Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ersöz G et al. | Effect of submaximal and incremental upper extremity exercise on platelet function and the role of blood shear stress. | 2002 | Thromb. Res. | pmid:12676189 |
Küsters S et al. | Effects of antihistamines on leukotriene and cytokine release from dispersed nasal polyp cells. | 2002 | Arzneimittelforschung | pmid:11878205 |
Tuersun K and Huang Y | [Changes of blood vessel active substances in acute pulmonary embolism induced by echinococus granulous cyst in rabbits]. | 2002 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:12490126 |
Zaitsu M et al. | Induction of thromboxane A2 synthesizing enzymes in DMSO-induced granulocytic differentiation of HL-60 cells. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468261 |
Thomson M et al. | The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468270 |
Bruno A et al. | Aspirin and urinary 11-dehydrothromboxane B(2) in African American stroke patients. | 2002 | Stroke | pmid:11779889 |
Jeng JH et al. | Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase. | 2002 | Free Radic. Biol. Med. | pmid:11978487 |
Streppa HK et al. | Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs in canine blood. | 2002 | Am. J. Vet. Res. | pmid:16206787 |
Jiang Z et al. | [The changes of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha(6-keto-PGF1 alpha) in the lungs of rats drowned in hypothermic-sea-water]. | 2002 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:14694611 |
Obase Y et al. | Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients. | 2002 | Chest | pmid:11796443 |
Cipollone F et al. | Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia: effects of statin therapy. | 2002 | Circulation | pmid:12135935 |
Association between ibuprofen, aspirin therapy found. | 2002 | J Am Dent Assoc | pmid:12136787 | |
Rinder HM et al. | Effects of meloxicam on platelet function in healthy adults: a randomized, double-blind, placebo-controlled trial. | 2002 | J Clin Pharmacol | pmid:12162470 |
Wong DA et al. | Discrete role for cytosolic phospholipase A(2)alpha in platelets: studies using single and double mutant mice of cytosolic and group IIA secretory phospholipase A(2). | 2002 | J. Exp. Med. | pmid:12163563 |
Signorello MG et al. | Effect of homocysteine on arachidonic acid release in human platelets. | 2002 | Eur. J. Clin. Invest. | pmid:11952814 |
Jones CJ et al. | In vivo effects of meloxicam and aspirin on blood, gastric mucosal, and synovial fluid prostanoid synthesis in dogs. | 2002 | Am. J. Vet. Res. | pmid:12428662 |
Buluç M et al. | Effect of misoprostol and indomethacin on cyclooxygenase induction and eicosanoid production in carrageenan-induced air pouch inflammation in rats. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428691 |
Gray PA et al. | Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors. | 2002 | Br. J. Pharmacol. | pmid:12429575 |
Valeri CR et al. | Circulation and hemostatic function of autologous fresh, liquid-preserved, and cryopreserved baboon platelets transfused to correct an aspirin-induced thrombocytopathy. | 2002 | Transfusion | pmid:12430680 |
Ferlito M et al. | Implication of Galpha i proteins and Src tyrosine kinases in endotoxin-induced signal transduction events and mediator production. | 2002 | J. Endotoxin Res. | pmid:12701623 |
Dionne RA et al. | Analgesia and COX-2 inhibition. | 2001 Nov-Dec | Clin. Exp. Rheumatol. | pmid:11695255 |
Resnick DK et al. | Regional and temporal changes in prostaglandin E2 and thromboxane B2 concentrations after spinal cord injury. | 2001 Nov-Dec | Spine J | pmid:14588301 |
Resnick DK et al. | Selective cyclooxygenase 2 inhibition lowers spinal cord prostaglandin concentrations after injury. | 2001 Nov-Dec | Spine J | pmid:14588302 |
Nakamura H et al. | Difference in urinary 11-dehydro TXB2 and LTE4 excretion in patients with rheumatoid arthritis. | 2001 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11993724 |
Rebrov BA | [Role of thromboxane A2 (B2) in the pathogenesis of stress proteinuria in healthy persons]. | 2001 Mar-Apr | Urologiia | pmid:11490711 |
Minuz P et al. | NCX4016 (NO-aspirin) inhibits thromboxane biosynthesis and tissue factor expression and activity in human monocytes. | 2001 Jul-Aug | Med. Sci. Monit. | pmid:11433179 |
