Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Tobelem G et al. | Further studies on a specific platelet antibody found in Bernard-Soulier syndrome and its effects on normal platelet function. | 1979 | Br. J. Haematol. | pmid:427045 |
Friedman LS et al. | Cardiovascular and pulmonary effects of thromboxane B2 in the dog. | 1979 | Circ. Res. | pmid:428069 |
Ciabattoni G et al. | Characterization of furosemide-induced activation of the renal prostaglandin system. | 1979 | Eur. J. Pharmacol. | pmid:393525 |
Svensson J | Structure and quantitative determination of the major urinary metabolite of thromboxane B2 in the guinea pig. | 1979 | Prostaglandins | pmid:472333 |
Langs DA et al. | Thromboxane molecules do not adopt the prostaglandin hairpin conformation. | 1979 | Nature | pmid:481594 |
Jonsson CE et al. | Prostaglandins and thromboxanes in burn injury in man. | 1979 | Scand J Plast Reconstr Surg | pmid:451477 |
Bailey JM et al. | Anti-inflammatory drugs in experimental atherosclerosis. Part 4. Inhibition of atherosclerosis in vivo and thromboxane synthesis and platelet aggregation in vitro. | 1979 | Atherosclerosis | pmid:454516 |
Taylor L et al. | Prostaglandin production by type II alveolar epithelial cells. | 1979 | Biochim. Biophys. Acta | pmid:435506 |
Russell NH et al. | Thrombocytopathy in preleukaemia: association with a defect of thromboxane A2 activity. | 1979 | Br. J. Haematol. | pmid:570847 |
Anhut H et al. | Prostaglandin D2 is the prevailing prostaglandin in the acute inflammatory exudate of urate arthritis in the chicken. | 1979 | Br. J. Pharmacol. | pmid:570865 |
Lewy RI et al. | Detection of thromboxane B2 in peripheral blood of patients with Prinzmetal's angina. | 1979 | Prostaglandins Med | pmid:575861 |
Ohuchi K et al. | Prostaglandins E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 levels in carrageenin-induced inflammatory exudates in the rat air-pouch granuloma. | 1979 | Prostaglandins Med | pmid:583576 |
Best L et al. | Effect of glucose on platelet thromboxane biosynthesis. | 1979 | Lancet | pmid:90876 |
Jarabak J and Fried J | Comparison of substrate specificities of the human placental NAD- and NADP-linked 15-hydroxyprostaglandin dehydrogenases. | 1979 | Prostaglandins | pmid:42948 |
Miura Y and Fukui N | Prostaglandins as possible triggers for liver regeneration after partial hepatectomy. A review. | 1979 | Cell Mol Biol Incl Cyto Enzymol | pmid:44483 |
Hassid A et al. | Prostaglandin synthesis in isolated rat kidney glomeruli. | 1979 | Proc. Natl. Acad. Sci. U.S.A. | pmid:286300 |
Le Breton GC et al. | 13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor. | 1979 | Proc. Natl. Acad. Sci. U.S.A. | pmid:291066 |
Chignard M et al. | Arachidonate-mediated bronchoconstriction and platelet activation are inhibited by microgram doses of compound L8027 which are not selective for thromboxane synthetase. | 1979 | Agents Actions Suppl. | pmid:291306 |
Peskar BA and Holland A | Plasma levels of immunoreactive 15-keto-13,14-dihydro-thromboxane B2 in guinea pigs during anaphylaxis and after histamine injection. | 1979 | Agents Actions Suppl. | pmid:294148 |
Anhut H et al. | Thromboxane B2 release and 3H-noradrenaline accumulation by a synaptosomal fraction of rat brain. | 1979 Jul-Aug | Pol J Pharmacol Pharm | pmid:523340 |
Pradalier A et al. | [Measurement of plasma and serum values of PGE2, PGF2 alpha and TXB2 during aspirin induced bronchospasm in asthmatics (author's transl)]. | 1979 Jul-Aug | Therapie | pmid:531778 |
Hagen AA et al. | Synthesis of prostaglandins and thromboxane B2 by cerebral arteries. | 1979 May-Jun | Stroke | pmid:462519 |
Best LC et al. | Studies on the role of calcium in the control of thromboxane B2 production. | 1980 | Artery | pmid:6783015 |
Patrono C et al. | Radioimmunoassay measurement of stable metabolites of platelet arachidonic acid: a convenient method for the in vitro and ex vivo evaluation of cyclo-oxygenase inhibitors. | 1980 | Agents Actions Suppl. | pmid:6787852 |
Poyser NL and Scott FM | Prostaglandin and thromboxane production by the rat uterus and ovary in vitro during the oestrous cycle. | 1980 | J. Reprod. Fertil. | pmid:7001011 |
