Thromboxane b2
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
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Introduction
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thromboxane b2?
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
PubChem Associated disorders and diseases
What pathways are associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thromboxane b2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Thromboxane b2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Thromboxane b2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thromboxane b2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Klosterhalfen B et al. | Time course of various inflammatory mediators during recurrent endotoxemia. | 1992 | Biochem. Pharmacol. | pmid:1599496 |
| Stenson WF and Lobos E | Inhibition of platelet thromboxane synthetase by sulfasalazine. | 1983 | Biochem. Pharmacol. | pmid:6135423 |
| Chang J et al. | Effects of thiazinamium chloride, promethazine and chlorpromazine on thromboxane B2 synthesis, phagocytosis and respiratory burst by rat alveolar macrophages. | 1983 | Biochem. Pharmacol. | pmid:6138040 |
| Deckmyn H et al. | Manipulation of the local thromboxane and prostacyclin balance in vivo by the antithrombotic compounds dazoxiben, acetylsalicylic acid and nafazatrom. | 1983 | Biochem. Pharmacol. | pmid:6578796 |
| Pestel S et al. | Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate. | 2003 | Biochem. Pharmacol. | pmid:12906929 |
| Ko FN et al. | Inhibition of collagen-induced platelet aggregation and adhesion by a pseudocyanide derivative of avicine isolated from Zanthoxylum integrifoliolum Merr. | 1993 | Biochem. Pharmacol. | pmid:8216367 |
| Krämer HJ et al. | Fish oil fatty acids and human platelets: dose-dependent decrease in dienoic and increase in trienoic thromboxane generation. | 1996 | Biochem. Pharmacol. | pmid:8937428 |
| Patscheke H | Thromboxane synthase inhibition potentiates washed platelet activation by endogenous and exogenous arachidonic acid. | 1985 | Biochem. Pharmacol. | pmid:3922373 |
| Segarnick DJ et al. | Precursor- and pool-dependent differential effects of ethanol on human platelet prostanoid synthesis. | 1985 | Biochem. Pharmacol. | pmid:3922375 |
| Vanderhoek JY et al. | Inhibitory potencies of fish oil hydroxy fatty acids on cellular lipoxygenases and platelet aggregation. | 1991 | Biochem. Pharmacol. | pmid:1831021 |
| Bakhle YS and Grantham CJ | Selective effect of pulmonary oedema on prostaglandin E2 pharmacokinetics in rat lung. | 1985 | Biochem. Pharmacol. | pmid:3935117 |
| Kanda N and Watanabe S | Suppressive effects of antimycotics on tumor necrosis factor-alpha-induced CCL27, CCL2, and CCL5 production in human keratinocytes. | 2006 | Biochem. Pharmacol. | pmid:16784723 |
| Klosterhalfen B et al. | Influence of heat shock protein 70 and metallothionein induction by zinc-bis-(DL-hydrogenaspartate) on the release of inflammatory mediators in a porcine model of recurrent endotoxemia. | 1996 | Biochem. Pharmacol. | pmid:8937427 |
| Chang WC et al. | Inhibition of thromboxane B2 and 6-ketoprostaglandin F1 alpha formation by anti-inflammatory drugs in carrageenin-induced granuloma. | 1978 | Biochem. Pharmacol. | pmid:619892 |
| Yu SM et al. | Dicentrine, a novel antiplatelet agent inhibiting thromboxane formation and increasing the cyclic AMP level of rabbit platelets. | 1992 | Biochem. Pharmacol. | pmid:1310852 |
| Spaethe SM et al. | Guinea pig whole blood 5-lipoxygenase assay: utility in the assessment of potential 5-lipoxygenase inhibitors. | 1992 | Biochem. Pharmacol. | pmid:1310855 |
| Tolman EL and Fuller BL | Inhibition of thromboxane synthesis in guinea pig lung and human platelets by clotrimazole and other imidazole antifungals. | 1983 | Biochem. Pharmacol. | pmid:6316985 |
