Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

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Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Fever D005334 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Glomerulonephritis D005921 35 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Burns D002056 34 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Uremia D014511 33 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Stroke D020521 32 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Hypothyroidism D007037 32 associated lipids
Proteinuria D011507 30 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Endometriosis D004715 29 associated lipids
Kidney Diseases D007674 29 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Endotoxemia D019446 27 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Angina Pectoris D000787 27 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Gastritis D005756 27 associated lipids
Nasal Polyps D009298 26 associated lipids
Ascites D001201 25 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Hyperemia D006940 25 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Cattle Diseases D002418 24 associated lipids
Fibrosis D005355 23 associated lipids
Pulmonary Edema D011654 23 associated lipids
Birth Weight D001724 23 associated lipids
Hypoxia D000860 23 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypersensitivity D006967 22 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Myocardial Infarction D009203 21 associated lipids
Anemia D000740 21 associated lipids
Helicobacter Infections D016481 21 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Myocardial Reperfusion Injury D015428 20 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Peptic Ulcer D010437 19 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Nephritis D009393 19 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

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Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Mizutani T et al. Effects of a thromboxane receptor antagonist (NT-126) and a thromboxane synthase inhibitor (OKY-O46) on protamine-induced circulatory changes in dogs. 2000 J. Cardiothorac. Vasc. Anesth. pmid:11139110
Alric L et al. Reactive oxygen intermediates and eicosanoid production by kupffer cells and infiltrated macrophages in acute and chronic liver injury induced in rats by CCl4. 2000 Inflamm. Res. pmid:11211921
Demasi M et al. Assay of cyclooxygenase-1 and 2 in human monocytes. 2000 Inflamm. Res. pmid:11211927
Yang G et al. Effects of prostaglandins and leukotrienes on hypoxic pulmonary vasoconstriction in rats. 2000 J. Tongji Med. Univ. pmid:11215045
Kitano T et al. Unwashed shed blood infusion causes deterioration in right ventricular function after coronary artery surgery. 2000 Anaesth Intensive Care pmid:11153289
Zeng W and Zhang M [Relationship between the alteration of 6-keto-PGF1 alpha and TXB2 in cervical mucus of patients with threatened preterm labor and the efficacy of magnesium sulfate treatment]. 2000 Hua Xi Yi Ke Da Xue Xue Bao pmid:12501615
Khan HH et al. Plasma CPU-86017 concentrations regarding suppression of ouabain-induced cardiac arrhythmias and decrease of heart rate in guinea pigs. 2000 Acta Pharmacol. Sin. pmid:11501061
Praticò D et al. Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis. 2000 Blood pmid:11090066
Heng W et al. [The role of platelet activation in the pathogenesis of asthma]. 2000 Zhonghua Jie He He Hu Xi Za Zhi pmid:11778515
Matsumoto H and Nakao T Elevated urinary excretion of thromboxane B2 in adults with minimal-change nephrotic syndrome. 2000 Clin. Nephrol. pmid:10661487
Leese PT et al. Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults: a randomized, controlled trial. 2000 J Clin Pharmacol pmid:10664917
Montini G et al. Renal glomerular response to the inhibition of prostaglandin E2 synthesis and protein loading after the relief of unilateral ureteropelvic junction obstruction. 2000 J. Urol. pmid:10647684
Chou TC et al. Mechanism of inhibition of platelet aggregation by HCL-31D. 2000 Eur. J. Pharmacol. pmid:10650152
Xu L et al. [Clinical and experimental study on effect of Chanbei Kechuanping in treating bronchial asthma]. 2000 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:11789166
Han G et al. [Inhibitory effect of panicoin on platelet activation and its mechanism]. 2000 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:11789213
Belton O et al. Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis. 2000 Circulation pmid:10952950
Sane S et al. Eicosapentaenoic acid reduces pulmonary edema in endotoxemic rats. 2000 J. Surg. Res. pmid:10945939