Lands WE et al. | Recent concepts on platelet function and dietary lipids in coronary thrombosis, vasospasm and angina. | 1980 | Herz | pmid:7007191 |
Subbiah MT et al. | Enhancement of thrombocyte aggregation and thromboxane B2 synthesis by diethylstilbestrol. | 1980 | Pharmacology | pmid:7220591 |
Ali AE et al. | Prostaglandin and thromboxane production by fibroblasts and vascular endothelial cells. | 1980 | Prostaglandins | pmid:7008090 |
Ohtsu E and Matsuzawa T | Metabolic alterations in the endogenous formation of 6 keto-prostaglandin F1 alpha, thromboxane B2 and prostaglandin E2 in the brain-stem of stroke-resistant spontaneously hypertensive rats. | 1980 | J. Nutr. Sci. Vitaminol. | pmid:7229740 |
Vargaftig BB et al. | Activation of guinea-pig platelets induced by convulxin, a substance extracted from the venom of Crotalus durissus cascavella. | 1980 | Eur. J. Pharmacol. | pmid:7009169 |
Giri SN and Krishna GA | Development of a dual isotopes techniques and two-stage column chromatography to characterize the prostaglandin F2alpha, E2 and Thromboxane B2 formed by the guinea pig lung. | 1980 | J Pharmacol Methods | pmid:7009992 |
Mathé AA et al. | Increased content of immunoreactive prostaglandin E in cerebrospinal fluid of patients with schizophrenia. | 1980 | Lancet | pmid:6101355 |
Mestel F et al. | Severe bleeding associated with defective thromboxane synthetase. | 1980 | Lancet | pmid:6101498 |
Pareti FI et al. | Platelets and the vessel wall: how much aspirin? | 1980 | Lancet | pmid:6101829 |
Jécsai G and Bagdány S | Quantitative determination of thromboxane synthesis in blood samples by video-densitometry. | 1980 | Acta Biochim. Biophys. Acad. Sci. Hung. | pmid:7282294 |
Hwang DH | Aggregation and inhibition of rat platelets, and the formation of endoperoxide metabolites. | 1980 | Prostaglandins Med | pmid:7413850 |
Cerskus AL et al. | Thromboxane B2 and 6-keto-prostaglandin F1 alpha synthesis during infusion of collagen and arachidonic acid in rabbits: inhibition by aspirin and sulfinpyrazone. | 1980 | Thromb. Res. | pmid:7414555 |
Tada M et al. | Significance of thromboxane A2 in myocardial ischemia in patients with coronary artery disease. | 1980 | Adv Myocardiol | pmid:7423053 |
Matsumoto M et al. | Thromboxane generation in patients with essential hypertension or cerebrovascular disease and effect of oral aspirin. | 1980 | Thromb. Haemost. | pmid:7423441 |
Davies GC et al. | Elevated plasma fibrinopeptide A and thromboxane B2 levels during cardiopulmonary bypass. | 1980 | Circulation | pmid:6965618 |
Kennedy MS et al. | In vitro synthesis of prostaglandins and related lipids by populations of human peripheral blood mononuclear cells. | 1980 | Prostaglandins | pmid:6967616 |
Galli C et al. | Modulation of prostaglandin production in tissues by dietary essential fatty acids. | 1980 | Acta Med. Scand. Suppl. | pmid:6935943 |
Wong PY et al. | The role of calmodulin in prostaglandin metabolism. | 1980 | Ann. N. Y. Acad. Sci. | pmid:6940495 |
Schrör K et al. | Preservation of ischemic myocardium by pinane thromboxane A2. | 1980 | Am. J. Physiol. | pmid:7356037 |
Hassid A and Dunn MJ | Microsomal prostaglandin biosynthesis of human kidney. | 1980 | J. Biol. Chem. | pmid:7358683 |
Kadowitz PJ and Hyman AL | Comparative effects of thromboxane B2 on the canine and feline pulmonary vascular bed. | 1980 | J. Pharmacol. Exp. Ther. | pmid:7365689 |
Schlondorff D and Folkert VW | Prostaglandin synthesis in glomeruli from rats with unilateral ureteral obstruction. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369028 |
Van Praag D and Farber SJ | Prostaglandin biosynthesis in normal and ureteral obstructed rabbit kidney; formation of a novel metabolite. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369029 |
Viinikka L and Ylikorkala O | Measurement of thromboxane B2 in human plasma or serum by radioimmunoassay. | 1980 | Prostaglandins | pmid:7465865 |
Lagarde M et al. | Increase of platelet thromboxane A2 formation and of its plasmatic half-life in diabetes mellitus. | 1980 | Thromb. Res. | pmid:7466751 |