Clayton HA et al. | A coculture model of intrahepatic islet transplantation: activation of Kupffer cells by islets and acinar tissue. | 2001 Jan-Feb | Cell Transplant | pmid:11294466 |
Uchiyama M et al. | Comparison between nonpulsatile and pulsatile machine perfusion preservation in liver transplantation from non-heart-beating donors. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267136 |
Oikawa K et al. | Elimination of Kupffer cells suppresses activation of nuclear factor kappa B and production of cytokines and eicosanoids in non-heart-beating donors. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267090 |
Okita M et al. | Effect of arachidonic acid-rich oil on lipids and arachidonate metabolites in ethanol- treated rats. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418023 |
Karamouzis M et al. | The response of muscle interstitial prostaglandin E(2)(PGE(2)), prostacyclin I(2)(PGI(2)) and thromboxane A(2)(TXA(2)) levels during incremental dynamic exercise in humans determined by in vivo microdialysis. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418021 |
Li G et al. | Cardiac ischemic preconditioning improves lung preservation in valve replacement operations. | 2001 | Ann. Thorac. Surg. | pmid:11235719 |
Agnoli GC et al. | Volume-induced natriuresis in healthy women: renal metabolism of prostacyclin and thromboxane, and physiological role of prostanoids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11237476 |
Liu ZQ et al. | [Effect of Astragalus injection on platelet function and plasma endothelin in patients with early stage diabetic nephropathy]. | 2001 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12577356 |
Qureshi AA et al. | Novel tocotrienols of rice bran suppress cholesterogenesis in hereditary hypercholesterolemic swine. | 2001 | J. Nutr. | pmid:11160537 |
Lin CL et al. | [Therapeutic mechanism of combination therapy of ligustrazine and nitrendipine in treating patients with chronic obstructive pulmonary disease]. | 2001 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12577373 |
Bölke E et al. | Changes of gut barrier function during anesthesia and cardiac surgery. | 2001 | Angiology | pmid:11515987 |
Riendeau D et al. | Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11160644 |
Al-Qattan KK et al. | Thromboxane-B2, prostaglandin-E2 and hypertension in the rat 2-kidney 1-clip model: a possible mechanism of the garlic induced hypotension. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161580 |
Sunose Y et al. | Effects of FK3311 on pulmonary ischemia-reperfusion injury in a canine model. | 2001 | J. Surg. Res. | pmid:11162041 |
Grace RF et al. | Effects of diclofenac in the rat tail ischaemia--reperfusion injury model of acute hyperalgesia. | 2001 | Pain | pmid:11166467 |
Watanabe T et al. | Enhanced platelet sensitivity to prostacyclin in patients in an active stage of Takayasu arteritis. | 2001 | Thromb. Res. | pmid:11672751 |
Ziegler BK et al. | Incomplete thromboxane inhibition with 100 mg of intravenous acetylsalicylic acid in patients with acute ST elevation myocardial infarction: a placebo-controlled pilot trial. | 2001 | Thromb. Res. | pmid:11672759 |
Nüsing RM et al. | Pathogenetic role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome: therapeutic use of the cyclooxygenase-2 inhibitor nimesulide. | 2001 | Clin. Pharmacol. Ther. | pmid:11673754 |
Llinás MT et al. | Role of COX-2-derived metabolites in regulation of the renal hemodynamic response to norepinephrine. | 2001 | Am. J. Physiol. Renal Physiol. | pmid:11592955 |
Kitamura R et al. | Thiopental enhances human platelet aggregation by increasing arachidonic acid release. | 2001 | Can. J. Physiol. Pharmacol. | pmid:11697744 |
Moreno JJ | Antiflammin-2 prevents HL-60 adhesion to endothelial cells and prostanoid production induced by lipopolysaccharides. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11181920 |
Iuliano L et al. | Angioplasty increases coronary sinus F2-isoprostane formation: evidence for in vivo oxidative stress during PTCA. | 2001 | J. Am. Coll. Cardiol. | pmid:11153776 |
Valeri CR et al. | Anemia-induced increase in the bleeding time: implications for treatment of nonsurgical blood loss. | 2001 | Transfusion | pmid:11493727 |
Ogata K et al. | Attenuation of ischemia and reperfusion injury of canine livers by inhibition of type II phospholipase A2 with LY329722. | 2001 | Transplantation | pmid:11374398 |
