Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Santillan-Doherty P et al. | Plasma thromboxane B2 concentrations and pulmonary vascular resistance during lung reperfusion. | 1997 Jul-Aug | J Invest Surg | pmid:9284000 |
Teraoka S et al. | Multicenter trial of the therapeutic effect of a newly developed antiplatelet agent, satigrel, on biopsy-proven chronic rejection after kidney transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9122990 |
Ishine N et al. | Hemodynamic analysis of post-reperfusion syndrome and the effect of preventing this syndrome using thromboxane A2 synthetase inhibitor (OKY-046) in swine liver transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123045 |
Suehiro T et al. | Value of caval effluent in predicting early graft function after orthotopic liver transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123086 |
Yagi T et al. | Hepatropic soluble vitamin E derivative EPC-K1 prevents warm ischemia/reperfusion injury of non-heart-beating donor liver transplantation in pigs. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123352 |
Yu J and Hu WS | [Effects of neferine on platelet aggregation in rabbits]. | 1997 | Yao Xue Xue Bao | pmid:11243209 |
Hellyer PW et al. | Effect of NG-nitro-L-arginine-methyl-ester on cardiopulmonary function and biosynthesis of cyclooxygenase products during porcine endotoxemia. | 1997 | Crit. Care Med. | pmid:9201060 |
Nanji AA et al. | Thromboxane inhibitors attenuate pathological changes in alcoholic liver disease in the rat. | 1997 | Gastroenterology | pmid:8978360 |
Liao CH et al. | Bakkenolide G, a natural PAF-receptor antagonist. | 1997 | J. Pharm. Pharmacol. | pmid:9466352 |
Barry MC et al. | Immunological and physiological responses to aortic surgery: effect of reperfusion on neutrophil and monocyte activation and pulmonary function. | 1997 | Br J Surg | pmid:9112905 |
Brus F et al. | Number and activation of circulating polymorphonuclear leukocytes and platelets are associated with neonatal respiratory distress syndrome severity. | 1997 | Pediatrics | pmid:9113943 |
Mitra A et al. | Thromboxane-mediated alveolar responses to acute obstruction of the pulmonary vasculature. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9117035 |
Bröijersén A et al. | No influence of simvastatin treatment on platelet function in vivo in patients with hypercholesterolemia. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9081681 |
Mori TA et al. | Interactions between dietary fat, fish, and fish oils and their effects on platelet function in men at risk of cardiovascular disease. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9081682 |
Hsieh YZ and Kuo KL | Analysis of prostaglandins by micellar electrokinetic capillary chromatography. | 1997 | J Chromatogr A | pmid:9084156 |
Davi G et al. | In vivo formation of 8-Epi-prostaglandin F2 alpha is increased in hypercholesterolemia. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409316 |
Todd MK et al. | Comparison of methods for evaluating exercise-induced changes in thromboxane B2 and beta-thromboglobulin. | 1997 | Med Sci Sports Exerc | pmid:9140910 |
Bishop-Bailey D et al. | Characterization of the induction of nitric oxide synthase and cyclo-oxygenase in rat aorta in organ culture. | 1997 | Br. J. Pharmacol. | pmid:9146896 |
Shinohara M et al. | [Responses to surgical stress in blood coagulation and fibrinolysis, platelet counts and thromboxane B2 after esophageal cancer operation]. | 1997 | Rinsho Byori | pmid:9121003 |
Cheng Z et al. | Pharmacokinetic and pharmacodynamic studies on phenylbutazone and oxyphenbutazone in goats. | 1997 | Vet. Rec. | pmid:9123796 |
Mao E et al. | [Pancreatic ischemia: a continuous injury factor in acute necrotic pancreatitis]. | 1997 | Zhonghua Wai Ke Za Zhi | pmid:10374521 |
Ringdahl BE et al. | Effect of nicotine on arachidonic acid metabolites and epithelial parameters in rat oral mucosa. | 1997 | J. Oral Pathol. Med. | pmid:9021551 |
Tang QZ et al. | [Effect of buyang huanwu decoction on platelet function and fibrinolytic activity of unstable angina pectoris patients]. | 1997 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:10322871 |
Chen SX et al. | [Effects of tetramethylpyrazine on platelet functions of advanced cases of lung carcinoma]. | 1997 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:10322873 |