| Medini L et al. | Diets rich in n-9, n-6 and n-3 fatty acids differentially affect the generation of inositol phosphates and of thromboxane by stimulated platelets, in the rabbit. | 1990 | Biochem. Pharmacol. | pmid:2105092 |
| Covatto RH and Niewiarowski S | Platelet thromboxane A2/prostaglandin H2 receptors in human volunteers on low doses of aspirin. | 1990 | Biochem. Pharmacol. | pmid:2145839 |
| Faili A et al. | Reduction by arachidonic acid of prostaglandin I2-induced cyclic AMP formation. Involvement of prostaglandins E2 and F2 alpha. | 1993 | Biochem. Pharmacol. | pmid:8388209 |
| Erman A et al. | The role of eicosanoids in cyclosporine nephrotoxicity in the rat. | 1989 | Biochem. Pharmacol. | pmid:2735953 |
| Grieve EM et al. | The reversal of experimental cyclosporin A nephrotoxicity by thromboxane synthetase inhibition. | 1993 | Biochem. Pharmacol. | pmid:8466554 |
| De La Cruz JP et al. | Effects of S-adenosyl-L-methionine on platelet thromboxane and vascular prostacyclin. | 1997 | Biochem. Pharmacol. | pmid:9264331 |
| de Gaetano G et al. | Low dose aspirin does not prevent fibrinolytic response to venous occlusion. | 1986 | Biochem. Pharmacol. | pmid:3755907 |
| Larsen LN et al. | Alpha- and beta- alkyl-substituted eicosapentaenoic acids: incorporation into phospholipids and effects on prostaglandin H synthase and 5-lipoxygenase. | 1998 | Biochem. Pharmacol. | pmid:9514074 |
| Weisman SM et al. | Differential effect of platelet-activating factor (PAF) receptor antagonists on peptide and PAF-stimulated prostaglandin release in unilateral ureteral obstruction. | 1988 | Biochem. Pharmacol. | pmid:2840083 |
| Bauer J et al. | Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. | 2011 | Biochem. Pharmacol. | pmid:20933508 |
| Yuk DY et al. | Antithrombotic and antiplatelet activities of 2-chloro-3-[4-(ethylcarboxy)-phenyl]-amino-1,4-naphthoquinone (NQ12), a newly synthesized 1,4-naphthoquinone derivative. | 2000 | Biochem. Pharmacol. | pmid:10974210 |
| Gairola CG and Tai HH | Cigarette smoke-induced alterations in the release of arachidonate metabolites by pulmonary alveolar macrophage from selenium-fed and selenium-deficient rats. | 1986 | Biochem. Pharmacol. | pmid:3015150 |
| Kerry R et al. | Beta-adrenoceptor antagonists and human platelets: relationship of effects to lipid solubility. | 1984 | Biochem. Pharmacol. | pmid:6147145 |
| Williamson EM et al. | Studies on the mechanism of action of 12-deoxyphorbolphenylacetate, a potent platelet aggregating tigliane ester. | 1981 | Biochem. Pharmacol. | pmid:6794576 |
| Lorenz RL et al. | Effects on prostanoid formation and pharmacokinetics of dazmegrel (UK-38,485), a novel thromboxane synthase inhibitor, in man. | 1986 | Biochem. Pharmacol. | pmid:3513767 |
| Chang TS et al. | Thromboxane A2 synthase inhibition and thromboxane A2 receptor blockade by 2-[(4-cyanophenyl)amino]-3-chloro-1,4-naphthalenedione (NQ-Y15) in rat platelets. | 1997 | Biochem. Pharmacol. | pmid:9271330 |
| Sumner H et al. | Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components. | 1992 | Biochem. Pharmacol. | pmid:1319159 |
| Opas EE et al. | Pharmacological modulation of eicosanoid levels and hyperalgesia in yeast-induced inflammation. | 1987 | Biochem. Pharmacol. | pmid:3103625 |
| Matsuoka I et al. | Inhibitory effect of 8-bromo cyclic GMP on an extracellular Ca2+-dependent arachidonic acid liberation in collagen-stimulated rabbit platelets. | 1989 | Biochem. Pharmacol. | pmid:2544181 |
| Palmer RM and Salmon JA | Comparison of the effects of some compounds on human neutrophil degranulation and leukotriene B4 and thromboxane B2 synthesis. | 1985 | Biochem. Pharmacol. | pmid:2986647 |
| Alanko J et al. | Catechol estrogens as inhibitors of leukotriene synthesis. | 1998 | Biochem. Pharmacol. | pmid:9413936 |