Jacobs C et al. 1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthase and aromatase. 2000 J. Med. Chem. pmid:10794700
Patrignani P et al. Effects of vitamin E supplementation on F(2)-isoprostane and thromboxane biosynthesis in healthy cigarette smokers. 2000 Circulation pmid:10920066
Nenci GG and Paliani U [Diabetes, coagulation and vascular events]. 2000 Recenti Prog Med pmid:10748654
Bailey SR et al. Actions and interactions of ADP, 5- HT, histamine and PAF on equine platelets. 2000 Res. Vet. Sci. pmid:10756136
Thomson M et al. Thromboxane-B(2) levels in serum of rabbits receiving a single intravenous dose of aqueous extract of garlic and onion. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11049697
Qu X et al. Selenium deficiency-induced alterations in the vascular system of the rat. 2000 Biol Trace Elem Res pmid:11051602
Rahman K and Billington D Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans. 2000 J. Nutr. pmid:11053504
De Somer F et al. Phosphorylcholine coating of extracorporeal circuits provides natural protection against blood activation by the material surface. 2000 Eur J Cardiothorac Surg pmid:11053824
Wang LL et al. Effects of MN-9202 on platelet aggregation, 5-HT release, TXB2 synthesis, and calcium mobilization in rabbit platelets in vitro. 2000 Acta Pharmacol. Sin. pmid:11360670
Naito Y et al. Increase in blood pressure with enhanced Na+, K+ -ATPase activity in stroke-prone spontaneously hypertensive rats after 4-weeks intake of rapeseed oil as the sole dietary fat. 2000 Pharmacol. Toxicol. pmid:11068856
Van Hecken A et al. Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers. 2000 J Clin Pharmacol pmid:11028250
Boyle JR et al. Endovascular AAA repair attenuates the inflammatory and renal responses associated with conventional surgery. 2000 J. Endovasc. Ther. pmid:11032254
De La Cruz JP et al. Antithrombotic potential of olive oil administration in rabbits with elevated cholesterol. 2000 Thromb. Res. pmid:11113274
Darlametsos IE et al. Effect of nifedipine in cyclosporine-induced nephrotoxicity in rats: roles of the thromboxane and endothelin systems. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090252
Cruz MA et al. Vascular reactivity to angiotensin II and eicosanoid production in the human placenta from term and preterm pregnancy. 2000 Gynecol. Obstet. Invest. pmid:11093047
Numminen H et al. The effect of acute ingestion of a large dose of alcohol on the hemostatic system and its circadian variation. 2000 Stroke pmid:10835443
Tsikas D et al. Solid- and liquid-phase extraction for the gas chromatographic-tandem mass spectrometric quantification of 2,3-dinor-thromboxane B2 and 2,3-dinor-6-oxo-prostaglandin F1 alpha in human urine. 2000 J Chromatogr A pmid:10941682
Cracowski JL et al. Human internal mammary artery contraction by isoprostaglandin f(2alpha) type-III [8-iso-prostaglandin F(2alpha)]. 2000 Eur. J. Pharmacol. pmid:10844110
Wang JS et al. Effect of strenuous arm exercise on oxidized-LDL-potentiated platelet activation in individuals with spinal cord injury. 2000 Thromb. Haemost. pmid:10928481
Thorwest M et al. Dietary fish oil reduces microvascular thrombosis in a porcine experimental model. 2000 Thromb. Res. pmid:10946095
McCann ME et al. Effect of intravenous infusion of omega-3 and omega-6 lipid emulsions on equine monocyte fatty acid composition and inflammatory mediator production in vitro. 2000 Shock pmid:10947170
Kamata K et al. Altered endothelium-dependent and -independent hyperpolarization and endothelium-dependent relaxation in carotid arteries isolated from streptozotocin-induced diabetic rats. 2000 Naunyn Schmiedebergs Arch. Pharmacol. pmid:10935533
Li JB et al. [A further research on physiopathological basis of "Liver Yang Forming Wind Syndrome"]. 2000 Hunan Yi Ke Da Xue Xue Bao pmid:12205996
Ohata T et al. Role of nitric oxide in a temperature dependent regulation of systemic vascular resistance in cardiopulmonary bypass. 2000 Eur J Cardiothorac Surg pmid:10973545
Togna GI et al. Cisplatin triggers platelet activation. 2000 Thromb. Res. pmid:10973681
Yuk DY et al. Antithrombotic and antiplatelet activities of 2-chloro-3-[4-(ethylcarboxy)-phenyl]-amino-1,4-naphthoquinone (NQ12), a newly synthesized 1,4-naphthoquinone derivative. 2000 Biochem. Pharmacol. pmid:10974210
Sabha M et al. Transdermal nicotine mimics the smoking-induced endothelial dysfunction. 2000 Clin. Pharmacol. Ther. pmid:10976548
van Haeringen NJ et al. Flurbiprofen and enantiomers in ophthalmic solution tested as inhibitors of prostanoid synthesis in human blood. 2000 J Ocul Pharmacol Ther pmid:10977130