Chong ZZ and Feng YP | Effects of dl-3-n-butylphthalide on production of TXB2 and 6-keto-PGF1 alpha in rat brain during focal cerebral ischemia and reperfusion. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10322905 |
Nygaard OP et al. | The inflammatory properties of contained and noncontained lumbar disc herniation. | 1997 | Spine | pmid:9383853 |
Matsumoto H et al. | Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9020023 |
Calzada C et al. | Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation. | 1997 | Biochem. J. | pmid:9230133 |
Serebruany VL et al. | Serial changes of the plasma prostanoids during myocardial ischemia-reperfusion in swine. Effects of magnesium, diltiazem, and a novel Mac-1 inhibitor. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9051723 |
Alavi N and Singh A | Events that stimulate release of thromboxane B2 in passive heymann nephritis. | 1997 | Proc. Soc. Exp. Biol. Med. | pmid:9034135 |
Okazawa A et al. | 8-Epi-PGF2alpha induces airflow obstruction and airway plasma exudation in vivo. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9032175 |
Keen HL et al. | Thromboxane is required for full expression of angiotensin hypertension in rats. | 1997 | Hypertension | pmid:9039120 |
Rodwell LT et al. | Effect of inhaled frusemide and oral indomethacin on the airway response to hypertonic saline challenge in asthmatic subjects. | 1997 | Thorax | pmid:9039247 |
Nanji AA et al. | Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat. | 1997 | Gastroenterology | pmid:9041257 |
Watanabe A et al. | Effect of TYB-2285 on lung anaphylaxis in actively sensitized rats. | 1997 | Gen. Pharmacol. | pmid:9013209 |
Lewis DA et al. | Production of endothelium-derived factors from sodded expanded polytetrafluoroethylene grafts. | 1997 | J. Vasc. Surg. | pmid:9013924 |
Liu CZ and Huang TF | Crovidisin, a collagen-binding protein isolated from snake venom of Crotalus viridis, prevents platelet-collagen interaction. | 1997 | Arch. Biochem. Biophys. | pmid:9016825 |
Yeh SL et al. | Effects of n-3 and n-6 fatty acids on plasma eicosanoids and liver antioxidant enzymes in rats receiving total parenteral nutrition. | 1997 | Nutrition | pmid:9058445 |
Feng J et al. | Effects of tetramethylpyrazine on the release of PGI2 and TXA2 in the hypoxic isolated rat heart. | 1997 | Mol. Cell. Biochem. | pmid:9059992 |
Wettstein M and Häussinger D | Cytoprotection by the osmolytes betaine and taurine in ischemia-reoxygenation injury in the perfused rat liver. | 1997 | Hepatology | pmid:9397998 |
Moutquin JM et al. | Do prostacyclin and thromboxane contribute to the "protective effect" of pregnancies with chronic hypertension? A preliminary prospective longitudinal study. | 1997 | Am. J. Obstet. Gynecol. | pmid:9423755 |
Henrion D et al. | Alteration of flow-induced dilatation in mesenteric resistance arteries of L-NAME treated rats and its partial association with induction of cyclo-oxygenase-2. | 1997 | Br. J. Pharmacol. | pmid:9146891 |
Murthy S et al. | Ischemia/reperfusion injury in the rat colon. | 1997 | Inflammation | pmid:9187961 |
Naran NH and Chetty N | The in vitro effect of ridogrel on platelet function in normocholesterolaemic and familial hypercholesterolaemic type IIa subjects. | 1997 | Thromb. Res. | pmid:9556227 |
Desideri N et al. | N-omega-carbethoxypentyl-4-quinolones: a new class of leukotriene biosynthesis inhibitors. | 1997 | Arch. Pharm. (Weinheim) | pmid:9230527 |
Yoshida T et al. | Improvement of renal function with selective thromboxane A2 synthetase inhibitor, DP-1904 in lupus nephritis. | 1997 | Adv. Exp. Med. Biol. | pmid:9561116 |
Müller M | In vivo measurement of interstitial TxB2-concentrations in skeletal muscle during ischemia and reperfusion. | 1997 | Adv. Exp. Med. Biol. | pmid:9561122 |
Arbogast E et al. | Intrauterine eicosanoid production in uncomplicated and hypertensive pregnancies: alterations of placental 12-hydroxyeicosatetraenoic acid. | 1997 | Adv. Exp. Med. Biol. | pmid:9561182 |
Takeda H et al. | Time course study for airway inflammation and responsiveness by repeated provocation of aeroantigen in guinea pigs. | 1997 | Prostaglandins | pmid:9491210 |
Vezza R et al. | Antivasoconstrictor and antiaggregatory activities of picotamide unrelated to thromboxane A2 antagonism. | 1997 | Thromb. Haemost. | pmid:9408024 |
Byrne A et al. | Continued thromboxane A2 formation despite administration of a platelet glycoprotein IIb/IIIa antagonist in patients undergoing coronary angioplasty. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409315 |