Coelho-Filho OR et al. | Pravastatin reduces myocardial lesions induced by acute inhibition of nitric oxide biosynthesis in normocholesterolemic rats. | 2001 | Int. J. Cardiol. | pmid:11461744 |
Wojakowski W and Gmiński J | Plasma levels of von willebrand factor, endothelin-1, prostacyclin and thromboxane in children from families with high risk of premature coronary artery disease. | 2001 | Scand. J. Clin. Lab. Invest. | pmid:11465346 |
Rosón MI et al. | Serotonin hypersensitivity in aorta of two kidney-two clip hypertensive rats: calcium contribution and prostanoids-nitric oxide interactions. | 2001 | Arch. Physiol. Biochem. | pmid:11471069 |
Catella-Lawson F et al. | Oral glycoprotein IIb/IIIa antagonism in patients with coronary artery disease. | 2001 | Am. J. Cardiol. | pmid:11472700 |
Takeyoshi I et al. | The effect of a selective cyclooxygenase-2 inhibitor in extended liver resection with ischemia in dogs. | 2001 | J. Surg. Res. | pmid:11516201 |
Guyton K et al. | Differential effects of 15-deoxy-delta(12,14)-prostaglandin J2 and a peroxisome proliferator-activated receptor gamma agonist on macrophage activation. | 2001 | J. Leukoc. Biol. | pmid:11310850 |
Muramatsu H et al. | [Correlation between the clinical effects of Seratrodast and the level of 11-dehydrothromboxane B2 in urine/sputum in bronchial asthma patients]. | 2001 | Arerugi | pmid:11517517 |
Calzada C et al. | 12(S)-Hydroperoxy-eicosatetraenoic acid increases arachidonic acid availability in collagen-primed platelets. | 2001 | J. Lipid Res. | pmid:11518767 |
Fritsma GA et al. | Monitoring the antiplatelet action of aspirin. | 2001 | JAAPA | pmid:11523339 |
Oketani K et al. | In vitro effects of E3040, a dual inhibitor of 5-lipoxygenase and thromboxane A(2) synthetase, on eicosanoid production. | 2001 | Eur. J. Pharmacol. | pmid:11430933 |
Urquhart P et al. | Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487303 |
Zoja C et al. | Mycophenolate mofetil combined with a cyclooxygenase-2 inhibitor ameliorates murine lupus nephritis. | 2001 | Kidney Int. | pmid:11473648 |
Alcaraz A et al. | Experimental kidney transplantation in pigs from non-heart-beating donors: evaluation of vasoactive substances and renal artery flow. | 2001 | Transplant. Proc. | pmid:11543815 |
Kijima Y et al. | Transcardiac 8-iso-prostaglandin F(2 alpha)generation from acute myocardial infarction heart: insight into abrupt reperfusion and oxidant stress. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334551 |
Gao YJ and Lee RM | Hydrogen peroxide induces a greater contraction in mesenteric arteries of spontaneously hypertensive rats through thromboxane A(2) production. | 2001 | Br. J. Pharmacol. | pmid:11739239 |
Domoki F et al. | Cyclooxygenase-2 inhibitor NS398 preserves neuronal function after hypoxia/ischemia in piglets. | 2001 | Neuroreport | pmid:11742239 |
Engström K et al. | Effect of low-dose aspirin in combination with stable fish oil on whole blood production of eicosanoids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11427037 |
McConnell JP et al. | Urinary 11-dehydro-thromboxane B(2) and coagulation activation markers measured within 24 h of human acute ischemic stroke. | 2001 | Neurosci. Lett. | pmid:11684346 |
Wan Y et al. | Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans. | 2001 | Am. J. Clin. Nutr. | pmid:11684527 |
Wang ZY et al. | Comparative study of platelet activation markers in diabetes mellitus patients complicated by cerebrovascular disease. | 2001 | Blood Coagul. Fibrinolysis | pmid:11685040 |
Gloor B et al. | Hydrocortisone treatment of early SIRS in acute experimental pancreatitis. | 2001 | Dig. Dis. Sci. | pmid:11680590 |
Wang WJ and Huang TF | A novel tetrameric venom protein, agglucetin from Agkistrodon acutus, acts as a glycoprotein Ib agonist. | 2001 | Thromb. Haemost. | pmid:11686327 |
Stichtenoth DO et al. | Effects of intravenous oxygen on prostacyclin and thromboxane formation in patients with peripheral occlusive arterial disease. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728174 |
Sunose Y et al. | Effect of a cyclooxygenase-2 inhibitor, FK3311, in a canine lung transplantation model. | 2001 | Ann. Thorac. Surg. | pmid:11603431 |
Minuz P et al. | NCX4016 (NO-Aspirin) has multiple inhibitory effects in LPS-stimulated human monocytes. | 2001 | Br. J. Pharmacol. | pmid:11606332 |
