Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Mahoney DA et al. | Urinary thromboxane B2 on allograft rejection. | 1981 | Lancet | pmid:6118500 |
Smith JB and Jubiz W | OKY-1581: a selective inhibitor of thromboxane synthesis in vivo and in vitro. | 1981 | Prostaglandins | pmid:7302264 |
Allen JB et al. | Irradiation decreases vascular prostacyclin formation with no concomitant effect on platelet thromboxane production. | 1981 | Lancet | pmid:6118629 |
Spector SL et al. | Clinical response and serum prostaglandin levels in aspirin idiosyncrasy. Effect of aspirin and a new nonsteroidal anti-inflammatory agent. | 1981 | Chest | pmid:7307588 |
Meyers KM et al. | Evaluation of the platelet storage pool deficiency in the feline counterpart of the Chediak-Higashi syndrome. | 1981 | Am. J. Hematol. | pmid:7315839 |
Mehta J and Mehta P | Significance of platelet function and thromboxane B2 levels across the human myocardial vascular bed. | 1981 | Acta Med. Scand. Suppl. | pmid:6948499 |
Stenson WF et al. | Metabolism of exogenous arachidonic acid by murine macrophage-like tumor cell lines. | 1981 | Prostaglandins | pmid:6803301 |
Chong BH et al. | Heparin-induced thrombocytopenia: effect of heparin platelet antibody on platelets. | 1981 | Br. J. Haematol. | pmid:7317283 |
Rubenstein MD et al. | Platelet activation in clinical coronary artery disease and spasm. | 1981 | Am. Heart J. | pmid:6455912 |
Gordon D et al. | Selective inhibition of thromboxane biosynthesis in human blood mononuclear cells and the effects of mitogen-stimulated lymphocyte proliferation. | 1981 | Br. J. Pharmacol. | pmid:7317694 |
Walker ID et al. | A double blind study of prostacyclin in cardiopulmonary bypass surgery. | 1981 | Br. J. Haematol. | pmid:6457624 |
Bray MA et al. | Prostaglandin generation by separated human blood mononuclear cell fractions. | 1981 | Int. J. Immunopharmacol. | pmid:6949878 |
Satoh K et al. | Augmented malondialdehyde production by platelets from patients with cerebrovascular disorders. | 1981 | Jpn. Circ. J. | pmid:7321143 |
Capitanio A et al. | Platelet abnormalities in renal transplantation. | 1981 | Proc Eur Dial Transplant Assoc | pmid:6460244 |
Kelly KL and Laychock SG | Prostaglandin synthesis and metabolism in isolated pancreatic islets of the rat. | 1981 | Prostaglandins | pmid:6803305 |
Matsumoto M et al. | Platelet aggregation induced by arachidonic acid and thromboxane generation in patients with hypertension or cerebrovascular disease. | 1981 | Prostaglandins Med | pmid:7323212 |
Smith MC and Dunn MJ | Impaired platelet thromboxane production in renal failure. | 1981 | Nephron | pmid:7329487 |
Lagarde M et al. | Inhibition of thrombin-induced platelet arachidonic acid release by 15-hydroperoxy-arachidonic acid. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7259783 |
Hirsh PD et al. | Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease. | 1981 | N. Engl. J. Med. | pmid:6894016 |
Sobel M et al. | Circulating platelet products in unstable angina pectoris. | 1981 | Circulation | pmid:6450001 |
Ylikorkala O and Viinikka L | Prostacyclin, thromboxane, and prostaglandin F2 alpha in maternal plasma during breast-feeding. | 1981 | Am. J. Obstet. Gynecol. | pmid:7011034 |
Kinney EL and Demers LM | Plasma 6 keto PGE1 alpha concentration in Raynaud's phenomenon. | 1981 | Prostaglandins Med | pmid:6895673 |
Barnett AH et al. | Circulating prostanoid levels, both basal and during the chlorpropamide alcohol flush, in non-insulin dependent diabetes. | 1981 | Clin. Endocrinol. (Oxf) | pmid:6895721 |
Greenwald JE et al. | Argentation thin layer chromatography of arachidonic acid metabolites isolated from human platelets. | 1981 | Prostaglandins | pmid:7208953 |
Morrison AR et al. | Thromboxane A2 is the major arachidonic acid metabolite of human cortical hydronephrotic tissue. | 1981 | Prostaglandins | pmid:6894498 |
She HS et al. | Metabolism of prostaglandin endoperoxide by microsomes from cat lung. | 1981 | Prostaglandins | pmid:6894797 |
Catalano PM et al. | Platelet recovery from aspirin inhibition in vivo; differing patterns under various assay conditions. | 1981 | Blood | pmid:7448419 |
Terragno A et al. | High performance liquid chromatography and UV detection for the separation and quantitation of prostaglandins. | 1981 | Prostaglandins | pmid:6894197 |
Halushka PV et al. | Increased platelet arachidonic acid metabolism in diabetes mellitus. | 1981 | Diabetes | pmid:6795072 |
Taylor L et al. | Prostaglandin production and cellular aging. | 1981 | Mech. Ageing Dev. | pmid:6946268 |