WÅ‚odarczyk Z et al. Effects of pentoxifylline treatment on delayed graft function in cadaveric kidney recipients. 2000 Transplant. Proc. pmid:10995988
Moosig F et al. Opsonization of apoptotic neutrophils by anti-neutrophil cytoplasmic antibodies (ANCA) leads to enhanced uptake by macrophages and increased release of tumour necrosis factor-alpha (TNF-alpha). 2000 Clin. Exp. Immunol. pmid:11122261
de Jong CL et al. Maternal thromboxane and prostacyclin levels in relation to fetal birth weight. 2000 Eur. J. Obstet. Gynecol. Reprod. Biol. pmid:11000507
Jacoby RF et al. The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis. 2000 Cancer Res. pmid:11016626
Ogura Y et al. Chemoprevention of biliary carcinogenesis in syrian hamsters by the novel carboxamide derivative IS-741 after initiation with N-nitrosobis(2-oxopropyl)amine (BOP). 2000 Carcinogenesis pmid:10910946
Sugimoto KI et al. Delayed hypotensive effect of the thromboxane A2/prostaglandin H2 receptor antagonist S-1452 in spontaneously hypertensive rats. 2000 Clin. Exp. Pharmacol. Physiol. pmid:10901388
Wang Z et al. [Clinical and experimental study on treatment of bronchial asthma with pingchuan oral liquid]. 2000 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:11938808
Köfeler HC et al. Effect of cytochrome P-450 inhibitors econazole, bifonazole and clotrimazole on prostanoid formation. 2000 Br. J. Pharmacol. pmid:10903961
Yu K et al. [Clinical observation on treatment of pediatric intractable nephropathy with modified taohong siwu decoction]. 2000 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:11938829
Toft G et al. Intravenously and topically applied magnesium in the prevention of arterial thrombosis. 2000 Thromb. Res. pmid:10904104
Shi X et al. [Effects of Salvia miltiorrhiza compound injection on serum endothelin, prostaglandin I2/thromboxane A2 ratio alteration following myocardial ischemia-reperfusion in patients undergoing intracardiac surgery]. 2000 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:11938858
Giedrojć J et al. [Investigation of prostaglandins in supernatant of cultured monocytes]. 2000 Prz. Lek. pmid:10907365
Arakida Y et al. Effect of combined leukotriene D(4) and thromboxane A(2) receptor antagonist on mediator-controlled resistance in guinea pigs. 2000 Eur. J. Pharmacol. pmid:10969159
Okada S et al. Perfusion of the hypothalamic paraventricular nucleus with N-methyl-D-aspartate produces thromboxane A2 and centrally activates adrenomedullary outflow in rats. 2000 Neuroscience pmid:10717438
Zaitsu M et al. Ulinastatin, an elastase inhibitor, inhibits the increased mRNA expression of prostaglandin H2 synthase-type 2 in Kawasaki disease. 2000 J. Infect. Dis. pmid:10720537
De La Cruz JP et al. Effect of DT-TX 30, a combined thromboxane synthase inhibitor and thromboxane receptor antagonist, on retinal vascularity in experimental diabetes mellitus. 2000 Thromb. Res. pmid:10680643
Nagano K et al. Prostanoids regulate proliferation of vascular smooth muscle cells induced by arginine vasopressin. 2000 Eur. J. Pharmacol. pmid:10686292
Weber AA et al. 40 mg of aspirin are not sufficient to inhibit platelet function under conditions of limited compliance. 2000 Thromb. Res. pmid:10709913
Okumura M et al. Renal production of thromboxane and prostaglandins in a rat model of type 2 diabetes. 2000 Life Sci. pmid:10670825
Wu TM et al. Inhibitory effect of hexapeptide (RGRHGD) on platelet aggregation. 2000 Thromb. Res. pmid:10674405
Jacobi K et al. Plasma levels of eicosanoids after transfusion of intraoperatively salvaged blood. 2000 Vox Sang. pmid:10729809
Tegeder I et al. Effects of selective and unselective cyclooxygenase inhibitors on prostanoid release from various rat organs. 2000 J. Pharmacol. Exp. Ther. pmid:10688636
Rioja I et al. An anti-inflammatory ditriazine inhibiting leukocyte functions and expression of inducible nitric oxide synthase and cyclo-oxygenase-2. 2000 Eur. J. Pharmacol. pmid:10844115
Tran HS et al. The cardiovascular hemodynamics and leukotriene kinetics during prostacyclin and anti-prostacyclin antibody infusions in septic shock. 2000 Shock pmid:10847636
Maccarrone M et al. Activation of different lipoxygenase isozymes induces apoptosis in human erythroleukemia and neuroblastoma cells. 2000 Biochem. Biophys. Res. Commun. pmid:10833416
Gardan B et al. Vasoconstrictor effects of iso-prostaglandin F2alpha type-III (8-iso-prostaglandin F2alpha) on human saphenous veins. 2000 J. Cardiovasc. Pharmacol. pmid:10813374
Suntres ZE and Shek PN Prophylaxis against lipopolysaccharide-induced lung injuries by liposome-entrapped dexamethasone in rats. 2000 Biochem. Pharmacol. pmid:10704946