Gerdemann R et al. | [Effect of flunixin meglumine on plasma prostanoid concentrations in horses with colic in the perioperative period]. | 1997 | DTW. Dtsch. Tierarztl. Wochenschr. | pmid:9410724 |
Kobayashi T et al. | Changes in platelet calcium concentration by thromboxane A2 stimulation in patients with nephrotic syndrome of childhood. | 1997 | Nephron | pmid:9375825 |
Chavali SR et al. | Decreased production of interleukin-1-beta, prostaglandin-E2 and thromboxane-B2, and elevated levels of interleukin-6 and -10 are associated with increased survival during endotoxic shock in mice consuming diets enriched with sesame seed oil supplemented with Quil-A saponin. | 1997 | Int. Arch. Allergy Immunol. | pmid:9338609 |
Neupert W et al. | Effects of ibuprofen enantiomers and its coenzyme A thioesters on human prostaglandin endoperoxide synthases. | 1997 | Br. J. Pharmacol. | pmid:9351505 |
Kulkarni P and Payne S | Eicosanoids in bovine retinal microcirculation. | 1997 | J Ocul Pharmacol Ther | pmid:9090614 |
Zahavi M and Zahavi J | Concomitant in vitro platelet hypofunction and increased thromboxane B2 (TXB2) generation and enhanced in vivo platelet activation. A distinct syndrome in thrombosis? | 1997 | Eur. J. Haematol. | pmid:9338626 |
Supanz S et al. | Effects of the novel thromboxane (TXA2) receptor antagonist linotroban on inulin and para-aminohippuric acid clearances in the conscious male and female rat. | 1997 | Arzneimittelforschung | pmid:9342416 |
Tulppala M et al. | Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production. | 1997 | Hum. Reprod. | pmid:9262298 |
Nanji AA et al. | Alterations in thromboxane synthase and thromboxane A2 receptors in experimental alcoholic liver disease. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9262373 |
Tu Y et al. | Effect of intra-arachnoid space perfusion on thromboxane A and prostacycline in experimental spinal cord injury. | 1997 | J. Tongji Med. Univ. | pmid:9639784 |
De La Cruz JP et al. | Effects of S-adenosyl-L-methionine on platelet thromboxane and vascular prostacyclin. | 1997 | Biochem. Pharmacol. | pmid:9264331 |
Siler-Khodr TM et al. | The effect of dexamethasone on CRH and prostanoid production from human term placenta. | 1997 | Prostaglandins | pmid:9373879 |
Li S and Tian H | [Oral low-dose magnesium gluconate preventing pregnancy induced hypertension]. | 1997 | Zhonghua Fu Chan Ke Za Zhi | pmid:9642379 |
Gresele P et al. | Platelet activation markers in patients with peripheral arterial disease--a prospective comparison of different platelet function tests. | 1997 | Thromb. Haemost. | pmid:9423790 |
Famaey JP | In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. | 1997 | Inflamm. Res. | pmid:9427063 |
Baskett A et al. | Effect of pentoxifylline, flunixin meglumine, and their combination on a model of endotoxemia in horses. | 1997 | Am. J. Vet. Res. | pmid:9361895 |
Shen ZQ et al. | Inhibitory effects of copper-aspirin complex on platelet aggregation. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10072923 |
Zeltsman D et al. | Pathophysiologic plasma levels of leukotriene C4 in relation to the hemodynamic dysfunction and mediator release of graded bacteremia. | 1997 | Shock | pmid:9110414 |
Cipollone F et al. | Differential suppression of thromboxane biosynthesis by indobufen and aspirin in patients with unstable angina. | 1997 | Circulation | pmid:9286937 |
Savla U et al. | Cyclic stretch of airway epithelium inhibits prostanoid synthesis. | 1997 | Am. J. Physiol. | pmid:9374729 |
Sheu JR et al. | Triflavin inhibits platelet-induced vasoconstriction in de-endothelialized aorta. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9437193 |
Kurosawa M et al. | Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis. | 1997 | J. Allergy Clin. Immunol. | pmid:9440541 |
Stichtenoth DO et al. | Effects of meloxicam and indomethacin on cyclooxygenase pathways in healthy volunteers. | 1997 | J. Investig. Med. | pmid:9084574 |
Cervar M et al. | Drug actions in preeclampsia: aspirin, but not magnesium chloride or dihydralazine, differentially inhibits cultured human trophoblast release of thromboxane and prostacyclin without affecting angiotensin II, endothelin-1, or leukotriene B4 secretion. | 1997 | Am. J. Obstet. Gynecol. | pmid:9024091 |
van Kooten F et al. | Platelet activation and lipid peroxidation in patients with acute ischemic stroke. | 1997 | Stroke | pmid:9259748 |