Young MK et al. | Aging: effects on the prostaglandin production by skeletal muscle of male rhesus monkeys (Macaca mulatta). | 1981 | Mech. Ageing Dev. | pmid:6946269 |
Honn KV and Meyer J | Thromboxanes and prostacyclin: positive and negative modulators of tumor growth. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6274330 |
Corby DG and O'Barr TP | Neonatal platelet function: a membrane-related phenomenon? | 1981 | Haemostasis | pmid:7250785 |
Wonders TR et al. | Reduced plasma thromboxane elevation during partial cardiopulmonary bypass in thrombocytopenic sheep. | 1981 | Trans Am Soc Artif Intern Organs | pmid:7331082 |
Mezzano D et al. | Evidence that platelet buoyant density, but not size, correlates with platelet age in man. | 1981 | Am. J. Hematol. | pmid:7270546 |
Hwang DH et al. | In vitro and in vivo effects of ethanol on the formation of endoperoxide metabolites in rat platelets. | 1981 | Lipids | pmid:6792442 |
Shaw JO | Effects of extracellular Ca2+ and the intracellular Ca2+ antagonist 8-(n,n-diethylamino)octyl-3,4,5-trimethoxybenzoate on rabbit platelet conversion of arachidonic acid into thromboxane. | 1981 | Prostaglandins | pmid:6789402 |
Tulenko TN | The actions of prostaglandins and cyclo-oxygenase inhibition on the resistance vessels supplying the human fetal placenta. | 1981 | Prostaglandins | pmid:6794096 |
Ingerman-Wojenski C et al. | Prostacyclin production in rabbit arteries in situ: inhibition by arachidonic acid-induced endothelial cell damage or by low-dose aspirin. | 1981 | Prostaglandins | pmid:6789404 |
Williamson EM et al. | Studies on the mechanism of action of 12-deoxyphorbolphenylacetate, a potent platelet aggregating tigliane ester. | 1981 | Biochem. Pharmacol. | pmid:6794576 |
Ylikorkala O et al. | Prostacyclin and thromboxane in diabetes. | 1981 | Br Med J (Clin Res Ed) | pmid:6794795 |
Lee SH et al. | Prostacyclin and thromboxane A2 in thrombotic thrombocytopenic purpura. | 1981 | Br Med J (Clin Res Ed) | pmid:6797537 |
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Wilhelm TE et al. | Selective inhibitors of platelet lipoxygenase: 4,7,10,13-eicosatetraynoic acid and 5,8,11,14-henicosatetraynoic acid. | 1981 | Prostaglandins | pmid:6784191 |
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Brox JH et al. | The effect of cod liver oil and corn oil on platelets and vessel wall in man. | 1981 | Thromb. Haemost. | pmid:7031981 |
Hirsh PD et al. | Prostaglandins and ischemic heart disease. | 1981 | Am. J. Med. | pmid:7032286 |
Dunham BM et al. | Role of prostaglandins in positive end-expiratory pressure-induced negative inotropism. | 1981 | Am. J. Physiol. | pmid:7034549 |
Strano A et al. | Thromboxane formation by platelets and platelet sensitivity to prostacyclin in patients with acute myocardial infarction. | 1981 | Thromb. Haemost. | pmid:7036402 |
Tsuboi T et al. | Effect of gliclazide on prostaglandin and thromboxane synthesis in guinea-pig platelets. | 1981 Jan 1-15 | Thromb. Res. | pmid:7233394 |
Randall MJ et al. | UK-37, 248, a novel, selective thromboxane synthetase inhibitor with platelet anti-aggregatory and anti-thrombotic activity. | 1981 Jul 1-15 | Thromb. Res. | pmid:6795753 |
Kelton JG et al. | Sex-related differences in the efficacy of acetylsalicylic acid (ASA) : the absorption of ASA and its effect on collagen-induced thromboxane B2 generation. | 1981 Oct 1-15 | Thromb. Res. | pmid:7330835 |
Mäkilä UM et al. | Regulation of prostacyclin and thromboxane production by human umbilical vessels: the effect of estradiol and progesterone in a superfusion model. | 1982 | Prostaglandins Leukot Med | pmid:7043492 |
Krausz MM et al. | Adverse effects of prostacyclin used to perfuse isolated lung lobes. | 1982 | Am. J. Physiol. | pmid:7044149 |
Chierchia S et al. | Failure of thromboxane A2 blockade to prevent attacks of vasospastic angina. | 1982 | Circulation | pmid:7116586 |
Sasagawa S et al. | Effects of thromboxane A2 injection on the rabbit coronary artery. I. Physiologic effects in healthy animals. | 1982 | Exp. Mol. Pathol. | pmid:7117494 |
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Suehiro A et al. | The role of platelet hyperfunction in thrombus formation in hyperlipidemia. | 1982 | Thromb. Res. | pmid:6803387 |
Mehta P et al. | Comparison of umbilical vein models for measurement of relative prostacyclin and thromboxane production. | 1982 | Prostaglandins | pmid:6820165 |
Nolan RD et al. | The pericardium as a source of prostacyclin in the dog, ox and rat. | 1982 | Prostaglandins | pmid:6820168 |
Pawlowski NA et al. | Uptake and metabolism of monohydroxy-eicosatetraenoic acids by macrophages. | 1982 | J. Exp. Med. | pmid:6951919 |