Turull A et al. | Acute effects of the anti-inflammatory cyclooxygenase-2 selective inhibitor, flosulide, on renal plasma flow and glomerular filtration rate in rats. | 2001 | Inflammation | pmid:11321358 |
Skovronsky DM et al. | Amyloid precursor protein and amyloid beta peptide in human platelets. Role of cyclooxygenase and protein kinase C. | 2001 | J. Biol. Chem. | pmid:11278299 |
Oketani K et al. | Effect of E3040, an inhibitor of 5-lipoxygenase and thromboxane synthase, on rat bowel damage induced by lipopolysaccharide. | 2001 | Eur. J. Pharmacol. | pmid:11557269 |
Franconi F et al. | Effect of gamma-hydroxybutyric acid on human platelet aggregation in vitro. | 2001 | Thromb. Res. | pmid:11369419 |
Loew D et al. | Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo. | 2001 | Clin. Pharmacol. Ther. | pmid:11372004 |
Hishinuma T et al. | Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728171 |
Yoshinari D et al. | Effects of a dual inhibitor of tumor necrosis factor-alpha and interleukin-1 on lipopolysaccharide-induced lung injury in rats: involvement of the p38 mitogen-activated protein kinase pathway. | 2001 | Crit. Care Med. | pmid:11373433 |
Feldman M et al. | Effects of low-dose aspirin on serum C-reactive protein and thromboxane B2 concentrations: a placebo-controlled study using a highly sensitive C-reactive protein assay. | 2001 | J. Am. Coll. Cardiol. | pmid:11419884 |
Kaaja R et al. | Increased thromboxane production in women with a history of venous thromboembolic event: effect of heparins. | 2001 | Br. J. Haematol. | pmid:11552994 |
Dubé JN et al. | Characterization of a partial prostaglandin endoperoxide H synthase-1 deficiency in a patient with a bleeding disorder. | 2001 | Br. J. Haematol. | pmid:11442478 |
Katoh M et al. | Inhibitory effects of TA-993 and its metabolite MB3 on platelet activation induced by collagen and U-46619 in human platelets. | 2001 | Biol. Pharm. Bull. | pmid:11379769 |
Miyake K et al. | Effects of olopatadine hydrochloride on the increase of histamine and peptide-leukotrienes concentrations in nasal lavage fluid following the antigen-antibody reaction in actively sensitized guinea pigs. | 2001 | Jpn. J. Pharmacol. | pmid:11388650 |
Gossmann J et al. | Pathophysiology of cyclosporine-induced nephrotoxicity in humans: a role for nitric oxide? | 2001 | Kidney Blood Press. Res. | pmid:11435743 |
Cantaro S et al. | Urinary excretion of vasoactive substances in chronic renal failure. | 2001 | Clin. Nephrol. | pmid:11393385 |
Kurokawa K et al. | Circadian characteristics of urinary leukotriene E(4) in healthy subjects and nocturnal asthmatic patients. | 2001 | Chest | pmid:11742908 |
Zhang LH et al. | Effects of extract F of red-rooted Salvia on mucosal lesions of gastric corpus and antrum induced by hemorrhagic shock-reperfusion in rats. | 2001 | World J. Gastroenterol. | pmid:11819852 |
Feldman M et al. | A comparison of every-third-day versus daily low-dose aspirin therapy on serum thromboxane concentrations in healthy men and women. | 2001 | Clin. Appl. Thromb. Hemost. | pmid:11190906 |
Tuppo EE et al. | Sign of lipid peroxidation as measured in the urine of patients with probable Alzheimer's disease. | 2001 | Brain Res. Bull. | pmid:11397549 |
Norio K et al. | Eicosanoids and delayed graft function in human renal transplantation. | 2001 | Transplant. Proc. | pmid:11406239 |
Galipeau D et al. | Chronic thromboxane synthase inhibition prevents fructose-induced hypertension. | 2001 | Hypertension | pmid:11641301 |
Tubaro E et al. | Anti-inflammatory and antiplatelet effects of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug. | 2001 | Arzneimittelforschung | pmid:11642006 |
Spinarová L et al. | [Physical training in patients with chornic heart failure: haemodynamics, effects]. | 2001 | Vnitr Lek | pmid:15635849 |
Tran HS et al. | Prostacyclin is neither sufficient alone nor necessary to cause pulmonary dysfunction: results from infusions of prostacyclin and antiprostacyclin antibody in porcine septic shock. | 2001 | Crit. Care Med. | pmid:11445706 |
Sontag W | Release of mediators by DMSO-differentiated HL-60 cells exposed to electric interferential current and the requirement of biochemical prestimulation. | 2001 | Int. J. Radiat. Biol. | pmid:11403712 |
Machin KL et al. | Pharmacodynamics of flunixin and ketoprofen in mallard ducks (Anas platyrhynchos). | 2001 | J. Zoo Wildl. Med. | pmid:12790425 |