Aibiki M and Cook JA | Ulinastatin, a human trypsin inhibitor, inhibits endotoxin-induced thromboxane B2 production in human monocytes. | 1997 | Crit. Care Med. | pmid:9118658 |
Sun ZT et al. | [Clinical and experimental study on treating bronchial asthma with xingbei granule]. | 1997 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9863090 |
Zhang XY and Qian XM | [Clinical study of sudden deafness treated with method of integrated traditional Chinese and Western medicine]. | 1997 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9863112 |
Chang TS et al. | Thromboxane A2 synthase inhibition and thromboxane A2 receptor blockade by 2-[(4-cyanophenyl)amino]-3-chloro-1,4-naphthalenedione (NQ-Y15) in rat platelets. | 1997 | Biochem. Pharmacol. | pmid:9271330 |
Wu JX et al. | [Effects and mechanism of emodin and sandostatin on pancreatic ischemia in acute haemorrhagic necrotizing pancreatitis]. | 1997 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9863132 |
Azevedo I et al. | Increased spontaneous release of tumour necrosis factor-alpha by alveolar macrophages from wheezy infants. | 1997 | Eur. Respir. J. | pmid:9272917 |
Hu DH et al. | [Effects of hypoxia and anisodamine on products of TXA2 and PGI2 in cultured intra-pulmonary arteriolar smooth muscle cells]. | 1997 | Sheng Li Xue Bao | pmid:9863190 |
Ku K et al. | Influences of dietary omega-3 polyunsaturated fatty acids on the recovery of cardiac and renal functions after preservation in hyperlipidemic rats. | 1997 | Transplantation | pmid:9275102 |
Li HP et al. | [The relationship between the activity of phospholipase A2 and acute hypoxic pulmonary arterial pressure]. | 1997 | Sheng Li Xue Bao | pmid:9863193 |
Lewis K et al. | Effect of neuropeptide Y on bradykinin-induced release of prostacyclin and thromboxane from guinea pig perfused lung. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9276148 |
Farker K et al. | Measurements of urinary prostaglandins in young ovulatory women during the menstrual cycle and in postmenopausal women. | 1997 | Prostaglandins | pmid:9373880 |
Matrougui K et al. | Impaired nitric oxide- and prostaglandin-mediated responses to flow in resistance arteries of hypertensive rats. | 1997 | Hypertension | pmid:9336397 |
Nanji AA et al. | Cholesterol supplementation prevents necrosis and inflammation but enhances fibrosis in alcoholic liver disease in the rat. | 1997 | Hepatology | pmid:9214456 |
Malini PL et al. | Thromboxane antagonism and cough induced by angiotensin-converting-enzyme inhibitor. | 1997 | Lancet | pmid:9217714 |
Fenner H | Differentiating among nonsteroidal antiinflammatory drugs by pharmacokinetic and pharmacodynamic profiles. | 1997 | Semin. Arthritis Rheum. | pmid:9219317 |
De la Cruz JP et al. | Effect of erythrocytes and prostacyclin production in the effect of fructose and sorbitol on platelet activation in human whole blood in vitro. | 1997 | Thromb. Res. | pmid:9219331 |
Abate A et al. | Inhibition of mediator release from anaphylactic guinea pig hearts by the novel phospholipase A2 inhibitor 3-(4-octadecylbenzoyl) acrylic acid. | 1997 | Inflamm. Res. | pmid:9297549 |
Davì G et al. | Diabetes mellitus, hypercholesterolemia, and hypertension but not vascular disease per se are associated with persistent platelet activation in vivo. Evidence derived from the study of peripheral arterial disease. | 1997 | Circulation | pmid:9236419 |
Johnson RD et al. | Aspirin induces increased expression of both prostaglandin H synthase-1 and prostaglandin H synthase-2 in cultured human placental trophoblast. | 1997 | Am. J. Obstet. Gynecol. | pmid:9240586 |
Fujinishi A et al. | Effects of nisoldipine on cytosolic calcium, platelet aggregation, and coagulation/fibrinolysis in patients with coronary artery disease. | 1997 | Angiology | pmid:9194537 |
Riendeau D et al. | Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. | 1997 | Br. J. Pharmacol. | pmid:9146894 |
Cook ME et al. | Comparative effects of nabumetone, sulindac, and ibuprofen on renal function. | 1997 | J. Rheumatol. | pmid:9195523 |
Hato T et al. | Outside-in signaling from integrin alpha IIb beta 3 into platelets in the absence of agonist-induced signaling. | 1997 | Int. J. Hematol. | pmid:9195778 |
Barbieri B et al. | p-Aminobenzoic acid, but not its metabolite p-acetamidobenzoic acid, inhibits thrombin induced thromboxane formation in human platelets in a non NSAID like manner. | 1997 | Thromb. Res. | pmid:9175234 |