| Lynch TJ et al. | Carbon tetrachloride-induced eicosanoid synthesis and enzyme release from rat peritoneal leucocytes. | 1985 | Biochem. Pharmacol. | pmid:2986650 |
| Rothberg KG and Hitchcock M | In vitro biosynthesis of cyclooxygenase metabolites in ovalbumin-sensitized and control lungs of guinea pigs. | 1982 | Biochem. Pharmacol. | pmid:6812589 |
| Liu FC et al. | A new insight of anti-platelet effects of sirtinol in platelets aggregation via cyclic AMP phosphodiesterase. | 2009 | Biochem. Pharmacol. | pmid:19426675 |
| Joseph S and MacDermot J | Stimulation of U937 human monocytic cells by thrombin results in inositol trisphosphate formation and the mobilisation of intracellular Ca2+ but not the synthesis of thromboxane B2. | 1991 | Biochem. Soc. Trans. | pmid:1889682 |
| Bone EA et al. | The effects of strontium and calcium ions on 5-hydroxytryptamine secretion and thromboxane B2 biosynthesis in washed human platelets. | 1980 | Biochem. Soc. Trans. | pmid:7450206 |
| Mitchell MD | Prostaglandins at parturition and in the neonatal infant. | 1980 | Biochem. Soc. Trans. | pmid:7450282 |
| Vincent JE et al. | The formation of thromboxane B2, leukotriene B4 and 12-hydroxyeicosatetraenoic acid by alveolar macrophages after activation during tumor growth in the rat. | 1990 | Biochim. Biophys. Acta | pmid:2154265 |
| Taylor L et al. | Prostaglandin production by type II alveolar epithelial cells. | 1979 | Biochim. Biophys. Acta | pmid:435506 |
| Shaw JO et al. | Activation of rabbit platelet phospholipase and thromboxane synthesis by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor). | 1981 | Biochim. Biophys. Acta | pmid:7213765 |
| Brouard C and Pascaud M | Effects of moderate dietary supplementations with n-3 fatty acids on macrophage and lymphocyte phospholipids and macrophage eicosanoid synthesis in the rat. | 1990 | Biochim. Biophys. Acta | pmid:2123401 |
| Powell WS | Metabolism of prostaglandins, prostaglandin analogs and thromboxane B2 by lung and liver microsomes from pregnant rabbits. | 1979 | Biochim. Biophys. Acta | pmid:518891 |
| Bellan JA et al. | Concentration-activity profile of the modulation of cyclooxygenase product formation by reduced glutathione in microsomal fractions from the goat lung. | 1990 | Biochim. Biophys. Acta | pmid:2114178 |
| Shaw JO and Lyons RM | Requirement for different Ca2+ pools in the activation of rabbit platelets II. Phospholipase activity. | 1982 | Biochim. Biophys. Acta | pmid:6800410 |
| Bartolini G et al. | Regulation of thromboxane A2 biosynthesis in platelet-free human monocytes and the possible role of polypeptide growth factor(s) in the induction of cyclooxygenase system. | 1986 | Biochim. Biophys. Acta | pmid:3085720 |
| Grundfest CC et al. | Acrolein: a potent modulator of lung macrophage arachidonic acid metabolism. | 1982 | Biochim. Biophys. Acta | pmid:6814492 |
| Aharony D et al. | Regulation of arachidonate-induced platelet aggregation by the lipoxygenase product, 12-hydroperoxyeicosatetraenoic acid. | 1982 | Biochim. Biophys. Acta | pmid:6814496 |
| Blackwell GJ et al. | Prostacyclin prolongs viability of washed human platelets. | 1982 | Biochim. Biophys. Acta | pmid:6291622 |
| Du JT et al. | Sex differences in arachidonate cyclo-oxygenase products in elicited rat peritoneal macrophages. | 1984 | Biochim. Biophys. Acta | pmid:6428458 |
| Horton AA and Wood JM | Prevention of Ca(2+)-induced or thromboxane B2-induced hepatocyte plasma membrane bleb formation by thromboxane receptor antagonists. | 1991 | Biochim. Biophys. Acta | pmid:1836358 |
| Fischer TH et al. | Kinetic evidence that arachidonate-induced calcium efflux from platelet microsomes involves a carrier-type ionophoric mechanism. | 1990 | Biochim. Biophys. Acta | pmid:2137712 |
| Cook-Johnson RJ et al. | Endothelial cell COX-2 expression and activity in hypoxia. | 2006 | Biochim. Biophys. Acta | pmid:17046322 |