Ames PR et al. Antioxidant susceptibility of pathogenic pathways in subjects with antiphospholipid antibodies: a pilot study. 2000 Lupus pmid:11199924
Wang ZG et al. Can endothelial seeding enhance patency and inhibit neointimal hyperplasia? Experimental studies and clinical trial of endothelial seeded venous prostheses. 2000 Int Angiol pmid:11201596
MacKay RJ et al. Effect of eltenac in horses with induced endotoxaemia. 2000 Equine Vet J Suppl pmid:11202378
de la Riva IJ et al. Effect of oral L-arginine administration for three weeks in two kidney-two clip hypertensive rats. 2000 Arch. Physiol. Biochem. pmid:11262599
Cryer B et al. Effects of cutaneous aspirin on the human stomach and duodenum. 1999 Sep-Oct Proc. Assoc. Am. Physicians pmid:10519166
Stewart KG et al. Estrogen decreases prostaglandin H synthase products from endothelial cells. 1999 Nov-Dec J. Soc. Gynecol. Investig. pmid:10643586
Tong H et al. Prostaglandin endoperoxide synthase-2 abundance is increased in brain tissues of late-gestation fetal sheep in response to cerebral hypoperfusion. 1999 May-Jun J. Soc. Gynecol. Investig. pmid:10376268
Uriu K et al. Effect of acute thromboxane A2 inhibition on the renal hemodynamics in a spontaneously non-insulin-dependent diabetic rat, Otsuka Long-Evans Tokushima Fatty rat. 1999 Jul-Aug J. Diabetes Complicat. pmid:10616856
Pestana M et al. Kidney graft-infiltrating cells synthesize significantly higher amounts of prostaglandin E2 pre and during acute rejection. 1999 Feb-Mar Transplant. Proc. pmid:10083119
van den Dorpel MA et al. Beneficial effects of conversion from cyclosporine to azathioprine on fibrinolysis in renal transplant recipients. 1999 Feb-Mar Transplant. Proc. pmid:10083130
Pearl JM et al. Effect of modified ultrafiltration on plasma thromboxane B2, leukotriene B4, and endothelin-1 in infants undergoing cardiopulmonary bypass. 1999 Ann. Thorac. Surg. pmid:10543508
Chen G et al. [The effect of the molecular triggers of hemostatic activity on thrombosis in early stage of electrical injuries]. 1999 Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi pmid:11501103
Liguori A et al. Loop diuretics enhance the secretion of prostacyclin in vitro, in healthy persons, and in patients with chronic heart failure. 1999 Eur. J. Clin. Pharmacol. pmid:10335906
Davis KA et al. Prostanoids: early mediators in the secondary injury that develops after unilateral pulmonary contusion. 1999 J Trauma pmid:10338399
Ishihara S et al. Effects of long-term hemofiltration on circulating mediators and superoxide production during continuous endotoxin administration. 1999 J Trauma pmid:10338409
Tegeder I et al. Comparison of inhibitory effects of meloxicam and diclofenac on human thromboxane biosynthesis after single doses and at steady state. 1999 Clin. Pharmacol. Ther. pmid:10340919
Stanczyk FZ et al. Effect of oral contraceptives containing 20 and 35 micrograms ethinyl estradiol on urinary prostacyclin and thromboxane metabolite levels in smokers and nonsmokers. 1999 Contraception pmid:10342082
McAdam BF et al. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:9874808
Catella-Lawson F et al. Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids. 1999 J. Pharmacol. Exp. Ther. pmid:10215647
Holt S et al. Acute cholestasis-induced renal failure: effects of antioxidants and ligands for the thromboxane A2 receptor. 1999 Kidney Int. pmid:9893136
Fujimoto Y et al. Sphingomyelin inhibits platelet 12-lipoxygenase activity. 1999 Eur. J. Pharmacol. pmid:10478636
Yang SY and Gao ZX Determination and clinical significance of plasma levels of prostaglandins in patients with acute brain injury. 1999 Surg Neurol pmid:10511080
Gust R et al. Role of cyclooxygenase-2 in oleic acid-induced acute lung injury. 1999 Am. J. Respir. Crit. Care Med. pmid:10508803
Thakur V et al. Antihypertensive effect of the combination of fosinopril and HCTZ is resistant to interference by nonsteroidal antiinflammatory drugs. 1999 Am. J. Hypertens. pmid:10509552
Véricel E et al. The influence of low intake of n-3 fatty acids on platelets in elderly people. 1999 Atherosclerosis pmid:10525140
Davì G et al. In vivo formation of 8-iso-prostaglandin f2alpha and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation. 1999 Circulation pmid:9892587
Serebruany VL et al. Effects of a novel Mac-1 inhibitor, NPC 15669, on hemostatic parameters during preconditioned myocardial infarction. 1999 Life Sci. pmid:10530802
de Meijer A et al. Meloxicam, 15 mg/day, spares platelet function in healthy volunteers. 1999 Clin. Pharmacol. Ther. pmid:10546927