | Am. J. Hematol. | pmid:7030066 |
Gross S and Worthington-White DA | The effects of PGF2 alpha, PGI2, and TxB2 on human CFU-C in healthy and leukemic patients. | 1984 | Am. J. Hematol. | pmid:6372442 |
Meyers KM et al. | Evaluation of the platelet storage pool deficiency in the feline counterpart of the Chediak-Higashi syndrome. | 1981 | Am. J. Hematol. | pmid:7315839 |
Horellou MH et al. | Familial and constitutional bleeding disorder due to platelet cyclo-oxygenase deficiency. | 1983 | Am. J. Hematol. | pmid:6404162 |
Carvalho AC et al. | Platelet function in acute respiratory failure. | 1987 | Am. J. Hematol. | pmid:2956879 |
Ryo R et al. | Deficiency of P62, a putative collagen receptor, in platelets from a patient with defective collagen-induced platelet aggregation. | 1992 | Am. J. Hematol. | pmid:1311144 |
Jones CM et al. | Arachidonic acid metabolites produced by platelet-depleted human blood monocytes: a possible role in thrombogenesis. | 1989 | Am. J. Hematol. | pmid:2741910 |
Antonucci R et al. | Enhancement of sickle erythrocyte adherence to endothelium by autologous platelets. | 1990 | Am. J. Hematol. | pmid:2109530 |
Del Principe D et al. | Vitamin E consumption by human blood platelets activated by latex particles. | 1986 | Am. J. Hematol. | pmid:3953557 |
Mezzano D et al. | Evidence that platelet buoyant density, but not size, correlates with platelet age in man. | 1981 | Am. J. Hematol. | pmid:7270546 |
Suarez CR et al. | Neonatal and maternal platelets: activation at time of birth. | 1988 | Am. J. Hematol. | pmid:2972197 |
Smock KJ and Rodgers GM | Laboratory evaluation of aspirin responsiveness. | 2010 | Am. J. Hematol. | pmid:20229592 |