| Busshardt E et al. | Regulation of hepatic parenchymal and non-parenchymal cell function by the diadenine nucleotides Ap3A and Ap4A. | 1989 | Biochim. Biophys. Acta | pmid:2563228 |
| Honda A et al. | Appearance of the arachidonic acid metabolic pathway in human promyelocytic leukemia (HL-60) cells during monocytic differentiation: enhancement of thromboxane synthesis by 1 alpha,25-dihydroxyvitamin D-3. | 1986 | Biochim. Biophys. Acta | pmid:3089289 |
| Kloprogge E et al. | Stimulus-aggregation coupling in platelets activated with PAF-acether. | 1986 | Biochim. Biophys. Acta | pmid:3089297 |
| Sekiya K and Okuda H | Inhibitory action of soluble elastin on thromboxane B2 formation in blood platelets. | 1984 | Biochim. Biophys. Acta | pmid:6320905 |
| Heemskerk JW et al. | Influence of dietary fatty acids on membrane fluidity and activation of rat platelets. | 1989 | Biochim. Biophys. Acta | pmid:2752022 |
| Ciabattoni G et al. | Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. | 1989 | Biochim. Biophys. Acta | pmid:2752040 |
| Patrignani P et al. | Fractional conversion of thromboxane A2 and B2 to urinary 2,3-dinor-thromboxane B2 and 11-dehydrothromboxane B2 in the cynomolgus monkey. | 1989 | Biochim. Biophys. Acta | pmid:2752041 |
| Roberts LJ et al. | Prostaglandin thromboxane, and 12-hydroxy-5,8,10,14-eicosatetraenoic acid production by ionophore-stimulated rat serosal mast cells. | 1979 | Biochim. Biophys. Acta | pmid:389290 |
| Fitzpatrick FA and Gorman RR | A comparison of imidazole and 9,11-azoprosta-5,13-dienoic acid. Two selective thromboxane synthetase inhibitors. | 1978 | Biochim. Biophys. Acta | pmid:629996 |
| Blache D et al. | Occurrence and biological effects of cholesteryl sulfate on blood platelets. | 1995 | Biochim. Biophys. Acta | pmid:8541337 |
| Orlandi M et al. | Thromboxane A2 synthase activity in platelet free human monocytes. | 1994 | Biochim. Biophys. Acta | pmid:7811713 |
| Hrboticky N et al. | Linoleic acid esterified in low density lipoprotein serves as substrate for increased arachidonic acid synthesis in differentiating monocytic cells. | 1996 | Biochim. Biophys. Acta | pmid:8765140 |
| Huang TF et al. | Characterization of a potent platelet aggregation inhibitor from Agkistrodon rhodostoma snake venom. | 1987 | Biochim. Biophys. Acta | pmid:3620499 |
| de Waart DR et al. | Studies on the urinary excretion of thromboxane B2 in Zellweger patients and control subjects: evidence for a major role for peroxisomes in the beta-oxidative chain-shortening of thromboxane B2. | 1994 | Biochim. Biophys. Acta | pmid:8155738 |
| Sato T et al. | Inhibition of platelet aggregation by unsaturated fatty acids through interference with a thromboxane-mediated process. | 1987 | Biochim. Biophys. Acta | pmid:3663714 |
| VanRollins M et al. | Metabolism of 7,10,13,16-docosatetraenoic acid to dihomo-thromboxane, 14-hydroxy-7,10,12-nonadecatrienoic acid and hydroxy fatty acids by human platelets. | 1985 | Biochim. Biophys. Acta | pmid:3918572 |
| Al-Madaney MM et al. | Effects of lipid-esterified conjugated linoleic acid isomers on platelet function: evidence for stimulation of platelet phospholipase activity. | 2003 | Biochim. Biophys. Acta | pmid:14729070 |
| Murphy CT et al. | Comparison of the role of protein kinase C in platelet functional responses induced by three different mechanisms, PAF, ionomycin and arachidonic acid. | 1991 | Biochim. Biophys. Acta | pmid:1661165 |
| Surya II et al. | Enhancement of platelet functions by low density lipoproteins. | 1992 | Biochim. Biophys. Acta | pmid:1420343 |
| Asbóth G et al. | The relation between thromboxane and prostaglandin synthesis in human decidua tissue: a comparison of eicosanoid synthesis in minced tissue with that in a cell-free preparation. | 1989 | Biochim. Biophys. Acta | pmid:2493805 |
| Teng CM et al. | Antiplatelet effect of butylidenephthalide. | 1987 | Biochim. Biophys. Acta | pmid:3109495 |
| Ko FN et al. | Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans. | 1990 | Biochim. Biophys. Acta | pmid:2162213 |
| Croft KD et al. | Onset of changes in phospholipid fatty acid composition and prostaglandin synthesis following dietary manipulation with n-6 and n-3 fatty acids in the rat. | 1985 | Biochim. Biophys. Acta | pmid:3995069 |
| Ko FN et al. | Inhibition on platelet activation by shikonin derivatives isolated from Arnebia euchroma. | 1995 | Biochim. Biophys. Acta | pmid:7548232 |
| Horton AA and Wood JM | Prevention of thromboxane B2-induced hepatocyte plasma membrane bleb formation by certain prostaglandins and a proteinase inhibitor. | 1990 | Biochim. Biophys. Acta | pmid:2107870 |
| Bernoud-Hubac N et al. | Low concentrations of reactive gamma-ketoaldehydes prime thromboxane-dependent human platelet aggregation via p38-MAPK activation. | 2009 | Biochim. Biophys. Acta | pmid:19233311 |
| Simon MF et al. | Selective inhibition of human platelet phospholipase A2 by buffering cytoplasmic calcium with the fluorescent indicator quin 2. Evidence for different calcium sensitivities of phospholipases A2 and C. | 1986 | Biochim. Biophys. Acta | pmid:3080024 |
| Miller OV et al. | Acetyl glycerylphosphorylcholine inhibition of prostaglandin I2-stimulated adenosine 3',5'-cyclic monophosphate levels in human platelets. Evidence for thromboxane A2 dependence. | 1982 | Biochim. Biophys. Acta | pmid:6285985 |
| Ko FN et al. | CIS-19, a novel platelet activating factor receptor antagonist: in vitro and in vivo studies. | 1993 | Biochim. Biophys. Acta | pmid:8380343 |
| Cerletti C et al. | Non-steroidal anti-inflammatory drugs react with two sites on platelet cyclo-oxygenase. Evidence from "in vivo" drug interaction studies in rats. | 1982 | Biochim. Biophys. Acta | pmid:6799004 |
| Teng CM et al. | Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng. | 1989 | Biochim. Biophys. Acta | pmid:2923911 |
| Croft KD et al. | Differential inhibition of thromboxane B2 and leukotriene B4 biosynthesis by two naturally occurring acetylenic fatty acids. | 1987 | Biochim. Biophys. Acta | pmid:2822134 |
| Hayashi Y et al. | Enzyme immunoassay of thromboxane B2. | 1983 | Biochim. Biophys. Acta | pmid:6407530 |
| Nichols FC et al. | Prostaglandin E2, prostaglandin E1 and thromboxane B2 release from human monocytes treated with C3b or bacterial lipopolysaccharide. | 1987 | Biochim. Biophys. Acta | pmid:3101743 |
| Chiabrando C et al. | Metabolism of thromboxane B2 in the isolated perfused rat kidney: mass spectrometric identification of urinary products. | 1989 | Biochim. Biophys. Acta | pmid:2597664 |
| Nieuwenhuys CM and Hornstra G | The effects of purified eicosapentaenoic and docosahexaenoic acids on arterial thrombosis tendency and platelet function in rats. | 1998 | Biochim. Biophys. Acta | pmid:9487152 |
| Lorenz RL et al. | A critical evaluation of urinary immunoreactive thromboxane: feasibility of its determination as a potential vascular risk indicator. | 1989 | Biochim. Biophys. Acta | pmid:2597697 |
| Asbóth G et al. | Conversion of arachidonic acid to prostanoids in the avian uterus. | 1983 | Biochim. Biophys. Acta | pmid:6402032 |
| Wu CC et al. | Antiplatelet effects of clausine-D isolated from Clausena excavata. | 1994 | Biochim. Biophys. Acta | pmid:7918571 |
| Malemud CJ et al. | Correlation of the biosynthesis of prostaglandin and cyclic AMP in monolayer cultures of rabbit articular chondrocytes. | 1982 | Biochim. Biophys. Acta | pmid:6280776 |
| Schafer AI et al. | Platelet lipoxygenase-dependent oxygen burst. Evidence for differential activation of lipoxygenase in intact and disrupted human platelets. | 1982 | Biochim. Biophys. Acta | pmid:6812645 |